Wei Cheng, PhD
Associate Research Scientist in Biostatistics
Research & Publications
Biography
Research Summary
My expertise and research interests include: clinical trials methodology, clinical research based on electronic health records, systematic reviews & evidence synthesis methods (e.g. network meta-analysis, diagnostic/prognostic accuracy reviews), generalized linear mixed models (e.g. usage in count data modeling, repeated measures, and cluster randomized trials), Bayesian approaches to health-care evaluation (e.g. hierarchical models, simultaneous evidence synthesis and cost-effectiveness modeling), etc.
Research Interests
Diagnosis; Health Services Research; Cohort Studies; Clinical Trial; Evidence-Based Medicine; Comparative Effectiveness Research; Electronic Health Records; Network Meta-Analysis; Systematic Review
Public Health Interests
Clinical Guidelines; Clinical Trials
Selected Publications
- Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis.Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Medicine 2021, 47:943-960.
- What Is the Best Evidence to Guide Management of Acute Achilles Tendon Ruptures? A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.Meulenkamp B, Woolnough T, Cheng W, Shorr R, Stacey D, Richards M, Gupta A, Fergusson D, Graham ID. What Is the Best Evidence to Guide Management of Acute Achilles Tendon Ruptures? A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Clinical Orthopaedics And Related Research 2021, 479:2119-2131.
- Venous Thromboembolism Prophylaxis in Critically Ill Adults: A Systematic Review and Network Meta-analysis.Fernando SM, Tran A, Cheng W, Sadeghirad B, Arabi YM, Cook DJ, Møller MH, Mehta S, Fowler RA, Burns KEA, Wells PS, Carrier M, Crowther MA, Scales DC, English SW, Kyeremanteng K, Kanji S, Kho ME, Rochwerg B. Venous Thromboembolism Prophylaxis in Critically Ill Adults: A Systematic Review and Network Meta-analysis. Chest 2021.
- Optimising weight-loss interventions in cancer patients-A systematic review and network meta-analysis.LeVasseur N, Cheng W, Mazzarello S, Clemons M, Vandermeer L, Jones L, Joy AA, Barbeau P, Wolfe D, Ahmadzai N, Hersi M, Stober C, Shorr R, Hilton J, Hutton B. Optimising weight-loss interventions in cancer patients-A systematic review and network meta-analysis. PloS One 2021, 16:e0245794.
- Adverse Events Among Emergency Department Patients With Cardiovascular Conditions: A Multicenter Study.Calder LA, Perry J, Yan JW, De Gorter R, Sivilotti MLA, Eagles D, Myslik F, Borgundvaag B, Émond M, McRae AD, Taljaard M, Thiruganasambandamoorthy V, Cheng W, Forster AJ, Stiell IG. Adverse Events Among Emergency Department Patients With Cardiovascular Conditions: A Multicenter Study. Annals Of Emergency Medicine 2021, 77:561-574.
- Are all stem cells equal? Systematic review, evidence map, and meta-analyses of preclinical stem cell-based therapies for bronchopulmonary dysplasia.Augustine S, Cheng W, Avey MT, Chan ML, Lingappa SMC, Hutton B, Thébaud B. Are all stem cells equal? Systematic review, evidence map, and meta-analyses of preclinical stem cell-based therapies for bronchopulmonary dysplasia. Stem Cells Translational Medicine 2020, 9:158-168.
- Impact of Timing of Preprocedural Opioids on Adverse Events in Procedural Sedation.Bhatt M, Cheng W, Roback MG, Johnson DW, Taljaard M, Farion KJ, Ali S, Beno S, Dixon A, McTimoney CM, Travassos G, McGahern C, Cantor Z, Fitzpatrick E, Dow N, Naranian T, Allard G. Impact of Timing of Preprocedural Opioids on Adverse Events in Procedural Sedation. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2020, 27:217-227.
- Accuracy of the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for predicting serious complications in adult patients with febrile neutropenia: A systematic review and meta-analysis.Zheng B, Toarta C, Cheng W, Taljaard M, Reaume N, Perry JJ. Accuracy of the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for predicting serious complications in adult patients with febrile neutropenia: A systematic review and meta-analysis. Critical Reviews In Oncology/hematology 2020, 149:102922.
- Diagnosis of ventilator-associated pneumonia in critically ill adult patients-a systematic review and meta-analysis.Fernando SM, Tran A, Cheng W, Klompas M, Kyeremanteng K, Mehta S, English SW, Muscedere J, Cook DJ, Torres A, Ranzani OT, Fox-Robichaud AE, Alhazzani W, Munshi L, Guyatt GH, Rochwerg B. Diagnosis of ventilator-associated pneumonia in critically ill adult patients-a systematic review and meta-analysis. Intensive Care Medicine 2020, 46:1170-1179.
- Does N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope?Thiruganasambandamoorthy V, McRae AD, Rowe BH, Sivilotti MLA, Mukarram M, Nemnom MJ, Booth RA, Calder LA, Stiell IG, Wells GA, Cheng W, Taljaard M. Does N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope? Annals Of Internal Medicine 2020, 172:648-655.
- Comparing Interventions for Management of Hot Flashes in Patients With Breast and Prostate Cancer: A Systematic Review With Meta-Analyses.Hutton B, Hersi M, Cheng W, Pratt M, Barbeau P, Mazzarello S, Ahmadzai N, Skidmore B, Morgan SC, Bordeleau L, Ginex PK, Sadeghirad B, Morgan RL, Cole KM, Clemons M. Comparing Interventions for Management of Hot Flashes in Patients With Breast and Prostate Cancer: A Systematic Review With Meta-Analyses. Oncology Nursing Forum 2020, 47:E86-E106.
- Citation impact was highly variable for reporting guidelines of health research: a citation analysis.Caulley L, Cheng W, Catalá-López F, Whelan J, Khoury M, Ferraro J, Husereau D, Altman DG, Moher D. Citation impact was highly variable for reporting guidelines of health research: a citation analysis. Journal Of Clinical Epidemiology 2020, 127:96-104.
- Combination Tests in the Diagnosis of Chronic Periprosthetic Joint Infection: Systematic Review and Development of a Stepwise Clinical Decision-Making Tool.Abdelbary H, Cheng W, Ahmadzai N, Carli AV, Shea BJ, Hutton B, Fergusson DA, Beaulé PE. Combination Tests in the Diagnosis of Chronic Periprosthetic Joint Infection: Systematic Review and Development of a Stepwise Clinical Decision-Making Tool. The Journal Of Bone And Joint Surgery. American Volume 2020, 102:114-124.
- Pharmacologic and surgical therapies for patients with Meniere's disease: A systematic review and network meta-analysis.Ahmadzai N, Cheng W, Kilty S, Esmaeilisaraji L, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Hutton B. Pharmacologic and surgical therapies for patients with Meniere's disease: A systematic review and network meta-analysis. PloS One 2020, 15:e0237523.
- Cohort Study of Features Used by Experts to Diagnose Transient Ischemic Attack.Fitzpatrick T, Gocan S, Wang CQ, Bourgoin A, Taljaard M, Cheng W, Dowlatshahi D, Stotts G, Shamy M. Cohort Study of Features Used by Experts to Diagnose Transient Ischemic Attack. The Neurohospitalist 2020, 10:245-249.
- External validation of machine learning models including newborn metabolomic markers for postnatal gestational age estimation in East and South-East Asian infants.Hawken S, Murphy MSQ, Ducharme R, Bota AB, Wilson LA, Cheng W, Tumulak MJ, Alcausin MML, Reyes ME, Qiu W, Potter BK, Little J, Walker M, Zhang L, Padilla C, Chakraborty P, Wilson K. External validation of machine learning models including newborn metabolomic markers for postnatal gestational age estimation in East and South-East Asian infants. Gates Open Research 2020, 4:164.
- Necrotizing Soft Tissue Infection: Diagnostic Accuracy of Physical Examination, Imaging, and LRINEC Score: A Systematic Review and Meta-Analysis.Fernando SM, Tran A, Cheng W, Rochwerg B, Kyeremanteng K, Seely AJE, Inaba K, Perry JJ. Necrotizing Soft Tissue Infection: Diagnostic Accuracy of Physical Examination, Imaging, and LRINEC Score: A Systematic Review and Meta-Analysis. Annals Of Surgery 2019, 269:58-65.
- Prognostic Accuracy of the HEART Score for Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain: A Systematic Review and Meta-analysis.Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Thiruganasambandamoorthy V, Kyeremanteng K, Perry JJ. Prognostic Accuracy of the HEART Score for Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain: A Systematic Review and Meta-analysis. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2019, 26:140-151.
- Adult CSF total protein upper reference limits should be age-partitioned and significantly higher than 0.45 g/L: a systematic review.Breiner A, Moher D, Brooks J, Cheng W, Hegen H, Deisenhammer F, McCudden CR, Bourque PR. Adult CSF total protein upper reference limits should be age-partitioned and significantly higher than 0.45 g/L: a systematic review. Journal Of Neurology 2019, 266:616-624.
- Comparative evaluation of group-based mindfulness-based stress reduction and cognitive behavioural therapy for the treatment and management of chronic pain: A systematic review and network meta-analysis.Khoo EL, Small R, Cheng W, Hatchard T, Glynn B, Rice DB, Skidmore B, Kenny S, Hutton B, Poulin PA. Comparative evaluation of group-based mindfulness-based stress reduction and cognitive behavioural therapy for the treatment and management of chronic pain: A systematic review and network meta-analysis. Evidence-based Mental Health 2019, 22:26-35.
- External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh.Murphy MS, Hawken S, Cheng W, Wilson LA, Lamoureux M, Henderson M, Pervin J, Chowdhury A, Gravett C, Lackritz E, Potter BK, Walker M, Little J, Rahman A, Chakraborty P, Wilson K. External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh. ELife 2019, 8.
- Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis.Lalu MM, Fergusson DA, Cheng W, Avey MT, Corbett D, Dowlatshahi D, Macleod MR, Sena ES, Moher D, Shorr R, McCann SK, Gray LJ, Hill MD, O'Connor A, Thayer K, Haggar F, Dobriyal A, Chung HS, Welton NJ, Hutton B. Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis. F1000Research 2019, 8:11.
- Diagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements: A Systematic Review.Carli AV, Abdelbary H, Ahmadzai N, Cheng W, Shea B, Hutton B, Sniderman J, Philip Sanders BS, Esmaeilisaraji L, Skidmore B, Gauthier-Kwan OY, Bunting AC, Gauthier P, Crnic A, Logishetty K, Moher D, Fergusson D, Beaulé PE. Diagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements: A Systematic Review. The Journal Of Bone And Joint Surgery. American Volume 2019, 101:635-649.
- Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis.Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Kyeremanteng K, English SW, Sekhon MS, Griesdale DEG, Dowlatshahi D, McCredie VA, Wijdicks EFM, Almenawer SA, Inaba K, Rajajee V, Perry JJ. Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis. BMJ (Clinical Research Ed.) 2019, 366:l4225.
- Pharmacological interventions for the treatment of delirium in critically ill adults.Burry L, Hutton B, Williamson DR, Mehta S, Adhikari NK, Cheng W, Ely EW, Egerod I, Fergusson DA, Rose L. Pharmacological interventions for the treatment of delirium in critically ill adults. The Cochrane Database Of Systematic Reviews 2019, 9:CD011749.
- A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss.Ahmadzai N, Kilty S, Cheng W, Esmaeilisaraji L, Wolfe D, Bonaparte JP, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Moher D, Hutton B. A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss. PloS One 2019, 14:e0221713.
- Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis.Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Vaillancourt C, Rowan KM, Harrison DA, Nolan JP, Kyeremanteng K, McIsaac DI, Guyatt GH, Perry JJ. Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis. BMJ (Clinical Research Ed.) 2019, 367:l6373.
- Pharmacologic and surgical therapies for patients with Meniere's disease: a protocol for a systematic review and meta-analysis.Ahmadzai N, Cheng W, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Esmaeilisaraji L, Kilty S, Hutton B. Pharmacologic and surgical therapies for patients with Meniere's disease: a protocol for a systematic review and meta-analysis. Systematic Reviews 2019, 8:341.
- Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis.Fernando SM, Tran A, Taljaard M, Cheng W, Rochwerg B, Seely AJE, Perry JJ. Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis. Annals Of Internal Medicine 2018, 168:266-275.
- Number needed to treat in indirect treatment comparison.Guyot P, Cheng W, Tremblay G, Copher R, Burnett H, Li X, Makin C. Number needed to treat in indirect treatment comparison. Journal Of Comparative Effectiveness Research 2018, 7:259-269.
- The efficacy and safety of topical tranexamic acid: A systematic review and meta-analysis.Montroy J, Hutton B, Moodley P, Fergusson NA, Cheng W, Tinmouth A, Lavallée LT, Fergusson DA, Breau RH. The efficacy and safety of topical tranexamic acid: A systematic review and meta-analysis. Transfusion Medicine Reviews 2018.