Research Departments & Organizations
Dr. Ko’s research centers on the health problems that have emerged as a consequence of rapid urbanization and social inequity. He coordinates a research and training program on urban slum health in Brazil and conducts prospective cohort studies on leptospirosis, dengue, meningitis and respiratory infections. His research combines multidisciplinary epidemiology, ecology and translational research-based approaches to identify prevention and control strategies that can be implemented in slum communities. More recently, Dr. Ko and his team has mobilized the public health research capacity at their site in the city of Salvador to investigate the on-going outbreak of Zika virus infection and microcephaly.
Specialized Terms: Urban slum health, Leptospirosis; Dengue; Bacterial meningitis; Vaccine preventable diseases; Zika viral infections
Extensive Research Description
- Disease determinants for urban leptospirosis
- Rapid serodiagnostic test for leptospirosis
- Natural history of urban leptospirosis
- Transmission of drug-resistant Streptococcus pneumoniae in Brazil
- Genome-level protein microarray serodiagnostic antigen discovery in leptospirosis
- Fogarty International Clinical Research Fellows Program: Burden of leptospirosis in slum communities
Zoonotic Disease and One Health Research Bangkok, Thailand (2015)
Emerging Infectious Diseases and Urbanization Salvador, Brazil (1995)
The Division of International Medicine and Infectious Disease, Weill Medical College of Cornell University (Cornell) has had a joint training and research program on endemic tropical diseases with Brazilian institutions in the city of Salvador since the 1964. More recently, the investigations of...
Cathelicidin Insufficiency in Patients with Fatal Leptospirosis.
Lindow JC, Wunder EA, Popper SJ, Min JN, Mannam P, Srivastava A, Yao Y, Hacker KP, Raddassi K, Lee PJ, Montgomery RR, Shaw AC, Hagan JE, Araújo GC, Nery N, Relman DA, Kim CC, Reis MG, Ko AI. Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. PLoS Pathogens 2016, 12:e1005943. 2016
Emergence of Congenital Zika Syndrome: Viewpoint From the Front Lines.
Costa F, Sarno M, Khouri R, de Paula Freitas B, Siqueira I, Ribeiro GS, Ribeiro HC, Campos GS, Alcântara LC, Reis MG, Weaver SC, Vasilakis N, Ko AI, Almeida AR. Emergence of Congenital Zika Syndrome: Viewpoint From the Front Lines. Annals Of Internal Medicine 2016, 164:689-91. 2016
Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil.
de Paula Freitas B, de Oliveira Dias JR, Prazeres J, Sacramento GA, Ko AI, Maia M, Belfort R. Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil. JAMA Ophthalmology 2016, 134:529-535. 2016
Spatiotemporal Determinants of Urban Leptospirosis Transmission: Four-Year Prospective Cohort Study of Slum Residents in Brazil.
Hagan JE, Moraga P, Costa F, Capian N, Ribeiro GS, Wunder EA, Felzemburgh RD, Reis RB, Nery N, Santana FS, Fraga D, Dos Santos BL, Santos AC, Queiroz A, Tassinari W, Carvalho MS, Reis MG, Diggle PJ, Ko AI. Spatiotemporal Determinants of Urban Leptospirosis Transmission: Four-Year Prospective Cohort Study of Slum Residents in Brazil. PLoS Neglected Tropical Diseases 2016, 10:e0004275. 2016
Global Morbidity and Mortality of Leptospirosis: A Systematic Review.
Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Neglected Tropical Diseases 2015, 9:e0003898. 2015
Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group.
Ko AI, Galvão Reis M, Ribeiro Dourado CM, Johnson WD, Riley LW. Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group. Lancet 1999, 354:820-5. 1999
Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region.
Rodriguez-Barraquer I, Costa F, Nascimento EJM, Nery N, Castanha PMS, Sacramento GA, Cruz J, Carvalho M, De Olivera D, Hagan JE, Adhikarla H, Wunder EA, Coêlho DF, Azar SR, Rossi SL, Vasilakis N, Weaver SC, Ribeiro GS, Balmaseda A, Harris E, Nogueira ML, Reis MG, Marques ETA, Cummings DAT, Ko AI. Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. Science (New York, N.Y.) 2019, 363:607-610. 2019