Titus Boggon, PhD
Associate Professor of Pharmacology and of Molecular Biophysics and Biochemistry
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Research Summary
Cellular signaling cascades that control cytoskeletal remodeling, adhesion, and migration, are critical to life. The Boggon lab uses structural biology and associated techniques to define the molecular level details that control these pathways. Our primary areas of interest are Rho GTPase and integrin signaling pathways, and the molecular basis for acquisition of cerebral vascular disease. We maintain a focus on the protein kinases involved in these areas.
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Research Interests
Biochemistry; Crystallography; Molecular Biology; Protein Kinases; Substrate Specificity; Signal Transduction; Hemangioma, Cavernous, Central Nervous System
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Selected Publications
- The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase.Stiegler AL, Boggon TJ. The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase. Structure (London, England : 1993) 2018, 26:1451-1461.e4.
- p190RhoGAP proteins contain pseudoGTPase domains.Stiegler AL, Boggon TJ. p190RhoGAP proteins contain pseudoGTPase domains. Nature Communications 2017, 8:506.
- CDC42 binds PAK4 via an extended GTPase-effector interface.Ha BH, Boggon TJ. CDC42 binds PAK4 via an extended GTPase-effector interface. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115:531-536.
- Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases.Hamill S, Lou HJ, Turk BE, Boggon TJ. Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases. Molecular Cell 2016, 62:397-408.
- Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B. Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nature Communications 2015, 6:7937.
- CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation.Draheim KM, Li X, Zhang R, Fisher OS, Villari G, Boggon TJ, Calderwood DA. CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. The Journal Of Cell Biology 2015, 208:987-1001.
- Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.Chen C, Ha BH, Thévenin AF, Lou HJ, Zhang R, Yip KY, Peterson JR, Gerstein M, Kim PM, Filippakopoulos P, Knapp S, Boggon TJ, Turk BE. Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity. Molecular Cell 2014, 53:140-7.
- Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.Liu W, Draheim KM, Zhang R, Calderwood DA, Boggon TJ. Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation. Molecular Cell 2013, 49:719-29.
- Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ. Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109:16107-12.