Skip to Main Content

Young Choi, MD

Professor Emeritus of Pathology; Director, Bridgeport Hospital Clinical Laboratories

Research Summary

One of the major treatment tools for breast cancer is antiestrogen treatment against estrogen Receptor-alpha (ERa) and it is the accepted therapeutic prognostic marker to predict the response of an individual breast cancer to antiestrogen therapy. However, approximately 50% of ERa positive breast cancers are de novo resistant to selective estrogen receptor modulators (SERMs) and many breast cancers acquire tamoxifen (Tam) resistance during progression due to de novo and acquired resistance to tamoxifen and seriously limit the efficacy of this treatment. The reasons for this lack of response are poorly understood. One of the mechanisms may be related to the second receptor ER-beta. I am pursuing the receptor to determine a possible targeted therapy for breast cancer.

Specialized Terms: Immunopathology; Molecular Pathology; Cytopathology and Clinical Pathology; Breast Cancer;

Extensive Research Description

Currently, ERa is the main therapeutic and prognostic marker for breast cancer but about 30% do not respond to the antiestrogens. Some studies have shown that ERb isoforms are predictive marker to antiestrogens. ERb isoforms also are significantly expressed in ERa negative tumors. Thus, ERb may be the potential targeted therapy in some ERa and ERa negative breast cancers. ERb isoforms mRNA by qPCR and protein expression by immunohistochemistry will be tested in both ERa positive and ERa negative breast cancer tissues, and also breast cancer cell lines (BCC). Then BCC will be subjected to estrogens and different antiestrogens to determine their responses, and their effects and analyzed for their potential therapeutic effects. We hypothesize that ERß will eventually play an important role in controlling growth of breast cancers. We believe that ERb isoforms may be new potential therapeutic targets to the patients with non-responder to the current available ERa targeted antiestrogen therapy, and also ERa negative breast cancers who have not received the benefit of the current antiestrogen therapy.

Coauthors

Research Interests

Breast Neoplasms; Pathology; Medical Laboratory Science; Selective Estrogen Receptor Modulators; Estrogen Receptor alpha

Selected Publications

  • Evidence-based medical practice and the outcomes of education.ChoiY, Krause L. Evidence-based medical practice and the outcomes of education. Modern Pathol 2011; 24:129A
  • ERß1, AIB-1 and TIF-2 expression in breast cancer-associated myofibroblasts.Choi Y. ERß1, AIB-1 and TIF-2 expression in breast cancer-associated myofibroblasts. Modern Pathol 2010; 23:40A.
  • Tissue –specific expression of estrogen receptor-ß wild type and its isoforms.Choi Y. Tissue –specific expression of estrogen receptor-ß wild type and its isoforms. Arch Pathol Lab Med 2009; 133:1632.
  • Diets and growth factors in breast cancer.Choi Y. Diets and growth factors in breast cancer. J of KAMA 2003, 9:27-34
  • Co-expression of ER-alpha and beta and over-expression of ER-beta in recurrent and metastatic breast cancer.Choi Y. Co-expression of ER-alpha and beta and over-expression of ER-beta in recurrent and metastatic breast cancer. Lab Investigation 2004 84:26A.