Research & Publications
Extensive Research Description
Complications from brain metastatic disease represents a growing problem as late cerebral relapses are becoming more common. My basic and translational research focuses on several pillars aimed at addressing neurologic complications of brain metastases or its treatment by (1) identifying mediators of metastasis-associated edema that can be given concurrently to further improve brain-active systemic therapies and patient outcomes, (2) identifying key immune cells driving radiation necrosis after treatment with stereotactic radiosurgery, and (3) determining key brain tumor infiltrating immune cell subsets and evaluating their effect on patient response and survival. My clinical research focuses on using immune therapy either alone or in combination with anti-angiogenesis inhibitors to treat melanoma and non-small cell lung cancer brain metastases. As a physician-scientist, my hope is to be able to move bench research efficiency to the clinic. Most importantly, I want to learn from the patients and their experience to inform my studies. My ultimate goal is to improve immune treatment options and quality of life for patients with metastatic brain malignancies.
Blood-Brain Barrier; Clinical Trials as Topic; Drug Combinations; Melanoma; Neoplasm Metastasis