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Sourav Ghosh, PhD

Associate Professor of Neurology and Pharmacology

Contact Information

Sourav Ghosh, PhD

Lab Location

Office Location

Mailing Address

  • Neurology

    300 Cedar Street, TAC S625B

    New Haven, CT, 06519

    United States

Rothlin Ghosh Lab

Research Summary

I co-lead our group with Carla Rothlin, Professor of Immunobiology and Pharmacology. We are interested in tissue morphogenesis, maintenance and repair with specific emphasis on the functional role of the immune system in development, tissue maintenance and repair/regeneration, as well as the role of cell polarity in these processes. One of the current interests in the lab is cell death and its clearance, and how this can function as a signal for specific effector responses during morphogenesis, homeostatic tissue renewal, or resolution and wound repair after damage. We hypothesize that the integration of cell death recognition, environmental signals (including tissue-specific signals) and the identity of the efferocyte (the cell that recognizes dead cells) determines the specificity for removal of dead/damaged cells, renewal of lost cells, or repair and regeneration. We use a variety of approaches including molecular, cell biology, immunology, imaging and genetics and mouse models of development/tissue homeostasis/injury or diseases to address fundamental biological mechanisms.

Current projects:

1. Astrocytes, oligodendrocytes and microglia during the formation, function and after injury in the nervous systems

2. Macrophage-stromal interactions during tissue homeostasis and wound repair

3. Tumorigenesis and tumor progression, including innate immune checkpoints and anti-tumor immunity

Coauthors

Research Interests

Glioblastoma; Immune System; Inflammation; Cell Death; Neurodegenerative Diseases; Neurodevelopmental Disorders

Selected Publications

  • Highlights from the Literature22(8), 1070–1072, 2020 | doi:10.1093/neuonc/noaa147
  • Highlights from the LiteratureNeuro-Oncology, Volume 22, Issue 11, November 2020, Pages 1564–1567, https://doi.org/10.1093/neuonc/noaa220
  • Cracking the Cell Death Code.Rothlin CV, Ghosh S. Cracking the Cell Death Code. Cold Spring Harbor Perspectives In Biology 2020, 12.
  • Lifting the innate immune barriers to antitumor immunity.Rothlin CV, Ghosh S. Lifting the innate immune barriers to antitumor immunity. Journal For Immunotherapy Of Cancer 2020, 8.
  • Author Correction: A conserved dendritic-cell regulatory program limits antitumour immunity.Maier B, Leader AM, Chen ST, Tung N, Chang C, LeBerichel J, Chudnovskiy A, Maskey S, Walker L, Finnigan JP, Kirkling ME, Reizis B, Ghosh S, D'Amore NR, Bhardwaj N, Rothlin CV, Wolf A, Flores R, Marron T, Rahman AH, Kenigsberg E, Brown BD, Merad M. Author Correction: A conserved dendritic-cell regulatory program limits antitumour immunity. Nature 2020, 582:E17.
  • Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model.Baptista-de-Souza D, Tavares-Ferreira D, Megat S, Sankaranarayanan I, Shiers S, Flores CM, Ghosh S, Luiz Nunes-de-Souza R, Canto-de-Souza A, Price TJ. Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model. Neurobiology Of Pain (Cambridge, Mass.) 2020, 8:100049.
  • Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo.Damisah EC, Hill RA, Rai A, Chen F, Rothlin CV, Ghosh S, Grutzendler J. Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo. Science Advances 2020, 6:eaba3239.
  • Highlights from the LiteratureNeuro-Oncology 21(7), 834–836, 2019 | doi:10.1093/neuonc/noz101
  • Highlights from the LiteratureNeuro-Oncology 21(10), 1223–1225, 2019 | doi:10.1093/neuonc/noz149
  • Highlights from the LiteratureNeuro-Oncology 22(2), 177–179, 2020 | doi:10.1093/neuonc/noz242
  • Induction of sterile type 2 inflammation.de Kouchkovsky DA, Ghosh S, Rothlin CV. Induction of sterile type 2 inflammation. Nature Materials 2019, 18:193-194.
  • Serous macrophages pack Bhlhe40 for a randonnée.Rothlin CV, Ghosh S. Serous macrophages pack Bhlhe40 for a randonnée. Nature Immunology 2019, 20:670-671.
  • Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function.Scott J, Thakar S, Mao Y, Qin H, Hejran H, Lee SY, Yu T, Klezovitch O, Cheng H, Mu Y, Ghosh S, Vasioukhin V, Zou Y. Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function. IScience 2019, 20:25-41.
  • Bringing on the itch.Waizman DA, Ghosh S, Rothlin CV. Bringing on the itch. ELife 2019, 8.
  • Funerals and Feasts: The Immunological Rites of Cell Death.Galimberti VE, Rothlin CV, Ghosh S. Funerals and Feasts: The Immunological Rites of Cell Death. The Yale Journal Of Biology And Medicine 2019, 92:663-674.
  • aPKC in neuronal differentiation, maturation and function.Hapak SM, Rothlin CV, Ghosh S. aPKC in neuronal differentiation, maturation and function. Neuronal Signaling 2019, 3:NS20190019.
  • Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage.Chang CF, Goods BA, Askenase MH, Hammond MD, Renfroe SC, Steinschneider AF, Landreneau MJ, Ai Y, Beatty HE, da Costa LHA, Mack M, Sheth KN, Greer DM, Huttner A, Coman D, Hyder F, Ghosh S, Rothlin CV, Love JC, Sansing LH. Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage. The Journal Of Clinical Investigation 2018, 128:607-624.
  • PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.Hapak SM, Rothlin CV, Ghosh S. PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization. Cellular And Molecular Life Sciences : CMLS 2018, 75:2735-2761.
  • aPKCζ-dependent Repression of Yap is Necessary for Functional Restoration of Irradiated Salivary Glands with IGF-1.Chibly AM, Wong WY, Pier M, Cheng H, Mu Y, Chen J, Ghosh S, Limesand KH. aPKCζ-dependent Repression of Yap is Necessary for Functional Restoration of Irradiated Salivary Glands with IGF-1. Scientific Reports 2018, 8:6347.
  • Axon Regeneration: Antagonistic Signaling Pairs in Neuronal Polarization.Hapak SM, Ghosh S, Rothlin CV. Axon Regeneration: Antagonistic Signaling Pairs in Neuronal Polarization. Trends In Molecular Medicine 2018, 24:615-629.
  • Coagulopathies and inflammatory diseases: '…glimpse of a Snark'.Del Carmen S, Hapak SM, Ghosh S, Rothlin CV. Coagulopathies and inflammatory diseases: '…glimpse of a Snark'. Current Opinion In Immunology 2018, 55:44-53.
  • Cenabis Bene: Treg Cells Invite Macrophages to Dine.Hughes LD, Ghosh S, Rothlin CV. Cenabis Bene: Treg Cells Invite Macrophages to Dine. Immunity 2018, 49:579-582.
  • Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.Bosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science (New York, N.Y.) 2017, 356:1072-1076.
  • Negative Regulation of Type 2 Immunity.de Kouchkovsky DA, Ghosh S, Rothlin CV. Negative Regulation of Type 2 Immunity. Trends In Immunology 2017, 38:154-167.
  • TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy.Akalu YT, Rothlin CV, Ghosh S. TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy. Immunological Reviews 2017, 276:165-177.
  • The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer.Uribe DJ, Mandell EK, Watson A, Martinez JD, Leighton JA, Ghosh S, Rothlin CV. The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer. PloS One 2017, 12:e0179979.
  • Death begets a new beginning.Bosurgi L, Hughes LD, Rothlin CV, Ghosh S. Death begets a new beginning. Immunological Reviews 2017, 280:8-25.
  • Chronicles of Cell Death Foretold: Specificities in the Mechanism of Disposal.Hughes LD, Bosurgi L, Ghosh S, Rothlin CV. Chronicles of Cell Death Foretold: Specificities in the Mechanism of Disposal. Frontiers In Immunology 2017, 8:1743.
  • The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity.Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science (New York, N.Y.) 2016, 352:99-103.
  • PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels.Lu R, Dalgalan D, Mandell EK, Parker SS, Ghosh S, Wilson JM. PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Molecular Biology Of The Cell 2015, 26:1523-31.
  • TAM receptor signaling in immune homeostasis.Rothlin CV, Carrera-Silva EA, Bosurgi L, Ghosh S. TAM receptor signaling in immune homeostasis. Annual Review Of Immunology 2015, 33:355-91.
  • Endosomal regulation of contact inhibition through the AMOT:YAP pathway.Cox CM, Mandell EK, Stewart L, Lu R, Johnson DL, McCarter SD, Tavares A, Runyan R, Ghosh S, Wilson JM. Endosomal regulation of contact inhibition through the AMOT:YAP pathway. Molecular Biology Of The Cell 2015, 26:2673-84.
  • Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.Kusne Y, Carrera-Silva EA, Perry AS, Rushing EJ, Mandell EK, Dietrich JD, Errasti AE, Gibbs D, Berens ME, Loftus JC, Hulme C, Yang W, Lu Z, Aldape K, Sanai N, Rothlin CV, Ghosh S. Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma. Science Signaling 2014, 7:ra75.
  • Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice.Kusne Y, Goldberg EL, Parker SS, Hapak SM, Maskaykina IY, Chew WM, Limesand KH, Brooks HL, Price TJ, Sanai N, Nikolich-Zugich J, Ghosh S. Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice. Age (Dordrecht, Netherlands) 2014, 36:199-212.
  • Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer.Rothlin CV, Leighton JA, Ghosh S. Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer. Inflammatory Bowel Diseases 2014, 20:1472-80.
  • Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population.Perry AS, Furusato B, Nagle RB, Ghosh S. Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population. Prostate Cancer 2014, 2014:481697.
  • Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.Melemedjian OK, Tillu DV, Moy JK, Asiedu MN, Mandell EK, Ghosh S, Dussor G, Price TJ. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Molecular Pain 2014, 10:45.
  • Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer.Bosurgi L, Bernink JH, Delgado Cuevas V, Gagliani N, Joannas L, Schmid ET, Booth CJ, Ghosh S, Rothlin CV. Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110:13091-6.
  • T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.Carrera Silva EA, Chan PY, Joannas L, Errasti AE, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton JA, Lemke G, Ghosh S, Rothlin CV. T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity 2013, 39:160-70.
  • Competing molecular interactions of aPKC isoforms regulate neuronal polarity.Parker SS, Mandell EK, Hapak SM, Maskaykina IY, Kusne Y, Kim JY, Moy JK, St John PA, Wilson JM, Gothard KM, Price TJ, Ghosh S. Competing molecular interactions of aPKC isoforms regulate neuronal polarity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110:14450-5.
  • ZIPping to pain relief: the role (or not) of PKMζ in chronic pain.Price TJ, Ghosh S. ZIPping to pain relief: the role (or not) of PKMζ in chronic pain. Molecular Pain 2013, 9:6.
  • BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state.Melemedjian OK, Tillu DV, Asiedu MN, Mandell EK, Moy JK, Blute VM, Taylor CJ, Ghosh S, Price TJ. BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state. Molecular Pain 2013, 9:12.
  • mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.Melemedjian OK, Khoutorsky A, Sorge RE, Yan J, Asiedu MN, Valdez A, Ghosh S, Dussor G, Mogil JS, Sonenberg N, Price TJ. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain 2013, 154:1080-91.
  • Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain.King T, Qu C, Okun A, Melemedjian OK, Mandell EK, Maskaykina IY, Navratilova E, Dussor GO, Ghosh S, Price TJ, Porreca F. Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain. Pain 2012, 153:1263-1273.
  • Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization.Asiedu MN, Tillu DV, Melemedjian OK, Shy A, Sanoja R, Bodell B, Ghosh S, Porreca F, Price TJ. Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2011, 31:6646-53.
  • Highlights from the LiteratureNeuro-Oncology 22(6), 754–756, 2020 | doi:10.1093/neuonc/noaa089
  • Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.Teo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, Chanda SK, Verma IM, Tergaonkar V. Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nature Cell Biology 2010, 12:758-67.
  • Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors.Ghosh S, Marquardt T, Thaler JP, Carter N, Andrews SE, Pfaff SL, Hunter T. Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105:335-40.
  • TAM receptors are pleiotropic inhibitors of the innate immune response.Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 2007, 131:1124-36.
  • Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival.Ghosh S, Tergaonkar V, Rothlin CV, Correa RG, Bottero V, Bist P, Verma IM, Hunter T. Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell 2006, 10:215-26.
  • Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains.Marquardt T, Shirasaki R, Ghosh S, Andrews SE, Carter N, Hunter T, Pfaff SL. Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell 2005, 121:127-39.
  • Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2.Shah OJ, Ghosh S, Hunter T. Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2. The Journal Of Biological Chemistry 2003, 278:16433-42.
  • Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.Lu Z, Ghosh S, Wang Z, Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell 2003, 4:499-515.
  • CK2 constitutively associates with and phosphorylates chicken erythroid ankyrin and regulates its ability to bind to spectrin.Ghosh S, Dorsey FC, Cox JV. CK2 constitutively associates with and phosphorylates chicken erythroid ankyrin and regulates its ability to bind to spectrin. Journal Of Cell Science 2002, 115:4107-15.
  • Dynamics of ankyrin-containing complexes in chicken embryonic erythroid cells: role of phosphorylation.Ghosh S, Cox JV. Dynamics of ankyrin-containing complexes in chicken embryonic erythroid cells: role of phosphorylation. Molecular Biology Of The Cell 2001, 12:3864-74.
  • Chicken erythroid AE1 anion exchangers associate with the cytoskeleton during recycling to the Golgi.Ghosh S, Cox KH, Cox JV. Chicken erythroid AE1 anion exchangers associate with the cytoskeleton during recycling to the Golgi. Molecular Biology Of The Cell 1999, 10:455-69.
  • Highlights from the LiteratureNeuro-oncology, 2020, doi.org/10.1093/neuonc/noaa246
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