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Tamas Horvath, DVM, PhD

Jean and David W. Wallace Professor of Comparative Medicine and Professor of Neuroscience and of Obstetrics, Gynecology, and Reproductive Sciences; Chair, Comparative Medicine

Contact Information

Tamas Horvath, DVM, PhD

Lab Location

Office Location

Mailing Address

  • Comparative Medicine

    PO Box 208016, 310 Cedar St

    New Haven, CT 06520-8016

    United States

Horvath Lab
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Research Summary

My main interest is the neuroendocrine regulation of homeostasis with particular emphasis on metabolic disorders, such as obesity and diabetes, and the effect of metabolic signals on higher brain functions and neurodegeneration. We have active research programs to pursue the role of synaptic plasticity in the mediation of peripheral hormones’ effects on the central nervous system.

We also study the role of mitochondrial membrane potential in normal and pathological brain functions with particular emphasis on the acute effect of mitochondria in neuronal transmission and neuroprotection. We combine classical neurobiological approaches, including electrophysiology and neuroanatomy, with endocrine and genetic techniques to better understand biological events at the level of the organism.

Specialized Terms: Neurobiology of obesity; Neuroendocrine physiology

Coauthors

Research Interests

Neuroendocrinology; Obesity; Physiology

Selected Publications

  • Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding.Dietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding. Cell 2015, 160: 1222-32. PMID: 25748653, PMCID: PMC4484787, DOI: 10.1016/j.cell.2015.02.024.
  • Hypothalamic POMC neurons promote cannabinoid-induced feeding.Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 2015, 519: 45-50. PMID: 25707796, PMCID: PMC4496586, DOI: 10.1038/nature14260.
  • Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nature Neuroscience 2014, 17: 908-10. PMID: 24880214, PMCID: PMC4113214, DOI: 10.1038/nn.3725.
  • Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC. Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding. Cell 2014, 156: 495-509. PMID: 24462248, PMCID: PMC4101521, DOI: 10.1016/j.cell.2014.01.008.
  • Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity.Dietrich MO, Liu ZW, Horvath TL. Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. Cell 2013, 155: 188-99. PMID: 24074868, PMCID: PMC4142434, DOI: 10.1016/j.cell.2013.09.004.
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