Yunhua (Cindy) Bao, MD
Associate Research Scientist
Research & Publications
Biography
Locations
Research Summary
Modeling congenital muscular dystrophy via induced pluripotent stem cells.
Specialized Terms: iPSCs, ESCs; Differentiation; Patients; Myogenesis; Transgenic
Extensive Research Description
- My past work was to creating transgenic mouse models to study the prostate cell populations and characterize the adult stem cell in prostate epithelial cell compartment. My current project is to modeling congenital muscular dystrophy via induced pluripotent stem cells. We focus onX-linked myotubular myopathy (XLMTM), a severe form of CMDs. Although thedeletion or point mutation of MTM1gene has been implicated in the etiology of this disorder, to date itspathogenesis is poorly understood. Recent progress in our understandingof human induced pluripotent stem cells (iPSCs) opened a new avenue formodeling human diseases. This dynamic recapitulation of disease process willhelp gain insight into disease pathogenesis and might potentially aid infinding specific therapeutic interventions such as gene-based therapy. Inthis study we are aimed to generate the iPSCs from somatic cells of patientswith XLMTM as well as to induce differentiation of these patient specific iPSCsinto functional myocytes.
Research Interests
Muscular Dystrophies; Neurobiology; Muscle Development; Induced Pluripotent Stem Cells
Research Image
IMG_2203
Selected Publications
- Epithelial cell-targeted transgene expression enables isolation of cyan fluorescent protein (CFP)-expressing prostate stem/progenitor cellsPeng W, Bao Y, Sawicki JA. Epithelial cell-targeted transgene expression enables isolation of cyan fluorescent protein (CFP)-expressing prostate stem/progenitor cells Transgenic Research 2011, 20: 1073-1086. PMID: 21222155, PMCID: PMC3090697, DOI: 10.1007/s11248-010-9478-2.
- Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasisHuang YH, Bao Y, Peng W, Goldberg M, Love K, Bumcrot DA, Cole G, Langer R, Anderson DG, Sawicki JA. Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 3426-3430. PMID: 19208807, PMCID: PMC2651300, DOI: 10.1073/pnas.0813348106.
- Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumorsPeng W, Anderson DG, Bao Y, Padera RF, Langer R, Sawicki JA. Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors The Prostate 2007, 67: 855-862. PMID: 17427200, DOI: 10.1002/pros.20576.
- Human coxsackie adenovirus receptor (CAR) expression in transgenic mouse prostate tumors enhances adenoviral delivery of genesBao Y, Peng W, Verbitsky A, Chen J, Wu L, Rauen KA, Sawicki JA. Human coxsackie adenovirus receptor (CAR) expression in transgenic mouse prostate tumors enhances adenoviral delivery of genes The Prostate 2005, 64: 401-407. PMID: 15761871, DOI: 10.1002/pros.20265.
- 1. Bao Y, Huttner AJ. Modeling neurogenetic disorders via induced pluripotent stem cells - a novel alternative for pathology. Modern Pathology 2011; 24 (suppl 1):390A1. Bao Y, Huttner AJ. Modeling neurogenetic disorders via induced pluripotent stem cells - a novel alternative for pathology. Modern Pathology 2011; 24 (suppl 1):390A