Sreeganga Chandra, PhD
Research & Publications
Biography
News
Research Summary
My lab explores two related themes, those of synapse loss and neurodegeneration. Synapse loss is an early, defining event in neurodegenerative diseases, such as Parkinson's disease. In these prolonged diseases, decreases in synapse density are the best correlates of disease progression.Yet, little is known about the pathways that maintain synapses and their roles in aging and neurodegeneration. We are characterizing familial neurodegeneration genes that encode synaptic proteins to understand this important step in disease pathogenesis. Our lab uses mouse models as well as iPSC derived neuronal models in combination with biochemical, cell biological and in vivo approaches to tackle these important questions.
Specialized Terms:
- Presynaptic Biology
- Synapse Maintenance
- Parkinson's Disease
- Neuronal Ceroid Lipofuscinosis
- Neurodegeneration
Extensive Research Description
- Role of the endolysosomal pathway in Parkinson's disease
- Protein palmitoylation and neuronal ceroid lipofuscinosis
- Identification of the physiological function of synucleins
- Role of CSP alpha in synapse maintenance
- Identification of novel synapse maintenance genes
Coauthors
Research Interests
Neurology; Neuronal Ceroid-Lipofuscinoses; Parkinson Disease; Synapses; Receptors, Presynaptic; Neurodegenerative Diseases
Research Images
Selected Publications
- Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease.Taguchi YV, Liu J, Ruan J, Pacheco J, Zhang X, Abbasi J, Keutzer J, Mistry PK, Chandra SS. Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2017, 37: 9617-9631. PMID: 28847804, PMCID: PMC5628407, DOI: 10.1523/JNEUROSCI.1525-17.2017.
- Synucleins Have Multiple Effects on Presynaptic Architecture.Vargas KJ, Schrod N, Davis T, Fernandez-Busnadiego R, Taguchi YV, Laugks U, Lucic V, Chandra SS. Synucleins Have Multiple Effects on Presynaptic Architecture. Cell Reports 2017, 18: 161-173. PMID: 28052246, PMCID: PMC5510332, DOI: 10.1016/j.celrep.2016.12.023.
- Synucleins regulate the kinetics of synaptic vesicle endocytosis.Vargas KJ, Makani S, Davis T, Westphal CH, Castillo PE, Chandra SS. Synucleins regulate the kinetics of synaptic vesicle endocytosis. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2014, 34: 9364-76. PMID: 25009269, PMCID: PMC4087213, DOI: 10.1523/JNEUROSCI.4787-13.2014.
- Identification of CSPα clients reveals a role in dynamin 1 regulation.Zhang YQ, Henderson MX, Colangelo CM, Ginsberg SD, Bruce C, Wu T, Chandra SS. Identification of CSPα clients reveals a role in dynamin 1 regulation. Neuron 2012, 74: 136-50. PMID: 22500636, PMCID: PMC3328141, DOI: 10.1016/j.neuron.2012.01.029.
- Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration.Chandra S, Gallardo G, Fernández-Chacón R, Schlüter OM, Südhof TC. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 2005, 123: 383-96. PMID: 16269331, DOI: 10.1016/j.cell.2005.09.028.