DownloadHi-Res Photo

Vincent Schulz, PhD

Associate Research Scientist in Pediatrics (Neonatology)

Research & Publications
Biography
News

Coauthors

Selected Publications

Terminal Erythroid Maturation Is Associated with Dynamic Changes in the Abundance of Histone Marks Associated with Active Transcription Elongation and RNA Polymerase II PausingMurphy Z, Couch T, Lillis J, Getman M, Lezon-Geyda K, Schulz V, Narla M, Gallagher P, Steiner L. Terminal Erythroid Maturation Is Associated with Dynamic Changes in the Abundance of Histone Marks Associated with Active Transcription Elongation and RNA Polymerase II Pausing. Blood 2019, 134: 154. DOI: 10.1182/blood-2019-129561.
Altered Splicing from a Mutated Alternate Branch Point Is Common in Severe Alpha-Spectrin Linked Inherited AnemiaLezon-Geyda K, Schulz V, Maksimova Y, Gallagher P. Altered Splicing from a Mutated Alternate Branch Point Is Common in Severe Alpha-Spectrin Linked Inherited Anemia. Blood 2018, 132: 503. DOI: 10.1182/blood-2018-99-117752.
MRTFA Augments Megakaryocyte Maturation By Enhancing the SRF Regulatory AxisRahman N, Schulz V, Wang L, Gallagher P, Denisenko O, Gualdrini F, Cyril E, Krause D. MRTFA Augments Megakaryocyte Maturation By Enhancing the SRF Regulatory Axis. Blood 2018, 132: 640. DOI: 10.1182/blood-2018-99-118954.
Sensing Force by Trigeminal Neurons of Acutely Mechanosensitive BirdsSchneider E, Mastrotto M, Laursen W, Schulz V, Goodman J, Funk O, Gallagher P, Gracheva E, Bagriantsev S. Sensing Force by Trigeminal Neurons of Acutely Mechanosensitive Birds. Biophysical Journal 2015, 108: 562a. DOI: 10.1016/j.bpj.2014.11.3080.
Severe Alpha-Spectrin Linked Recessive Hereditary SpherocytosisLezon-Geyda K, Maksimova Y, Schulz V, Forget B, Gallagher P. Severe Alpha-Spectrin Linked Recessive Hereditary Spherocytosis. Blood 2014, 124: 4011. DOI: 10.1182/blood.v124.21.4011.4011.
The Patient With Transfusion-Dependent Anemia: Diagnosis and Directed Management With Targeted Next Generation Sequencing and Copy Number AnalysisSchulz V, Maksimova Y, Lezon-Geyda K, Gallagher P. The Patient With Transfusion-Dependent Anemia: Diagnosis and Directed Management With Targeted Next Generation Sequencing and Copy Number Analysis. Blood 2013, 122: 3419. DOI: 10.1182/blood.v122.21.3419.3419.
Enhancers and Super Enhancers Are Associated With Genes That Control Phenotypic Traits In Primary Human Erythroid CellsSchulz V, Lezon-Geyda K, Maksimova Y, Gallagher P. Enhancers and Super Enhancers Are Associated With Genes That Control Phenotypic Traits In Primary Human Erythroid Cells. Blood 2013, 122: 1200. DOI: 10.1182/blood.v122.21.1200.1200.
Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemiaKim Y, Schulz VP, Satake N, Gruber TA, Teixeira AM, Halene S, Gallagher PG, Krause DS. Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia. Leukemia 2013, 28: 945-948. PMID: 24157583, PMCID: PMC3981934, DOI: 10.1038/leu.2013.314.
Identification of Biologicaly Relevant Enhancers in Human Erythroid CellsSu M, Steiner L, Bogardus H, Schulz V, Hardison R, Gallagher P. Identification of Biologicaly Relevant Enhancers in Human Erythroid Cells. Blood 2012, 120: 368. DOI: 10.1182/blood.v120.21.368.368.
Pooled Short Hairpin (shRNA) Library Screen Coupled with Next-Generation Sequencing Efficiently Uncover Transcriptional Network in Neural Lineage Development of Human Embryonic Stem Cells (P02.016)Szekely A, Zhang Y, Reed B, Schulz V, Wang Z, Euskirchen G, Snyder M, Ivanova N, Weissman S. Pooled Short Hairpin (shRNA) Library Screen Coupled with Next-Generation Sequencing Efficiently Uncover Transcriptional Network in Neural Lineage Development of Human Embryonic Stem Cells (P02.016). Neurology 2012, 78: p02.016-p02.016. DOI: 10.1212/wnl.78.1_meetingabstracts.p02.016.
Pooled Short Hairpin (shRNA) Library Screen Coupled with Next-Generation Sequencing Efficiently Uncover Transcriptional Network in Neural Lineage Development of Human Embryonic Stem Cells (IN8-1.009)Szekely A, Zhang Y, Reed B, Schulz V, Wang Z, Euskirchen G, Snyder M, Ivanova N, Weissman S. Pooled Short Hairpin (shRNA) Library Screen Coupled with Next-Generation Sequencing Efficiently Uncover Transcriptional Network in Neural Lineage Development of Human Embryonic Stem Cells (IN8-1.009). Neurology 2012, 78: in8-1.009-in8-1.009. DOI: 10.1212/wnl.78.1_meetingabstracts.in8-1.009.
Primitive Erythroid Progenitors Are Regulated by Hypoxia and Display An Aerobic Glycolytic Metabolic Profile,Baron M, Isern J, Fraser S, He Z, Ma'ayan A, Schulz V, Tuck D, Gallagher P. Primitive Erythroid Progenitors Are Regulated by Hypoxia and Display An Aerobic Glycolytic Metabolic Profile,. Blood 2011, 118: 3159. DOI: 10.1182/blood.v118.21.3159.3159.
Integrated Genome-Wide CTCF and CohesinSA1 Occupancy and Expression Analyses in ErythropoiesisSchulz V, Steiner L, Maksimova Y, Gallagher P. Integrated Genome-Wide CTCF and CohesinSA1 Occupancy and Expression Analyses in Erythropoiesis. Blood 2011, 118: 1305. DOI: 10.1182/blood.v118.21.1305.1305.
Transfusion-Dependent Alpha-Spectrin Deficient Hemolytic Anemia Due to Maternal Uniparental DisomyBogardus H, Schulz V, Maksimova Y, Miller B, Forget B, Gallagher P. Transfusion-Dependent Alpha-Spectrin Deficient Hemolytic Anemia Due to Maternal Uniparental Disomy. Blood 2011, 118: 1030. DOI: 10.1182/blood.v118.21.1030.1030.
Unbiased Identification of Functional Barrier Insulators in Primary Human Erythroid Cells,Steiner L, Schulz V, Maksimova Y, Seidel N, Bodine D, Gallagher P. Unbiased Identification of Functional Barrier Insulators in Primary Human Erythroid Cells,. Blood 2011, 118: 3385. DOI: 10.1182/blood.v118.21.3385.3385.
Abstract PD01-06: Activation of the Insulin-Like Growth Factor Pathway Distinguishes African American from European American Patients with Triple-Negative Breast Cancer by Gene Expression ProfilingLindner R, Offor O, Chaves J, Lezon-Geyda K, Halligan K, Fischbach N, Shaw M, Schulz V, Harris L, Tuck D. Abstract PD01-06: Activation of the Insulin-Like Growth Factor Pathway Distinguishes African American from European American Patients with Triple-Negative Breast Cancer by Gene Expression Profiling. Cancer Research 2010, 70: pd01-06-pd01-06. DOI: 10.1158/0008-5472.sabcs10-pd01-06.
Dynamic CO-Localization of GATA1, NFE2, and EKLF and Changes in Gene Expression During HematopoiesisSteiner L, Schulz V, Maksimova Y, Mahajan M, Bodine D, Gallagher P. Dynamic CO-Localization of GATA1, NFE2, and EKLF and Changes in Gene Expression During Hematopoiesis. Blood 2010, 116: 741. DOI: 10.1182/blood.v116.21.741.741.
A Common Regulatory Signature Associated with Barrier Insulators in Human Primary Erythroid CellsSteiner L, Maksimova Y, Schulz V, Gallagher P. A Common Regulatory Signature Associated with Barrier Insulators in Human Primary Erythroid Cells. Blood 2010, 116: 3868. DOI: 10.1182/blood.v116.21.3868.3868.
Intermediate Steps In Erythroid, Megakaryocytic and Myeloid Lineage SpecificationLian Z, Mahajan M, Schulz V, Gulcicek E, Krause D, Weissman S. Intermediate Steps In Erythroid, Megakaryocytic and Myeloid Lineage Specification. Blood 2010, 116: 4778. DOI: 10.1182/blood.v116.21.4778.4778.
The HDAC Inhibitor TSA Inhibits Cell Proliferation, Induces Apoptosis and Down-Regulates HER2 Protein and Gene Expression as a Single Agent and in Combination with Trastuzumab in Trastuzumab-Sensitive and -Resistant Breast Cancer Cell Lines.Radke S, Perincheri S, Schulz V, Lerner B, Kumar A, Chandrasekan L, Tuck D, Harris L. The HDAC Inhibitor TSA Inhibits Cell Proliferation, Induces Apoptosis and Down-Regulates HER2 Protein and Gene Expression as a Single Agent and in Combination with Trastuzumab in Trastuzumab-Sensitive and -Resistant Breast Cancer Cell Lines. Cancer Research 2009, 69: 3133-3133. DOI: 10.1158/0008-5472.sabcs-09-3133.
Genome-Wide Profiling of Archived Material from CALGB 9840 and 9342 for Paclitaxel (P) and Trastuzumab (T) Response Biomarkers Using Gene Expression and Copy Number Analysis.Harris L, Parker J, Broadwater G, Schulz V, Halligan K, Geyda K, Seidman A, Berry D, Winer E, Hudis C, Krasnitz A, Hicks J, Tuck D, Perou C. Genome-Wide Profiling of Archived Material from CALGB 9840 and 9342 for Paclitaxel (P) and Trastuzumab (T) Response Biomarkers Using Gene Expression and Copy Number Analysis. Cancer Research 2009, 69: 4032-4032. DOI: 10.1158/0008-5472.sabcs-09-4032.
Patterns of Monomethylation of Histone H3 Lysine 27 Influence Gene Expression in a Cell-Type Specific Manner.Steiner L, Schulz V, Maksimova Y, Wong C, Tuck D, Gallagher P. Patterns of Monomethylation of Histone H3 Lysine 27 Influence Gene Expression in a Cell-Type Specific Manner. Blood 2009, 114: 4585. DOI: 10.1182/blood.v114.22.4585.4585.
Genome Expression Profiling of the First Hematopoietic Progenitors of the Mouse Embryo.Baron M, Isern J, Fraser S, He Z, Tuck D, Schulz V, Gallagher P. Genome Expression Profiling of the First Hematopoietic Progenitors of the Mouse Embryo. Blood 2009, 114: 2536. DOI: 10.1182/blood.v114.22.2536.2536.
Genome Wide Profiling of USF1 and USF2 Occupancy in Human Primary Erythroid Cells.Steiner L, Schulz V, Maksimova Y, Tuck D, Gallagher P. Genome Wide Profiling of USF1 and USF2 Occupancy in Human Primary Erythroid Cells. Blood 2009, 114: 1456. DOI: 10.1182/blood.v114.22.1456.1456.
EBNA1—A virally encoded protein binds cellular host promoters in a unique sequence and directly interferes with cellular gene expression. Implications for genomics approaches in drug designCanaan A, Schulz V, Mahajan M, Urban A, Weissman S. EBNA1—A virally encoded protein binds cellular host promoters in a unique sequence and directly interferes with cellular gene expression. Implications for genomics approaches in drug design. Antiviral Research 2009, 82: a69-a70. DOI: 10.1016/j.antiviral.2009.02.171.
Chromatin Architecture and Transcription Factor Occupancy of Erythrocyte Membrane Genes Studied by Chromatin Immunoprecipitation on Microarrays (ChIP-chip)Steiner L, Maksimova Y, Wong C, Schulz V, Gallagher P. Chromatin Architecture and Transcription Factor Occupancy of Erythrocyte Membrane Genes Studied by Chromatin Immunoprecipitation on Microarrays (ChIP-chip). Blood 2008, 112: 2436. DOI: 10.1182/blood.v112.11.2436.2436.
Insulator Elements in Erythrocyte Membrane GenesSteiner L, Maksimova Y, Lin J, Owen A, Schulz V, Bodine D, Gallagher P. Insulator Elements in Erythrocyte Membrane Genes. Blood 2008, 112: 3584. DOI: 10.1182/blood.v112.11.3584.3584.
OTT-MKL1 and MKL1 Inhibit Wnt Signaling.Halene S, Cheng E, Schulz V, Tuck D, Krause D. OTT-MKL1 and MKL1 Inhibit Wnt Signaling. Blood 2008, 112: 2250. DOI: 10.1182/blood.v112.11.2250.2250.
Allelic dropout in long QT syndrome genetic testing: A possible mechanism underlying false-negative resultsTester D, Cronk L, Carr J, Schulz V, Salisbury B, Judson R, Ackerman M. Allelic dropout in long QT syndrome genetic testing: A possible mechanism underlying false-negative results. Heart Rhythm 2006, 3: 815-821. PMID: 16818214, DOI: 10.1016/j.hrthm.2006.03.016.
The Pattern of Polymorphism in Arabidopsis thalianaNordborg M, Hu T, Ishino Y, Jhaveri J, Toomajian C, Zheng H, Bakker E, Calabrese P, Gladstone J, Goyal R, Jakobsson M, Kim S, Morozov Y, Padhukasahasram B, Plagnol V, Rosenberg N, Shah C, Wall J, Wang J, Zhao K, Kalbfleisch T, Schulz V, Kreitman M, Bergelson J. The Pattern of Polymorphism in Arabidopsis thaliana. PLOS Biology 2005, 3: e196. PMID: 15907155, PMCID: PMC1135296, DOI: 10.1371/journal.pbio.0030196.
Repeat long QT syndrome genetic testing of phenotype positive cases: Prevalence and etiology of detection missesWill M, Tester D, Salisbury B, Carr J, Schulz V, Judson R, Ackerman M. Repeat long QT syndrome genetic testing of phenotype positive cases: Prevalence and etiology of detection misses. Heart Rhythm 2005, 2: s132. DOI: 10.1016/j.hrthm.2005.02.412.
Allelic drop-out in long QT syndrome genetic testing: A possible mechanism underlying false negative resultsTester D, Will M, Salisbury B, Carr J, Schulz V, Judson R, Ackerman M. Allelic drop-out in long QT syndrome genetic testing: A possible mechanism underlying false negative results. Heart Rhythm 2005, 2: s7. DOI: 10.1016/j.hrthm.2005.02.034.
Schizosaccharomyces pombe pfh1+Encodes an Essential 5′ to 3′ DNA Helicase That Is a Member of thePIF1 Subfamily of DNA HelicasesZhou J, Qi H, Schulz V, Mateyak M, Monson E, Zakian V. Schizosaccharomyces pombe pfh1+Encodes an Essential 5′ to 3′ DNA Helicase That Is a Member of thePIF1 Subfamily of DNA Helicases. Molecular Biology Of The Cell 2002, 13: 2180-2191. PMID: 12058079, PMCID: PMC117634, DOI: 10.1091/mbc.02-02-0021.
Haplotype Variation and Linkage Disequilibrium in 313 Human GenesStephens J, Schneider J, Tanguay D, Choi J, Acharya T, Stanley S, Jiang R, Messer C, Chew A, Han J, Duan J, Carr J, Lee M, Koshy B, Kumar A, Zhang G, Newell W, Windemuth A, Xu C, Kalbfleisch T, Shaner S, Arnold K, Schulz V, Drysdale C, Nandabalan K, Judson R, Ruaño G, Vovis G. Haplotype Variation and Linkage Disequilibrium in 313 Human Genes. Science 2001, 293: 489-493. PMID: 11452081, DOI: 10.1126/science.1059431.
Pif1p Helicase, a Catalytic Inhibitor of Telomerase in YeastZhou J, Monson E, Teng S, Schulz V, Zakian V. Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast. Science 2000, 289: 771-774. PMID: 10926538, DOI: 10.1126/science.289.5480.771.
Telomere Length Regulation by the Pif1 DNA HelicaseMonson E, Schulz V, Zakian V. Telomere Length Regulation by the Pif1 DNA Helicase. 1997, 97-110. DOI: 10.1007/978-1-4615-5365-6_7.
Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cellsSchulz V, Zakian V, Ogburn C, McKay J, Jarzebowicz A, Martin G, Edland S. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Human Genetics 1996, 97: 750-754. PMID: 8641691, DOI: 10.1007/bf02346184.
The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formationSchulz V, Zakian V. The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation. Cell 1994, 76: 145-155. PMID: 8287473, DOI: 10.1016/0092-8674(94)90179-1.
Translation initiation of IS50R read-through transcriptsSchulz V, Reznikoff W. Translation initiation of IS50R read-through transcripts. Journal Of Molecular Biology 1991, 221: 65-80. PMID: 1717696, DOI: 10.1016/0022-2836(91)80205-9.
In vitro secondary structure analysis of mRNA from lacZ translation initiation mutantsSchulz V, Reznikoff W. In vitro secondary structure analysis of mRNA from lacZ translation initiation mutants. Journal Of Molecular Biology 1990, 211: 427-445. PMID: 2106583, DOI: 10.1016/0022-2836(90)90363-q.
Pseudorevertants of a lac promoter mutation reveal overlapping nascent promotersKarls R, Schulz V, Jovanovich S, Flynn S, Pak A, Reznikoff W. Pseudorevertants of a lac promoter mutation reveal overlapping nascent promoters. Nucleic Acids Research 1989, 17: 3927-3949. PMID: 2499870, PMCID: PMC317870, DOI: 10.1093/nar/17.10.3927.

Edit Profile

Contact Information

Research & Publications

Biography

News

Coauthors

Selected Publications