Alia Bazzy-Asaad, MD

Associate Professor of Pediatrics (Respiratory); Director, Pediatric Asthma Care Team (PACT) and Pediatric Asthma Program; Medical Director, Pediatric Respiratory Care Unit

Research Departments & Organizations

Pediatrics: Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine

Office of Cooperative Research

Research Interests

Asthma; England; Pediatrics; Respiration Disorders; Respiratory Muscles

Research Summary

Our research interests have focused on trying to understand the role of respiratory muscle fatigue in the development of respiratory failure in children. In particular, studying sites along the neuromuscular axis that could potentially fail and lead to impaired performance of the respiratory muscles. Examples of these include phrenic neural activation, neuromuscular transmission and utilization of energy substrate by the muscle. We have determined that neuromuscular transmission failure plays an important in the development of muscle fatigue in the newborn diaphragm, and that this relates to impaired release of neurotransmitter from the nerve terminals. Because of the important role of calcium in neurotransmitter release, we are focusing on the differences between presynaptic calcium channels subtypes in newborn and mature neuromuscular junction.

A second research interest has been childhood asthma. We currently have 2 areas that are being developed in the laboratory. One is to try to understand the mechanisms underlying the development of chronic asthma in childhood, and in particular how airway inflammation might modulate airway smooth muscle function. We will be examining the effect of chronic exposure to several cytokines on ion channel activity in airway smooth muscle, and how this affects the contractile properties of the muscle. We are also interested in performing clinical studies to determine whether the increase in exhaled nitric oxide (NO) that is observed in children with asthma is secondary to increased production or decreased absorption of NO in the lungs. This has implications on understanding the pathogenesis of the inflammatory process in asthma.

Specialized Terms: Respiratory Muscle Fatigue in Children; Development of Chronic Asthma in Children; Pathogenesis of Inflammatory Process in Asthma

Clinical Trials

Conditions Study Title
Genetics - Adult, Genetics - Pediatric A Study Evaluating the Long Term Safety and Efficacy of VX-659 Combination Therapy

Activities

  • Asthma Causing Genes United Kingdom; United Kingdom (2008)

    Professor Bracken collaborates with colleagues at Oxford University in a study of the genes that may increase susceptibility to asthma development and severity in children.

Selected Publications

See list of PubMed publications

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Contact Info

Alia Bazzy-Asaad, MD
Office Location
Fitkin Memorial Pavilion
789 Howard Avenue, Ste Suite 510

New Haven, CT 06519
Mailing Address
Pediatric Pulmonology, Allergy, Immunology & Sleep MedicinePO Box 208064
New Haven, CT 06520-8064