Sorin Fedeles, PhD, MBA
Assistant Professor Adjunct
Research & Publications
Biography
News
Coauthors
Selected Publications
- Disrupting polycystin-2 EF hand Ca2+ affinity does not alter channel function or contribute to polycystic kidney disease.Vien TN, Ng LCT, Smith JM, Dong K, Krappitz M, Gainullin VG, Fedeles S, Harris PC, Somlo S, DeCaen PG. Disrupting polycystin-2 EF hand Ca2+ affinity does not alter channel function or contribute to polycystic kidney disease. Journal Of Cell Science 2020, 133 PMID: 33199522, PMCID: PMC7774883, DOI: 10.1242/jcs.255562.
- Spliced XBP1 Rescues Renal Interstitial Inflammation Due to Loss of Sec63 in Collecting Ducts.Ishikawa Y, Fedeles S, Marlier A, Zhang C, Gallagher AR, Lee AH, Somlo S. Spliced XBP1 Rescues Renal Interstitial Inflammation Due to Loss of Sec63 in Collecting Ducts. Journal Of The American Society Of Nephrology : JASN 2019 PMID: 30745418, PMCID: PMC6405156, DOI: 10.1681/ASN.2018060614.
- Isolated polycystic liver disease genes define effectors of polycystin-1 function.Besse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J, Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, Watnick T, Pei YP, Torres VE, Somlo S. Isolated polycystic liver disease genes define effectors of polycystin-1 function. The Journal Of Clinical Investigation 2017, 127: 3558. PMID: 28862642, PMCID: PMC5669574, DOI: 10.1172/JCI96729.
- Is it Time to Fold the Cysts Away?Krappitz M, Gallagher AR, Fedeles S. Is it Time to Fold the Cysts Away? Trends In Molecular Medicine 2016, 22: 997-999. PMID: 27793600, DOI: 10.1016/j.molmed.2016.10.001.
- Hepatocystin is Essential for TRPM7 Function During Early Embryogenesis.Overton JD, Komiya Y, Mezzacappa C, Nama K, Cai N, Lou L, Fedeles SV, Habas R, Runnels LW. Hepatocystin is Essential for TRPM7 Function During Early Embryogenesis. Scientific Reports 2015, 5: 18395. PMID: 26671672, PMCID: PMC4680877, DOI: 10.1038/srep18395.
- Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.Fedeles SV, So JS, Shrikhande A, Lee SH, Gallagher AR, Barkauskas CE, Somlo S, Lee AH. Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity. The Journal Of Clinical Investigation 2015, 125: 1955-67. PMID: 25844898, PMCID: PMC4463201, DOI: 10.1172/JCI78863.
- Altered trafficking and stability of polycystins underlie polycystic kidney disease.Cai Y, Fedeles SV, Dong K, Anyatonwu G, Onoe T, Mitobe M, Gao JD, Okuhara D, Tian X, Gallagher AR, Tang Z, Xie X, Lalioti MD, Lee AH, Ehrlich BE, Somlo S. Altered trafficking and stability of polycystins underlie polycystic kidney disease. The Journal Of Clinical Investigation 2014, 124: 5129-44. PMID: 25365220, PMCID: PMC4348948, DOI: 10.1172/JCI67273.
- Polycystin-1: a master regulator of intersecting cystic pathways.Fedeles SV, Gallagher AR, Somlo S. Polycystin-1: a master regulator of intersecting cystic pathways. Trends In Molecular Medicine 2014, 20: 251-60. PMID: 24491980, PMCID: PMC4008641, DOI: 10.1016/j.molmed.2014.01.004.
- Steviol retards renal cyst growth through reduction of CFTR expression and inhibition of epithelial cell proliferation in a mouse model of polycystic kidney disease.Yuajit C, Muanprasat C, Gallagher AR, Fedeles SV, Kittayaruksakul S, Homvisasevongsa S, Somlo S, Chatsudthipong V. Steviol retards renal cyst growth through reduction of CFTR expression and inhibition of epithelial cell proliferation in a mouse model of polycystic kidney disease. Biochemical Pharmacology 2014, 88: 412-21. PMID: 24518257, DOI: 10.1016/j.bcp.2014.01.038.
- N-glycosylation determines the abundance of the transient receptor potential channel TRPP2.Hofherr A, Wagner C, Fedeles S, Somlo S, Köttgen M. N-glycosylation determines the abundance of the transient receptor potential channel TRPP2. The Journal Of Biological Chemistry 2014, 289: 14854-67. PMID: 24719335, PMCID: PMC4031537, DOI: 10.1074/jbc.M114.562264.
- Cell polarity and cystic kidney disease.Fedeles S, Gallagher AR. Cell polarity and cystic kidney disease. Pediatric Nephrology (Berlin, Germany) 2013, 28: 1161-72. PMID: 23161205, DOI: 10.1007/s00467-012-2337-z.
- Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.Lang S, Benedix J, Fedeles SV, Schorr S, Schirra C, Schäuble N, Jalal C, Greiner M, Hassdenteufel S, Tatzelt J, Kreutzer B, Edelmann L, Krause E, Rettig J, Somlo S, Zimmermann R, Dudek J. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Journal Of Cell Science 2012, 125: 1958-69. PMID: 22375059, PMCID: PMC4074215, DOI: 10.1242/jcs.096727.
- A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.Fedeles SV, Tian X, Gallagher AR, Mitobe M, Nishio S, Lee SH, Cai Y, Geng L, Crews CM, Somlo S. A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nature Genetics 2011, 43: 639-47. PMID: 21685914, PMCID: PMC3547075, DOI: 10.1038/ng.860.