Featured Publications
Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Klompas M, Kyeremanteng K, Mehta S, English SW, Muscedere J, Cook DJ, Torres A, Ranzani OT, Fox-Robichaud AE, Alhazzani W, Munshi L, Guyatt GH, Rochwerg B. Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis. Intensive Care Medicine 2020, 46: 1170-1179. PMID: 32306086, PMCID: PMC7223448, DOI: 10.1007/s00134-020-06036-z.Peer-Reviewed Original ResearchConceptsVentilator-associated pneumoniaEndotracheal aspiratesChest radiographyDiagnosis of VAPBronchoscopic sampling methodsIll adult patientsPhysical examination findingsEnglish-language studiesUnnecessary antimicrobial useAdult patientsVAP diagnosisPurulent secretionsExamination findingsPhysical examinationClinical indicatorsAntibiotic treatmentHistopathological analysisStudy qualitySystematic reviewAntimicrobial usePooled sensitivityDiagnosisPneumoniaReference standardRadiography
2019
Pharmacological interventions for the treatment of delirium in critically ill adults
Burry L, Hutton B, Williamson DR, Mehta S, Adhikari NK, Cheng W, Ely EW, Egerod I, Fergusson DA, Rose L. Pharmacological interventions for the treatment of delirium in critically ill adults. 2019, 9: cd011749. PMID: 31479532, PMCID: PMC6719921, DOI: 10.1002/14651858.cd011749.pub2.Peer-Reviewed Original ResearchConceptsTreatment of deliriumIntensive care unitComa-free daysDuration of deliriumNon-pharmacological interventionsLong-term outcomesIll adultsPharmacological interventionsMechanical ventilationAgonist dexmedetomidineDrug classesICU stayIll patientsReview authorsPatient outcomesOvid MEDLINELonger intensive care unitLong-term cognitive outcomesActive drug treatmentAvailable pharmacological interventionsMultiple pharmacological interventionsLonger ICU stayIll adult patientsResolution of symptomsHigh dependency unit