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Xinran Liu, MD, PhD

Senior Research Scientist in Cell Biology; Director of CCMI Electron Microscopy Core Facility, Center for Cellular and Molecular Imaging

Contact Information

Xinran Liu, MD, PhD

Mailing Addresses

  • P. O. Box 208002

    New Haven, CT 06520-8002

    United States

  • Center for Cellular and Molecular Imaging

    333 Cedar Street

    New Haven, CT 06510

    United States

Research Summary

My research has been focused on 1) identifying synaptic proteins and its relation to synaptic structural specialization; 2) analyzing and characterizing the synaptic ultrastructural organization in genetically engineered animals; 3) correlating EM finding with electrophysiological recording on the mechanism of synaptic exocytosis and vesicle recycling. Currently we are: 1) developing electron tomography on synapses, this technique makes it possible to examine structural details in the 3D contest. 2) utilizing low-temperature methods to prepare cell and tissue samples aiming to reveal the dynamic events that associate with synaptic transmission or endocytosis.

Extensive Research Description

As one of the core facilities in the Medical School, We offer a wide range of services from conventional and immuno- electron microscopy to electron tomography. Our experienced staff routinely perform sample processing, sectioning and imaging for a set fee. Our facility is open to users who have had prior training in electron microscopy. The training on use of electron microscope and sample preparation is provided on a one-on-one basis throughout the year.

Coauthors

Research Images

Selected Publications