Alan Anticevic, PhD

Associate Professor of Psychiatry; Director, Division of Neurocognition, Neurocomputation, and Neurogenetics (N3), Psychiatry

Research Departments & Organizations

Psychiatry: Anticevic Lab | Center for the Translational Neuroscience of Alcoholism | Clinical Neuroscience Research Unit | Connecticut Mental Health Center | Neurocognition, Neurocomputation, and Neurogenetics, Division of | Neuroscience Research Training Program (NRTP) | Obsessive Compulsive Disorder Research Clinic | Psychology Section

Interdepartmental Neuroscience Program

Research Interests

Affect; Cognition; Computational Biology; Diagnosis, Computer-Assisted; Emotions; Memory, Short-Term; Mental Disorders; Neuroimaging; Schizophrenia; Substance-Related Disorders

Extensive Research Description

Our group's research focus is centered on computational and cognitive neuroscience of mental illness. Specifically, we study at the neural system level mechanisms involved in higher order cognitive operations, such as working memory, as well as their interaction with neural systems involved in affective processes, with the aim of understanding how these computations may go awry in the context of severe mental illness. Methodologically, we use use a combination of tools, such as task-based, resting-state, pharmacological multi-modal neuroimaging, as well as computational modeling approaches to map neural alterations that lead to poor mental health outcomes. The combination of these tools informs a quantitative and personalized 'Computational Psychiatry' framework for development of neuro-behavioral markers that can explicitly inform treatment. The overarching goal of the group is to develop neurobiologically principled and computationally grounded mapping between neural and behavioral levels of analyses in people to inform personalized and rational treatment design for mental health symptoms.


Specific Research Areas

  • Pharmacological Neuroimaging & Computational Modeling
  • Cognition-Affective Computations in Mental Illness
  • Mapping Neuro-behavioral Variation to Inform Mental Health Treatments
  • Computational Informatics Architectures for Multi-modal Imaging

Clinical Trials

Conditions Study Title
Diseases of the Nervous System, Mental Health & Behavioral Research Examination of Glutamate and mGluR5 in Psychiatric Disorders
Addictive Behaviors, Alcohol Addiction, Mental Health & Behavioral Research Saracatinib and Alcohol Drinking
Diseases of the Nervous System, Mental Health & Behavioral Research Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder

Activities

  • Applications of functional connectivity to the study of schizophrenia Chengdu, China (2013)

    This collaborative project with Dr. Gong Qiyong focuses on using functional connectivity and other neuroimaging modalities to better understand the neurobiology of schizophrenia.

  • Applications of functional connectivity to the study of 1st episode psychosis with Dr. Fei Wang China (2012)

    This collaborative project with Dr. Fei Wang focuses on applications of functional connectivity to the study of 1st episode psychosis and individuals during more chronic phases of the illness.

  • Simulation studies of global-based functional connectivity: dealing with individual variability in connectivity patterns Ljubljana, Slovenia (2010)

    Ongoing method development collaboration.

Selected Publications

See list of PubMed publications

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