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Yalai Bai, PhD, MD

Research Scientist; Technical Director of Tissue Procurement and Distribution Service, Pathology Department

Contact Information

Yalai Bai, PhD, MD

Mailing Address

  • Pathology

    310 Cedar Street, PO Box 208023

    New Haven, CT 06520-8023

    United States

Coauthors

Selected Publications

  • A new tool for technical standardization of the Ki67 immunohistochemical assay.Aung TN, Acs B, Warrell J, Bai Y, Gaule P, Martinez-Morilla S, Vathiotis I, Shafi S, Moutafi M, Gerstein M, Freiberg B, Fulton R, Rimm DL. A new tool for technical standardization of the Ki67 immunohistochemical assay. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2021, 34: 1261-1270. PMID: 33536573, PMCID: PMC8222064, DOI: 10.1038/s41379-021-00745-6.
  • An Open-Source, Automated Tumor-Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer.Bai Y, Cole K, Martinez-Morilla S, Ahmed FS, Zugazagoitia J, Staaf J, Bosch A, Ehinger A, Nimeus E, Hartman J, Acs B, Rimm DL. An Open-Source, Automated Tumor-Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2021, 27: 5557-5565. PMID: 34088723, PMCID: PMC8530841, DOI: 10.1158/1078-0432.CCR-21-0325.
  • An international multicenter study to evaluate reproducibility of automated scoring for assessment of Ki67 in breast cancer.Rimm DL, Leung SCY, McShane LM, Bai Y, Bane AL, Bartlett JMS, Bayani J, Chang MC, Dean M, Denkert C, Enwere EK, Galderisi C, Gholap A, Hugh JC, Jadhav A, Kornaga EN, Laurinavicius A, Levenson R, Lima J, Miller K, Pantanowitz L, Piper T, Ruan J, Srinivasan M, Virk S, Wu Y, Yang H, Hayes DF, Nielsen TO, Dowsett M. An international multicenter study to evaluate reproducibility of automated scoring for assessment of Ki67 in breast cancer. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2019, 32: 59-69. PMID: 30143750, DOI: 10.1038/s41379-018-0109-4.
  • Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study.Acs B, Pelekanou V, Bai Y, Martinez-Morilla S, Toki M, Leung SCY, Nielsen TO, Rimm DL. Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2019, 99: 107-117. PMID: 30181553, DOI: 10.1038/s41374-018-0123-7.
  • Elevated T cell activation score is associated with improved survival of breast cancer.Lu L, Bai Y, Wang Z. Elevated T cell activation score is associated with improved survival of breast cancer. Breast Cancer Research And Treatment 2017, 164: 689-696. PMID: 28488141, DOI: 10.1007/s10549-017-4281-x.
  • Objective, domain-specific HER2 measurement in uterine and ovarian serous carcinomas and its clinical significance.Carvajal-Hausdorf DE, Schalper KA, Bai Y, Black J, Santin AD, Rimm DL. Objective, domain-specific HER2 measurement in uterine and ovarian serous carcinomas and its clinical significance. Gynecologic Oncology 2017, 145: 154-158. PMID: 28196634, PMCID: PMC5941302, DOI: 10.1016/j.ygyno.2017.02.002.
  • Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomas.Lazova R, Pornputtapong N, Halaban R, Bosenberg M, Bai Y, Chai H, Krauthammer M. Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomas. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2017, 30: 640-649. PMID: 28186096, PMCID: PMC5413430, DOI: 10.1038/modpathol.2016.237.
  • Early and multiple origins of metastatic lineages within primary tumors.Zhao ZM, Zhao B, Bai Y, Iamarino A, Gaffney SG, Schlessinger J, Lifton RP, Rimm DL, Townsend JP. Early and multiple origins of metastatic lineages within primary tumors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 2140-5. PMID: 26858460, PMCID: PMC4776530, DOI: 10.1073/pnas.1525677113.
  • Quantitative measurements of HER2 and phospho-HER2 expression: correlation with pathologic response to neoadjuvant chemotherapy and trastuzumab.Cheng H, Bai Y, Sikov W, Sinclair N, Bossuyt V, Abu-Khalaf MM, Harris LN, Rimm DL. Quantitative measurements of HER2 and phospho-HER2 expression: correlation with pathologic response to neoadjuvant chemotherapy and trastuzumab. BMC Cancer 2014, 14: 326. PMID: 24885187, PMCID: PMC4037428, DOI: 10.1186/1471-2407-14-326.
  • Comparison of HER2 and phospho-HER2 expression between biopsy and resected breast cancer specimens using a quantitative assessment method.Bai Y, Cheng H, Bordeaux J, Neumeister V, Kumar S, Rimm DL, Stern DF. Comparison of HER2 and phospho-HER2 expression between biopsy and resected breast cancer specimens using a quantitative assessment method. PloS One 2013, 8: e79901. PMID: 24278211, PMCID: PMC3836903, DOI: 10.1371/journal.pone.0079901.
  • Optimal tumor sampling for immunostaining of biomarkers in breast carcinoma.Tolles J, Bai Y, Baquero M, Harris LN, Rimm DL, Molinaro AM. Optimal tumor sampling for immunostaining of biomarkers in breast carcinoma. Breast Cancer Research : BCR 2011, 13: R51. PMID: 21592345, PMCID: PMC3218938, DOI: 10.1186/bcr2882.
  • Quantitative assessment shows loss of antigenic epitopes as a function of pre-analytic variables.Bai Y, Tolles J, Cheng H, Siddiqui S, Gopinath A, Pectasides E, Camp RL, Rimm DL, Molinaro AM. Quantitative assessment shows loss of antigenic epitopes as a function of pre-analytic variables. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2011, 91: 1253-61. PMID: 21519325, PMCID: PMC3145004, DOI: 10.1038/labinvest.2011.75.
  • Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.Bai Y, Ahmad U, Wang Y, Li JH, Choy JC, Kim RW, Kirkiles-Smith N, Maher SE, Karras JG, Bennett CF, Bothwell AL, Pober JS, Tellides G. Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation. The Journal Of Biological Chemistry 2008, 283: 6832-42. PMID: 18192275, DOI: 10.1074/jbc.M706021200.
  • Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation.Wang Y, Bai Y, Qin L, Zhang P, Yi T, Teesdale SA, Zhao L, Pober JS, Tellides G. Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation. Circulation Research 2007, 101: 560-9. PMID: 17656678, DOI: 10.1161/CIRCRESAHA.107.151068.
  • Recruitment of CXCR3+ and CCR5+ T cells and production of interferon-gamma-inducible chemokines in rejecting human arteries.Burns WR, Wang Y, Tang PC, Ranjbaran H, Iakimov A, Kim J, Cuffy M, Bai Y, Pober JS, Tellides G. Recruitment of CXCR3+ and CCR5+ T cells and production of interferon-gamma-inducible chemokines in rejecting human arteries. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2005, 5: 1226-36. PMID: 15888026, DOI: 10.1111/j.1600-6143.2005.00892.x.
  • CD2 is a dominant target for allogeneic responses.Bai Y, Fu S, Honig S, Wang Y, Qin L, Chen D, Bromberg JS. CD2 is a dominant target for allogeneic responses. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2002, 2: 618-26. PMID: 12201362, DOI: 10.1034/j.1600-6143.2002.20706.x.
  • L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance.Bai Y, Liu J, Wang Y, Honig S, Qin L, Boros P, Bromberg JS. L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 168: 1579-89. PMID: 11823485, DOI: 10.4049/jimmunol.168.4.1579.
  • Regulation of the association between PSTPIP and CD2 in murine T cells.Bai Y, Ding Y, Spencer S, Lasky LA, Bromberg JS. Regulation of the association between PSTPIP and CD2 in murine T cells. Experimental And Molecular Pathology 2001, 71: 115-24. PMID: 11599917, DOI: 10.1006/exmp.2001.2388.
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