Timothy Nottoli, PhD
Research Scientist in Comparative Medicine; Co-director, Yale Genome Editing Center
Research & Publications
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Selected Publications
- Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease.Srivastava R, Zhang J, Go GW, Narayanan A, Nottoli TP, Mani A. Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease. Cell Reports 2015, 13:746-759.
- Dynamic migration and cell-cell interactions of early reprogramming revealed by high-resolution time-lapse imaging.Megyola CM, Gao Y, Teixeira AM, Cheng J, Heydari K, Cheng EC, Nottoli T, Krause DS, Lu J, Guo S. Dynamic migration and cell-cell interactions of early reprogramming revealed by high-resolution time-lapse imaging. Stem Cells (Dayton, Ohio) 2013, 31:895-905.
- Kinesin 5B (KIF5B) is required for progression through female meiosis and proper chromosomal segregation in mitotic cells.Kidane D, Sakkas D, Nottoli T, McGrath J, Sweasy JB. Kinesin 5B (KIF5B) is required for progression through female meiosis and proper chromosomal segregation in mitotic cells. PloS One 2013, 8:e58585.
- Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage.Mistry PK, Liu J, Yang M, Nottoli T, McGrath J, Jain D, Zhang K, Keutzer J, Chuang WL, Mehal WZ, Zhao H, Lin A, Mane S, Liu X, Peng YZ, Li JH, Agrawal M, Zhu LL, Blair HC, Robinson LJ, Iqbal J, Sun L, Zaidi M. Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107:19473-8.
- Chimeric mice reveal clonal development of pancreatic acini, but not islets.Swenson ES, Xanthopoulos J, Nottoli T, McGrath J, Theise ND, Krause DS. Chimeric mice reveal clonal development of pancreatic acini, but not islets. Biochemical And Biophysical Research Communications 2009, 379:526-31.
- Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response.Lin ZP, Zhu YL, Johnson DR, Rice KP, Nottoli T, Hains BC, McGrath J, Waxman SG, Sartorelli AC. Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response. Molecular Pharmacology 2008, 73:243-51.
- Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6.Jiang Z, Asplin JR, Evan AP, Rajendran VM, Velazquez H, Nottoli TP, Binder HJ, Aronson PS. Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nature Genetics 2006, 38:474-8.
- Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter.Chen R, Tilley MR, Wei H, Zhou F, Zhou FM, Ching S, Quan N, Stephens RL, Hill ER, Nottoli T, Han DD, Gu HH. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103:9333-8.
- Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface.West-Mays JA, Sivak JM, Papagiotas SS, Kim J, Nottoli T, Williams T, Fini ME. Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface. Differentiation; Research In Biological Diversity 2003, 71:206-16.
- Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development.Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T. Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development (Cambridge, England) 2002, 129:2733-47.
- AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle.West-Mays JA, Zhang J, Nottoli T, Hagopian-Donaldson S, Libby D, Strissel KJ, Williams T. AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle. Developmental Biology 1999, 206:46-62.
- AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice.Nottoli T, Hagopian-Donaldson S, Zhang J, Perkins A, Williams T. AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95:13714-9.
- The HPV16 E5 protein: expression, detection, and stable complex formation with transmembrane proteins in COS cells.Hwang ES, Nottoli T, Dimaio D. The HPV16 E5 protein: expression, detection, and stable complex formation with transmembrane proteins in COS cells. Virology 1995, 211:227-33.
- Transcription factor E2 regulates BPV-1 DNA replication in vitro by direct protein-protein interaction.Yang L, Mohr I, Li R, Nottoli T, Sun S, Botchan M. Transcription factor E2 regulates BPV-1 DNA replication in vitro by direct protein-protein interaction. Cold Spring Harbor Symposia On Quantitative Biology 1991, 56:335-46.
- The E2 transactivator of bovine papillomavirus type 1 is expressed from multiple promoters.Vaillancourt P, Nottoli T, Choe J, Botchan MR. The E2 transactivator of bovine papillomavirus type 1 is expressed from multiple promoters. Journal Of Virology 1990, 64:3927-37.