Taylor J. Keding, PhD
Research & Publications
Biography
Research Summary
Taylor's research broadly focuses on the interactions between brain and pubertal development, environmental adversity, and psychiatric risk. More specifically, he aims to characterize typical structural and functional brain development during childhood and adolescence and how the timing and tempo of puberty is mediated by neurodevelopment. He is also interested in how neurodevelopment is altered by early-life adversity and how these changes confer risk for psychiatric symptoms. His work makes extensive use of structural and functional MRI, computational modeling, and data science/machine learning approaches.
Research Interests
Brain; Child Development; Puberty; Radiographic Image Interpretation, Computer-Assisted; Stress, Physiological; Stress, Psychological; Computational Biology; Clinical Decision-Making; Machine Learning
Selected Publications
- Neural circuit markers of familial risk for depression among healthy youth in the Adolescent Brain Cognitive Development (ABCD) StudyHolt-Gosselin B, Keding T, Poulin R, Brieant A, Rueter A, Hendrickson T, Perrone A, Byington N, Houghton A, Miranda-Dominguez O, Feczko E, Fair D, Joormann J, Gee D. Neural circuit markers of familial risk for depression among healthy youth in the Adolescent Brain Cognitive Development (ABCD) Study Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023 PMID: 37182734, DOI: 10.1016/j.bpsc.2023.05.001.
- Violence Exposure and Amygdala-Prefrontal Circuit Maturation: Developmental Markers of Psychiatric Risk in YouthKeding T, Herringa R. Violence Exposure and Amygdala-Prefrontal Circuit Maturation: Developmental Markers of Psychiatric Risk in Youth Biological Psychiatry 2022, 91: s47-s48. DOI: 10.1016/j.biopsych.2022.02.140.
- Differential Patterns of Delayed Emotion Circuit Maturation in Abused Girls With and Without Internalizing PsychopathologyKeding T, Heyn S, Russell J, Zhu X, Cisler J, McLaughlin K, Herringa R. Differential Patterns of Delayed Emotion Circuit Maturation in Abused Girls With and Without Internalizing Psychopathology American Journal Of Psychiatry 2021, 178: 1026-1036. PMID: 34407623, PMCID: PMC8570983, DOI: 10.1176/appi.ajp.2021.20081192.
- Childhood exposure to interpersonal violence is associated with greater transdiagnostic integration of psychiatric symptomsRussell JD, Keding TJ, He Q, Li JJ, Herringa RJ. Childhood exposure to interpersonal violence is associated with greater transdiagnostic integration of psychiatric symptoms Psychological Medicine 2020, 52: 1883-1891. PMID: 33161911, PMCID: PMC8106688, DOI: 10.1017/s0033291720003712.
- 12. Neural Circuit Markers of Familial Risk for Depression Among Healthy Youth in the Adolescent Brain Cognitive Development (ABCD) StudyHolt-Gosselin B, Keding T, Poulin R, Brieant A, Rueter A, Hendrickson T, Perrone A, Byington N, Houghton A, Miranda-Dominguez O, Feczko E, Fair D, Joormann J, Gee D. 12. Neural Circuit Markers of Familial Risk for Depression Among Healthy Youth in the Adolescent Brain Cognitive Development (ABCD) Study Biological Psychiatry 2023, 93: s74. DOI: 10.1016/j.biopsych.2023.02.195.
- Longitudinal hippocampal circuit change differentiates persistence and remission of pediatric posttraumatic stress disorderGeorge G, Keding T, Heyn S, Herringa R. Longitudinal hippocampal circuit change differentiates persistence and remission of pediatric posttraumatic stress disorder Depression And Anxiety 2021, 39: 8-18. PMID: 34843625, PMCID: PMC8763137, DOI: 10.1002/da.23229.
- Differential DNA Methylation Is Associated With Hippocampal Abnormalities in Pediatric Posttraumatic Stress DisorderEnsink JBM, Keding TJ, Henneman P, Venema A, Papale LA, Alisch RS, Westerman Y, van Wingen G, Zantvoord J, Middeldorp CM, Mannens MMAM, Herringa RJ, Lindauer R. Differential DNA Methylation Is Associated With Hippocampal Abnormalities in Pediatric Posttraumatic Stress Disorder Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 6: 1063-1070. PMID: 33964519, PMCID: PMC8568739, DOI: 10.1016/j.bpsc.2021.04.016.
- Longitudinal Functional Brain Correlates of Persistence and Remission in Pediatric PTSDGeorge G, Keding T, Herringa R. Longitudinal Functional Brain Correlates of Persistence and Remission in Pediatric PTSD Biological Psychiatry 2021, 89: s299. DOI: 10.1016/j.biopsych.2021.02.745.
- Neurobehavioral correlates of impaired emotion recognition in pediatric PTSDHeyn SA, Schmit C, Keding TJ, Wolf R, Herringa RJ. Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD Development And Psychopathology 2021, 34: 946-956. PMID: 33487187, PMCID: PMC9717496, DOI: 10.1017/s0954579420001704.
- Longitudinal Functional Brain Correlates of Persistence and Remission in Pediatric PTSDGeorge G, Keding T, Herringa R. Longitudinal Functional Brain Correlates of Persistence and Remission in Pediatric PTSD Biological Psychiatry 2020, 87: s67. DOI: 10.1016/j.biopsych.2020.02.193.
- Brain Age Estimates of Structural Development in Emotion Circuitry Differentiate Resilient and Susceptible Abused GirlsKeding T, Heyn S, Zhu X, McLaughlin K, Cisler J, Herringa R. Brain Age Estimates of Structural Development in Emotion Circuitry Differentiate Resilient and Susceptible Abused Girls Biological Psychiatry 2020, 87: s104-s105. DOI: 10.1016/j.biopsych.2020.02.285.
- T62. Mechanisms of Differential Threat-Related Face Processing Among Youth With Trauma-Related Affective Psychopathology: A Multimodal Eye-Tracking and fMRI StudyHeyn S, Schmit C, Keding T, Herringa R. T62. Mechanisms of Differential Threat-Related Face Processing Among Youth With Trauma-Related Affective Psychopathology: A Multimodal Eye-Tracking and fMRI Study Biological Psychiatry 2019, 85: s152. DOI: 10.1016/j.biopsych.2019.03.385.
- F45. Feature Learning of the Developing Amygdala: Predicting Age, Maltreatment, and Psychopathology Using Multimodal Connectomics in YouthKeding T, Heyn S, Russell J, Herringa R. F45. Feature Learning of the Developing Amygdala: Predicting Age, Maltreatment, and Psychopathology Using Multimodal Connectomics in Youth Biological Psychiatry 2019, 85: s229-s230. DOI: 10.1016/j.biopsych.2019.03.582.
- F100GENOME-WIDE DNA METHYLATION DIFFERENCES AND THEIR RELATIONSHIP WITH NEURAL ABNORMALITIES IN YOUTH WITH AND WITHOUT POSTTRAUMATIC STRESS DISORDEREnsink J, Keding T, Henneman P, Zantvoord J, Middeldorp C, Mannens M, Herringa R, Lindauer R. F100GENOME-WIDE DNA METHYLATION DIFFERENCES AND THEIR RELATIONSHIP WITH NEURAL ABNORMALITIES IN YOUTH WITH AND WITHOUT POSTTRAUMATIC STRESS DISORDER European Neuropsychopharmacology 2019, 29: s1163-s1164. DOI: 10.1016/j.euroneuro.2018.08.180.
- Abnormal Prefrontal Development in Pediatric Posttraumatic Stress Disorder: A Longitudinal Structural and Functional Magnetic Resonance Imaging StudyHeyn SA, Keding TJ, Ross MC, Cisler JM, Mumford JA, Herringa RJ. Abnormal Prefrontal Development in Pediatric Posttraumatic Stress Disorder: A Longitudinal Structural and Functional Magnetic Resonance Imaging Study Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 4: 171-179. PMID: 30343133, PMCID: PMC6371792, DOI: 10.1016/j.bpsc.2018.07.013.
- T57. Abnormal Development of Amygdala Functional Connectivity During Emotion Processing in Pediatric Post-Traumatic Stress DisorderKeding T, Motzkin J, Herringa R. T57. Abnormal Development of Amygdala Functional Connectivity During Emotion Processing in Pediatric Post-Traumatic Stress Disorder Biological Psychiatry 2018, 83: s150-s151. DOI: 10.1016/j.biopsych.2018.02.393.
- 412 Longitudinal Neurodevelopmental Trajectories in Pediatric PTSDKeding T, Heyn S, Motzkin J, Mumford J, Herringa R. 412 Longitudinal Neurodevelopmental Trajectories in Pediatric PTSD Biological Psychiatry 2017, 81: s168. DOI: 10.1016/j.biopsych.2017.02.429.
- Paradoxical Prefrontal–Amygdala Recruitment to Angry and Happy Expressions in Pediatric Posttraumatic Stress DisorderKeding TJ, Herringa RJ. Paradoxical Prefrontal–Amygdala Recruitment to Angry and Happy Expressions in Pediatric Posttraumatic Stress Disorder Neuropsychopharmacology 2016, 41: 2903-2912. PMID: 27329685, PMCID: PMC5061882, DOI: 10.1038/npp.2016.104.
- Default-Mode Network Abnormalities in Pediatric Posttraumatic Stress DisorderPatriat R, Birn RM, Keding TJ, Herringa RJ. Default-Mode Network Abnormalities in Pediatric Posttraumatic Stress Disorder Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 319-327. PMID: 27015723, PMCID: PMC4808564, DOI: 10.1016/j.jaac.2016.01.010.
- Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress DisorderKeding TJ, Herringa RJ. Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder Neuropsychopharmacology 2014, 40: 537-545. PMID: 25212487, PMCID: PMC4289962, DOI: 10.1038/npp.2014.239.