Song Pang
Director, FIB-SEM Collaboration Core
Research & Publications
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Selected Publications
- Enhanced FIB-SEM Sample Preparation Methods and Pipeline for Comparative BiologyPang S. Enhanced FIB-SEM Sample Preparation Methods and Pipeline for Comparative Biology. Microscopy And Microanalysis 2023, 29: 1187-1187. PMID: 37613191, DOI: 10.1093/micmic/ozad067.611.
- Methods of enhanced FIB-SEM sample preparation and image acquisitionPang S, Xu C. Methods of enhanced FIB-SEM sample preparation and image acquisition. 2023, 177: 269-300. PMID: 37451770, DOI: 10.1016/bs.mcb.2023.01.019.
- A complete reconstruction of the early visual system of an adult insectChua N, Makarova A, Gunn P, Villani S, Cohen B, Thasin M, Wu J, Shefter D, Pang S, Xu C, Hess H, Polilov A, Chklovskii D. A complete reconstruction of the early visual system of an adult insect. Current Biology 2023, 33: 4611-4623.e4. PMID: 37774707, DOI: 10.1016/j.cub.2023.09.021.
- Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touchHandler A, Zhang Q, Pang S, Nguyen T, Iskols M, Nolan-Tamariz M, Cattel S, Plumb R, Sanchez B, Ashjian K, Shotland A, Brown B, Kabeer M, Turecek J, DeLisle M, Rankin G, Xiang W, Pavarino E, Africawala N, Santiago C, Lee W, Xu C, Ginty D. Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch. Neuron 2023, 111: 3211-3229.e9. PMID: 37725982, PMCID: PMC10773061, DOI: 10.1016/j.neuron.2023.08.023.
- 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscleNikolaev Y, Ziolkowski L, Pang S, Li W, Feketa V, Xu C, Gracheva E, Bagriantsev S. 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle. Science Advances 2023, 9: eadi4147. PMID: 37703368, PMCID: PMC10499330, DOI: 10.1126/sciadv.adi4147.
- Multiscale head anatomy of Megaphragma (Hymenoptera: Trichogrammatidae)Desyatirkina I, Makarova A, Pang S, Xu C, Hess H, Polilov A. Multiscale head anatomy of Megaphragma (Hymenoptera: Trichogrammatidae). Arthropod Structure & Development 2023, 76: 101299. PMID: 37666087, DOI: 10.1016/j.asd.2023.101299.
- A Serotonergic Axon-Cilium Synapse Drives Nuclear Signaling to Maintain Chromatin AccessibilitySheu S, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli H, Houser J, Sanchez-Martinez S, Brauchi S, Banala S, Freeman M, Xu C, Kirchhausen T, Hess H, Lavis L, Li Y, Chaumont-Dubel S, Clapham D. A Serotonergic Axon-Cilium Synapse Drives Nuclear Signaling to Maintain Chromatin Accessibility. Microscopy And Microanalysis 2023, 29: 1091-1091. PMID: 37613506, DOI: 10.1093/micmic/ozad067.561.
- Towards Generalizable Organelle Segmentation in Volume Electron MicroscopyHeinrich L, Patton W, Bennett D, Ackerman D, Park G, Bogovic J, Eckstein N, Petruncio A, Clements J, Pang S, Xu C, Funke J, Korff W, Hess H, Lippincott-Schwartz J, Saalfeld S, Weigel A, Team C. Towards Generalizable Organelle Segmentation in Volume Electron Microscopy. Microscopy And Microanalysis 2023, 29: 975-975. PMID: 37613645, DOI: 10.1093/micmic/ozad067.487.
- Comparative connectomics and escape behavior in larvae of closely related Drosophila speciesZhu J, Boivin J, Pang S, Xu C, Lu Z, Saalfeld S, Hess H, Ohyama T. Comparative connectomics and escape behavior in larvae of closely related Drosophila species. Current Biology 2023, 33: 2491-2503.e4. PMID: 37285846, DOI: 10.1016/j.cub.2023.05.043.
- En bloc preparation of Drosophila brains enables high-throughput FIB-SEM connectomicsLu Z, Xu C, Hayworth K, Pang S, Shinomiya K, Plaza S, Scheffer L, Rubin G, Hess H, Rivlin P, Meinertzhagen I. En bloc preparation of Drosophila brains enables high-throughput FIB-SEM connectomics. Frontiers In Neural Circuits 2022, 16: 917251. PMID: 36589862, PMCID: PMC9801301, DOI: 10.3389/fncir.2022.917251.
- The 3D ultrastructure of the chordotonal organs in the antenna of a microwasp remains complex although simplifiedDiakova A, Makarova A, Pang S, Xu C, Hess H, Polilov A. The 3D ultrastructure of the chordotonal organs in the antenna of a microwasp remains complex although simplified. Scientific Reports 2022, 12: 20172. PMID: 36424494, PMCID: PMC9691716, DOI: 10.1038/s41598-022-24390-4.
- A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibilitySheu SH, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli HA, Houser J, Sanchez-Martinez S, Brauchi SE, Banala S, Freeman M, Xu CS, Kirchhausen T, Hess HF, Lavis L, Li Y, Chaumont-Dubel S, Clapham DE. A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell 2022, 185: 3390-3407.e18. PMID: 36055200, PMCID: PMC9789380, DOI: 10.1016/j.cell.2022.07.026.
- Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons.Zhu PP, Hung HF, Batchenkova N, Nixon-Abell J, Henderson J, Zheng P, Renvoisé B, Pang S, Xu CS, Saalfeld S, Funke J, Xie Y, Svara F, Hess HF, Blackstone C. Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons. Human Molecular Genetics 2022, 31: 2779-2795. PMID: 35348668, PMCID: PMC9402237, DOI: 10.1093/hmg/ddac072.
- Regulation of liver subcellular architecture controls metabolic homeostasisParlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamışlıgil GS. Regulation of liver subcellular architecture controls metabolic homeostasis. Nature 2022, 603: 736-742. PMID: 35264794, PMCID: PMC9014868, DOI: 10.1038/s41586-022-04488-5.
- Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissuesXu C, Pang S, Shtengel G, Müller A, Ritter A, Hoffman H, Takemura S, Lu Z, Pasolli H, Iyer N, Chung J, Bennett D, Weigel A, Freeman M, van Engelenburg S, Walther T, Farese R, Lippincott-Schwartz J, Mellman I, Solimena M, Hess H. Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues. Nature 2021, 599: e5-e5. PMID: 34732896, DOI: 10.1038/s41586-021-04132-8.
- Whole-cell organelle segmentation in volume electron microscopyHeinrich L, Bennett D, Ackerman D, Park W, Bogovic J, Eckstein N, Petruncio A, Clements J, Pang S, Xu CS, Funke J, Korff W, Hess HF, Lippincott-Schwartz J, Saalfeld S, Weigel AV. Whole-cell organelle segmentation in volume electron microscopy. Nature 2021, 599: 141-146. PMID: 34616042, DOI: 10.1038/s41586-021-03977-3.
- An open-access volume electron microscopy atlas of whole cells and tissuesXu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. An open-access volume electron microscopy atlas of whole cells and tissues. Nature 2021, 599: 147-151. PMID: 34616045, PMCID: PMC9004664, DOI: 10.1038/s41586-021-03992-4.
- Protocol for preparation of heterogeneous biological samples for 3D electron microscopy: a case study for insectsPolilov A, Makarova A, Pang S, Shan Xu C, Hess H. Protocol for preparation of heterogeneous biological samples for 3D electron microscopy: a case study for insects. Scientific Reports 2021, 11: 4717. PMID: 33633143, PMCID: PMC7907262, DOI: 10.1038/s41598-021-83936-0.
- 3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cellsMüller A, Schmidt D, Xu CS, Pang S, D’Costa J, Kretschmar S, Münster C, Kurth T, Jug F, Weigert M, Hess HF, Solimena M. 3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells. Journal Of Cell Biology 2020, 220: e202010039. PMID: 33326005, PMCID: PMC7748794, DOI: 10.1083/jcb.202010039.
- Transforming FIB-SEMFocused Ion Beam Scanning Electron Microscopy (FIB-SEM) Systems for Large-Volume ConnectomicsConnectomics and Cell BiologyCell biologyXu C, Pang S, Hayworth K, Hess H. Transforming FIB-SEMFocused Ion Beam Scanning Electron Microscopy (FIB-SEM) Systems for Large-Volume ConnectomicsConnectomics and Cell BiologyCell biology. 2020, 155: 221-243. DOI: 10.1007/978-1-0716-0691-9_12.
- Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cellsHoffman DP, Shtengel G, Xu CS, Campbell KR, Freeman M, Wang L, Milkie DE, Pasolli HA, Iyer N, Bogovic JA, Stabley DR, Shirinifard A, Pang S, Peale D, Schaefer K, Pomp W, Chang CL, Lippincott-Schwartz J, Kirchhausen T, Solecki DJ, Betzig E, Hess HF. Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells. Science 2020, 367 PMID: 31949053, PMCID: PMC7339343, DOI: 10.1126/science.aaz5357.
- Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid ToxicityIoannou MS, Jackson J, Sheu SH, Chang CL, Weigel AV, Liu H, Pasolli HA, Xu CS, Pang S, Matthies D, Hess HF, Lippincott-Schwartz J, Liu Z. Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity. Cell 2019, 177: 1522-1535.e14. PMID: 31130380, DOI: 10.1016/j.cell.2019.04.001.
- Cortical column and whole-brain imaging with molecular contrast and nanoscale resolutionGao R, Asano SM, Upadhyayula S, Pisarev I, Milkie DE, Liu TL, Singh V, Graves A, Huynh GH, Zhao Y, Bogovic J, Colonell J, Ott CM, Zugates C, Tappan S, Rodriguez A, Mosaliganti KR, Sheu SH, Pasolli HA, Pang S, Xu CS, Megason SG, Hess H, Lippincott-Schwartz J, Hantman A, Rubin GM, Kirchhausen T, Saalfeld S, Aso Y, Boyden ES, Betzig E. Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Science 2019, 363 PMID: 30655415, PMCID: PMC6481610, DOI: 10.1126/science.aau8302.
- Breaking Barriers of FIB-SEM for Large Volume Connectomics and Cell BiologyXu C, Hayworth K, Pang S, Lu Z, Hess H. Breaking Barriers of FIB-SEM for Large Volume Connectomics and Cell Biology. Microscopy And Microanalysis 2018, 24: 1228-1229. DOI: 10.1017/s1431927618006621.
- The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular VesiclesCoulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA. The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Reports 2018, 24: 973-986.e8. PMID: 30044992, PMCID: PMC6178983, DOI: 10.1016/j.celrep.2018.06.100.
- A novel sheet-like virus particle array is a hallmark of Zika virus infectionLiu J, Kline B, Kenny T, Smith D, Soloveva V, Beitzel B, Pang S, Lockett S, Hess H, Palacios G, Kuhn J, Sun M, Zeng X. A novel sheet-like virus particle array is a hallmark of Zika virus infection. Emerging Microbes & Infections 2018, 7: 1-11. PMID: 29691373, PMCID: PMC5915449, DOI: 10.1038/s41426-018-0071-8.
- High resolution inspection with wafer plane die: database defect detectionHess C, Wihl M, Shi R, Xiong Y, Pang S. High resolution inspection with wafer plane die: database defect detection. Proceedings Of SPIE--the International Society For Optical Engineering 2008, 7122: 71221a-71221a-11. DOI: 10.1117/12.801867.
- Wafer plane inspection with soft resist thresholdingHess C, Shi R, Wihl M, Xiong Y, Pang S. Wafer plane inspection with soft resist thresholding. Proceedings Of SPIE--the International Society For Optical Engineering 2008, 7122: 71221c-71221c-11. DOI: 10.1117/12.801866.
- Wafer plane inspection evaluated for photomask productionGallagher E, Badger K, Lawliss M, Kodera Y, Azpiroz J, Pang S, Zhang H, Eugenieva E, Clifford C, Goonesekera A, Tian Y. Wafer plane inspection evaluated for photomask production. Proceedings Of SPIE--the International Society For Optical Engineering 2008, 7122: 71221b-71221b-9. DOI: 10.1117/12.801945.
- A novel approach: high resolution inspection with wafer plane defect detectionHess C, Wihl M, Shi R, Xiong Y, Pang S. A novel approach: high resolution inspection with wafer plane defect detection. Proceedings Of SPIE--the International Society For Optical Engineering 2008, 7028: 70281f-70281f-11. DOI: 10.1117/12.793056.
- Wafer plane inspection for advanced reticle defectsNagpal R, Ghadiali F, Kim J, Huang T, Pang S. Wafer plane inspection for advanced reticle defects. Proceedings Of SPIE--the International Society For Optical Engineering 2008, 7028: 70281h-70281h-8. DOI: 10.1117/12.793058.
- Tunable Bragg grating filters in SOI waveguidesLiao L, Liu A, Pang S, Paniccia M. Tunable Bragg grating filters in SOI waveguides. 2004, ithe2. DOI: 10.1364/ipr.2004.ithe2.
- Fabrication of Boron-Doped CVD Diamond MicroelectrodesCooper J, Pang S, Albin S, Zheng J, Johnson R. Fabrication of Boron-Doped CVD Diamond Microelectrodes. Analytical Chemistry 1998, 70: 464-467. PMID: 21644744, DOI: 10.1021/ac970762l.