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Themis Kyriakides, PhD

Professor of Pathology; Director, Graduate Programs, Pathology

Research Summary

The main area of my research is the elucidation of the molecular events that dictate the course of healing and especially inflammation and angiogenesis following ischemia, injury and the implantation of biomaterials and scaffolds for regenerative medicine applications. In addition, through the process of molecular dissection of cell-matrix interactions, we aim to incorporate rational design in the development of bioengineering applications such as tissue-engineered vascular grafts and hydrogels. Based on our recent findings in genetically modified mice, we have developed a concept that involves exploiting the biology of thrombospodin-2 to improve diabetic wound healing. Finally, we have expanded our biomaterial studies to include bulk metallic glass-based implants and have explored the impact of nanotopography on cell function.

Specialized Terms: Angiogenesis; Extracellular matrix remodeling; Inflammation; Cell fusion; Wound healing; Foreign body response; Tissue Engineering, Biomaterials; Nanomaterials; Bulk Metallic Glass

Extensive Research Description

Our specialized research interests include cellular and molecular events; the interface between implanted biomaterials and tissues; biomaterial-induced inflammation, wound healing, tissue engineering with a focus on angiogenesis, and extracellular matrix remodeling; in vivo work on genetically-modified mice; gene delivery from biomaterials; development of bioactive and biodegradable polymers; modification of glucose sensors; development of artificial skin.

Coauthors

Research Interests

Cell Fusion; Education, Medical; Extracellular Matrix; Foreign Bodies; Inflammation; Pathology; Wound Healing; Animal Experimentation; Nanomedicine; Translational Medical Research

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Selected Publications