Yingke Xu, PhD

• Derek Toomre
• Dianqing (Dan) Wu
• Hongying Shen
• James Duncan
• Jiasheng Zhang
• Jonathan Bogan
• Liang Liang
• Thomas Melia
• Titus Boggon
• Wang Min

Biophysics; Cell Biology; Microscopy; Membrane Transport Proteins; Optogenetics

• Phospholipase D as a key modulator of cancer progression.Yao Y, Wang X, Li H, Fan J, Qian X, Li H, Xu Y. Phospholipase D as a key modulator of cancer progression. Biological Reviews Of The Cambridge Philosophical Society 2020, 95: 911-935 PubMed ID: 32073216, DOI: 10.1111/brv.12592.
• Deep learning enables structured illumination microscopy with low light levels and enhanced speed.Jin L, Liu B, Zhao F, Hahn S, Dong B, Song R, Elston TC, Xu Y, Hahn KM. Deep learning enables structured illumination microscopy with low light levels and enhanced speed. Nature Communications 2020, 11: 1934 PubMed ID: 32321916, PMCID: PMC7176720, DOI: 10.1038/s41467-020-15784-x.
• Proximity proteomics identifies novel function of Rab14 in trafficking of Ebola virus matrix protein VP40.Fan J, Liu X, Mao F, Yue X, Lee I, Xu Y. Proximity proteomics identifies novel function of Rab14 in trafficking of Ebola virus matrix protein VP40. Biochemical And Biophysical Research Communications 2020, 527: 387-392 PubMed ID: 32327259, DOI: 10.1016/j.bbrc.2020.04.041.
• The PI(4)P phosphatase Sac2 controls insulin granule docking and release.Nguyen PM, Gandasi NR, Xie B, Sugahara S, Xu Y, Idevall-Hagren O. The PI(4)P phosphatase Sac2 controls insulin granule docking and release. The Journal Of Cell Biology 2019, 218: 3714-3729 PubMed ID: 31533953, PMCID: PMC6829663, DOI: 10.1083/jcb.201903121.
• Simultaneous Two-Angle Axial Ratiometry for Fast Live and Long-Term Three-Dimensional Super-Resolution Fluorescence Imaging.Liu W, Kuang C, Yuan Y, Zhang Z, Chen Y, Han Y, Xu L, Zhang M, Zhang YH, Xu Y, Liu X. Simultaneous Two-Angle Axial Ratiometry for Fast Live and Long-Term Three-Dimensional Super-Resolution Fluorescence Imaging. The Journal Of Physical Chemistry Letters 2019, 10: 7811-7816 PubMed ID: 31804831, DOI: 10.1021/acs.jpclett.9b03093.
• Sec3 knockdown inhibits TGF-β induced epithelial-mesenchymal transition through the down-regulation of Akt phosphorylation in A549 cells.Qian X, Zhou X, Shentu P, Yao Y, Jiao D, Chen Q, Zhou J, Xu Y. Sec3 knockdown inhibits TGF-β induced epithelial-mesenchymal transition through the down-regulation of Akt phosphorylation in A549 cells. Biochemical And Biophysical Research Communications 2019, 519: 253-260 PubMed ID: 31495494, DOI: 10.1016/j.bbrc.2019.08.145.
• Three-dimensional super-resolved live cell imaging through polarized multi-angle TIRF.Zheng C, Zhao G, Liu W, Chen Y, Zhang Z, Jin L, Xu Y, Kuang C, Liu X. Three-dimensional super-resolved live cell imaging through polarized multi-angle TIRF. Optics Letters 2018, 43: 1423-1426 PubMed ID: 29600995, DOI: 10.1364/OL.43.001423.
• Optogenetic control of epithelial-mesenchymal transition in cancer cells.Zhou X, Wang J, Chen J, Qi Y, Di Nan, Jin L, Qian X, Wang X, Chen Q, Liu X, Xu Y. Optogenetic control of epithelial-mesenchymal transition in cancer cells. Scientific Reports 2018, 8: 14098 PubMed ID: 30237527, PMCID: PMC6147862, DOI: 10.1038/s41598-018-32539-3.
• Inverse matrix based phase estimation algorithm for structured illumination microscopy.Cao R, Chen Y, Liu W, Zhu D, Kuang C, Xu Y, Liu X. Inverse matrix based phase estimation algorithm for structured illumination microscopy. Biomedical Optics Express 2018, 9: 5037-5051 PubMed ID: 30319920, PMCID: PMC6179402, DOI: 10.1364/BOE.9.005037.
• Multi-color live-cell super-resolution volume imaging with multi-angle interference microscopy.Chen Y, Liu W, Zhang Z, Zheng C, Huang Y, Cao R, Zhu D, Xu L, Zhang M, Zhang YH, Fan J, Jin L, Xu Y, Kuang C, Liu X. Multi-color live-cell super-resolution volume imaging with multi-angle interference microscopy. Nature Communications 2018, 9: 4818 PubMed ID: 30446673, PMCID: PMC6240104, DOI: 10.1038/s41467-018-07244-4.
• Excess cholesterol inhibits glucose-stimulated fusion pore dynamics in insulin exocytosis.Xu Y, Toomre DK, Bogan JS, Hao M. Excess cholesterol inhibits glucose-stimulated fusion pore dynamics in insulin exocytosis. Journal Of Cellular And Molecular Medicine 2017, 21: 2950-2962 PubMed ID: 28544529, PMCID: PMC5661106, DOI: 10.1111/jcmm.13207.
• Differential requirement for N-ethylmaleimide-sensitive factor in endosomal trafficking of transferrin receptor from anterograde trafficking of vesicular stomatitis virus glycoprotein G.Fan J, Zhou X, Wang Y, Kuang C, Sun Y, Liu X, Toomre D, Xu Y. Differential requirement for N-ethylmaleimide-sensitive factor in endosomal trafficking of transferrin receptor from anterograde trafficking of vesicular stomatitis virus glycoprotein G. FEBS Letters 2017, 591: 273-281 PubMed ID: 27995606, DOI: 10.1002/1873-3468.12532.
• Rab8A regulates insulin-stimulated GLUT4 translocation in C2C12 myoblasts.Li H, Ou L, Fan J, Xiao M, Kuang C, Liu X, Sun Y, Xu Y. Rab8A regulates insulin-stimulated GLUT4 translocation in C2C12 myoblasts. FEBS Letters 2017, 591: 491-499 PubMed ID: 28079283, DOI: 10.1002/1873-3468.12555.
• Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis.Zhou X, Shentu P, Xu Y. Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis. Journal Of Diabetes Research 2017, 2017: 1683678 PubMed ID: 28529958, PMCID: PMC5424486, DOI: 10.1155/2017/1683678.
• A Hierarchical Convolutional Neural Network for vesicle fusion event classification.Li H, Mao Y, Yin Z, Xu Y. A Hierarchical Convolutional Neural Network for vesicle fusion event classification. Computerized Medical Imaging And Graphics : The Official Journal Of The Computerized Medical Imaging Society 2017, 60: 22-34 PubMed ID: 28669577, DOI: 10.1016/j.compmedimag.2017.04.003.
• Silver Nanowires for Reconfigurable Bloch Surface Waves.Zhang D, Wang R, Xiang Y, Kuai Y, Kuang C, Badugu R, Xu Y, Wang P, Ming H, Liu X, Lakowicz JR. Silver Nanowires for Reconfigurable Bloch Surface Waves. ACS Nano 2017, 11: 10446-10451 PubMed ID: 28921957, PMCID: PMC5656513, DOI: 10.1021/acsnano.7b05638.
• Fluorescent Nanowire Ring Illumination for Wide-Field Far-Field Subdiffraction Imaging.Liu X, Kuang C, Hao X, Pang C, Xu P, Li H, Liu Y, Yu C, Xu Y, Nan D, Shen W, Fang Y, He L, Liu X, Yang Q. Fluorescent Nanowire Ring Illumination for Wide-Field Far-Field Subdiffraction Imaging. Physical Review Letters 2017, 118: 076101 PubMed ID: 28256876, DOI: 10.1103/PhysRevLett.118.076101.
• Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action.Xu Y, Nan D, Fan J, Bogan JS, Toomre D. Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action. Journal Of Cell Science 2016, 129: 2085-95 PubMed ID: 27076519, PMCID: PMC4878990, DOI: 10.1242/jcs.174805.
• Transport Mechanisms of Solid Lipid Nanoparticles across Caco-2 Cell Monolayers and their Related Cytotoxicology.Chai GH, Xu Y, Chen SQ, Cheng B, Hu FQ, You J, Du YZ, Yuan H. Transport Mechanisms of Solid Lipid Nanoparticles across Caco-2 Cell Monolayers and their Related Cytotoxicology. ACS Applied Materials & Interfaces 2016, 8: 5929-40 PubMed ID: 26860241, DOI: 10.1021/acsami.6b00821.
• Virtual k-Space Modulation Optical Microscopy.Kuang C, Ma Y, Zhou R, Zheng G, Fang Y, Xu Y, Liu X, So PT. Virtual k-Space Modulation Optical Microscopy. Physical Review Letters 2016, 117: 028102 PubMed ID: 27447529, PMCID: PMC5548665, DOI: 10.1103/PhysRevLett.117.028102.
• Objective comparison of particle tracking methods.Chenouard N, Smal I, de Chaumont F, Maška M, Sbalzarini IF, Gong Y, Cardinale J, Carthel C, Coraluppi S, Winter M, Cohen AR, Godinez WJ, Rohr K, Kalaidzidis Y, Liang L, Duncan J, Shen H, Xu Y, Magnusson KE, Jaldén J, Blau HM, Paul-Gilloteaux P, Roudot P, Kervrann C, Waharte F, Tinevez JY, Shorte SL, Willemse J, Celler K, van Wezel GP, Dan HW, Tsai YS, Ortiz de Solórzano C, Olivo-Marin JC, Meijering E. Objective comparison of particle tracking methods. Nature Methods 2014, 11: 281-9 PubMed ID: 24441936, PMCID: PMC4131736, DOI: 10.1038/nmeth.2808.
• A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.Zhang Y, Tang W, Zhang H, Niu X, Xu Y, Zhang J, Gao K, Pan W, Boggon TJ, Toomre D, Min W, Wu D. A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils. Developmental Cell 2013, 27: 215-226 PubMed ID: 24176643, PMCID: PMC3834565, DOI: 10.1016/j.devcel.2013.09.021.
• Cholesterol accumulation increases insulin granule size and impairs membrane trafficking.Bogan JS, Xu Y, Hao M. Cholesterol accumulation increases insulin granule size and impairs membrane trafficking. Traffic (Copenhagen, Denmark) 2012, 13: 1466-80 PubMed ID: 22889194, PMCID: PMC3465494, DOI: 10.1111/j.1600-0854.2012.01407.x.
• Dual-mode of insulin action controls GLUT4 vesicle exocytosis.Xu Y, Rubin BR, Orme CM, Karpikov A, Yu C, Bogan JS, Toomre DK. Dual-mode of insulin action controls GLUT4 vesicle exocytosis. The Journal Of Cell Biology 2011, 193: 643-53 PubMed ID: 21555461, PMCID: PMC3166865, DOI: 10.1083/jcb.201008135.
• Using light to see and control membrane traffic.Xu Y, Melia TJ, Toomre DK. Using light to see and control membrane traffic. Current Opinion In Chemical Biology 2011, 15: 822-30 PubMed ID: 22079055, DOI: 10.1016/j.cbpa.2011.10.016.
• Bi-directional transport of GLUT4 vesicles near the plasma membrane of primary rat adipocytes.Xu YK, Xu KD, Li JY, Feng LQ, Lang D, Zheng XX. Bi-directional transport of GLUT4 vesicles near the plasma membrane of primary rat adipocytes. Biochemical And Biophysical Research Communications 2007, 359: 121-8 PubMed ID: 17532293, DOI: 10.1016/j.bbrc.2007.05.075.