William Chang, MD, PhD

• Alfred Bothwell
• Daniel Jane-Wit
• Diane Krause
• Francesc Lopez-Giraldez
• George Tellides
• Gregory Tietjen
• Jordan Pober
• Laura Niklason
• Lawrence Young
• Lin Wang
• Lingfeng Qin
• Maria Figetakis
• W. Mark Saltzman
• Xinran Liu
• Yan Huang
• Yibing Qyang
• Zhenwu Zhuang

Biotechnology; Cell Biology; Kidney; Organoids

• Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro.Kosyakova N, Kao DD, Figetakis M, López-Giráldez F, Spindler S, Graham M, James KJ, Won Shin J, Liu X, Tietjen GT, Pober JS, Chang WG. Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro. NPJ Regenerative Medicine 2020, 5: 1 PubMed ID: 31934351, PMCID: PMC6944695, DOI: 10.1038/s41536-019-0086-3.
• Tools for Kidney Tissue Engineering: Bioreactor Systems, Scaffolds, and Cell SourcesChang WG. (2019). Tools for Kidney Tissue Engineering: Bioreactor Systems, Scaffolds, and Cell Sources. In R. L. Reis, & M. E. Gomes (Eds.), Encyclopedia of Tissue Engineering and Regenerative Medicine, Vol. 1 (pp. 199–208). Academic Press: Elsevier.
• NSAID associated bilateral renal infarctions: a case report.Jeon Y, Lis JB, Chang WG. NSAID associated bilateral renal infarctions: a case report. International Journal Of Nephrology And Renovascular Disease 2019, 12: 177-181 PubMed ID: 31447577, PMCID: PMC6682756, DOI: 10.2147/IJNRD.S212010.
• A short discourse on vascular tissue engineering.Chang WG, Niklason LE. A short discourse on vascular tissue engineering. NPJ Regenerative Medicine 2017, 2 PubMed ID: 29057097, PMCID: PMC5649630, DOI: 10.1038/s41536-017-0011-6.
• ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction.Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y. ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction. JCI Insight 2016, 1 PubMed ID: 27525311, PMCID: PMC4982472, DOI: 10.1172/jci.insight.80920.
• Blocking MHC class II on human endothelium mitigates acute rejection.Abrahimi P, Qin L, Chang WG, Bothwell AL, Tellides G, Saltzman WM, Pober JS. Blocking MHC class II on human endothelium mitigates acute rejection. JCI Insight 2016, 1 PubMed ID: 26900601, PMCID: PMC4756651, DOI: 10.1172/jci.insight.85293.
• Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli.Chang WG, Fornoni A, Tietjen G, Mendez JJ, Niklason LE, Saltzman WM, Pober JS. Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli. Tissue Engineering. Part A 2015, 21: 2673-9 PubMed ID: 26414101, PMCID: PMC4652181, DOI: 10.1089/ten.TEA.2015.0060.
• Controlled protein delivery in the generation of microvascular networks.Andrejecsk JW, Chang WG, Pober JS, Saltzman WM. Controlled protein delivery in the generation of microvascular networks. Drug Delivery And Translational Research 2015, 5: 75-88 PubMed ID: 25767747, PMCID: PMC4354697, DOI: 10.1007/s13346-012-0122-y.
• Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9.Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS. Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9. Circulation Research 2015, 117: 121-8 PubMed ID: 25940550, PMCID: PMC4490936, DOI: 10.1161/CIRCRESAHA.117.306290.
• Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation.Devalliere J, Chang WG, Andrejecsk JW, Abrahimi P, Cheng CJ, Jane-wit D, Saltzman WM, Pober JS. Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2014, 28: 908-22 PubMed ID: 24221087, PMCID: PMC3898640, DOI: 10.1096/fj.13-238527.
• In vitro self-assembly of human pericyte-supported endothelial microvessels in three-dimensional coculture: a simple model for interrogating endothelial-pericyte interactions.Waters JP, Kluger MS, Graham M, Chang WG, Bradley JR, Pober JS. In vitro self-assembly of human pericyte-supported endothelial microvessels in three-dimensional coculture: a simple model for interrogating endothelial-pericyte interactions. Journal Of Vascular Research 2013, 50: 324-31 PubMed ID: 23860328, PMCID: PMC3879598, DOI: 10.1159/000353303.
• Paracrine exchanges of molecular signals between alginate-encapsulated pericytes and freely suspended endothelial cells within a 3D protein gel.Andrejecsk JW, Cui J, Chang WG, Devalliere J, Pober JS, Saltzman WM. Paracrine exchanges of molecular signals between alginate-encapsulated pericytes and freely suspended endothelial cells within a 3D protein gel. Biomaterials 2013, 34: 8899-908 PubMed ID: 23973174, PMCID: PMC3839675, DOI: 10.1016/j.biomaterials.2013.08.008.
• Pericytes modulate endothelial sprouting.Chang WG, Andrejecsk JW, Kluger MS, Saltzman WM, Pober JS. Pericytes modulate endothelial sprouting. Cardiovascular Research 2013, 100: 492-500 PubMed ID: 24042014, PMCID: PMC3826704, DOI: 10.1093/cvr/cvt215.
• GDP-mannose-4,6-dehydratase is a cytosolic partner of tankyrase 1 that inhibits its poly(ADP-ribose) polymerase activity.Bisht KK, Dudognon C, Chang WG, Sokol ES, Ramirez A, Smith S. GDP-mannose-4,6-dehydratase is a cytosolic partner of tankyrase 1 that inhibits its poly(ADP-ribose) polymerase activity. Molecular And Cellular Biology 2012, 32: 3044-53 PubMed ID: 22645305, PMCID: PMC3434517, DOI: 10.1128/MCB.00258-12.
• Protein requirements for sister telomere association in human cells.Canudas S, Houghtaling BR, Kim JY, Dynek JN, Chang WG, Smith S. Protein requirements for sister telomere association in human cells. The EMBO Journal 2007, 26: 4867-78 PubMed ID: 17962804, PMCID: PMC2099466, DOI: 10.1038/sj.emboj.7601903.
• NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.Chang W, Dynek JN, Smith S. NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. The Biochemical Journal 2005, 391: 177-84 PubMed ID: 16076287, PMCID: PMC1276914, DOI: 10.1042/BJ20050885.
• Impact of E1a modifications on tumor-selective adenoviral replication and toxicity.Sauthoff H, Pipiya T, Heitner S, Chen S, Bleck B, Reibman J, Chang W, Norman RG, Rom WN, Hay JG. Impact of E1a modifications on tumor-selective adenoviral replication and toxicity. Molecular Therapy : The Journal Of The American Society Of Gene Therapy 2004, 10: 749-57 PubMed ID: 15451459, DOI: 10.1016/j.ymthe.2004.07.014.
• A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2.Houghtaling BR, Cuttonaro L, Chang W, Smith S. A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Current Biology : CB 2004, 14: 1621-31 PubMed ID: 15380063, DOI: 10.1016/j.cub.2004.08.052.
• TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres.Chang W, Dynek JN, Smith S. TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes & Development 2003, 17: 1328-33 PubMed ID: 12782650, PMCID: PMC196064, DOI: 10.1101/gad.1077103.
• Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.Cook BD, Dynek JN, Chang W, Shostak G, Smith S. Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Molecular And Cellular Biology 2002, 22: 332-42 PubMed ID: 11739745, PMCID: PMC134233, DOI: 10.1128/mcb.22.1.332-342.2002.
• The Vibrio cholerae O139 Calcutta bacteriophage CTXphi is infectious and encodes a novel repressor.Davis BM, Kimsey HH, Chang W, Waldor MK. The Vibrio cholerae O139 Calcutta bacteriophage CTXphi is infectious and encodes a novel repressor. Journal Of Bacteriology 1999, 181: 6779-87 PubMed ID: 10542181, PMCID: PMC94144.