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Walter Kernan, MD

Professor of Medicine (General Medicine)

Contact Information

Walter Kernan, MD

Mailing Address

  • ES Harkness Hall A

    367 Cedar Street

    New Haven, CT 06510

    United States

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Research Summary

The major focus of my research has been on the clinical epidemiology of cerebrovascular disease and the interface between primary care and stroke treatment. With colleagues in our section and in the Department of Neurology, this research has included clinical trials of new therapies for prevention of recurrent stroke (estrogen, thiazolidinediones), cohort studies of prognosis, case–control studies of risk factors, and cross-sectional examinations of quality of care. My current work includes several studies on the prevalence and course of impaired glucose metabolism among patients with a recent stroke. In addition to work on cerebrovascular disease, my research includes efforts to measure and improve clinical instruction of medical students in the ambulatory setting.

Specialized Terms: Clinical epidemiology of cerebrovascular disease; Interface between primary care and stroke treatment; Medical education

Coauthors

Research Interests

Cerebrovascular Disorders; Clinical Clerkship; Education, Medical; Epidemiology; Internal Medicine; Stroke; Physicians, Primary Care

Selected Publications

  • Factors associated with medical students' career choices regarding internal medicine.Hauer KE, Durning SJ, Kernan WN, Fagan MJ, Mintz M, O'Sullivan PS, Battistone M, DeFer T, Elnicki M, Harrell H, Reddy S, Boscardin CK, Schwartz MD. Factors associated with medical students' career choices regarding internal medicine. JAMA 2008, 300: 1154-64. PMID: 18780844, DOI: 10.1001/jama.300.10.1154.
  • Disagreement between students and preceptors regarding the value of teaching behaviors for ambulatory care settings.Kernan WN, Hershman W, Alper EJ, Lee MY, Viscoli CM, Perry JR, O'Connor PG. Disagreement between students and preceptors regarding the value of teaching behaviors for ambulatory care settings. Teaching And Learning In Medicine 2008, 20: 143-50. PMID: 18444201, DOI: 10.1080/10401330801991667.
  • Obstructive sleep apnea as a risk factor for stroke and death.Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. The New England Journal Of Medicine 2005, 353: 2034-41. PMID: 16282178, DOI: 10.1056/NEJMoa043104.
  • Pioglitazone improves insulin sensitivity among nondiabetic patients with a recent transient ischemic attack or ischemic stroke.Kernan WN, Inzucchi SE, Viscoli CM, Brass LM, Bravata DM, Shulman GI, McVeety JC, Horwitz RI. Pioglitazone improves insulin sensitivity among nondiabetic patients with a recent transient ischemic attack or ischemic stroke. Stroke; A Journal Of Cerebral Circulation 2003, 34: 1431-6. PMID: 12730556, DOI: 10.1161/01.STR.0000071108.00234.0E.
  • Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke.Kernan WN, Inzucchi SE, Viscoli CM, Brass LM, Bravata DM, Shulman GI, McVeety JC, Horwitz RI. Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke. Neurology 2003, 60: 1447-51. PMID: 12743229, DOI: 10.1212/01.wnl.0000063318.66140.a3.
  • Boosting enrollment in neurology trials with Local Identification and Outreach Networks (LIONs).Kernan WN, Viscoli CM, Demarco D, Mendes B, Shrauger K, Schindler JL, McVeety JC, Sicklick A, Moalli D, Greco P, Bravata DM, Eisen S, Resor L, Sena K, Story D, Brass LM, Furie KL, Gutmann L, Hinnau E, Gorman M, Lovejoy AM, Inzucchi SE, Young LH, Horwitz RI. Boosting enrollment in neurology trials with Local Identification and Outreach Networks (LIONs). Neurology 2009, 72: 1345-51. PMID: 19365056, PMCID: PMC2677492, DOI: 10.1212/WNL.0b013e3181a0fda3.
  • Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke.Kernan WN, Viscoli CM, Inzucchi SE, Brass LM, Bravata DM, Shulman GI, McVeety JC. Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke. Archives Of Internal Medicine 2005, 165: 227-33. PMID: 15668371, DOI: 10.1001/archinte.165.2.227.
  • Phenylpropanolamine and the risk of hemorrhagic stroke.Kernan WN, Viscoli CM, Brass LM, Broderick JP, Brott T, Feldmann E, Morgenstern LB, Wilterdink JL, Horwitz RI. Phenylpropanolamine and the risk of hemorrhagic stroke. The New England Journal Of Medicine 2000, 343: 1826-32. PMID: 11117973, DOI: 10.1056/NEJM200012213432501.
  • Preserving Research Integrity for Participants and the Public: Successful Defense against a Subpoena to Unblind an On-Going NIH TrialJAMA Intern Med 2014;174:1-3
  • The Selling of Primary Care 2015.Kernan WN, Elnicki DM, Hauer KE. The Selling of Primary Care 2015. Journal Of General Internal Medicine 2015, 30: 1376-80. PMID: 26173527, PMCID: PMC4539323, DOI: 10.1007/s11606-015-3364-9.
  • Pioglitazone after Ischemic Stroke or Transient Ischemic AttackNew England Journal of Medicine 2016;374:1321-1331
  • A prognostic system for transient ischemia or minor stroke.Kernan WN, Horwitz RI, Brass LM, Viscoli CM, Taylor KJ. A prognostic system for transient ischemia or minor stroke. Annals Of Internal Medicine 1991, 114: 552-7. PMID: 2001088, DOI: 10.7326/0003-4819-114-7-552.
  • The stroke prognosis instrument II (SPI-II) : A clinical prediction instrument for patients with transient ischemia and nondisabling ischemic stroke.Kernan WN, Viscoli CM, Brass LM, Makuch RW, Sarrel PM, Roberts RS, Gent M, Rothwell P, Sacco RL, Liu RC, Boden-Albala B, Horwitz RI. The stroke prognosis instrument II (SPI-II) : A clinical prediction instrument for patients with transient ischemia and nondisabling ischemic stroke. Stroke; A Journal Of Cerebral Circulation 2000, 31: 456-62. PMID: 10657422, DOI: 10.1161/01.str.31.2.456.
  • Metabolic rehabilitation: science gathers to support a new intervention to prevent stroke.Kernan WN, Inzucchi SE. Metabolic rehabilitation: science gathers to support a new intervention to prevent stroke. Stroke; A Journal Of Cerebral Circulation 2011, 42: 3333-5. PMID: 21998067, PMCID: PMC3226842, DOI: 10.1161/STROKEAHA.111.632489.
  • Obesity: a stubbornly obvious target for stroke prevention.Kernan WN, Inzucchi SE, Sawan C, Macko RF, Furie KL. Obesity: a stubbornly obvious target for stroke prevention. Stroke; A Journal Of Cerebral Circulation 2013, 44: 278-86. PMID: 23111440, DOI: 10.1161/STROKEAHA.111.639922.
  • Pioglitazone after Ischemic Stroke or Transient Ischemic Attack.Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, Brass LM, Schwartz GG, Adams HP, Berger L, Carolei A, Clark W, Coull B, Ford GA, Kleindorfer D, O'Leary JR, Parsons MW, Ringleb P, Sen S, Spence JD, Tanne D, Wang D, Winder TR. Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. The New England Journal Of Medicine 2016, 374: 1321-31. PMID: 26886418, PMCID: PMC4887756, DOI: 10.1056/NEJMoa1506930.
  • Smoking cessation and outcome after ischemic stroke or TIA.Epstein KA, Viscoli CM, Spence JD, Young LH, Inzucchi SE, Gorman M, Gerstenhaber B, Guarino PD, Dixit A, Furie KL, Kernan WN. Smoking cessation and outcome after ischemic stroke or TIA. Neurology 2017, 89: 1723-1729. PMID: 28887378, PMCID: PMC5644463, DOI: 10.1212/WNL.0000000000004524.
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