Yong Zhu, PhD
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Research Summary
Dr. Zhu's research interests are oriented towards the use of the molecular epidemiological approach in the study of genetic susceptibility biomarkers and their interactions with environmental exposures in human disease development. Dr. Zhu has been developing and validating novel phenotypic and genotypic assays and biomarkers for several cancer types, including non-Hodgkin's Lymphoma, breast, bladder, lung and prostate cancer. By utilizing various techniques in genetics, epigenetics, cytogenetics, cell biology, and computational biology, my studies have identified biomarkers that can characterize inherited predisposition and cellular response to environmental factors. Current research focuses on studying the role of two transcriptional factors, circadian genes and microRNAs, in tumorigenesis.
Specialized Terms:Circadian genes; MicroRNAs; Shift-work; Breast Cancer; Lymphoma; Prostate Cancer
Extensive Research Description
- Molecular Epidemiology of Circadian Genes and Human Cancers
- Molecular Epidemiology of Methylation-related Genes and Human Cancers
- Molecular Epidemiology of Micro-RNA and Human Cancers
Coauthors
Research Interests
Breast Neoplasms; Environmental Health; Genetics, Medical; Public Health; Testicular Neoplasms; Molecular Epidemiology
Public Health Interests
Cancer; Environmental Health; Genetics, Genomics, Epigenetics
Selected Publications
- Period3 structural variation: a circadian biomarker associated with breast cancer in young women.Zhu Y, Brown HN, Zhang Y, Stevens RG, Zheng T. Period3 structural variation: a circadian biomarker associated with breast cancer in young women. Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology 2005, 14: 268-70 PubMed ID: 15668506.
- An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology.Zhu Y, Spitz MR, Amos CI, Lin J, Schabath MB, Wu X. An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology. Cancer Research 2004, 64: 2251-7 PubMed ID: 15026370, DOI: 10.1158/0008-5472.can-03-2800.
- Does "clock" matter in prostate cancer?Zhu Y, Zheng T, Stevens RG, Zhang Y, Boyle P. Does "clock" matter in prostate cancer? Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology 2006, 15: 3-5 PubMed ID: 16434577, PMCID: PMC2366206, DOI: 10.1158/1055-9965.EPI-05-0631.
- microRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis.Hoffman AE, Zheng T, Yi C, Leaderer D, Weidhaas J, Slack F, Zhang Y, Paranjape T, Zhu Y. microRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis. Cancer Research 2009, 69: 5970-7 PubMed ID: 19567675, PMCID: PMC2716085, DOI: 10.1158/0008-5472.CAN-09-0236.
- Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis.Yi CH, Zheng T, Leaderer D, Hoffman A, Zhu Y. Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis. Cancer Letters 2009, 284: 149-56 PubMed ID: 19457610, PMCID: PMC3182267, DOI: 10.1016/j.canlet.2009.04.017.
- Clock-cancer connection in non-Hodgkin's lymphoma: a genetic association study and pathway analysis of the circadian gene cryptochrome 2.Hoffman AE, Zheng T, Stevens RG, Ba Y, Zhang Y, Leaderer D, Yi C, Holford TR, Zhu Y. Clock-cancer connection in non-Hodgkin's lymphoma: a genetic association study and pathway analysis of the circadian gene cryptochrome 2. Cancer Research 2009, 69: 3605-13 PubMed ID: 19318546, PMCID: PMC3175639, DOI: 10.1158/0008-5472.CAN-08-4572.