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Slav Bagriantsev, PhD

Associate Professor of Cellular & Molecular Physiology

Contact Information

Slav Bagriantsev, PhD

Lab Location

Office Location

Mailing Address

  • Cellular & Molecular Physiology

    Sterling Hall of Medicine, B-Wing, 333 Cedar St

    New Haven, CT 06510

    United States

The Slav Lab

Research Summary

Our laboratory uses a multidisciplinary approach to study the molecular basis of sensory physiology, with a focus on mechano- and temperature-sensitivity. We apply electrophysiology, molecular biology and biochemistry to understand the molecular basis of the sense of touch and temperature.

Specialized Terms: Neuroscience, Sensory Physiology, Mechanoreceptors, Thermoreceptors, Electrophysiology, Biophysics, Biochemistry, Ion channels, Tactile Specialists, Ducks.

Coauthors

Research Interests

Biochemistry; Biophysics; Ducks; Electrophysiology; Ion Channels; Mechanoreceptors; Neurosciences; Pacinian Corpuscles; Sensory Receptor Cells; Trigeminal Ganglion; Thermoreceptors; Potassium Channels; Anseriformes; Transient Receptor Potential Channels; Voltage-Gated Sodium Channels

Selected Publications

  • Lamellar cells in Pacinian and Meissner corpuscles are touch sensors.Nikolaev YA, Feketa VV, Anderson EO, Schneider ER, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. Science Advances 2020, 6 PMID: 33328243, PMCID: PMC7744075, DOI: 10.1126/sciadv.abe6393.
  • CNGA3 acts as a cold sensor in hypothalamic neurons.Feketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN, Gracheva EO. CNGA3 acts as a cold sensor in hypothalamic neurons. ELife 2020, 9 PMID: 32270761, PMCID: PMC7182431, DOI: 10.7554/eLife.55370.
  • Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors.Zheng W, Nikolaev YA, Gracheva EO, Bagriantsev SN. Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 17547-17555. PMID: 31413193, PMCID: PMC6717272, DOI: 10.1073/pnas.1910213116.
  • A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels.Zheng W, Gracheva EO, Bagriantsev SN. A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels. ELife 2019, 8 PMID: 30628892, PMCID: PMC6349400, DOI: 10.7554/eLife.44003.
  • A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds.Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds. Cell Reports 2019, 26: 1979-1987.e3. PMID: 30784581, PMCID: PMC6420409, DOI: 10.1016/j.celrep.2019.01.100.
  • Osmolyte Depletion and Thirst Suppression Allow Hibernators to Survive for Months without Water.Feng NY, Junkins MS, Merriman DK, Bagriantsev SN, Gracheva EO. Osmolyte Depletion and Thirst Suppression Allow Hibernators to Survive for Months without Water. Current Biology : CB 2019, 29: 3053-3058.e3. PMID: 31495581, PMCID: PMC6759396, DOI: 10.1016/j.cub.2019.07.038.
  • TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels.Anderson EO, Schneider ER, Matson JD, Gracheva EO, Bagriantsev SN. TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels. Cell Reports 2018, 23: 701-708. PMID: 29669276, PMCID: PMC5929159, DOI: 10.1016/j.celrep.2018.03.094.
  • Somatosensory Neurons Enter a State of Altered Excitability during Hibernation.Hoffstaetter LJ, Mastrotto M, Merriman DK, Dib-Hajj SD, Waxman SG, Bagriantsev SN, Gracheva EO. Somatosensory Neurons Enter a State of Altered Excitability during Hibernation. Current Biology : CB 2018, 28: 2998-3004.e3. PMID: 30174191, PMCID: PMC6173314, DOI: 10.1016/j.cub.2018.07.020.
  • Molecular basis of tactile specialization in the duck bill.Schneider ER, Anderson EO, Mastrotto M, Matson JD, Schulz VP, Gallagher PG, LaMotte RH, Gracheva EO, Bagriantsev SN. Molecular basis of tactile specialization in the duck bill. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 13036-13041. PMID: 29109250, PMCID: PMC5724259, DOI: 10.1073/pnas.1708793114.
  • Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters.Matos-Cruz V, Schneider ER, Mastrotto M, Merriman DK, Bagriantsev SN, Gracheva EO. Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters. Cell Reports 2017, 21: 3329-3337. PMID: 29262313, PMCID: PMC5741102, DOI: 10.1016/j.celrep.2017.11.083.
  • Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels.Laursen WJ, Schneider ER, Merriman DK, Bagriantsev SN, Gracheva EO. Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 11342-11347. PMID: 27638213, PMCID: PMC5056056, DOI: 10.1073/pnas.1604269113.
  • Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation.Laursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia N, Shulman GI, Bagriantsev SN, Gracheva EO. Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 1607-12. PMID: 25605929, PMCID: PMC4321293, DOI: 10.1073/pnas.1421419112.
  • Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl.Schneider ER, Mastrotto M, Laursen WJ, Schulz VP, Goodman JB, Funk OH, Gallagher PG, Gracheva EO, Bagriantsev SN. Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 14941-6. PMID: 25246547, PMCID: PMC4205607, DOI: 10.1073/pnas.1413656111.
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