Xuchen Zhang, MD, PhD
Associate Professor of Pathology; Associate Director, Gastrointestinal & Liver Pathology; Director, Gastrointestinal & Liver Pathology Fellowship Program
Research & Publications
Biography
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Research Summary
Specialized Terms: Liver and gastrointestinal pathology; Neoplastic and non-neoplastic pulmonary pathology;
Extensive Research Description
Molecular pathogenesis of lung aging, innate immunity and oxidative stress in lung injury; risk factors, tumor microenvironment and morpho-molecular classification of colorectal carcinoma and liver tumors; drug-induced GI and liver injuries.
Coauthors
Research Interests
Barrett Esophagus; Esophageal Neoplasms; Fatty Liver; Gastritis; Gastrointestinal Neoplasms; Liver Diseases; Liver Neoplasms; Pancreatic Diseases; Lung Injury; Chemical and Drug Induced Liver Injury
Research Images
Selected Publications
- Hepatocellular Carcinoma: Role of Pathology in the Era of Precision Medicine.Vyas M, Zhang X. Hepatocellular Carcinoma: Role of Pathology in the Era of Precision Medicine. Clinics In Liver Disease 2020, 24: 591-610. PMID: 33012447, DOI: 10.1016/j.cld.2020.07.010.
- Fibronodular hepatocellular carcinoma-a new variant of liver cancer: clinical, pathological and radiological correlation.Tefera J, Revzin M, Chapiro J, Savic L, Mulligan D, Batra R, Taddei T, Jain D, Zhang X. Fibronodular hepatocellular carcinoma-a new variant of liver cancer: clinical, pathological and radiological correlation. Journal Of Clinical Pathology 2021, 74: 31-35. PMID: 32430483, PMCID: PMC7674234, DOI: 10.1136/jclinpath-2020-206574.
- Macrotrabecular Hepatocellular Carcinoma: An Aggressive Subtype of Hepatocellular Carcinoma.Jeon Y, Benedict M, Taddei T, Jain D, Zhang X. Macrotrabecular Hepatocellular Carcinoma: An Aggressive Subtype of Hepatocellular Carcinoma. The American Journal Of Surgical Pathology 2019, 43: 943-948. PMID: 31135484, DOI: 10.1097/PAS.0000000000001289.
- Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis?Kumar D, Hafez O, Jain D, Zhang X. Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis? Human Pathology 2021, 113: 39-46. PMID: 33905775, DOI: 10.1016/j.humpath.2021.04.008.
- HNF-1β is a More Sensitive and Specific Marker Than C-Reactive Protein for Identifying Biliary Differentiation in Primary Hepatic Carcinomas.Patil PA, Taddei T, Jain D, Zhang X. HNF-1β is a More Sensitive and Specific Marker Than C-Reactive Protein for Identifying Biliary Differentiation in Primary Hepatic Carcinomas. Archives Of Pathology & Laboratory Medicine 2022, 146: 220-226. PMID: 34086854, DOI: 10.5858/arpa.2020-0725-OA.
- Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis.Patel N, Vyas M, Celli R, Jain D, Zhang X. Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis. The American Journal Of Surgical Pathology 2020, 44: 241-246. PMID: 31498179, DOI: 10.1097/PAS.0000000000001369.
- Era of universal testing of microsatellite instability in colorectal cancer.Zhang X, Li J. Era of universal testing of microsatellite instability in colorectal cancer. World Journal Of Gastrointestinal Oncology 2013, 5: 12-9. PMID: 23556052, PMCID: PMC3613766, DOI: 10.4251/wjgo.v5.i2.12.
- Clinicopathological significance of neutrophil-rich colorectal carcinoma.Rottmann BG, Patel N, Ahmed M, Deng Y, Ciarleglio M, Vyas M, Jain D, Zhang X. Clinicopathological significance of neutrophil-rich colorectal carcinoma. Journal Of Clinical Pathology 2021 PMID: 34312298, DOI: 10.1136/jclinpath-2021-207702.
- Glucose Metabolic Reprogramming and Cell Proliferation Arrest in Colorectal Micropapillary Carcinoma.Vyas M, Patel N, Celli R, Wajapeyee N, Jain D, Zhang X. Glucose Metabolic Reprogramming and Cell Proliferation Arrest in Colorectal Micropapillary Carcinoma. Gastroenterology Research 2019, 12: 128-134. PMID: 31236153, PMCID: PMC6575135, DOI: 10.14740/gr1145.
- Morphological spectrum of immune check-point inhibitor therapy-associated gastritis.Johncilla M, Grover S, Zhang X, Jain D, Srivastava A. Morphological spectrum of immune check-point inhibitor therapy-associated gastritis. Histopathology 2020, 76: 531-539. PMID: 31692018, DOI: 10.1111/his.14029.
- Pathologic Manifestations of Gastrointestinal and Hepatobiliary Injury in Immune Checkpoint Inhibitor Therapy.Patil PA, Zhang X. Pathologic Manifestations of Gastrointestinal and Hepatobiliary Injury in Immune Checkpoint Inhibitor Therapy. Archives Of Pathology & Laboratory Medicine 2021, 145: 571-582. PMID: 32338534, DOI: 10.5858/arpa.2020-0070-RA.
- Histologic patterns of liver injury induced by anti-PD-1 therapy.Zhang D, Hart J, Ding X, Zhang X, Feely M, Yassan L, Alpert L, Soldevila-Pico C, Zhang X, Liu X, Lai J. Histologic patterns of liver injury induced by anti-PD-1 therapy. Gastroenterology Report 2020, 8: 50-55. PMID: 32467761, PMCID: PMC7244961, DOI: 10.1093/gastro/goz044.
- Immune Checkpoint Inhibitor-Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Helicobacter pylori Gastritis and Celiac Disease.Irshaid L, Robert ME, Zhang X. Immune Checkpoint Inhibitor-Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Helicobacter pylori Gastritis and Celiac Disease. Archives Of Pathology & Laboratory Medicine 2021, 145: 191-200. PMID: 33501492, DOI: 10.5858/arpa.2019-0700-OA.
- Checkpoint Inhibitor Colitis Shows Drug-Specific Differences in Immune Cell Reaction That Overlap With Inflammatory Bowel Disease and Predict Response to Colitis Therapy.Lo YC, Price C, Blenman K, Patil P, Zhang X, Robert ME. Checkpoint Inhibitor Colitis Shows Drug-Specific Differences in Immune Cell Reaction That Overlap With Inflammatory Bowel Disease and Predict Response to Colitis Therapy. American Journal Of Clinical Pathology 2021, 156: 214-228. PMID: 33555016, DOI: 10.1093/ajcp/aqaa217.
- Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy.Zhang X, Jain D. Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy. Annals Of The New York Academy Of Sciences 2020, 1482: 163-176. PMID: 32892349, DOI: 10.1111/nyas.14462.
- Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update.Turbiville D, Zhang X. Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update. World Journal Of Gastroenterology : WJG 2020, 26: 5597-5605. PMID: 33071524, PMCID: PMC7545394, DOI: 10.3748/wjg.v26.i37.5597.
- Clinical utility of genomic analysis in adults with idiopathic liver disease.Hakim A, Zhang X, DeLisle A, Oral EA, Dykas D, Drzewiecki K, Assis DN, Silveira M, Batisti J, Jain D, Bale A, Mistry PK, Vilarinho S. Clinical utility of genomic analysis in adults with idiopathic liver disease. Journal Of Hepatology 2019, 70: 1214-1221. PMID: 31000363, PMCID: PMC6526061, DOI: 10.1016/j.jhep.2019.01.036.
- Calcifying Nested Stromal-Epithelial Tumor of the Liver: An Update and Literature Review.Benedict M, Zhang X. Calcifying Nested Stromal-Epithelial Tumor of the Liver: An Update and Literature Review. Archives Of Pathology & Laboratory Medicine 2019, 143: 264-268. PMID: 30354275, DOI: 10.5858/arpa.2017-0346-RS.
- Calcifying nested stromal-epithelial tumor: a clinicopathologic and molecular genetic study of eight cases highlighting metastatic potential and recurrent CTNNB1 and TERT promoter alterations.Papke DJ, Dong F, Zhang X, Kozielski R, Basturk O, Fletcher CDM, Zhao L. Calcifying nested stromal-epithelial tumor: a clinicopathologic and molecular genetic study of eight cases highlighting metastatic potential and recurrent CTNNB1 and TERT promoter alterations. Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc 2021, 34: 1696-1703. PMID: 33994539, DOI: 10.1038/s41379-021-00822-w.
- Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation.Beech C, Freedman-Weiss M, Salem R, Jain D, Zhang X. Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation. Gastroenterology Research 2019, 12: 185-190. PMID: 31523327, PMCID: PMC6731045, DOI: 10.14740/gr1201.
- The microscopic anatomy of the esophagus including the individual layers, specialized tissues, and unique components and their responses to injury.Zhang X, Patil D, Odze RD, Zhao L, Lisovsky M, Guindi M, Riddell R, Bellizzi A, Yantiss RK, Nalbantoglu I, Appelman HD. The microscopic anatomy of the esophagus including the individual layers, specialized tissues, and unique components and their responses to injury. Annals Of The New York Academy Of Sciences 2018, 1434: 304-318. PMID: 29761508, DOI: 10.1111/nyas.13705.
- Lymphocytic esophagitis: a histologic pattern with emerging clinical ramifications.Lisovsky M, Westerhoff M, Zhang X. Lymphocytic esophagitis: a histologic pattern with emerging clinical ramifications. Annals Of The New York Academy Of Sciences 2016, 1381: 133-138. PMID: 27635640, DOI: 10.1111/nyas.13260.
- Morphologic and Immunohistochemical Characteristics of Anorectal Melanoma.Charifa A, Zhang X. Morphologic and Immunohistochemical Characteristics of Anorectal Melanoma. International Journal Of Surgical Pathology 2018, 26: 725-729. PMID: 29759015, DOI: 10.1177/1066896918773177.
- Non-alcoholic fatty liver disease: An expanded review.Benedict M, Zhang X. Non-alcoholic fatty liver disease: An expanded review. World Journal Of Hepatology 2017, 9: 715-732. PMID: 28652891, PMCID: PMC5468341, DOI: 10.4254/wjh.v9.i16.715.
- Pathology of Alcoholic Liver Disease.Celli R, Zhang X. Pathology of Alcoholic Liver Disease. Journal Of Clinical And Translational Hepatology 2014, 2: 103-9. PMID: 26357621, PMCID: PMC4521259, DOI: 10.14218/JCTH.2014.00010.
- Histopathologic manifestations of drug-induced hepatotoxicity.Zhang X, Ouyang J, Thung SN. Histopathologic manifestations of drug-induced hepatotoxicity. Clinics In Liver Disease 2013, 17: 547-64, vii-viii. PMID: 24099017, DOI: 10.1016/j.cld.2013.07.004.
- Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same?Zhang X, Zhu H, Yang X, Adsay VN, Jain D. Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same? Pathology, Research And Practice 2017, 213: 997-1001. PMID: 28599853, DOI: 10.1016/j.prp.2017.03.013.
- Intestinal metaplasia of appendiceal endometriosis is not uncommon and may mimic appendiceal mucinous neoplasm.Vyas M, Wong S, Zhang X. Intestinal metaplasia of appendiceal endometriosis is not uncommon and may mimic appendiceal mucinous neoplasm. Pathology, Research And Practice 2017, 213: 39-44. PMID: 27913053, DOI: 10.1016/j.prp.2016.10.011.
- Interval colorectal carcinoma: An unsolved debate.Benedict M, Neto AG, Zhang X. Interval colorectal carcinoma: An unsolved debate. World Journal Of Gastroenterology : WJG 2015, 21: 12735-41. PMID: 26668498, PMCID: PMC4671029, DOI: 10.3748/wjg.v21.i45.12735.
- Cathepsin E promotes pulmonary emphysema via mitochondrial fission.Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ. Cathepsin E promotes pulmonary emphysema via mitochondrial fission. The American Journal Of Pathology 2014, 184: 2730-41. PMID: 25239563, PMCID: PMC4188869, DOI: 10.1016/j.ajpath.2014.06.017.
- Toll-like receptor 4 deficiency causes pulmonary emphysema.Zhang X, Shan P, Jiang G, Cohn L, Lee PJ. Toll-like receptor 4 deficiency causes pulmonary emphysema. The Journal Of Clinical Investigation 2006, 116: 3050-9. PMID: 17053835, PMCID: PMC1616193, DOI: 10.1172/JCI28139.
- Deep learning-assisted differentiation of pathologically proven atypical and typical hepatocellular carcinoma (HCC) versus non-HCC on contrast-enhanced MRI of the liver.Oestmann PM, Wang CJ, Savic LJ, Hamm CA, Stark S, Schobert I, Gebauer B, Schlachter T, Lin M, Weinreb JC, Batra R, Mulligan D, Zhang X, Duncan JS, Chapiro J. Deep learning-assisted differentiation of pathologically proven atypical and typical hepatocellular carcinoma (HCC) versus non-HCC on contrast-enhanced MRI of the liver. European Radiology 2021, 31: 4981-4990. PMID: 33409782, PMCID: PMC8222094, DOI: 10.1007/s00330-020-07559-1.
- Characterization of Chronic Gastritis in Lynch Syndrome Patients With Gastric Adenocarcinoma.Saulino D, Chen R, Wang K, Shen M, Zhang X, Westerhoff M, Cheng J, Lin J, Zhang X, Feely M, Liu X. Characterization of Chronic Gastritis in Lynch Syndrome Patients With Gastric Adenocarcinoma. Gastroenterology Research 2021, 14: 13-20. PMID: 33737995, PMCID: PMC7935615, DOI: 10.14740/gr1359.
- α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study.Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP. α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study. British Journal Of Cancer 2021, 124: 1988-1996. PMID: 33824478, PMCID: PMC8184895, DOI: 10.1038/s41416-021-01363-4.
- A Novel Treatment for Metastatic Serous Cystadenocarcinoma Using a Microwave Ablation: Case Report and Review of the Literature.Murtha TD, Cornman-Homonoff J, Ayyagari R, Zhang X, Salem RR. A Novel Treatment for Metastatic Serous Cystadenocarcinoma Using a Microwave Ablation: Case Report and Review of the Literature. Pancreas 2021, 50: 434-440. PMID: 33835976, DOI: 10.1097/MPA.0000000000001785.
- Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy.McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee A, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. Journal Of Hepatology 2021, 75: 647-658. PMID: 33991637, PMCID: PMC8285256, DOI: 10.1016/j.jhep.2021.04.050.
- Pathological characteristics of liver sinusoidal thrombosis in COVID-19 patients: A series of 43 cases.Kondo R, Kawaguchi N, McConnell MJ, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Sun Z, Utsumi T, Strazzabosco M, Iwakiri Y. Pathological characteristics of liver sinusoidal thrombosis in COVID-19 patients: A series of 43 cases. Hepatology Research : The Official Journal Of The Japan Society Of Hepatology 2021, 51: 1000-1006. PMID: 34260803, PMCID: PMC8444906, DOI: 10.1111/hepr.13696.
- Splenic-vasculature involvement is associated with poor prognosis in resected distal pancreatic cancer.Yin F, Saad M, Lin J, Jackson CR, Ren B, Lawson C, Karamchandani DM, Bernabeu BQ, Jiang W, Dhir T, Zheng R, Schultz CW, Zhang D, Thomas CL, Zhang X, Lai J, Schild M, Zhang X, Xie H, Liu X. Splenic-vasculature involvement is associated with poor prognosis in resected distal pancreatic cancer. Gastroenterology Report 2021, 9: 139-145. PMID: 34026221, PMCID: PMC8128010, DOI: 10.1093/gastro/goaa084.
- Bartonellosis in transplant recipients: A retrospective single center experience.Pischel L, Radcliffe C, Vilchez GA, Charifa A, Zhang XC, Grant M. Bartonellosis in transplant recipients: A retrospective single center experience. World Journal Of Transplantation 2021, 11: 244-253. PMID: 34164299, PMCID: PMC8218350, DOI: 10.5500/wjt.v11.i6.244.
- Hepatocellular Carcinoma: Does the Background Liver With or Without Cirrhosis Matter?Jain A, Mazer B, Deng Y, Ciarleglio M, Jain D, Taddei T, Zhang X. Hepatocellular Carcinoma: Does the Background Liver With or Without Cirrhosis Matter? American Journal Of Clinical Pathology 2022, 157: 305-313. PMID: 34542582, DOI: 10.1093/ajcp/aqab125.
- Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis.González IA, Fuller LD, Zhang X, Papke DJ, Zhao L, Zhang D, Liao X, Liu X, Fiel MI, Zhang X. Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis. American Journal Of Clinical Pathology 2022, 157: 434-442. PMID: 34596220, DOI: 10.1093/ajcp/aqab142.
- Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.Ranjan K, Hedl M, Sinha S, Zhang X, Abraham C. Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response. The Journal Of Clinical Investigation 2021, 131 PMID: 34623328, PMCID: PMC8409591, DOI: 10.1172/JCI145472.
- Pathogenic BRCA2 germline variants in combined hepatocellular-cholangiocarcinoma.Li H, Zhang X, Finberg KE, Walther Z, Jain D, Gibson J. Pathogenic BRCA2 germline variants in combined hepatocellular-cholangiocarcinoma. Pathology International 2022, 72: 138-140. PMID: 34808016, DOI: 10.1111/pin.13188.
- Pathologic Diagnosis of Nonalcoholic Fatty Liver Disease.Lai J, Wang HL, Zhang X, Wang H, Liu X. Pathologic Diagnosis of Nonalcoholic Fatty Liver Disease. Archives Of Pathology & Laboratory Medicine 2021 PMID: 34871361, DOI: 10.5858/arpa.2021-0339-RA.
- A digital pathology tool for quantification of color features in histologic specimens.Reschke M, DiRito JR, Stern D, Day W, Plebanek N, Harris M, Hosgood SA, Nicholson ML, Haakinson DJ, Zhang X, Mehal WZ, Ouyang X, Pober JS, Saltzman WM, Tietjen GT. A digital pathology tool for quantification of color features in histologic specimens. Bioengineering & Translational Medicine 2022, 7: e10242. PMID: 35111944, PMCID: PMC8780932, DOI: 10.1002/btm2.10242.
- Cytoskeletal dynamics regulates stromal invasion behavior of distinct liver cancer subtypes.Nguyen RY, Xiao H, Gong X, Arroyo A, Cabral AT, Fischer TT, Flores KM, Zhang X, Robert ME, Ehrlich BE, Mak M. Cytoskeletal dynamics regulates stromal invasion behavior of distinct liver cancer subtypes. Communications Biology 2022, 5: 202. PMID: 35241781, PMCID: PMC8894393, DOI: 10.1038/s42003-022-03121-5.
- Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model.Berz AM, Santana JG, Iseke S, Gross M, Pekurovsky V, Laage Gaupp F, Savic LJ, Borde T, Gottwald LA, Boustani AM, Gebauer B, Lin M, Zhang X, Schlachter T, Madoff DC, Chapiro J. Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model. Journal Of Vascular And Interventional Radiology : JVIR 2022 PMID: 35346859, DOI: 10.1016/j.jvir.2022.03.026.
- Heterogeneity of hepatic steatosis definitions and reporting of donor liver frozen sections among pathologists: A multicenter survey.Ho S, Kuo E, Allende D, Wang HL, Westerhoff M, Graham RP, Saxena R, Gonzalez RS, Fiel MI, Yang Z, Zhang X, Liu X. Heterogeneity of hepatic steatosis definitions and reporting of donor liver frozen sections among pathologists: A multicenter survey. Liver Transplantation : Official Publication Of The American Association For The Study Of Liver Diseases And The International Liver Transplantation Society 2022 PMID: 35377545, DOI: 10.1002/lt.26466.
- Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis.Chava S, Bugide S, Zhang X, Gupta R, Wajapeyee N. Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis. IScience 2022, 25: 104211. PMID: 35494243, PMCID: PMC9048069, DOI: 10.1016/j.isci.2022.104211.
- An Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach.Wang JD, Sebastian C, Walther Z, Suresh T, Lacy J, Zhang X, Jain D. An Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach. Archives Of Pathology & Laboratory Medicine 2022 PMID: 35512224, DOI: 10.5858/arpa.2021-0457-OA.
- Hepatocellular adenoma: Where are we now?Wang X, Zhang X. Hepatocellular adenoma: Where are we now? World Journal Of Gastroenterology : WJG 2022, 28: 1384-1393. PMID: 35582672, PMCID: PMC9048476, DOI: 10.3748/wjg.v28.i14.1384.
- Prominent Pseudoacini in Focal Nodular Hyperplasia: A Potential Diagnostic Pitfall.Wang D, González IA, Russo PA, Jain D, Zhang X. Prominent Pseudoacini in Focal Nodular Hyperplasia: A Potential Diagnostic Pitfall. The American Journal Of Surgical Pathology 2022 PMID: 35749760, DOI: 10.1097/PAS.0000000000001931.