Research Departments & Organizations
Professor DeWan seeks to understand how variation in the human genome contributes to complex human diseases. Using high-throughput technologies, he conducts genome-wide association studies to map disease susceptibility loci. His work also emphasizes the development of methods that improve the way in which this information is interpreted and utilized by disease researchers. He is also interested in the role that the interaction between genetic and environmental factors plays on disease susceptibility. His past work mapping disease genes has led to the discovery of susceptibility loci for age-related macular degeneration, non-syndromic hearing loss, renal function and myopia. Current projects include a genetic study of childhood asthma in collaboration with the Yale Center for Perinatal, Pediatric and Environmental Epidemiology, a study of genetic susceptibility loci for sepsis in collaboration with investigators at the Norwegian University of Science and Technology and studies to identify genetic factors contributing to acute lymphoblastic leukemia and lung cancer.
Specialized Terms: Genetic epidemiology; Statistical genetics; Asthma; Sepsis; leukemia; lung cancer
Extensive Research Description
1R01HL116742, DeWan (PI) 01/15/13-12/31/18 (NCE)
“Family-specific genetic variants contributing to asthma susceptibility”
The goal is to use a family-based whole-exome sequencing strategy to identify family-specific variants segregating with asthma and study the distribution of functional variants across all known asthma genes.
R03CA219724, DeWan/Ma (MPI) 08/01/17 – 07/31/19
"Identification of microRNA variants associated with acute lymphoblastic leukemia"
The goal is to identify genetic variants in miRNAs and miRNA binding sites associated with acute lymphoblastic leukemia (ALL) by reanalyzing data from the largest study of the genetics of ALL to date.
Genome-wide association study in patients with bacterial bloodstream infections Trondheim, Norway (2012 - 2020)
The goal of this project is to conduct a genomewide association study of patients admitted to the hospital in Nord-Trondelag County, Norway with confirmed bacterial bloodstream infections (BSI) along with a set of controls drawn from the same source population to identify genetic variants...