Alan Anticevic, PhD

Assistant Professor of Psychiatry and of Psychology; Co-Director, Division of Neurocognition, Neurocomputation, and Neurogenetics (N3)

Research Departments & Organizations

Psychiatry: Anticevic Lab | Center for the Translational Neuroscience of Alcoholism | Clinical Neuroscience Research Unit | Connecticut Mental Health Center | Neurocognition, Neurocomputation, and Neurogenetics, Division of | Neuroscience Research Training Program (NRTP) | Obsessive Compulsive Disorder Research Clinic | Psychology Section

Interdepartmental Neuroscience Program

Research Interests

Affect; Cognition; Computational Biology; Diagnosis, Computer-Assisted; Emotions; Memory, Short-Term; Mental Disorders; Neuroimaging; Schizophrenia; Substance-Related Disorders

Extensive Research Description

Broadly, our group is interested in cognitive neuroscience of psychiatric illness. We seek to better understand, at the neural system level, the neural mechanisms behind cognitive and affective deficits in neuropsychiatric illness. Specifically, the research in our group focuses on understanding these processes in schizophrenia, bipolar illness and addiction. We use a combination of tools to better understand the neural systems involved in processing affective stimuli and their interaction with neural systems involved in goal-directed cognitive operations such as working memory. Methodologically, our lab harnesses the combination of task-based, resting-state, pharmacological functional neuroimaging, as well as computational modeling approaches to mechanistically understand neural circuit dysfunction in psychiatric disorders. Our experimental approaches depend on the combination of these tools to better understand the mechanistic links between neural circuit dysfunction and complex cognitive and affective processes and behaviors. The overarching objective of the lab is better understand the underlying neural circuit dysfunction in complex mental illness such as schizophrenia, with the aim of developing better neural markers and informing rationally-guided pharmacological treatments.

Research Areas

Area 1: Pharmacological Neuroimaging & Computational Modeling

Area 2: Cognition-Emotion Interactions in Psychiatric Illness

Area 3: Functional Connectivity & Individual Differences in Psychiatric Illness

Clinical Trials

Conditions Study Title
Diseases of the Nervous System, Mental Health & Behavioral Research Examination of Glutamate and mGluR5 in Psychiatric Disorders
Addictive Behaviors, Alcohol Addiction, Mental Health & Behavioral Research Saracatinib and Alcohol Drinking
Diseases of the Nervous System, Mental Health & Behavioral Research Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder

Activities

  • Applications of functional connectivity to the study of schizophrenia Chengdu, China (2013)

    This collaborative project with Dr. Gong Qiyong focuses on using functional connectivity and other neuroimaging modalities to better understand the neurobiology of schizophrenia.

  • Applications of functional connectivity to the study of 1st episode psychosis with Dr. Fei Wang China (2012)

    This collaborative project with Dr. Fei Wang focuses on applications of functional connectivity to the study of 1st episode psychosis and individuals during more chronic phases of the illness.

  • Simulation studies of global-based functional connectivity: dealing with individual variability in connectivity patterns Ljubljana, Slovenia (2010)

    Ongoing method development collaboration.

Selected Publications

See list of PubMed publications

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