Todd Constable, PhD
Research & Publications
Biography
News
Research Summary
My research is focused on developing and validating novel approaches to functional Magnetic Resonance Imaging (fMRI) and using these methods to improve our understanding of brain function. This work includes approaches for quantitative neuroimaging and methods for assessing brain function via connectivity mapping. These developments are applied in the neurosurgical environment to localizing epileptogenic tissue and mapping function prior to surgical intervention. These studies provide a framework for validating the fMRI techniques through comparisons with cortical stimulation, behavioral analyses, Wada testing, and patient outcomes. They also improve our understanding of the link between fMRI signal changes and neuronal activity, through comparisons of fMRI in vivo with EEG/ERP recordings obtained in patients with depth electrodes and/or subdural grids. We are also interested in better understanding basic language and memory processing in humans and factors that influence the networks revealed by neuroimaging.
Specialized Terms: Development of MRI techniques to allow faster scanning and/or to provide functional information; Quantitative information and high quality pictures of anatomy; Application of new methods to answer fundamental questions in basic science and medicine with emphasis on applications in neuroscience.
Extensive Research Description
Dr. Todd Constable's research primarily focuses on functional magnetic resonance (MR) and understanding cognitive processes that are related to language and memory and how these processes may be altered in different disease states or with different medications. An important aspect of some of the imaging techniques he is developing is the ability to separate indirect physiologic changes associated with particular diseases or medications from those that directly impact neuronal processes.
Coauthors
Research Interests
Anatomy; Diagnostic Imaging; Magnetic Resonance Imaging; Neurosurgery; Radiology; Neuroimaging
Selected Publications
- Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity.Finn ES, Shen X, Scheinost D, Rosenberg MD, Huang J, Chun MM, Papademetris X, Constable RT. Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity. Nature Neuroscience 2015, 18: 1664-71. PMID: 26457551, PMCID: PMC5008686, DOI: 10.1038/nn.4135.
- Using connectome-based predictive modeling to predict individual behavior from brain connectivity.Shen X, Finn ES, Scheinost D, Rosenberg MD, Chun MM, Papademetris X, Constable RT. Using connectome-based predictive modeling to predict individual behavior from brain connectivity. Nature Protocols 2017, 12: 506-518. PMID: 28182017, PMCID: PMC5526681, DOI: 10.1038/nprot.2016.178.
- Can brain state be manipulated to emphasize individual differences in functional connectivity?Finn ES, Scheinost D, Finn DM, Shen X, Papademetris X, Constable RT. Can brain state be manipulated to emphasize individual differences in functional connectivity? NeuroImage 2017, 160: 140-151. PMID: 28373122, PMCID: PMC8808247, DOI: 10.1016/j.neuroimage.2017.03.064.
- Task-induced brain state manipulation improves prediction of individual traits.Greene AS, Gao S, Scheinost D, Constable RT. Task-induced brain state manipulation improves prediction of individual traits. Nature Communications 2018, 9: 2807. PMID: 30022026, PMCID: PMC6052101, DOI: 10.1038/s41467-018-04920-3.
- Topographic organization of the cerebral cortex and brain cartography.Eickhoff SB, Constable RT, Yeo BT. Topographic organization of the cerebral cortex and brain cartography. NeuroImage 2018, 170: 332-347. PMID: 28219775, PMCID: PMC5563483, DOI: 10.1016/j.neuroimage.2017.02.018.
- Brain connectivity related to working memory performance.Hampson M, Driesen NR, Skudlarski P, Gore JC, Constable RT. Brain connectivity related to working memory performance. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2006, 26: 13338-43. PMID: 17182784, PMCID: PMC2677699, DOI: 10.1523/JNEUROSCI.3408-06.2006.
- Connectivity-behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability.Hampson M, Tokoglu F, Sun Z, Schafer RJ, Skudlarski P, Gore JC, Constable RT. Connectivity-behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability. NeuroImage 2006, 31: 513-9. PMID: 16497520, DOI: 10.1016/j.neuroimage.2005.12.040.
- The individual functional connectome is unique and stable over months to years.Horien C, Shen X, Scheinost D, Constable RT. The individual functional connectome is unique and stable over months to years. NeuroImage 2019, 189: 676-687. PMID: 30721751, PMCID: PMC6422733, DOI: 10.1016/j.neuroimage.2019.02.002.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Mental Health & Behavioral Research | Ketamine for Adolescent Suicidality |
| Mental Health & Behavioral Research | Study of Brain Function Across the Lifespan |
| Mental Health & Behavioral Research | Ketamine in Borderline Personality Disorder |
| Child Development & Autism | Understanding Neurodevelopment in Autism |
| Diseases of the Nervous System; Genetics - Adult; Genetics - Pediatric; Mental Health & Behavioral Research | Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART) |
| Children's Health; Diseases of the Endocrine System; Immune System | Study to investigate adipocyte cell and lipid turnover in obese adolescents |
| Children's Health; Diseases of the Nervous System | Why Are Patients With Absence Seizures Absent? A Brain Imaging Study |