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Stuart Seropian, MD

Professor of Internal Medicine (Hematology); Acting Director, Stem Cell Transplantation; Chairman, Car-T Cell Joint Steering Committee; Director, Unrelated Donor Transplant Program, Stem Cell Transplantation; Co-Director, Immune Effector Cell Therapy; Co-Director, Adult CAR T-Cell Therapy Program

Contact Information

Stuart Seropian, MD

Mailing Address

  • Yale Cancer Center

    PO Box 208028, 333 Cedar Street, TMP 3

    New Haven, CT 06520-8028

    United States

Research Summary

Research endeavors include studies to improve outcomes of stem cell transplantation including novel agents to more effectively treat leukemia and new agents to reduce the risk of complications related to therapy.


Research Interests

Hematologic Diseases; Hematopoietic Stem Cells; Hodgkin Disease; Leukemia; Lymphocytes; Lymphoma; Lymphoma, Non-Hodgkin; Plasma Cells; Bone Marrow Transplantation; Clinical Trials, Phase III as Topic

Public Health Interests

Cancer; Clinical Trials

Selected Publications

  • Disorders of LymphocytesLacy J, Seropian, S, Disorders of Lymphocytes, Andreoli: in Cecil Essentials of Medicine, 9th ed. 2014
  • LeukemiaRoberts K, Seropian S, Marks, P, Leukemia, Perez and Brady’s In Principles and Practice of Radiation Oncology, Halperin E, Perez C, and Brady L eds. Sixth edition. 2013
  • Total-Body and HemiBody IrradiationRoberts K, Chen, Z, Seropian S. Total-Body and HemiBody Irradiation, Perez and Brady’s Principles and Practice of Radiation Oncology, Halperin E, Perez C, and Brady L eds. Sixth edition. 2013
  • LymphomaIsufi I, Seropian S, Lymphoma, Oncology in Primary Care. Rose, MG, Devita VT, Lawrence TS, Rosenberg SA, 1st edition, 2013
  • Plasma Cell DisordersSeropian S, Isufi I, Plasma Cell Disorders, Oncology in Primary Care. Rose, MG, Devita VT, Lawrence TS, Rosenberg SA, 1st edition, 2013
  • New Approaches to allografting in non-Hodgkin's lymphoma.Seropian S, Cooper DL. New Approaches to allografting in non-Hodgkin's lymphoma. Progress in Oncology, 2004 Jones and Bartlett.
  • Hodgkin's DiseaseSeropian S, Cooper DL. Hodgkin's Diseases in Annual of Lymphoid Malignancies. Cavelli F, Longo D eds. 2000
  • Autologous Stem Cell TransplantationCooper DL, Seropian S, Autologous Stem Cell Transplantation, in Principles and Practice of Oncology. Devita VT, Hellman S, Rosenberg S eds. 6th edition, 2000.

Clinical Trials

ConditionsStudy Title
Non-Hodgkin's LymphomaA Randomized, Phase IIB, Multicenter, Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in Patients With Relapse or Refractory Peripheral T-cell Lymphoma (PTCL)
Non-Hodgkin's LymphomaA Phase 1 Study of SEA-TGT (SGN-TGT) in Subjects With Advanced Malignancies
Multiple MyelomaNovel Combination of Belantamab Mafodotin and Elotuzumab to Enhance Therapeutic Efficacy in Multiple Myeloma
Multiple MyelomaEffective Quadruplet Utilization After Treatment Evaluation (EQUATE): A Randomized Phase 3 Trial for Newly Diagnosed Multiple Myeloma Not Intended for Early Autologous Transplantation
Non-Hodgkin's LymphomaA Phase 1/2 Study of Oral LOXO-305 in Patients With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) or Non-Hodgkin Lymphoma (NHL)
Non-Hodgkin's LymphomaA Phase 1, Open-Label, Multicenter, Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of Anti-CD70 Allogeneic CRISPR-Cas9-Engineered T Cells (CTX130) in Subjects With Relapsed or Refractory T or B Cell Malignancies
Multiple MyelomaA Phase 1, Open-label, Dose Finding Study of CC-93269, a BCMA X CD3 T Cell Engaging Antibody, in Subjects With Relapsed and Refractory Multiple Myeloma.
Multiple MyelomaA Randomized Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Patients With Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease Positive After Frontline Autologous Stem Cell Transplant
Hodgkin's LymphomaA Phase III, Randomized Study of Nivolumab (Opdivo) Plus AVD or Brentuximab Vedotin (Adcetris) Plus AVD in Patients (Age >/= 12 Years) With Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma
Multiple MyelomaDaratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM)
Lymphoid LeukemiaA Randomized Phase III Study of Ibrutinib Plus Obinutuzumab Versus Ibrutinib Plus Venetoclax and Obinutuzumab in Untreated Older Patients (>/= 70 Years of Age) With Chronic Lymphocytic Leukemia (CLL)
Non-Hodgkin's LymphomaA Randomized Phase III Trial of Consolidation With Autologous Hematopoietic Cell Transplantation Followed by Maintenance Rituximab vs. Maintenance Rituximab Alone for Patients With Mantle Cell Lymphoma in Minimal Residual Disease-Negative First Complete Remission
Non-Hodgkin's LymphomaA Randomized Double-Blind Phase III Study of Ibrutinib During and Following Autologous Stem Cell Transplantation Versus Placebo in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma of the Activated B-Cell Subtype
Lymphoid Leukemia; Non-Hodgkin's Lymphoma; Phase IAn Open-Label, Multicenter, Phase I Trial Evaluating the Safety and Pharmacokinetics of Escalating Doses of BTCT4465A in Patients With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia