2020
Regulation and Function of RNA Pseudouridylation in Human Cells
Borchardt EK, Martinez NM, Gilbert WV. Regulation and Function of RNA Pseudouridylation in Human Cells. Annual Review Of Genetics 2020, 54: 1-28. PMID: 32870730, PMCID: PMC8007080, DOI: 10.1146/annurev-genet-112618-043830.Peer-Reviewed Original ResearchConceptsRNA pseudouridylationHuman cellsRNA-binding proteinDistinct RNA sequencesMRNA pseudouridylationPseudouridine synthasesMolecular functionsRNA metabolismPseudouridylationGene expressionRNA conformationRNA targetsProtein productionRNA sequencesMessenger RNADiverse classRNATherapeutic mRNAWidespread effectsDestabilizing interactionsCellsRecent advancesSplicingSynthasesPotential effects
2017
Translation initiation factor eIF4G1 preferentially binds yeast transcript leaders containing conserved oligo-uridine motifs
Zinshteyn B, Rojas-Duran MF, Gilbert WV. Translation initiation factor eIF4G1 preferentially binds yeast transcript leaders containing conserved oligo-uridine motifs. RNA 2017, 23: 1365-1375. PMID: 28546148, PMCID: PMC5558906, DOI: 10.1261/rna.062059.117.Peer-Reviewed Original ResearchConceptsTranscript leaderEIF4GTranslational controlInitiation factorsRNA sequencesSpecific mRNAsEukaryotic initiation factor 4GRNA-binding preferencesGeneral initiation factorsIntrinsic sequence preferencesImportant cellular functionsCellular stress responseTranslation initiation factorTranslation of mRNAsOrganismal developmentYeast genesRibosome profilingContext-dependent differencesTranslational regulationCellular functionsPreferential translationYeast speciesKey mRNAsGene expressionSequence preference