Albert Sinusas, MD

Professor of Medicine (Cardiology); Director, Translational Research Imaging Center; Director, Cardiovascular Imaging

Research Departments & Organizations

Internal Medicine: Cardiovascular Medicine: Yale Translational Research Imaging Center (Y-TRIC)

Bioimaging Sciences

Clinical Radiology

Vascular Biology and Therapeutics Program

Office of Cooperative Research

Research Interests

Cardiology; Cardiovascular System; Echocardiography; Magnetic Resonance Imaging; Myocardial Perfusion Imaging; Positron-Emission Tomography; Tomography, Emission-Computed, Single-Photon; Translational Medical Research

Research Summary

My research is directed at development of noninvasive imaging approaches for the assessment of myocardial viability, angiogenesis, and post–infarction remodeling. This translational research employs the 3–D modalities of SPECT, PET, echocardiography and MR imaging for assessment of regional myocardial perfusion, function and metabolism, in an animal physiology laboratory, employing large and small animal models of myocardial ischemia and infarction, and peripheral arterial disease. My laboratory is currently focused on targeted molecular imaging, developing non–invasive nuclear imaging strategies for identifying the hypoxic stimulus for angiogenesis, and targeted imaging of selected integrins previously established to modulate the angiogenic process, and evaluation of the role of matrix metalloproteinases on post–infarction remodeling. The investigation of these biological processes involves, in vitro cellular and whole heart preparations, as well as ex vivo and in vivo imaging in both small and large animal models, using dedicated high–resolution and real–time 3D ultrasound imaging, hybrid SPECT–CT and PET–CT imaging, cardiac MR imaging, and fluorescent imaging systems.

Specialized Terms: Advanced cardiovascular and molecular imaging

Clinical Trials

Conditions Study Title
Diseases of the Cardiovascular System An International Study to Evaluate Diagnostic Efficacy of Flurpiridaz (18F) Injection PET MPI in the Detection of Coronary Artery Disease (CAD)
Diseases of the Cardiovascular System Empagliflozin in Heart Failure: Diuretic and Cardio-Renal Effects (EMPA)

Selected Publications

See list of PubMed publications

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