Forrester Lee, MD
Professor Emeritus of Medicine (Cardiology)
Research & Publications
Biography
News
Research Summary
My research interests span three areas:
- Clinical research in therapies for congestive heart treatment and clinical outcomes in heart transplantation. I am affiliated with the Yale Heart Failure and Transplant Center;
- Studies in heart rate variability as a method of noninvasively probing cardiovascular autonomic regulatory mechanisms in health and disease. This research includes classical methods of time series analysis as well as more recent methods based on chaos/complexity theory and nonlinear dynamics;
- Studies of health care access by African Americans and other minority populations in relation to cardiovascular disease.
Specialized Terms: Congestive heart treatment; Heart rate variability; Minority population cardiovascular health care access
Coauthors
Research Interests
Cardiology; Heart Failure; Heart Rate; Health Care Quality, Access, and Evaluation; Cultural Diversity; Minority Health
Selected Publications
- Effects of Reiki on autonomic activity early after acute coronary syndrome.Friedman RS, Burg MM, Miles P, Lee F, Lampert R. Effects of Reiki on autonomic activity early after acute coronary syndrome. Journal Of The American College Of Cardiology 2010, 56:995-6.
- Common genes contribute to depressive symptoms and heart rate variability: the Twins Heart Study.Su S, Lampert R, Lee F, Bremner JD, Snieder H, Jones L, Murrah NV, Goldberg J, Vaccarino V. Common genes contribute to depressive symptoms and heart rate variability: the Twins Heart Study. Twin Research And Human Genetics : The Official Journal Of The International Society For Twin Studies 2010, 13:1-9.
- Pleiotropy of C-reactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins.Su S, Lampert R, Zhao J, Bremner JD, Miller A, Snieder H, Lee F, Khan D, Goldberg J, Vaccarino V. Pleiotropy of C-reactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins. The American Journal Of Cardiology 2009, 104:1748-54.
- Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men.Lampert R, Bremner JD, Su S, Miller A, Lee F, Cheema F, Goldberg J, Vaccarino V. Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men. American Heart Journal 2008, 156:759.e1-7.
- Effects of psychologic stress on repolarization and relationship to autonomic and hemodynamic factors.Lampert R, Shusterman V, Burg MM, Lee FA, Earley C, Goldberg A, McPherson CA, Batsford WP, Soufer R. Effects of psychologic stress on repolarization and relationship to autonomic and hemodynamic factors. Journal Of Cardiovascular Electrophysiology 2005, 16:372-7.
- Circadian variation of sustained ventricular tachycardia in patients with coronary artery disease and implantable cardioverter-defibrillators.Lampert R, Rosenfeld L, Batsford W, Lee F, McPherson C. Circadian variation of sustained ventricular tachycardia in patients with coronary artery disease and implantable cardioverter-defibrillators. Circulation 1994, 90:241-7.
- The feasibility of high-dose chemotherapy in breast cancer patients with impaired left ventricular function.Rose M, Lee FA, Gollerkeri A, D'Andrea E, Psyrri A, Bdolah-Abram T, Burtness BA. The feasibility of high-dose chemotherapy in breast cancer patients with impaired left ventricular function. Bone Marrow Transplantation 2000, 26:133-9.
- Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients.Russell RR, Chyun D, Song S, Sherwin RS, Tamborlane WV, Lee FA, Pfeifer MA, Rife F, Wackers FJ, Young LH. Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients. American Journal Of Physiology. Endocrinology And Metabolism 2001, 281:E1029-36.
- Racial differences in the use of cardiac procedures in patients with acute myocardial infarction.Funk M, Ostfeld AM, Chang VM, Lee FA. Racial differences in the use of cardiac procedures in patients with acute myocardial infarction. Nursing Research 2002, 51:148-57.
- Heart rate variability during the week of September 11, 2001.Lampert R, Baron SJ, McPherson CA, Lee FA. Heart rate variability during the week of September 11, 2001. JAMA 2002, 288:575.
- Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial.Lampert R, Ickovics JR, Viscoli CJ, Horwitz RI, Lee FA. Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial. The American Journal Of Cardiology 2003, 91:137-42.
- Comparative costs of home positive inotropic infusion versus in-hospital care in patients awaiting cardiac transplantation.Upadya SP, Sedrakyan A, Saldarriaga C, Nystrom K, Bozzo J, Lee FA, Katz SD. Comparative costs of home positive inotropic infusion versus in-hospital care in patients awaiting cardiac transplantation. Journal Of Cardiac Failure 2004, 10:384-9.
- Home continuous positive inotropic infusion as a bridge to cardiac transplantation in patients with end-stage heart failure.Upadya S, Lee FA, Saldarriaga C, Verma S, Sedrakyan A, Nystrom K, Katz SD. Home continuous positive inotropic infusion as a bridge to cardiac transplantation in patients with end-stage heart failure. The Journal Of Heart And Lung Transplantation : The Official Publication Of The International Society For Heart Transplantation 2004, 23:466-72.
- Depressed autonomic nervous system function in African Americans and individuals of lower social class: a potential mechanism of race- and class-related disparities in health outcomes.Lampert R, Ickovics J, Horwitz R, Lee F. Depressed autonomic nervous system function in African Americans and individuals of lower social class: a potential mechanism of race- and class-related disparities in health outcomes. American Heart Journal 2005, 150:153-60.
- Long-term assessment of cardiac function after dose-dense and -intense sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) as adjuvant therapy for high risk breast cancer.Abu-Khalaf MM, Juneja V, Chung GG, DiGiovanna MP, Sipples R, McGurk M, Zelterman D, Haffty B, Reiss M, Wackers FJ, Lee FA, Burtness BA. Long-term assessment of cardiac function after dose-dense and -intense sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) as adjuvant therapy for high risk breast cancer. Breast Cancer Research And Treatment 2007, 104:341-9.
- Effect of acetylcholinesterase inhibition with pyridostigmine on cardiac parasympathetic function in sedentary adults and trained athletes.Dewland TA, Androne AS, Lee FA, Lampert RJ, Katz SD. Effect of acetylcholinesterase inhibition with pyridostigmine on cardiac parasympathetic function in sedentary adults and trained athletes. American Journal Of Physiology. Heart And Circulatory Physiology 2007, 293:H86-92.
- Pacemaker therapy for early and late sinus node dysfunction in orthotopic heart transplant recipients: a single-center experience.Luebbert JJ, Lee FA, Rosenfeld LE. Pacemaker therapy for early and late sinus node dysfunction in orthotopic heart transplant recipients: a single-center experience. Pacing And Clinical Electrophysiology : PACE 2008, 31:1108-12.
- Depressive symptoms and heart rate variability: evidence for a shared genetic substrate in a study of twins.Vaccarino V, Lampert R, Bremner JD, Lee F, Su S, Maisano C, Murrah NV, Jones L, Jawed F, Afzal N, Ashraf A, Goldberg J. Depressive symptoms and heart rate variability: evidence for a shared genetic substrate in a study of twins. Psychosomatic Medicine 2008, 70:628-36.
- A twin study of metabolic syndrome and autonomic tone.Gehi AK, Lampert R, Veledar E, Lee F, Goldberg J, Jones L, Murrah N, Ashraf A, Vaccarino V. A twin study of metabolic syndrome and autonomic tone. Journal Of Cardiovascular Electrophysiology 2009, 20:422-8.
- Cumulative stress and autonomic dysregulation in a community sample.Lampert R, Tuit K, Hong KI, Donovan T, Lee F, Sinha R. Cumulative stress and autonomic dysregulation in a community sample. Stress (Amsterdam, Netherlands) 2016, 19:269-79.
- Improving Outcomes in INTERMACS Category 1 Patients with Pre-LVAD, Awake Venous-Arterial Extracorporeal Membrane Oxygenation Support.Mori M, McCloskey G, Geirsson A, Mangi AA, Yun JJ, Jacoby D, Ahmad T, Bellumkonda L, Lee F, Chen ME, Bonde P. Improving Outcomes in INTERMACS Category 1 Patients with Pre-LVAD, Awake Venous-Arterial Extracorporeal Membrane Oxygenation Support. ASAIO Journal (American Society For Artificial Internal Organs : 1992) 2019, 65:819-826.
- Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients.Feher A, Srivastava A, Quail MA, Boutagy NE, Khanna P, Wilson L, Miller EJ, Liu YH, Lee F, Sinusas AJ. Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients. JACC. Cardiovascular Imaging 2020, 13:109-120.
- Blood Conservation Strategy at Time of Left Ventricular Assist Device Placement Improves Survival.Stawiarski K, Agboola O, Park J, Mangi A, Geirsson A, Lee F, Jacoby D, Bellumkonda L, Ahmad T, Chou J, Testani JM, Chen M, McCloskey G, Bonde P. Blood Conservation Strategy at Time of Left Ventricular Assist Device Placement Improves Survival. The Journal Of Heart And Lung Transplantation : The Official Publication Of The International Society For Heart Transplantation 2020, 39:S151.
- The Effects of Less Invasive Extra-Pericardial Placement of Left Ventricular Assist Devices on Right Ventricular Failure in the Early Postoperative Period.Stawiarski K, Agboola O, Park J, Mangi A, Geirsson A, Bellumkonda L, Lee F, Chen M, Jacoby D, Chou J, Ahmad T, Testani JM, McCloskey G, Bonde P. The Effects of Less Invasive Extra-Pericardial Placement of Left Ventricular Assist Devices on Right Ventricular Failure in the Early Postoperative Period. The Journal Of Heart And Lung Transplantation : The Official Publication Of The International Society For Heart Transplantation 2020, 39:S151-S152.
- Impact of Preoperative Lymphopenia on Survival Following Left Ventricular Assist Device Placement.Stawiarski K, Agboola O, Park J, Geirsson A, Jacoby D, Bellumkonda L, Ahmad T, Chou J, Lee F, Mangi A, Bonde P. Impact of Preoperative Lymphopenia on Survival Following Left Ventricular Assist Device Placement. ASAIO Journal (American Society For Artificial Internal Organs : 1992) 2021, 67:650-657.