Xuchen Zhang, MD, PhD

• Alexander B. Pine
• Alfred Lee
• Allen Bale
• Andrew Wang
• Carlos Fernandez-Hernando
• Christina Price
• Clara Abraham
• David Mulligan
• David N. Assis
• Deepika Kumar
• Dhanpat Jain
• Donald Turbiville
• Hyung Chun
• ILKe Nalbantoglu
• James Duncan
• Jeffrey Weinreb
• Jenn Batisti
• Joanna Gibson
• John Hwa
• Joshua Cornman-Homonoff
• Julius Chapiro
• Karin Finberg
• Kim Blenman
• Lauren Cohn
• Lauren Pischel
• Margarita Revzin
• Maria Ciarleglio
• Marie Robert
• Marina Silveira
• Mario Strazzabosco
• Matthew Grant
• Matthew McConnell
• Mollie Freedman-Weiss
• Pramod Mistry
• Raj Ayyagari
• Ramesh Batra
• Robert Homer
• Ronald Salem
• Serena Wong
• Silvia Vilarinho
• Tamar Taddei
• Todd Schlachter
• Yasuko Iwakiri
• Zenta Walther

Barrett Esophagus; Esophageal Neoplasms; Fatty Liver; Gastritis; Gastrointestinal Neoplasms; Liver Diseases; Liver Neoplasms; Pancreatic Diseases; Lung Injury; Chemical and Drug Induced Liver Injury

• Hepatocellular Carcinoma: Role of Pathology in the Era of Precision Medicine.Vyas M, Zhang X. Hepatocellular Carcinoma: Role of Pathology in the Era of Precision Medicine. Clinics In Liver Disease 2020, 24: 591-610. PMID: 33012447, DOI: 10.1016/j.cld.2020.07.010.
• Fibronodular hepatocellular carcinoma-a new variant of liver cancer: clinical, pathological and radiological correlation.Tefera J, Revzin M, Chapiro J, Savic L, Mulligan D, Batra R, Taddei T, Jain D, Zhang X. Fibronodular hepatocellular carcinoma-a new variant of liver cancer: clinical, pathological and radiological correlation. Journal Of Clinical Pathology 2021, 74: 31-35. PMID: 32430483, PMCID: PMC7674234, DOI: 10.1136/jclinpath-2020-206574.
• Macrotrabecular Hepatocellular Carcinoma: An Aggressive Subtype of Hepatocellular Carcinoma.Jeon Y, Benedict M, Taddei T, Jain D, Zhang X. Macrotrabecular Hepatocellular Carcinoma: An Aggressive Subtype of Hepatocellular Carcinoma. The American Journal Of Surgical Pathology 2019, 43: 943-948. PMID: 31135484, DOI: 10.1097/PAS.0000000000001289.
• Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis?Kumar D, Hafez O, Jain D, Zhang X. Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis? Human Pathology 2021, 113: 39-46. PMID: 33905775, DOI: 10.1016/j.humpath.2021.04.008.
• HNF-1β is a More Sensitive and Specific Marker Than C-Reactive Protein for Identifying Biliary Differentiation in Primary Hepatic Carcinomas.Patil PA, Taddei T, Jain D, Zhang X. HNF-1β is a More Sensitive and Specific Marker Than C-Reactive Protein for Identifying Biliary Differentiation in Primary Hepatic Carcinomas. Archives Of Pathology & Laboratory Medicine 2021 PMID: 34086854, DOI: 10.5858/arpa.2020-0725-OA.
• Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis.Patel N, Vyas M, Celli R, Jain D, Zhang X. Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis. The American Journal Of Surgical Pathology 2020, 44: 241-246. PMID: 31498179, DOI: 10.1097/PAS.0000000000001369.
• Era of universal testing of microsatellite instability in colorectal cancer.Zhang X, Li J. Era of universal testing of microsatellite instability in colorectal cancer. World Journal Of Gastrointestinal Oncology 2013, 5: 12-9. PMID: 23556052, PMCID: PMC3613766, DOI: 10.4251/wjgo.v5.i2.12.
• Clinicopathological significance of neutrophil-rich colorectal carcinoma.Rottmann BG, Patel N, Ahmed M, Deng Y, Ciarleglio M, Vyas M, Jain D, Zhang X. Clinicopathological significance of neutrophil-rich colorectal carcinoma. Journal Of Clinical Pathology 2021 PMID: 34312298, DOI: 10.1136/jclinpath-2021-207702.
• Glucose Metabolic Reprogramming and Cell Proliferation Arrest in Colorectal Micropapillary Carcinoma.Vyas M, Patel N, Celli R, Wajapeyee N, Jain D, Zhang X. Glucose Metabolic Reprogramming and Cell Proliferation Arrest in Colorectal Micropapillary Carcinoma. Gastroenterology Research 2019, 12: 128-134. PMID: 31236153, PMCID: PMC6575135, DOI: 10.14740/gr1145.
• Morphological spectrum of immune check-point inhibitor therapy-associated gastritis.Johncilla M, Grover S, Zhang X, Jain D, Srivastava A. Morphological spectrum of immune check-point inhibitor therapy-associated gastritis. Histopathology 2020, 76: 531-539. PMID: 31692018, DOI: 10.1111/his.14029.
• Pathologic Manifestations of Gastrointestinal and Hepatobiliary Injury in Immune Checkpoint Inhibitor Therapy.Patil PA, Zhang X. Pathologic Manifestations of Gastrointestinal and Hepatobiliary Injury in Immune Checkpoint Inhibitor Therapy. Archives Of Pathology & Laboratory Medicine 2021, 145: 571-582. PMID: 32338534, DOI: 10.5858/arpa.2020-0070-RA.
• Histologic patterns of liver injury induced by anti-PD-1 therapy.Zhang D, Hart J, Ding X, Zhang X, Feely M, Yassan L, Alpert L, Soldevila-Pico C, Zhang X, Liu X, Lai J. Histologic patterns of liver injury induced by anti-PD-1 therapy. Gastroenterology Report 2020, 8: 50-55. PMID: 32467761, PMCID: PMC7244961, DOI: 10.1093/gastro/goz044.
• Immune Checkpoint Inhibitor-Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Helicobacter pylori Gastritis and Celiac Disease.Irshaid L, Robert ME, Zhang X. Immune Checkpoint Inhibitor-Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Helicobacter pylori Gastritis and Celiac Disease. Archives Of Pathology & Laboratory Medicine 2021, 145: 191-200. PMID: 33501492, DOI: 10.5858/arpa.2019-0700-OA.
• Checkpoint Inhibitor Colitis Shows Drug-Specific Differences in Immune Cell Reaction That Overlap With Inflammatory Bowel Disease and Predict Response to Colitis Therapy.Lo YC, Price C, Blenman K, Patil P, Zhang X, Robert ME. Checkpoint Inhibitor Colitis Shows Drug-Specific Differences in Immune Cell Reaction That Overlap With Inflammatory Bowel Disease and Predict Response to Colitis Therapy. American Journal Of Clinical Pathology 2021, 156: 214-228. PMID: 33555016, DOI: 10.1093/ajcp/aqaa217.
• Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy.Zhang X, Jain D. Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy. Annals Of The New York Academy Of Sciences 2020, 1482: 163-176. PMID: 32892349, DOI: 10.1111/nyas.14462.
• Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update.Turbiville D, Zhang X. Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update. World Journal Of Gastroenterology : WJG 2020, 26: 5597-5605. PMID: 33071524, PMCID: PMC7545394, DOI: 10.3748/wjg.v26.i37.5597.
• Clinical utility of genomic analysis in adults with idiopathic liver disease.Hakim A, Zhang X, DeLisle A, Oral EA, Dykas D, Drzewiecki K, Assis DN, Silveira M, Batisti J, Jain D, Bale A, Mistry PK, Vilarinho S. Clinical utility of genomic analysis in adults with idiopathic liver disease. Journal Of Hepatology 2019, 70: 1214-1221. PMID: 31000363, PMCID: PMC6526061, DOI: 10.1016/j.jhep.2019.01.036.
• Calcifying Nested Stromal-Epithelial Tumor of the Liver: An Update and Literature Review.Benedict M, Zhang X. Calcifying Nested Stromal-Epithelial Tumor of the Liver: An Update and Literature Review. Archives Of Pathology & Laboratory Medicine 2019, 143: 264-268. PMID: 30354275, DOI: 10.5858/arpa.2017-0346-RS.
• Calcifying nested stromal-epithelial tumor: a clinicopathologic and molecular genetic study of eight cases highlighting metastatic potential and recurrent CTNNB1 and TERT promoter alterations.Papke DJ, Dong F, Zhang X, Kozielski R, Basturk O, Fletcher CDM, Zhao L. Calcifying nested stromal-epithelial tumor: a clinicopathologic and molecular genetic study of eight cases highlighting metastatic potential and recurrent CTNNB1 and TERT promoter alterations. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2021, 34: 1696-1703. PMID: 33994539, DOI: 10.1038/s41379-021-00822-w.
• Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation.Beech C, Freedman-Weiss M, Salem R, Jain D, Zhang X. Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation. Gastroenterology Research 2019, 12: 185-190. PMID: 31523327, PMCID: PMC6731045, DOI: 10.14740/gr1201.
• The microscopic anatomy of the esophagus including the individual layers, specialized tissues, and unique components and their responses to injury.Zhang X, Patil D, Odze RD, Zhao L, Lisovsky M, Guindi M, Riddell R, Bellizzi A, Yantiss RK, Nalbantoglu I, Appelman HD. The microscopic anatomy of the esophagus including the individual layers, specialized tissues, and unique components and their responses to injury. Annals Of The New York Academy Of Sciences 2018, 1434: 304-318. PMID: 29761508, DOI: 10.1111/nyas.13705.
• Lymphocytic esophagitis: a histologic pattern with emerging clinical ramifications.Lisovsky M, Westerhoff M, Zhang X. Lymphocytic esophagitis: a histologic pattern with emerging clinical ramifications. Annals Of The New York Academy Of Sciences 2016, 1381: 133-138. PMID: 27635640, DOI: 10.1111/nyas.13260.
• Morphologic and Immunohistochemical Characteristics of Anorectal Melanoma.Charifa A, Zhang X. Morphologic and Immunohistochemical Characteristics of Anorectal Melanoma. International Journal Of Surgical Pathology 2018, 26: 725-729. PMID: 29759015, DOI: 10.1177/1066896918773177.
• Non-alcoholic fatty liver disease: An expanded review.Benedict M, Zhang X. Non-alcoholic fatty liver disease: An expanded review. World Journal Of Hepatology 2017, 9: 715-732. PMID: 28652891, PMCID: PMC5468341, DOI: 10.4254/wjh.v9.i16.715.
• Pathology of Alcoholic Liver Disease.Celli R, Zhang X. Pathology of Alcoholic Liver Disease. Journal Of Clinical And Translational Hepatology 2014, 2: 103-9. PMID: 26357621, PMCID: PMC4521259, DOI: 10.14218/JCTH.2014.00010.
• Histopathologic manifestations of drug-induced hepatotoxicity.Zhang X, Ouyang J, Thung SN. Histopathologic manifestations of drug-induced hepatotoxicity. Clinics In Liver Disease 2013, 17: 547-64, vii-viii. PMID: 24099017, DOI: 10.1016/j.cld.2013.07.004.
• Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same?Zhang X, Zhu H, Yang X, Adsay VN, Jain D. Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same? Pathology, Research And Practice 2017, 213: 997-1001. PMID: 28599853, DOI: 10.1016/j.prp.2017.03.013.
• Intestinal metaplasia of appendiceal endometriosis is not uncommon and may mimic appendiceal mucinous neoplasm.Vyas M, Wong S, Zhang X. Intestinal metaplasia of appendiceal endometriosis is not uncommon and may mimic appendiceal mucinous neoplasm. Pathology, Research And Practice 2017, 213: 39-44. PMID: 27913053, DOI: 10.1016/j.prp.2016.10.011.
• Interval colorectal carcinoma: An unsolved debate.Benedict M, Neto AG, Zhang X. Interval colorectal carcinoma: An unsolved debate. World Journal Of Gastroenterology : WJG 2015, 21: 12735-41. PMID: 26668498, PMCID: PMC4671029, DOI: 10.3748/wjg.v21.i45.12735.
• Cathepsin E promotes pulmonary emphysema via mitochondrial fission.Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ. Cathepsin E promotes pulmonary emphysema via mitochondrial fission. The American Journal Of Pathology 2014, 184: 2730-41. PMID: 25239563, PMCID: PMC4188869, DOI: 10.1016/j.ajpath.2014.06.017.
• Toll-like receptor 4 deficiency causes pulmonary emphysema.Zhang X, Shan P, Jiang G, Cohn L, Lee PJ. Toll-like receptor 4 deficiency causes pulmonary emphysema. The Journal Of Clinical Investigation 2006, 116: 3050-9. PMID: 17053835, PMCID: PMC1616193, DOI: 10.1172/JCI28139.
• Deep learning-assisted differentiation of pathologically proven atypical and typical hepatocellular carcinoma (HCC) versus non-HCC on contrast-enhanced MRI of the liver.Oestmann PM, Wang CJ, Savic LJ, Hamm CA, Stark S, Schobert I, Gebauer B, Schlachter T, Lin M, Weinreb JC, Batra R, Mulligan D, Zhang X, Duncan JS, Chapiro J. Deep learning-assisted differentiation of pathologically proven atypical and typical hepatocellular carcinoma (HCC) versus non-HCC on contrast-enhanced MRI of the liver. European Radiology 2021, 31: 4981-4990. PMID: 33409782, PMCID: PMC8222094, DOI: 10.1007/s00330-020-07559-1.
• Characterization of Chronic Gastritis in Lynch Syndrome Patients With Gastric Adenocarcinoma.Saulino D, Chen R, Wang K, Shen M, Zhang X, Westerhoff M, Cheng J, Lin J, Zhang X, Feely M, Liu X. Characterization of Chronic Gastritis in Lynch Syndrome Patients With Gastric Adenocarcinoma. Gastroenterology Research 2021, 14: 13-20. PMID: 33737995, PMCID: PMC7935615, DOI: 10.14740/gr1359.
• α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study.Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP. α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study. British Journal Of Cancer 2021, 124: 1988-1996. PMID: 33824478, PMCID: PMC8184895, DOI: 10.1038/s41416-021-01363-4.
• A Novel Treatment for Metastatic Serous Cystadenocarcinoma Using a Microwave Ablation: Case Report and Review of the Literature.Murtha TD, Cornman-Homonoff J, Ayyagari R, Zhang X, Salem RR. A Novel Treatment for Metastatic Serous Cystadenocarcinoma Using a Microwave Ablation: Case Report and Review of the Literature. Pancreas 2021, 50: 434-440. PMID: 33835976, DOI: 10.1097/MPA.0000000000001785.
• Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy.McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee A, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. Journal Of Hepatology 2021, 75: 647-658. PMID: 33991637, PMCID: PMC8285256, DOI: 10.1016/j.jhep.2021.04.050.
• Pathological characteristics of liver sinusoidal thrombosis in COVID-19 patients: A series of 43 cases.Kondo R, Kawaguchi N, McConnell MJ, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Sun Z, Utsumi T, Strazzabosco M, Iwakiri Y. Pathological characteristics of liver sinusoidal thrombosis in COVID-19 patients: A series of 43 cases. Hepatology Research : The Official Journal Of The Japan Society Of Hepatology 2021, 51: 1000-1006. PMID: 34260803, PMCID: PMC8444906, DOI: 10.1111/hepr.13696.
• Splenic-vasculature involvement is associated with poor prognosis in resected distal pancreatic cancer.Yin F, Saad M, Lin J, Jackson CR, Ren B, Lawson C, Karamchandani DM, Bernabeu BQ, Jiang W, Dhir T, Zheng R, Schultz CW, Zhang D, Thomas CL, Zhang X, Lai J, Schild M, Zhang X, Xie H, Liu X. Splenic-vasculature involvement is associated with poor prognosis in resected distal pancreatic cancer. Gastroenterology Report 2021, 9: 139-145. PMID: 34026221, PMCID: PMC8128010, DOI: 10.1093/gastro/goaa084.
• Bartonellosis in transplant recipients: A retrospective single center experience.Pischel L, Radcliffe C, Vilchez GA, Charifa A, Zhang XC, Grant M. Bartonellosis in transplant recipients: A retrospective single center experience. World Journal Of Transplantation 2021, 11: 244-253. PMID: 34164299, PMCID: PMC8218350, DOI: 10.5500/wjt.v11.i6.244.
• Hepatocellular Carcinoma: Does the Background Liver With or Without Cirrhosis Matter?Jain A, Mazer B, Deng Y, Ciarleglio M, Jain D, Taddei T, Zhang X. Hepatocellular Carcinoma: Does the Background Liver With or Without Cirrhosis Matter? American Journal Of Clinical Pathology 2021 PMID: 34542582, DOI: 10.1093/ajcp/aqab125.
• Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis.González IA, Fuller LD, Zhang X, Papke DJ, Zhao L, Zhang D, Liao X, Liu X, Fiel MI, Zhang X. Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis. American Journal Of Clinical Pathology 2021 PMID: 34596220, DOI: 10.1093/ajcp/aqab142.
• Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.Ranjan K, Hedl M, Sinha S, Zhang X, Abraham C. Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response. The Journal Of Clinical Investigation 2021, 131 PMID: 34623328, PMCID: PMC8409591, DOI: 10.1172/JCI145472.
• Pathogenic BRCA2 germline variants in combined hepatocellular-cholangiocarcinoma.Li H, Zhang X, Finberg KE, Walther Z, Jain D, Gibson J. Pathogenic BRCA2 germline variants in combined hepatocellular-cholangiocarcinoma. Pathology International 2021 PMID: 34808016, DOI: 10.1111/pin.13188.
• Pathologic Diagnosis of Nonalcoholic Fatty Liver Disease.Lai J, Wang HL, Zhang X, Wang H, Liu X. Pathologic Diagnosis of Nonalcoholic Fatty Liver Disease. Archives Of Pathology & Laboratory Medicine 2021 PMID: 34871361, DOI: 10.5858/arpa.2021-0339-RA.