Yi-Hwa Liu, PhD
Senior Research Scientist in Medicine (Cardiology); Associate Director of Cardiovascular Nuclear Imaging Core Laboratory, Internal Medicine (Cardiovascular Medicine)
Research & Publications
Biography
News
Research Summary
My primary research has been focused on new developments of automatic quantification and iterative image restoration and reconstruction methods for nuclear cardiac tomographic imaging. The new developments promise to improve image resolution and enhance detection of abnormalities of myocardial perfusion and left ventricular function. My recent work is focused on small animal imaging techniques using hybrid coded aperture collimation, and developments of “hot-spot” quantification methods for molecular targeted cardiac images using innovative stochastic methodology incorporated with dual-isotope SPECT and hybrid SPECT/CT imaging techniques. I have been also directing a developmental project for remote reading/processing tools for nuclear cardiac imaging using secured cloud computing technology.
Specialized Terms: Nuclear Cardiac Imaging
Coauthors
Research Interests
Cardiology; Nuclear Medicine; Ventricular Function, Left; Myocardial Perfusion Imaging
Selected Publications
- New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: methodology and validation.Liu YH, Sinusas AJ, Khaimov D, Gebuza BI, Wackers FJ. New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: methodology and validation. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2005, 12: 55-65. PMID: 15682366, DOI: 10.1016/j.nuclcard.2004.09.015.
- A new method for SPECT quantification of targeted radiotracers uptake in the myocardium.Li S, Dobrucki LW, Sinusas AJ, Liu YH. A new method for SPECT quantification of targeted radiotracers uptake in the myocardium. Medical Image Computing And Computer-assisted Intervention : MICCAI ... International Conference On Medical Image Computing And Computer-Assisted Intervention 2005, 8: 684-91. PMID: 16686019, DOI: 10.1007/11566489_84.
- Aperture collimation correction and maximum-likelihood image reconstruction for near-field coded aperture imaging of single photon emission computerized tomography.Mu Z, Liu YH. Aperture collimation correction and maximum-likelihood image reconstruction for near-field coded aperture imaging of single photon emission computerized tomography. IEEE Transactions On Medical Imaging 2006, 25: 701-11. PMID: 16768235, DOI: 10.1109/tmi.2006.873298.
- Quantification of nuclear cardiac images: the Yale approach.Liu YH. Quantification of nuclear cardiac images: the Yale approach. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2007, 14: 483-91. PMID: 17679055, DOI: 10.1016/j.nuclcard.2007.06.005.
- A novel three-dimensional image reconstruction method for near-field coded aperture single photon emission computerized tomography.Mu Z, Hong B, Li S, Liu YH. A novel three-dimensional image reconstruction method for near-field coded aperture single photon emission computerized tomography. Medical Physics 2009, 36: 1533-42. PMID: 19544769, PMCID: PMC2832028, DOI: 10.1118/1.3103490.
- Accuracy and reproducibility of absolute quantification of myocardial focal tracer uptake from molecularly targeted SPECT/CT: a canine validation.Liu YH, Sahul Z, Weyman CA, Dione DP, Dobrucki WL, Mekkaoui C, Brennan MP, Ryder WJ, Sinusas AJ. Accuracy and reproducibility of absolute quantification of myocardial focal tracer uptake from molecularly targeted SPECT/CT: a canine validation. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2011, 52: 453-60. PMID: 21321271, PMCID: PMC3137905, DOI: 10.2967/jnumed.110.082214.
- New approach to quantification of molecularly targeted radiotracer uptake from hybrid cardiac SPECT/CT: methodology and validation.Li S, Sinusas AJ, Dobrucki LW, Liu YH. New approach to quantification of molecularly targeted radiotracer uptake from hybrid cardiac SPECT/CT: methodology and validation. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2013, 54: 2175-81. PMID: 24221992, DOI: 10.2967/jnumed.113.123208.
- High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function.Palyo RJ, Sinusas A, Liu YH. High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2016, 57: 893-9. PMID: 26848173, DOI: 10.2967/jnumed.115.164632.
- SPECT Imaging of 2-D and 3-D Distributed Sources with Near-Field Coded Aperture Collimation: Computer Simulation and Real Data Validation.Mu Z, Dobrucki LW, Liu YH. SPECT Imaging of 2-D and 3-D Distributed Sources with Near-Field Coded Aperture Collimation: Computer Simulation and Real Data Validation. Journal Of Medical And Biological Engineering 2016, 36: 32-43. PMID: 27069461, PMCID: PMC4791458, DOI: 10.1007/s40846-016-0111-6.
- A blind deconvolution method incorporated with anatomical-based filtering for partial volume correction: Validations with 123 I-mIBG cardiac SPECT/CT.Wu J, Liu H, Hashemi Zonouz T, Sandoval VM, Mohy-Ud-Din H, Lampert RJ, Sinusas AJ, Liu C, Liu YH. A blind deconvolution method incorporated with anatomical-based filtering for partial volume correction: Validations with 123 I-mIBG cardiac SPECT/CT. Medical Physics 2017, 44: 6435-6446. PMID: 28994458, DOI: 10.1002/mp.12622.
- Quantification and Determination of Normal 123I-Meta Iodobenzylguanidine Heart-to-Mediastinum Ratio (HMR) from Cardiac SPECT/CT and Correlation with Planar HMR.Alvi R, Miller EJ, Hashemi Zonouz T, Sandoval V, Tariq N, Lampert R, Sinusas AJ, Liu YH. Quantification and Determination of Normal 123I-Meta Iodobenzylguanidine Heart-to-Mediastinum Ratio (HMR) from Cardiac SPECT/CT and Correlation with Planar HMR. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2018, 59: 652-658. PMID: 28916622, DOI: 10.2967/jnumed.117.197152.
- A new approach to quantification of end-diastolic volume and ejection fraction from SPECT equilibrium radionuclide angiocardiography: methodology and phantom validation.Hashemi-Zonouz T, Wu J, Sandoval V, Allahverdi SH, Fazzone-Chettiar R, Liu Y-H. A new approach to quantification of end-diastolic volume and ejection fraction from SPECT equilibrium radionuclide angiocardiography: methodology and phantom validation. J Med Biol Eng 2019; 39:393-402.
- Cardiovascular ImagingYi-Hwa Liu and Frans J.Th Wackers, CRC Press, Taylor & Francis Group, London, UK, 2011(ISBN: 978-1-84076-109-2).
- Hybrid Imaging in Cardioavascular MedicineYi-Hwa Liu and Albert J. Sinusas, CRC Press, Taylor & Francis Group, London, UK, 2017 (ISBN: 978-1-4665-9537-8).
- A robust segmentation method with triple-factor non-negative matrix factorization for myocardial blood flow quantification from dynamic 82 Rb positron emission tomography.Liu H, Wu J, Sun JY, Wu TH, Ramesh FC, Thorn S, Sinusas AJ, Liu YH. A robust segmentation method with triple-factor non-negative matrix factorization for myocardial blood flow quantification from dynamic 82 Rb positron emission tomography. Medical Physics 2019, 46: 5002-5013. PMID: 31444909, DOI: 10.1002/mp.13783.
- Deep learning-based attenuation map generation for myocardial perfusion SPECT.Shi L, Onofrey JA, Liu H, Liu YH, Liu C. Deep learning-based attenuation map generation for myocardial perfusion SPECT. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 47: 2383-2395. PMID: 32219492, DOI: 10.1007/s00259-020-04746-6.
- Quantification of myocardial blood flow (MBF) and reserve (MFR) incorporated with a novel segmentation approach: Assessments of quantitative precision and the lower limit of normal MBF and MFR in patients.Liu H, Thorn S, Wu J, Fazzone-Chettiar R, Sandoval V, Miller EJ, Sinusas AJ, Liu YH. Quantification of myocardial blood flow (MBF) and reserve (MFR) incorporated with a novel segmentation approach: Assessments of quantitative precision and the lower limit of normal MBF and MFR in patients. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021, 28: 1236-1248. PMID: 32715416, DOI: 10.1007/s12350-020-02278-y.
- Noise reduction with cross-tracer and cross-protocol deep transfer learning for low-dose PET.Liu H, Wu J, Lu W, Onofrey JA, Liu YH, Liu C. Noise reduction with cross-tracer and cross-protocol deep transfer learning for low-dose PET. Physics In Medicine And Biology 2020, 65: 185006. PMID: 32924973, DOI: 10.1088/1361-6560/abae08.
- Anger recall mental stress decreases 123I-metaiodobenzylguanidine (123I-MIBG) uptake and increases heterogeneity of cardiac sympathetic activity in the myocardium in patients with ischemic cardiomyopathy.Avendaño R, Hashemi-Zonouz T, Sandoval V, Liu C, Burg M, Sinusas AJ, Lampert R, Liu YH. Anger recall mental stress decreases 123I-metaiodobenzylguanidine (123I-MIBG) uptake and increases heterogeneity of cardiac sympathetic activity in the myocardium in patients with ischemic cardiomyopathy. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2022, 29: 798-809. PMID: 33034036, DOI: 10.1007/s12350-020-02372-1.
- Diagnostic accuracy of stress-only myocardial perfusion SPECT improved by deep learning.Liu H, Wu J, Miller EJ, Liu C, Yaqiang, Liu, Liu YH. Diagnostic accuracy of stress-only myocardial perfusion SPECT improved by deep learning. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 48: 2793-2800. PMID: 33511425, DOI: 10.1007/s00259-021-05202-9.
- Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis.Feher A, Boutagy NE, Oikonomou EK, Thorn S, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis. The Journal Of Rheumatology 2021, 48: 1574-1582. PMID: 34266986, DOI: 10.3899/jrheum.210040.
- Association Between Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography Imaging and Adverse Events in Patients With Autoimmune Rheumatic Disease.Feher A, Boutagy NE, Oikonomou EK, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. Association Between Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography Imaging and Adverse Events in Patients With Autoimmune Rheumatic Disease. Circulation. Cardiovascular Imaging 2021, 14: e012208. PMID: 34503339, PMCID: PMC8475774, DOI: 10.1161/CIRCIMAGING.120.012208.
- Post-reconstruction attenuation correction for SPECT myocardium perfusion imaging facilitated by deep learning-based attenuation map generation.Liu H, Wu J, Shi L, Liu Y, Miller E, Sinusas A, Liu YH, Liu C. Post-reconstruction attenuation correction for SPECT myocardium perfusion imaging facilitated by deep learning-based attenuation map generation. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021 PMID: 34671940, DOI: 10.1007/s12350-021-02817-1.
- Direct and indirect strategies of deep-learning-based attenuation correction for general purpose and dedicated cardiac SPECT.Chen X, Zhou B, Xie H, Shi L, Liu H, Holler W, Lin M, Liu YH, Miller EJ, Sinusas AJ, Liu C. Direct and indirect strategies of deep-learning-based attenuation correction for general purpose and dedicated cardiac SPECT. European Journal Of Nuclear Medicine And Molecular Imaging 2022 PMID: 35169887, DOI: 10.1007/s00259-022-05718-8.
- Cross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT.Chen X, Hendrik Pretorius P, Zhou B, Liu H, Johnson K, Liu YH, King MA, Liu C. Cross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2022 PMID: 35474443, DOI: 10.1007/s12350-022-02978-7.
- Increasing angular sampling through deep learning for stationary cardiac SPECT image reconstruction.Xie H, Thorn S, Chen X, Zhou B, Liu H, Liu Z, Lee S, Wang G, Liu YH, Sinusas AJ, Liu C. Increasing angular sampling through deep learning for stationary cardiac SPECT image reconstruction. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2022 PMID: 35508796, DOI: 10.1007/s12350-022-02972-z.