Stephanie Thorn, MSc, PhD

• Albert Sinusas
• Andrew Koo
• Attila Feher
• Chi Liu
• Dana Peters
• Daniela Tirziu
• Demetrios Braddock
• Denise Esserman
• Enrique M. De La Cruz
• Ewa Folta-Stogniew
• Guangxiao Yang
• Hamid Mojibian
• Henry C. Hsia
• Jean-Dominique Gallezot
• Jiasheng Zhang
• Joseph Madri
• Lawrence Young
• Paul Stabach
• Rachel Lampert
• Richard Carson
• Steffen Huber
• Tassos C. Kyriakides
• Wenxiang Cao
• Yi-Hwa Liu
• Yiyun Huang

Heart Failure; Myocardial Infarction; Radionuclide Imaging; Myocardial Reperfusion Injury; Myocardial Ischemia; Hypertrophy, Right Ventricular; Heart Failure, Diastolic; Diseases; Positron Emission Tomography Computed Tomography; Single Photon Emission Computed Tomography Computed Tomography; Computed Tomography Angiography

• In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues.Kenk M, Greene M, Thackeray J, deKemp RA, Lortie M, Thorn S, Beanlands RS, DaSilva JN. In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues. Nuclear Medicine And Biology 2007, 34: 71-7. PMID: 17210463, DOI: 10.1016/j.nucmedbio.2006.10.002.
• Collagen-based matrices improve the delivery of transplanted circulating progenitor cells: development and demonstration by ex vivo radionuclide cell labeling and in vivo tracking with positron-emission tomography.Zhang Y, Thorn S, DaSilva JN, Lamoureux M, DeKemp RA, Beanlands RS, Ruel M, Suuronen EJ. Collagen-based matrices improve the delivery of transplanted circulating progenitor cells: development and demonstration by ex vivo radionuclide cell labeling and in vivo tracking with positron-emission tomography. Circulation. Cardiovascular Imaging 2008, 1: 197-204. PMID: 19808543, DOI: 10.1161/CIRCIMAGING.108.781120.
• In vivo assessment of myocardial glucose uptake by positron emission tomography in adults with the PRKAG2 cardiac syndrome.Ha AC, Renaud JM, Dekemp RA, Thorn S, Dasilva J, Garrard L, Yoshinaga K, Abraham A, Green MS, Beanlands RS, Gollob MH. In vivo assessment of myocardial glucose uptake by positron emission tomography in adults with the PRKAG2 cardiac syndrome. Circulation. Cardiovascular Imaging 2009, 2: 485-91. PMID: 19920047, DOI: 10.1161/CIRCIMAGING.109.853291.
• Distinct early signaling events resulting from the expression of the PRKAG2 R302Q mutant of AMPK contribute to increased myocardial glycogen.Folmes KD, Chan AY, Koonen DP, Pulinilkunnil TC, Baczkó I, Hunter BE, Thorn S, Allard MF, Roberts R, Gollob MH, Light PE, Dyck JR. Distinct early signaling events resulting from the expression of the PRKAG2 R302Q mutant of AMPK contribute to increased myocardial glycogen. Circulation. Cardiovascular Genetics 2009, 2: 457-66. PMID: 20031621, DOI: 10.1161/CIRCGENETICS.108.834564.
• Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats.Greene M, Thackeray JT, Kenk M, Thorn SL, Bevilacqua L, Harper ME, Beanlands RS, Dasilva JN. Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats. Canadian Journal Of Physiology And Pharmacology 2009, 87: 196-202. PMID: 19295660, DOI: 10.1139/y09-001.
• Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program.Klein R, Renaud JM, Ziadi MC, Thorn SL, Adler A, Beanlands RS, deKemp RA. Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2010, 17: 600-16. PMID: 20387135, DOI: 10.1007/s12350-010-9225-3.
• Kinetic model-based factor analysis of dynamic sequences for 82-rubidium cardiac positron emission tomography.Klein R, Beanlands RS, Wassenaar RW, Thorn SL, Lamoureux M, DaSilva JN, Adler A, deKemp RA. Kinetic model-based factor analysis of dynamic sequences for 82-rubidium cardiac positron emission tomography. Medical Physics 2010, 37: 3995-4010. PMID: 20879561, DOI: 10.1118/1.3438474.
• Alterations of pre- and postsynaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicity.Kenk M, Thackeray JT, Thorn SL, Dhami K, Chow BJ, Ascah KJ, DaSilva JN, Beanlands RS. Alterations of pre- and postsynaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicity. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2010, 17: 254-63. PMID: 20182926, DOI: 10.1007/s12350-009-9190-x.
• Reduced CGP12177 binding to cardiac β-adrenoceptors in hyperglycemic high-fat-diet-fed, streptozotocin-induced diabetic rats.Thackeray JT, Parsa-Nezhad M, Kenk M, Thorn SL, Kolajova M, Beanlands RS, DaSilva JN. Reduced CGP12177 binding to cardiac β-adrenoceptors in hyperglycemic high-fat-diet-fed, streptozotocin-induced diabetic rats. Nuclear Medicine And Biology 2011, 38: 1059-66. PMID: 21831645, DOI: 10.1016/j.nucmedbio.2011.04.002.
• Uniformity and repeatability of normal resting myocardial blood flow in rats using [13N]-ammonia and small animal PET.Lamoureux M, Thorn S, Dumouchel T, Renaud JM, Klein R, Mason S, Lortie M, DaSilva JN, Beanlands RS, deKemp RA. Uniformity and repeatability of normal resting myocardial blood flow in rats using [13N]-ammonia and small animal PET. Nuclear Medicine Communications 2012, 33: 917-25. PMID: 22692581, DOI: 10.1097/MNM.0b013e328355d8bc.
• Analysis of (R)- and (S)-[(11)C]rolipram kinetics in canine myocardium for the evaluation of phosphodiesterase-4 with PET.Lortie M, DaSilva JN, Kenk M, Thorn S, Davis D, Birnie D, Beanlands RS, deKemp RA. Analysis of (R)- and (S)-[(11)C]rolipram kinetics in canine myocardium for the evaluation of phosphodiesterase-4 with PET. Molecular Imaging And Biology : MIB : The Official Publication Of The Academy Of Molecular Imaging 2012, 14: 225-36. PMID: 21424298, DOI: 10.1007/s11307-011-0482-6.
• A three-dimensional model-based partial volume correction strategy for gated cardiac mouse PET imaging.Dumouchel T, Thorn S, Kordos M, DaSilva J, Beanlands RS, deKemp RA. A three-dimensional model-based partial volume correction strategy for gated cardiac mouse PET imaging. Physics In Medicine And Biology 2012, 57: 4309-34. PMID: 22705820, DOI: 10.1088/0031-9155/57/13/4309.
• (18)F-FDG cell labeling may underestimate transplanted cell homing: more accurate, efficient, and stable cell labeling with hexadecyl-4-[(18)F]fluorobenzoate for in vivo tracking of transplanted human progenitor cells by positron emission tomography.Zhang Y, Dasilva JN, Hadizad T, Thorn S, Kuraitis D, Renaud JM, Ahmadi A, Kordos M, Dekemp RA, Beanlands RS, Suuronen EJ, Ruel M. (18)F-FDG cell labeling may underestimate transplanted cell homing: more accurate, efficient, and stable cell labeling with hexadecyl-4-[(18)F]fluorobenzoate for in vivo tracking of transplanted human progenitor cells by positron emission tomography. Cell Transplantation 2012, 21: 1821-35. PMID: 22469629, DOI: 10.3727/096368911X637416.
• Preclinical evaluation of biopolymer-delivered circulating angiogenic cells in a swine model of hibernating myocardium.Giordano C, Thorn SL, Renaud JM, Al-Atassi T, Boodhwani M, Klein R, Kuraitis D, Dwivedi G, Zhang P, Dasilva JN, Ascah KJ, Dekemp RA, Suuronen EJ, Beanlands RS, Ruel M. Preclinical evaluation of biopolymer-delivered circulating angiogenic cells in a swine model of hibernating myocardium. Circulation. Cardiovascular Imaging 2013, 6: 982-91. PMID: 24089461, DOI: 10.1161/CIRCIMAGING.113.000185.
• Repeatable noninvasive measurement of mouse myocardial glucose uptake with 18F-FDG: evaluation of tracer kinetics in a type 1 diabetes model.Thorn SL, deKemp RA, Dumouchel T, Klein R, Renaud JM, Wells RG, Gollob MH, Beanlands RS, DaSilva JN. Repeatable noninvasive measurement of mouse myocardial glucose uptake with 18F-FDG: evaluation of tracer kinetics in a type 1 diabetes model. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2013, 54: 1637-44. PMID: 23940301, DOI: 10.2967/jnumed.112.110114.
• Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model.Thorn SL, Gollob MH, Harper ME, Beanlands RS, Dekemp RA, Dasilva JN. Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model. EJNMMI Research 2013, 3: 48. PMID: 23829931, PMCID: PMC3707764, DOI: 10.1186/2191-219X-3-48.
• MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16.Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, van Ijcken W, Grosveld F, Dekemp RA, Boushel R, Harper ME, Rudnicki MA. MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metabolism 2013, 17: 210-24. PMID: 23395168, PMCID: PMC3641657, DOI: 10.1016/j.cmet.2013.01.004.
• Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions.Mailloux RJ, Xuan JY, McBride S, Maharsy W, Thorn S, Holterman CE, Kennedy CR, Rippstein P, deKemp R, da Silva J, Nemer M, Lou M, Harper ME. Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions. The Journal Of Biological Chemistry 2014, 289: 14812-28. PMID: 24727547, PMCID: PMC4031535, DOI: 10.1074/jbc.M114.550574.
• The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium.Ahmadi A, McNeill B, Vulesevic B, Kordos M, Mesana L, Thorn S, Renaud JM, Manthorp E, Kuraitis D, Toeg H, Mesana TG, Davis DR, Beanlands RS, DaSilva JN, deKemp RA, Ruel M, Suuronen EJ. The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium. Biomaterials 2014, 35: 4749-58. PMID: 24631247, DOI: 10.1016/j.biomaterials.2014.02.028.
• Reply: Noninvasive measurement of mouse myocardial glucose uptake with 18F-FDG.Thorn SL, deKemp R, Dumouchel T, Klein R, Renaud JN, Wells RG, Gollob M, Beanlands RS, DaSilva JN. Reply: Noninvasive measurement of mouse myocardial glucose uptake with 18F-FDG. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2014, 55: 866-7. PMID: 24652829, DOI: 10.2967/jnumed.114.138214.
• Scatter and crosstalk corrections for (99m)Tc/(123)I dual-radionuclide imaging using a CZT SPECT system with pinhole collimators.Fan P, Hutton BF, Holstensson M, Ljungberg M, Hendrik Pretorius P, Prasad R, Ma T, Liu Y, Wang S, Thorn SL, Stacy MR, Sinusas AJ, Liu C. Scatter and crosstalk corrections for (99m)Tc/(123)I dual-radionuclide imaging using a CZT SPECT system with pinhole collimators. Medical Physics 2015, 42: 6895-911. PMID: 26632046, DOI: 10.1118/1.4934830.
• ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy.Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT. ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nature Communications 2015, 6: 10006. PMID: 26624227, PMCID: PMC4686714, DOI: 10.1038/ncomms10006.
• Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiology.Thorn S, Sinusas AJ. Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiology. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2015, 22: 673-6. PMID: 25698482, DOI: 10.1007/s12350-015-0081-z.
• Insulin therapy normalizes reduced myocardial β-adrenoceptors at both the onset and after sustained hyperglycemia in diabetic rats.Haley JM, Thackeray JT, Kolajova M, Thorn SL, DaSilva JN. Insulin therapy normalizes reduced myocardial β-adrenoceptors at both the onset and after sustained hyperglycemia in diabetic rats. Life Sciences 2015, 132: 101-7. PMID: 25934520, DOI: 10.1016/j.lfs.2015.03.024.
• Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.Cattin ME, Wang J, Weldrick JJ, Roeske CL, Mak E, Thorn SL, DaSilva JN, Wang Y, Lusis AJ, Burgon PG. Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. The Journal Of Biological Chemistry 2015, 290: 26699-714. PMID: 26359501, PMCID: PMC4646324, DOI: 10.1074/jbc.M115.678433.
• PET imaging of a collagen matrix reveals its effective injection and targeted retention in a mouse model of myocardial infarction.Ahmadi A, Thorn SL, Alarcon EI, Kordos M, Padavan DT, Hadizad T, Cron GO, Beanlands RS, DaSilva JN, Ruel M, deKemp RA, Suuronen EJ. PET imaging of a collagen matrix reveals its effective injection and targeted retention in a mouse model of myocardial infarction. Biomaterials 2015, 49: 18-26. PMID: 25725551, DOI: 10.1016/j.biomaterials.2015.01.016.
• Cardiac β-Adrenoceptor Expression Is Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes Progresses.Haley JM, Thackeray JT, Thorn SL, DaSilva JN. Cardiac β-Adrenoceptor Expression Is Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes Progresses. PloS One 2015, 10: e0127581. PMID: 25996498, PMCID: PMC4440709, DOI: 10.1371/journal.pone.0127581.
• Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method.Wu J, Lin SF, Gallezot JD, Chan C, Prasad R, Thorn S, Stacy MR, Huang Y, Zonouz TH, Liu YH, Lampert RJ, Carson RE, Sinusas AJ, Liu C. Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2016, 57: 1226-32. PMID: 27081169, DOI: 10.2967/jnumed.115.171710.
• Effects of an endothelin receptor antagonist, Macitentan, on right ventricular substrate utilization and function in a Sugen 5416/hypoxia rat model of severe pulmonary arterial hypertension.Drozd K, Ahmadi A, Deng Y, Jiang B, Petryk J, Thorn S, Stewart D, Beanlands R, deKemp RA, DaSilva JN, Mielniczuk LM. Effects of an endothelin receptor antagonist, Macitentan, on right ventricular substrate utilization and function in a Sugen 5416/hypoxia rat model of severe pulmonary arterial hypertension. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2017, 24: 1979-1989. PMID: 27688036, DOI: 10.1007/s12350-016-0663-4.
• T1-refBlochi: high resolution 3D post-contrast T1 myocardial mapping based on a single 3D late gadolinium enhancement volume, Bloch equations, and a reference T1.Hu C, Sinusas AJ, Huber S, Thorn S, Stacy MR, Mojibian H, Peters DC. T1-refBlochi: high resolution 3D post-contrast T1 myocardial mapping based on a single 3D late gadolinium enhancement volume, Bloch equations, and a reference T1. Journal Of Cardiovascular Magnetic Resonance : Official Journal Of The Society For Cardiovascular Magnetic Resonance 2017, 19: 63. PMID: 28821300, PMCID: PMC5563030, DOI: 10.1186/s12968-017-0375-1.
• Editorial in response to: PET/CT evaluation of 18F-FDG uptake in pericoronary adipose tissue in patients with stable coronary artery disease: Independent predictor of atherosclerotic lesion formation? : Is there prognostic value in evaluation of 18F-FDG uptake in the pericoronary adipose tissue?Thorn SL, Sinusas AJ. Editorial in response to: PET/CT evaluation of 18F-FDG uptake in pericoronary adipose tissue in patients with stable coronary artery disease: Independent predictor of atherosclerotic lesion formation? : Is there prognostic value in evaluation of 18F-FDG uptake in the pericoronary adipose tissue? Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2017, 24: 1085-1088. PMID: 26976143, DOI: 10.1007/s12350-016-0458-7.
• Simplified Quantification and Acquisition Protocol for 123I-MIBG Dynamic SPECT.Wu J, Gallezot JD, Lu Y, Ye Q, Liu H, Esserman DA, Kyriakides TC, Thorn S, Zonouz TH, Liu YH, Lampert R, Sinusas AJ, Carson RE, Liu C. Simplified Quantification and Acquisition Protocol for 123I-MIBG Dynamic SPECT. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2018, 59: 1574-1580. PMID: 29476001, DOI: 10.2967/jnumed.117.202143.
• Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure.Pfau D, Thorn SL, Zhang J, Mikush N, Renaud JM, Klein R, deKemp RA, Wu X, Hu X, Sinusas AJ, Young LH, Tirziu D. Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure. Scientific Reports 2019, 9: 5791. PMID: 30962467, PMCID: PMC6453892, DOI: 10.1038/s41598-019-42113-0.
• Incisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study.Shah A, Sumpio BJ, Tsay C, Swallow M, Dash B, Thorn SL, Sinusas AJ, Koo A, Hsia HC, Au A. Incisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study. Annals Of Plastic Surgery 2019, 82: S222-S227. PMID: 30855392, DOI: 10.1097/SAP.0000000000001842.
• A robust segmentation method with triple-factor non-negative matrix factorization for myocardial blood flow quantification from dynamic 82 Rb positron emission tomography.Liu H, Wu J, Sun JY, Wu TH, Ramesh FC, Thorn S, Sinusas AJ, Liu YH. A robust segmentation method with triple-factor non-negative matrix factorization for myocardial blood flow quantification from dynamic 82 Rb positron emission tomography. Medical Physics 2019, 46: 5002-5013. PMID: 31444909, DOI: 10.1002/mp.13783.
• Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling.Thorn SL, Barlow SC, Feher A, Stacy MR, Doviak H, Jacobs J, Zellars K, Renaud JM, Klein R, deKemp RA, Khakoo AY, Lee T, Spinale FG, Sinusas AJ. Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling. Circulation. Cardiovascular Imaging 2019, 12: e009055. PMID: 31707811, PMCID: PMC7250243, DOI: 10.1161/CIRCIMAGING.119.009055.
• Direct List Mode Parametric Reconstruction for Dynamic Cardiac SPECT.Shi L, Lu Y, Wu J, Gallezot JD, Boutagy N, Thorn S, Sinusas AJ, Carson RE, Liu C. Direct List Mode Parametric Reconstruction for Dynamic Cardiac SPECT. IEEE Transactions On Medical Imaging 2020, 39: 119-128. PMID: 31180845, PMCID: PMC7030971, DOI: 10.1109/TMI.2019.2921969.