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Edward Vincent Faustino, MD, MHS

Associate Professor of Pediatrics (Critical Care); Visiting Professor of Pediatrics (University of the Philippines College of Medicine); Principal Investigator, Pathobiology, Epidemiology and Interventions against Thrombotic and Hemostatic Outcomes (PEITHO) Program, Pediatrics

Research Summary

Dr. Faustino studies treatment strategies that could improve the outcomes of critically ill children. He is currently focused on the prevention of blood clots in these children. He conducts observational and interventional studies to understand how blood clots form in children.

Specialized Terms: venous thrombosis; thromboembolism; anticoagulation; hemostasis; thrombin generation; platelet; clinical trial; biomarker; risk prediction model; critical care; child

Extensive Research Description

Dr. Faustino is a patient-oriented researcher who focuses on improving the outcomes of critically ill children. His research is focused on the prevention of venous thrombosis and its complications in children. He is the Principal Investigator of the Pathobiology, Epidemiology and Interventions against Thrombotic and Hemostatic Outcomes (PEITHO) Program. The goals of the PEITHO Program are (1) to conduct multi center observational studies that will inform the design and execution of interventional studies on venous thrombosis in children, (2) to conduct multi center randomized clinical trials on the prevention of venous thrombosis in children that will inform clinical practice, and (3) to leverage observational and interventional studies to understand the pathobiology of venous thrombosis in children.

Dr. Faustino is primarily investigating catheter-related thrombosis because the use of central venous catheters is the most common cause of venous thrombosis in children. He has conducted observational studies on the epidemiology of catheter-related thrombosis in critically ill children, completed surveys on thromboprophylaxis in pediatric intensive care units, identified potential biomarkers for catheter-related thrombosis and established collaborations with other researchers invested in the prevention of venous thrombosis. He recently completed a randomized clinical trial on early thromboprophylaxis against catheter-related thrombosis in critically ill children.

Dr. Faustino's ongoing studies include:

1. Age-dependent efficacy of enoxaparin against catheter-related thrombosis in critically ill children. The goal of these studies is to investigate the differential efficacy of enoxaparin between critically ill infants and older children against catheter-related thrombosis.

2. Role of platelets in catheter-related thrombosis in infants. The goal of these studies is to understand the role of platelets in the development of catheter-related thrombosis in infants.

3. Venous thrombosis in children at high risk of bleeding. The goal of these studies is to identify effective strategies against venous thrombosis in surgical or seriously injured children.

4. Venous thrombosis in critically ill adolescents. The goal of these studies is to identify the optimal strategy to prevent venous thrombosis in critically ill adolescents.

Research Interests

Anticoagulants; Blood Platelets; Child; Critical Care; Hemostasis; Pediatrics; Thrombin; Thromboembolism; Biomarkers; Clinical Trial; Venous Thrombosis

Clinical Trials

ConditionsStudy Title
Diseases in Infants & Newborns; Infectious DiseasesEvaluation of Pharmacokinetics, Safety, and Tolerability of Ceftazidime-avibactam in Neonates and Infants. (NOOR)
Children's Health; Genetics - PediatricPediatric Genomics Discovery Program (PGDP)