TuKiet Lam, PhD, BA

• Adam V Wisnewski
• Alvaro Duque
• Amy Arnsten
• Angelique Bordey
• Angus Nairn
• Anne Eichmann
• Anthony Koleske
• Caroline Zeiss
• Chirag Parikh
• Erica Herzog
• Ethan Foscue
• Ethan Marin
• Gang Peng
• George Anderson
• Georgia Charkoftaki
• Hideyuki Takahashi
• Hongyu Zhao
• Huanxing Sun
• Irina Esterlis
• James W Murphy
• Jane Taylor
• Jesse Rinehart
• Jonathan Ellman
• Jorge Galán
• Jose Gomez Villalobos
• Junhui Zhang
• Justin Belcher
• Kei-Hoi Cheung
• Kenneth Williams
• Laura Niklason
• Lin Shao
• Lloyd G. Cantley
• Maksym Minasyan
• María Lara-Tejero
• Marina Picciotto
• Mark Gerstein
• Mridu Gulati
• Nadia Ameen
• Neera Dahl
• Nenad Sestan
• Nicola Santoro
• Paul Lombroso
• Perry Miller
• Raimund Herzog
• Richard Lifton
• Rolando Garcia Milian
• Sherman Weissman
• Shrikant Mane
• Sonia Caprio
• Sreeganga Chandra
• Stephen Strittmatter
• Thomas Biederer
• Titus Boggon
• Vanessa Marie Baratta
• Vasilis Vasiliou
• William Sessa
• Wonnie Ryu
• Xinran Liu

Chromatography, High Pressure Liquid; Lipids; Metabolism; Peptide Mapping; Peptides; Proteins; Research Design; Tissue Extracts; Spectrometry, Mass, Electrospray Ionization; Proteomics; Tandem Mass Spectrometry

Aging; Biomarkers; Cancer; Cardiovascular Diseases; Respiratory Disease/Infections

• Nutrient Composition and Fatty Acid and Protein Profiles of Selected Fish By-Products.Kandyliari A, Mallouchos A, Papandroulakis N, Golla JP, Lam TT, Sakellari A, Karavoltsos S, Vasiliou V, Kapsokefalou M. Nutrient Composition and Fatty Acid and Protein Profiles of Selected Fish By-Products. Foods (Basel, Switzerland) 2020, 9 PMID: 32075005, PMCID: PMC7074476, DOI: 10.3390/foods9020190.
• An omic approach to congenital diaphragmatic hernia: a pilot study of genomic, microRNA, and metabolomic profiling.Piersigilli F, Syed M, Lam TT, Dotta A, Massoud M, Vernocchi P, Quagliariello A, Putignani L, Auriti C, Salvatori G, Bagolan P, Bhandari V. An omic approach to congenital diaphragmatic hernia: a pilot study of genomic, microRNA, and metabolomic profiling. Journal Of Perinatology : Official Journal Of The California Perinatal Association 2020, 40: 952-961. PMID: 32080334, DOI: 10.1038/s41372-020-0623-3.
• Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea.Ahsan MK, Figueora-Hall L, Baratta VM, Garcia-Milian R, Lam TT, Hoque KM, Salas PJ, Ameen NA. Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2020, 319: G121-G132. PMID: 32567324, PMCID: PMC7500270, DOI: 10.1152/ajpgi.00076.2020.
• Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma-Associated Interstitial Lung Disease.Ryu C, Walia A, Ortiz V, Perry C, Woo S, Reeves BC, Sun H, Winkler J, Kanyo JE, Wang W, Vukmirovic M, Ristic N, Stratton EA, Meena SR, Minasyan M, Kurbanov D, Liu X, Lam TT, Farina G, Gomez JL, Gulati M, Herzog EL. Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma-Associated Interstitial Lung Disease. Arthritis & Rheumatology (Hoboken, N.J.) 2020, 72: 1905-1915. PMID: 32602227, PMCID: PMC8081728, DOI: 10.1002/art.41418.
• Development and Validation of LC-MS-MS Assay for the Determination of the Emerging Alkylating Agent Laromustine and Its Active Metabolite in Human Plasma.Nassar AF, Wisnewski AV, Wu T, Lam TT, King I. Development and Validation of LC-MS-MS Assay for the Determination of the Emerging Alkylating Agent Laromustine and Its Active Metabolite in Human Plasma. Journal Of Chromatographic Science 2019, 57: 195-203. PMID: 30395213, DOI: 10.1093/chromsci/bmy100.
• Phosphoproteomic analysis of cocaine memory extinction and reconsolidation in the nucleus accumbens.Torregrossa MM, MacDonald M, Stone KL, Lam TT, Nairn AC, Taylor JR. Phosphoproteomic analysis of cocaine memory extinction and reconsolidation in the nucleus accumbens. Psychopharmacology 2019, 236: 531-543. PMID: 30411139, PMCID: PMC6374162, DOI: 10.1007/s00213-018-5071-9.
• ProteomicsBrowser: MS/proteomics data visualization and investigation.Peng G, Wilson R, Tang Y, Lam TT, Nairn AC, Williams K, Zhao H. ProteomicsBrowser: MS/proteomics data visualization and investigation. Bioinformatics (Oxford, England) 2019, 35: 2313-2314. PMID: 30462190, PMCID: PMC6596887, DOI: 10.1093/bioinformatics/bty958.
• Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid.Kiapour AM, Sieker JT, Proffen BL, Lam TT, Fleming BC, Murray MM. Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid. PloS One 2019, 14: e0212662. PMID: 30822327, PMCID: PMC6396923, DOI: 10.1371/journal.pone.0212662.
• Identification of new biomarkers of bronchopulmonary dysplasia using metabolomics.Piersigilli F, Lam TT, Vernocchi P, Quagliariello A, Putignani L, Aghai ZH, Bhandari V. Identification of new biomarkers of bronchopulmonary dysplasia using metabolomics. Metabolomics : Official Journal Of The Metabolomic Society 2019, 15: 20. PMID: 30830433, DOI: 10.1007/s11306-019-1482-9.
• Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells.Charkoftaki G, Thompson DC, Golla JP, Garcia-Milian R, Lam TT, Engel J, Vasiliou V. Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells. Chemico-biological Interactions 2019, 304: 88-96. PMID: 30851239, PMCID: PMC7988342, DOI: 10.1016/j.cbi.2019.02.030.
• Development of Targeted Mass Spectrometry-Based Approaches for Quantitation of Proteins Enriched in the Postsynaptic Density (PSD).Wilson RS, Rauniyar N, Sakaue F, Lam TT, Williams KR, Nairn AC. Development of Targeted Mass Spectrometry-Based Approaches for Quantitation of Proteins Enriched in the Postsynaptic Density (PSD). Proteomes 2019, 7 PMID: 30986977, PMCID: PMC6630806, DOI: 10.3390/proteomes7020012.
• Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions.Farasyn T, Crowe A, Hatley O, Neuhoff S, Alam K, Kanyo J, Lam T, Ding K, Yue W. Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions. Journal Of Pharmaceutical Sciences 2019, 108: 3443-3456. PMID: 31047942, PMCID: PMC6759397, DOI: 10.1016/j.xphs.2019.04.019.
• A single phosphoacceptor residue in BGLF3 is essential for transcription of Epstein-Barr virus late genes.Li J, Walsh A, Lam TT, Delecluse HJ, El-Guindy A. A single phosphoacceptor residue in BGLF3 is essential for transcription of Epstein-Barr virus late genes. PLoS Pathogens 2019, 15: e1007980. PMID: 31461506, PMCID: PMC6713331, DOI: 10.1371/journal.ppat.1007980.
• Phosphorylation of human placental aromatase CYP19A1.Ghosh D, Egbuta C, Kanyo J, Lam TT. Phosphorylation of human placental aromatase CYP19A1. The Biochemical Journal 2019, 476: 3313-3331. PMID: 31652308, PMCID: PMC7069221, DOI: 10.1042/BCJ20190633.
• Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring.Rauniyar N, Yu X, Cantley J, Voss E, Belcher J, Colangelo C, Stone K, Dahl N, Parikh C, Lam TT, Cantley LG. Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring. Proteomics. Clinical Applications 2018, 12: e1700157. PMID: 29573172, PMCID: PMC6736530, DOI: 10.1002/prca.201700157.
• Isoform-Level Interpretation of High-Throughput Proteomics Data Enabled by Deep Integration with RNA-seq.Carlyle BC, Kitchen RR, Zhang J, Wilson R, Lam TT, Rozowsky JS, Williams KR, Sestan N, Gerstein M, Nairn AC. Isoform-Level Interpretation of High-Throughput Proteomics Data Enabled by Deep Integration with RNA-seq. Journal Of Proteome Research 2018, 17: 3431-3444. PMID: 30125121, PMCID: PMC6392456, DOI: 10.1021/acs.jproteome.8b00310.
• Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates.Goel RK, Meyer M, Paczkowska M, Reimand J, Vizeacoumar F, Vizeacoumar F, Lam TT, Lukong KE. Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates. Proteome Science 2018, 16: 16. PMID: 30140170, PMCID: PMC6098843, DOI: 10.1186/s12953-018-0143-7.
• Granulocyte-Colony-Stimulating Factor Alters the Proteomic Landscape of the Ventral Tegmental Area.Mervosh NL, Wilson R, Rauniyar N, Hofford RS, Kutlu MG, Calipari ES, Lam TT, Kiraly DD. Granulocyte-Colony-Stimulating Factor Alters the Proteomic Landscape of the Ventral Tegmental Area. Proteomes 2018, 6 PMID: 30249060, PMCID: PMC6313867, DOI: 10.3390/proteomes6040035.
• Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol.Bertholomey ML, Stone K, Lam TT, Bang S, Wu W, Nairn AC, Taylor JR, Torregrossa MM. Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol. Proteomes 2018, 6 PMID: 30322021, PMCID: PMC6313880, DOI: 10.3390/proteomes6040041.
• Evaluation of the Phosphoproteome of Mouse Alpha 4/Beta 2-Containing Nicotinic Acetylcholine Receptors In Vitro and In Vivo.Miller MB, Wilson RS, Lam TT, Nairn AC, Picciotto MR. Evaluation of the Phosphoproteome of Mouse Alpha 4/Beta 2-Containing Nicotinic Acetylcholine Receptors In Vitro and In Vivo. Proteomes 2018, 6 PMID: 30326594, PMCID: PMC6313896, DOI: 10.3390/proteomes6040042.
• Mapping the Proteome of the Synaptic Cleft through Proximity Labeling Reveals New Cleft Proteins.Cijsouw T, Ramsey AM, Lam TT, Carbone BE, Blanpied TA, Biederer T. Mapping the Proteome of the Synaptic Cleft through Proximity Labeling Reveals New Cleft Proteins. Proteomes 2018, 6 PMID: 30487426, PMCID: PMC6313906, DOI: 10.3390/proteomes6040048.
• Rice calcium-dependent protein kinase OsCPK17 targets plasma membrane intrinsic protein and sucrose-phosphate synthase and is required for a proper cold stress response.Almadanim MC, Alexandre BM, Rosa MTG, Sapeta H, Leitão AE, Ramalho JC, Lam TT, Negrão S, Abreu IA, Oliveira MM. Rice calcium-dependent protein kinase OsCPK17 targets plasma membrane intrinsic protein and sucrose-phosphate synthase and is required for a proper cold stress response. Plant, Cell & Environment 2017, 40: 1197-1213. PMID: 28102545, DOI: 10.1111/pce.12916.
• A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease.Goffredo M, Santoro N, Tricò D, Giannini C, D'Adamo E, Zhao H, Peng G, Yu X, Lam TT, Pierpont B, Caprio S, Herzog RI. A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease. Nutrients 2017, 9 PMID: 28640216, PMCID: PMC5537762, DOI: 10.3390/nu9070642.
• A multiregional proteomic survey of the postnatal human brain.Carlyle BC, Kitchen RR, Kanyo JE, Voss EZ, Pletikos M, Sousa AMM, Lam TT, Gerstein MB, Sestan N, Nairn AC. A multiregional proteomic survey of the postnatal human brain. Nature Neuroscience 2017, 20: 1787-1795. PMID: 29184206, PMCID: PMC5894337, DOI: 10.1038/s41593-017-0011-2.
• The repeat region of cortactin is intrinsically disordered in solution.Li X, Tao Y, Murphy JW, Scherer AN, Lam TT, Marshall AG, Koleske AJ, Boggon TJ. The repeat region of cortactin is intrinsically disordered in solution. Scientific Reports 2017, 7: 16696. PMID: 29196701, PMCID: PMC5711941, DOI: 10.1038/s41598-017-16959-1.
• Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition.Musante V, Li L, Kanyo J, Lam TT, Colangelo CM, Cheng SK, Brody AH, Greengard P, Le Novère N, Nairn AC. Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. ELife 2017, 6 PMID: 28613156, PMCID: PMC5515580, DOI: 10.7554/eLife.24998.
• MELK Promotes Melanoma Growth by Stimulating the NF-κB Pathway.Janostiak R, Rauniyar N, Lam TT, Ou J, Zhu LJ, Green MR, Wajapeyee N. MELK Promotes Melanoma Growth by Stimulating the NF-κB Pathway. Cell Reports 2017, 21: 2829-2841. PMID: 29212029, PMCID: PMC5726781, DOI: 10.1016/j.celrep.2017.11.033.
• Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity.Miller MB, Yan Y, Machida K, Kiraly DD, Levy AD, Wu YI, Lam TT, Abbott T, Koleske AJ, Eipper BA, Mains RE. Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity. ACS Chemical Neuroscience 2017, 8: 1554-1569. PMID: 28418645, PMCID: PMC5517348, DOI: 10.1021/acschemneuro.7b00076.
• Proteomics data on MAP Kinase Kinase 3 knock out bone marrow derived macrophages exposed to cigarette smoke extract.Srivastava R, Mannam P, Rauniyar N, Lam TT, Luo R, Lee PJ, Srivastava A. Proteomics data on MAP Kinase Kinase 3 knock out bone marrow derived macrophages exposed to cigarette smoke extract. Data In Brief 2017, 13: 320-325. PMID: 28653025, PMCID: PMC5476452, DOI: 10.1016/j.dib.2017.05.049.
• Data-Independent Acquisition and Parallel Reaction Monitoring Mass Spectrometry Identification of Serum Biomarkers for Ovarian Cancer.Rauniyar N, Peng G, Lam TT, Zhao H, Mor G, Williams KR. Data-Independent Acquisition and Parallel Reaction Monitoring Mass Spectrometry Identification of Serum Biomarkers for Ovarian Cancer. Biomarker Insights 2017, 12: 1177271917710948. PMID: 28615921, PMCID: PMC5462478, DOI: 10.1177/1177271917710948.
• Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth.Glass LN, Swapna G, Chavadi SS, Tufariello JM, Mi K, Drumm JE, Lam TT, Zhu G, Zhan C, Vilchéze C, Arcos J, Chen Y, Bi L, Mehta S, Porcelli SA, Almo SC, Yeh SR, Jacobs WR, Torrelles JB, Chan J. Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth. PLoS Pathogens 2017, 13: e1006515. PMID: 28753640, PMCID: PMC5549992, DOI: 10.1371/journal.ppat.1006515.
• Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Klein ZA, Takahashi H, Ma M, Stagi M, Zhou M, Lam TT, Strittmatter SM. Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. Neuron 2017, 95: 281-296.e6. PMID: 28728022, PMCID: PMC5558861, DOI: 10.1016/j.neuron.2017.06.026.
• Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex.McClure-Begley TD, Esterlis I, Stone KL, Lam TT, Grady SR, Colangelo CM, Lindstrom JM, Marks MJ, Picciotto MR. Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. ENeuro 2016, 3 PMID: 27559543, PMCID: PMC4985585, DOI: 10.1523/ENEURO.0166-16.2016.
• Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation.Henderson MX, Wirak GS, Zhang YQ, Dai F, Ginsberg SD, Dolzhanskaya N, Staropoli JF, Nijssen PC, Lam TT, Roth AF, Davis NG, Dawson G, Velinov M, Chandra SS. Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Acta Neuropathologica 2016, 131: 621-37. PMID: 26659577, PMCID: PMC4791186, DOI: 10.1007/s00401-015-1512-2.
• Phosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIα Regulation Inversely Induced by Cocaine Memory Extinction versus Reconsolidation.Rich MT, Abbott TB, Chung L, Gulcicek EE, Stone KL, Colangelo CM, Lam TT, Nairn AC, Taylor JR, Torregrossa MM. Phosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIα Regulation Inversely Induced by Cocaine Memory Extinction versus Reconsolidation. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2016, 36: 7613-27. PMID: 27445140, PMCID: PMC4951572, DOI: 10.1523/JNEUROSCI.1108-16.2016.
• SILAC based protein profiling data of MKK3 knockout mouse embryonic fibroblasts.Srivastava A, Shinn AS, Lam TT, Lee PJ, Mannam P. SILAC based protein profiling data of MKK3 knockout mouse embryonic fibroblasts. Data In Brief 2016, 7: 418-22. PMID: 26977448, PMCID: PMC4782019, DOI: 10.1016/j.dib.2016.02.034.
• O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking.Vishwanatha KS, Bäck N, Lam TT, Mains RE, Eipper BA. O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking. The Journal Of Biological Chemistry 2016, 291: 9835-50. PMID: 26961877, PMCID: PMC4850319, DOI: 10.1074/jbc.M115.711838.
• Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis.Sun H, Zhu Y, Pan H, Chen X, Balestrini JL, Lam TT, Kanyo JE, Eichmann A, Gulati M, Fares WH, Bai H, Feghali-Bostwick CA, Gan Y, Peng X, Moore MW, White ES, Sava P, Gonzalez AL, Cheng Y, Niklason LE, Herzog EL. Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis. Arthritis & Rheumatology (Hoboken, N.J.) 2016, 68: 1251-61. PMID: 26749424, PMCID: PMC5547894, DOI: 10.1002/art.39575.
• MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation.Mannam P, Rauniyar N, Lam TT, Luo R, Lee PJ, Srivastava A. MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation. Free Radical Biology & Medicine 2016, 101: 102-115. PMID: 27717867, DOI: 10.1016/j.freeradbiomed.2016.10.001.
• MKK3 deletion improves mitochondrial quality.Srivastava A, McGinniss J, Wong Y, Shinn AS, Lam TT, Lee PJ, Mannam P. MKK3 deletion improves mitochondrial quality. Free Radical Biology & Medicine 2015, 87: 373-84. PMID: 26119780, DOI: 10.1016/j.freeradbiomed.2015.06.024.
• YPED: an integrated bioinformatics suite and database for mass spectrometry-based proteomics research.Colangelo CM, Shifman M, Cheung KH, Stone KL, Carriero NJ, Gulcicek EE, Lam TT, Wu T, Bjornson RD, Bruce C, Nairn AC, Rinehart J, Miller PL, Williams KR. YPED: an integrated bioinformatics suite and database for mass spectrometry-based proteomics research. Genomics, Proteomics & Bioinformatics 2015, 13: 25-35. PMID: 25712262, PMCID: PMC4411476, DOI: 10.1016/j.gpb.2014.11.002.
• Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ. Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease. PLoS Biology 2014, 12: e1001923. PMID: 25093460, PMCID: PMC4122355, DOI: 10.1371/journal.pbio.1001923.
• Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.Shibata S, Arroyo JP, Castañeda-Bueno M, Puthumana J, Zhang J, Uchida S, Stone KL, Lam TT, Lifton RP. Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 15556-61. PMID: 25313067, PMCID: PMC4217463, DOI: 10.1073/pnas.1418342111.
• Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl.Ma XM, Miller MB, Vishwanatha KS, Gross MJ, Wang Y, Abbott T, Lam TT, Mains RE, Eipper BA. Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl. Molecular Biology Of The Cell 2014, 25: 1458-71. PMID: 24600045, PMCID: PMC4004595, DOI: 10.1091/mbc.E13-04-0215.
• A gut lipid messenger links excess dietary fat to dopamine deficiency.Tellez LA, Medina S, Han W, Ferreira JG, Licona-Limón P, Ren X, Lam TT, Schwartz GJ, de Araujo IE. A gut lipid messenger links excess dietary fat to dopamine deficiency. Science (New York, N.Y.) 2013, 341: 800-2. PMID: 23950538, DOI: 10.1126/science.1239275.
• Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants.Antinone SE, Ghadge GD, Lam TT, Wang L, Roos RP, Green WN. Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants. The Journal Of Biological Chemistry 2013, 288: 21606-17. PMID: 23760509, PMCID: PMC3724620, DOI: 10.1074/jbc.M113.487231.
• Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1.Bansal N, Zhang M, Bhaskar A, Itotia P, Lee E, Shlyakhtenko LS, Lam TT, Fritz A, Berezney R, Lyubchenko YL, Stafford WF, Thapar R. Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1. Biochemistry 2013, 52: 520-36. PMID: 23286197, PMCID: PMC3580866, DOI: 10.1021/bi301074r.
• Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.Marin EP, Derakhshan B, Lam TT, Davalos A, Sessa WC. Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases. Circulation Research 2012, 110: 1336-44. PMID: 22496122, PMCID: PMC3428238, DOI: 10.1161/CIRCRESAHA.112.269514.
• The prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination.Krishnan N, Lam TT, Fritz A, Rempinski D, O'Loughlin K, Minderman H, Berezney R, Marzluff WF, Thapar R. The prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination. Molecular And Cellular Biology 2012, 32: 4306-22. PMID: 22907757, PMCID: PMC3486140, DOI: 10.1128/MCB.00382-12.
• Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization.Zhang M, Lam TT, Tonelli M, Marzluff WF, Thapar R. Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization. Biochemistry 2012, 51: 3215-31. PMID: 22439849, PMCID: PMC3328597, DOI: 10.1021/bi2018255.
• Complex interactions in EML cell stimulation by stem cell factor and IL-3.Ye ZJ, Gulcicek E, Stone K, Lam T, Schulz V, Weissman SM. Complex interactions in EML cell stimulation by stem cell factor and IL-3. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 4882-7. PMID: 21383156, PMCID: PMC3064389, DOI: 10.1073/pnas.1018002108.
• Functional genomic and proteomic analysis reveals disruption of myelin-related genes and translation in a mouse model of early life neglect.Bordner KA, George ED, Carlyle BC, Duque A, Kitchen RR, Lam TT, Colangelo CM, Stone KL, Abbott TB, Mane SM, Nairn AC, Simen AA. Functional genomic and proteomic analysis reveals disruption of myelin-related genes and translation in a mouse model of early life neglect. Frontiers In Psychiatry 2011, 2: 18. PMID: 21629843, PMCID: PMC3098717, DOI: 10.3389/fpsyt.2011.00018.
• Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons.Bianchetta MJ, Lam TT, Jones SN, Morabito MA. Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2011, 31: 12029-35. PMID: 21849563, PMCID: PMC3190401, DOI: 10.1523/JNEUROSCI.2388-11.2011.
• N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion.Fogel AI, Li Y, Giza J, Wang Q, Lam TT, Modis Y, Biederer T. N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion. The Journal Of Biological Chemistry 2010, 285: 34864-74. PMID: 20739279, PMCID: PMC2966101, DOI: 10.1074/jbc.M110.120865.
• Palmitoylation of nicotinic acetylcholine receptors.Alexander JK, Govind AP, Drisdel RC, Blanton MP, Vallejo Y, Lam TT, Green WN. Palmitoylation of nicotinic acetylcholine receptors. Journal Of Molecular Neuroscience : MN 2010, 40: 12-20. PMID: 19693711, PMCID: PMC3523180, DOI: 10.1007/s12031-009-9246-z.
• Diversification of a Salmonella virulence protein function by ubiquitin-dependent differential localization.Patel JC, Hueffer K, Lam TT, Galán JE. Diversification of a Salmonella virulence protein function by ubiquitin-dependent differential localization. Cell 2009, 137: 283-94. PMID: 19379694, PMCID: PMC2673707, DOI: 10.1016/j.cell.2009.01.056.
• Posttranslational modifications on protein kinase c isozymes. Effects of epinephrine and phorbol esters.Robles-Flores M, Meléndez L, García W, Mendoza-Hernández G, Lam TT, Castañeda-Patlán C, González-Aguilar H. Posttranslational modifications on protein kinase c isozymes. Effects of epinephrine and phorbol esters. Biochimica Et Biophysica Acta 2008, 1783: 695-712. PMID: 18295358, DOI: 10.1016/j.bbamcr.2007.07.011.
• Keck Foundation Biotechnology Resource Laboratory, Yale University.Stone KL, Bjornson RD, Blasko GG, Bruce C, Cofrancesco R, Carriero NJ, Colangelo CM, Crawford JK, Crawford JM, daSilva NC, Deluca JD, Elliott JI, Elliott MM, Flory PJ, Folta-Stogniew EJ, Gulcicek E, Kong Y, Lam TT, Lee JY, Lin A, LoPresti MB, Mane SM, McMurray WJ, Tikhonova IR, Westman S, Williams NA, Wu TL, Hongyu Z, Williams KR. Keck Foundation Biotechnology Resource Laboratory, Yale University. The Yale Journal Of Biology And Medicine 2007, 80: 195-211. PMID: 18449392, PMCID: PMC2347368.
• Interaction of packaging motor with the polymerase complex of dsRNA bacteriophage.Lísal J, Kainov DE, Lam TT, Emmett MR, Wei H, Gottlieb P, Marshall AG, Tuma R. Interaction of packaging motor with the polymerase complex of dsRNA bacteriophage. Virology 2006, 351: 73-9. PMID: 16643976, DOI: 10.1016/j.virol.2006.03.025.
• Impact of environmental conditions on the marine natural product bryostatin 1.Manning TJ, Rhodes E, Land M, Parkman R, Sumner B, Lam TT, Marshall AG, Phillips D. Impact of environmental conditions on the marine natural product bryostatin 1. Natural Product Research 2006, 20: 611-28. PMID: 16835096, DOI: 10.1080/14786410500462645.
• Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states.Lísal J, Lam TT, Kainov DE, Emmett MR, Marshall AG, Tuma R. Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states. Nature Structural & Molecular Biology 2005, 12: 460-6. PMID: 15834422, DOI: 10.1038/nsmb927.
• Identifying bryostatins and potential precursors from the bryozoan Bugula neritina.Manning TJ, Land M, Rhodes E, Chamberlin L, Rudloe J, Phillips D, Lam TT, Purcell J, Cooper HJ, Emmett MR, Marshall AG. Identifying bryostatins and potential precursors from the bryozoan Bugula neritina. Natural Product Research 2005, 19: 467-91. PMID: 15938194, DOI: 10.1080/14786410412331280041.
• Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction.Cooper HJ, Tatham MH, Jaffray E, Heath JK, Lam TT, Marshall AG, Hay RT. Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction. Analytical Chemistry 2005, 77: 6310-9. PMID: 16194093, DOI: 10.1021/ac058019d.
• Multicomponent internal recalibration of an LC-FTICR-MS analysis employing a partially characterized complex peptide mixture: systematic and random errors.Yanofsky CM, Bell AW, Lesimple S, Morales F, Lam TT, Blakney GT, Marshall AG, Carrillo B, Lekpor K, Boismenu D, Kearney RE. Multicomponent internal recalibration of an LC-FTICR-MS analysis employing a partially characterized complex peptide mixture: systematic and random errors. Analytical Chemistry 2005, 77: 7246-54. PMID: 16285672, DOI: 10.1021/ac050640q.
• Key interactions in HIV-1 maturation identified by hydrogen-deuterium exchange.Lanman J, Lam TT, Emmett MR, Marshall AG, Sakalian M, Prevelige PE. Key interactions in HIV-1 maturation identified by hydrogen-deuterium exchange. Nature Structural & Molecular Biology 2004, 11: 676-7. PMID: 15208693, DOI: 10.1038/nsmb790.
• Identification of sites of ubiquitination in proteins: a fourier transform ion cyclotron resonance mass spectrometry approach.Cooper HJ, Heath JK, Jaffray E, Hay RT, Lam TT, Marshall AG. Identification of sites of ubiquitination in proteins: a fourier transform ion cyclotron resonance mass spectrometry approach. Analytical Chemistry 2004, 76: 6982-8. PMID: 15571350, DOI: 10.1021/ac0401063.
• Identification of novel interactions in HIV-1 capsid protein assembly by high-resolution mass spectrometry.Lanman J, Lam TT, Barnes S, Sakalian M, Emmett MR, Marshall AG, Prevelige PE. Identification of novel interactions in HIV-1 capsid protein assembly by high-resolution mass spectrometry. Journal Of Molecular Biology 2003, 325: 759-72. PMID: 12507478.
• Mapping of protein:protein contact surfaces by hydrogen/deuterium exchange, followed by on-line high-performance liquid chromatography-electrospray ionization Fourier-transform ion-cyclotron-resonance mass analysis.Lam TT, Lanman JK, Emmett MR, Hendrickson CL, Marshall AG, Prevelige PE. Mapping of protein:protein contact surfaces by hydrogen/deuterium exchange, followed by on-line high-performance liquid chromatography-electrospray ionization Fourier-transform ion-cyclotron-resonance mass analysis. Journal Of Chromatography. A 2002, 982: 85-95. PMID: 12489858.
• Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella.Chen M, Sun H, Boot M, Shao L, Chang SJ, Wang W, Lam TT, Lara-Tejero M, Rego EH, Galán JE. Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella. Science (New York, N.Y.) 2020, 369: 450-455. PMID: 32703879, PMCID: PMC8020367, DOI: 10.1126/science.aaz1333.
• Cerebrospinal fluid proteome evaluation in major depressive disorder by mass spectrometry.Franzen AD, Lam TT, Williams KR, Nairn AC, Duman RS, Sathyanesan M, Kumar V, Carpenter LL, Newton SS. Cerebrospinal fluid proteome evaluation in major depressive disorder by mass spectrometry. BMC Psychiatry 2020, 20: 481. PMID: 32998701, PMCID: PMC7528485, DOI: 10.1186/s12888-020-02874-9.
• Differential Protein Expression in Striatal D1- and D2-Dopamine Receptor-Expressing Medium Spiny Neurons.Mansuri MS, Peng G, Wilson RS, Lam TT, Zhao H, Williams KR, Nairn AC. Differential Protein Expression in Striatal D1- and D2-Dopamine Receptor-Expressing Medium Spiny Neurons. Proteomes 2020, 8 PMID: 33066078, PMCID: PMC7709116, DOI: 10.3390/proteomes8040027.
• Granulocyte-Colony Stimulating Factor Reduces Cocaine-Seeking and Downregulates Glutamatergic Synaptic Proteins in Medial Prefrontal Cortex.Hofford RS, Euston TJ, Wilson RS, Meckel KR, Peck EG, Godino A, Landry JA, Calipari ES, Lam TT, Kiraly DD. Granulocyte-Colony Stimulating Factor Reduces Cocaine-Seeking and Downregulates Glutamatergic Synaptic Proteins in Medial Prefrontal Cortex. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2021, 41: 1553-1565. PMID: 33361463, PMCID: PMC7896012, DOI: 10.1523/JNEUROSCI.1452-20.2020.
• Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 Signaling.Zhang L, Lin TV, Yuan Q, Sadoul R, Lam TT, Bordey A. Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 Signaling. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2021, 41: 3799-3807. PMID: 33741723, PMCID: PMC8084316, DOI: 10.1523/JNEUROSCI.0766-20.2021.
• Cocaine self-administration induces sex-dependent protein expression in the nucleus accumbens.López AJ, Johnson AR, Euston TJ, Wilson R, Nolan SO, Brady LJ, Thibeault KC, Kelly SJ, Kondev V, Melugin P, Kutlu MG, Chuang E, Lam TT, Kiraly DD, Calipari ES. Cocaine self-administration induces sex-dependent protein expression in the nucleus accumbens. Communications Biology 2021, 4: 883. PMID: 34272455, PMCID: PMC8285523, DOI: 10.1038/s42003-021-02358-w.
• Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure.Lee AM, Mansuri MS, Wilson RS, Lam TT, Nairn AC, Picciotto MR. Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure. Frontiers In Molecular Neuroscience 2021, 14: 657064. PMID: 34335180, PMCID: PMC8317211, DOI: 10.3389/fnmol.2021.657064.
• Liver-Dependent Lung Remodeling during Systemic Inflammation Shapes Responses to Secondary Infection.Odom CV, Kim Y, Burgess CL, Baird LA, Korkmaz FT, Na E, Shenoy AT, Arafa EI, Lam TT, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. Liver-Dependent Lung Remodeling during Systemic Inflammation Shapes Responses to Secondary Infection. Journal Of Immunology (Baltimore, Md. : 1950) 2021, 207: 1891-1902. PMID: 34470857, PMCID: PMC8631467, DOI: 10.4049/jimmunol.2100254.
• Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates.Leslie SN, Kanyo J, Datta D, Wilson RS, Zeiss C, Duque A, Lam TT, Arnsten AFT, Nairn AC. Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates. Frontiers In Aging Neuroscience 2021, 13: 767322. PMID: 34867294, PMCID: PMC8637411, DOI: 10.3389/fnagi.2021.767322.