Suleyman Coskun, PhD, MSc
Research & Publications
Biography
Research Summary
My research focus is to identify the key cancer driver genes and their epigenetic regulations in brain tumors. Among various types, we primarily focus on genomic analyses of the two of the most common forms of intracranial tumors, namely meningiomas and gliomas. Integrating ChIP sequencing with RNA-seq and Exome Seq data, we are able to study such complex mechanisms in high-throughput fashion. Modifications to both DNA and histones have a profound effect on transcription and are the best understood of epigenetic changes. Elucidating underlying mechanisms regulating cancer development and progression will lead not only to a better understanding of how the cell of origin may arise in cancer, but also helps to identify root causes to target in order to eradicate cancer.
Coauthors
Selected Publications
- Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells.Coşkun S, Chao H, Vasavada H, Heydari K, Gonzales N, Zhou X, de Crombrugghe B, Hirschi KK. Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells. Cell Reports 2014, 9:581-90.
- Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell 2010, 7:606-17.
- Hemogenic endothelial cell specification requires c-Kit, Notch signaling, and p27-mediated cell-cycle control.Marcelo KL, Sills TM, Coskun S, Vasavada H, Sanglikar S, Goldie LC, Hirschi KK. Hemogenic endothelial cell specification requires c-Kit, Notch signaling, and p27-mediated cell-cycle control. Developmental Cell 2013, 27:504-15.
- Integrated genomic analyses of de novo pathways underlying atypical meningiomas.Harmancı AS, Youngblood MW, Clark VE, Coşkun S, Henegariu O, Duran D, Erson-Omay EZ, Kaulen LD, Lee TI, Abraham BJ, Simon M, Krischek B, Timmer M, Goldbrunner R, Omay SB, Baranoski J, Baran B, Carrión-Grant G, Bai H, Mishra-Gorur K, Schramm J, Moliterno J, Vortmeyer AO, Bilgüvar K, Yasuno K, Young RA, Günel M. Integrated genomic analyses of de novo pathways underlying atypical meningiomas. Nature Communications 2017, 8:14433.
- Integrated genomic characterization of IDH1-mutant glioma malignant progression.Bai H, Harmanci AS, Erson-Omay EZ, Li J, Coskun S, Simon M, Krischek B, Özduman K, Omay SB, Sorensen EA, Turcan S, Bakirciglu M, Carrión-Grant G, Murray PB, Clark VE, Ercan-Sencicek AG, Knight J, Sencar L, Altinok S, Kaulen LD, Gülez B, Timmer M, Schramm J, Mishra-Gorur K, Henegariu O, Moliterno J, Louvi A, Chan TA, Tannheimer SL, Pamir MN, Vortmeyer AO, Bilguvar K, Yasuno K, Günel M. Integrated genomic characterization of IDH1-mutant glioma malignant progression. Nature Genetics 2016, 48:59-66.
- Vascular Niche in HSC Development, Maintenance and RegulationTissue-Specific Stem Cell Niche, Springer International Publishing, Turksen, K. (Ed.) (2015)
- Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture.Cuchiara ML, Coskun S, Banda OA, Horter KL, Hirschi KK, West JL. Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture. Biotechnology And Bioengineering 2016, 113:870-81.