Shu-Xia Li, PhD

• Ajay Manhapra
• Andreas Coppi
• Arjun Venkatesh
• Bobak Jack Mortazavi
• Chenxi Huang
• Erica Spatz
• Frederick Warner
• Harlan Krumholz
• James V. Freeman
• Jeffrey Testani
• Jeptha Curtis
• Joann Sweasy
• John Hwa
• Jonathan Bates
• Joseph Akar
• Joseph Ross
• Karen Anderson
• Karthik Murugiah
• Kumar Dharmarajan
• Leora Horwitz
• Lisa Gale Suter
• Mary Tinetti
• Nancy Kim
• Nihar Desai
• Rachel Dreyer
• Steven Spivack
• Susannah M. Bernheim
• Xiao Xu
• Yongfei Wang
• Zhenqiu Lin

Quality of Health Care; Clinical Trial; Treatment Outcome

• Long-term trends in short-term outcomes in acute myocardial infarction.Nguyen HL, Saczynski JS, Gore JM, Waring ME, Lessard D, Yarzebski J, Reed G, Spencer FA, Li SX, Goldberg RJ. Long-term trends in short-term outcomes in acute myocardial infarction. The American Journal Of Medicine 2011, 124: 939-46. PMID: 21962314, PMCID: PMC3185241, DOI: 10.1016/j.amjmed.2011.05.023.
• DNA repair and personalized breast cancer therapy.Li SX, Sjolund A, Harris L, Sweasy JB. DNA repair and personalized breast cancer therapy. Environmental And Molecular Mutagenesis 2010, 51: 897-908. PMID: 20872853, PMCID: PMC2962983, DOI: 10.1002/em.20606.
• Changes in gene expression predicting local control in cervical cancer: results from Radiation Therapy Oncology Group 0128.Weidhaas JB, Li SX, Winter K, Ryu J, Jhingran A, Miller B, Dicker AP, Gaffney D. Changes in gene expression predicting local control in cervical cancer: results from Radiation Therapy Oncology Group 0128. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2009, 15: 4199-206. PMID: 19509178, PMCID: PMC2758917, DOI: 10.1158/1078-0432.CCR-08-2257.
• A DNA polymerase beta mutant from colon cancer cells induces mutations.Lang T, Maitra M, Starcevic D, Li SX, Sweasy JB. A DNA polymerase beta mutant from colon cancer cells induces mutations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 6074-9. PMID: 15075389, PMCID: PMC395925, DOI: 10.1073/pnas.0308571101.
• Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site.Maitra M, Gudzelak A, Li SX, Matsumoto Y, Eckert KA, Jager J, Sweasy JB. Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site. The Journal Of Biological Chemistry 2002, 277: 35550-60. PMID: 12121998, DOI: 10.1074/jbc.M204953200.
• A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability.Shah AM, Conn DA, Li SX, Capaldi A, Jäger J, Sweasy JB. A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability. Biochemistry 2001, 40: 11372-81. PMID: 11560485.
• Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity.Shah AM, Li SX, Anderson KS, Sweasy JB. Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity. The Journal Of Biological Chemistry 2001, 276: 10824-31. PMID: 11154692, DOI: 10.1074/jbc.M008680200.
• Procedure intensity and the cost of care.Chen SI, Dharmarajan K, Kim N, Strait KM, Li SX, Safavi KC, Lindenauer PK, Krumholz HM, Lagu T. Procedure intensity and the cost of care. Circulation. Cardiovascular Quality And Outcomes 2012, 5: 308-13. PMID: 22576844, PMCID: PMC3415230, DOI: 10.1161/CIRCOUTCOMES.112.966069.
• Hospital patterns of use of positive inotropic agents in patients with heart failure.Partovian C, Gleim SR, Mody PS, Li SX, Wang H, Strait KM, Allen LA, Lagu T, Normand SL, Krumholz HM. Hospital patterns of use of positive inotropic agents in patients with heart failure. Journal Of The American College Of Cardiology 2012, 60: 1402-9. PMID: 22981548, PMCID: PMC3636773, DOI: 10.1016/j.jacc.2012.07.011.
• Spending more, doing more, or both? An alternative method for quantifying utilization during hospitalizations.Lagu T, Krumholz HM, Dharmarajan K, Partovian C, Kim N, Mody PS, Li SX, Strait KM, Lindenauer PK. Spending more, doing more, or both? An alternative method for quantifying utilization during hospitalizations. Journal Of Hospital Medicine 2013, 8: 373-9. PMID: 23757115, PMCID: PMC4014449, DOI: 10.1002/jhm.2046.
• Contraindicated initiation of β-blocker therapy in patients hospitalized for heart failure.Dharmarajan K, Masoudi FA, Spertus JA, Li SX, Krumholz HM. Contraindicated initiation of β-blocker therapy in patients hospitalized for heart failure. JAMA Internal Medicine 2013, 173: 1547-9. PMID: 23797379, PMCID: PMC4043342, DOI: 10.1001/jamainternmed.2013.7717.
• Acute decompensated heart failure is routinely treated as a cardiopulmonary syndrome.Dharmarajan K, Strait KM, Lagu T, Lindenauer PK, Tinetti ME, Lynn J, Li SX, Krumholz HM. Acute decompensated heart failure is routinely treated as a cardiopulmonary syndrome. PloS One 2013, 8: e78222. PMID: 24250751, PMCID: PMC3824040, DOI: 10.1371/journal.pone.0078222.
• Dominance of furosemide for loop diuretic therapy in heart failure: time to revisit the alternatives?Bikdeli B, Strait KM, Dharmarajan K, Partovian C, Coca SG, Kim N, Li SX, Testani JM, Khan U, Krumholz HM. Dominance of furosemide for loop diuretic therapy in heart failure: time to revisit the alternatives? Journal Of The American College Of Cardiology 2013, 61: 1549-50. PMID: 23500272, PMCID: PMC4038646, DOI: 10.1016/j.jacc.2012.12.043.
• Variation exists in rates of admission to intensive care units for heart failure patients across hospitals in the United States.Safavi KC, Dharmarajan K, Kim N, Strait KM, Li SX, Chen SI, Lagu T, Krumholz HM. Variation exists in rates of admission to intensive care units for heart failure patients across hospitals in the United States. Circulation 2013, 127: 923-9. PMID: 23355624, PMCID: PMC3688061, DOI: 10.1161/CIRCULATIONAHA.112.001088.
• Patterns of change in nesiritide use in patients with heart failure: how hospitals react to new information.Partovian C, Li SX, Xu X, Lin H, Strait KM, Hwa J, Krumholz HM. Patterns of change in nesiritide use in patients with heart failure: how hospitals react to new information. JACC. Heart Failure 2013, 1: 318-324. PMID: 24621935, PMCID: PMC5322944, DOI: 10.1016/j.jchf.2013.04.005.
• "Phenotyping" hospital value of care for patients with heart failure.Xu X, Li SX, Lin H, Normand SL, Kim N, Ott LS, Lagu T, Duan M, Kroch EA, Krumholz HM. "Phenotyping" hospital value of care for patients with heart failure. Health Services Research 2014, 49: 2000-16. PMID: 24974769, PMCID: PMC4254136, DOI: 10.1111/1475-6773.12197.
• Hospital variation in intravenous inotrope use for patients hospitalized with heart failure: insights from Get With The Guidelines.Allen LA, Fonarow GC, Grau-Sepulveda MV, Hernandez AF, Peterson PN, Partovian C, Li SX, Heidenreich PA, Bhatt DL, Peterson ED, Krumholz HM. Hospital variation in intravenous inotrope use for patients hospitalized with heart failure: insights from Get With The Guidelines. Circulation. Heart Failure 2014, 7: 251-60. PMID: 24488983, PMCID: PMC5459367, DOI: 10.1161/CIRCHEARTFAILURE.113.000761.
• National patterns of risk-standardized mortality and readmission after hospitalization for acute myocardial infarction, heart failure, and pneumonia: update on publicly reported outcomes measures based on the 2013 release.Suter LG, Li SX, Grady JN, Lin Z, Wang Y, Bhat KR, Turkmani D, Spivack SB, Lindenauer PK, Merrill AR, Drye EE, Krumholz HM, Bernheim SM. National patterns of risk-standardized mortality and readmission after hospitalization for acute myocardial infarction, heart failure, and pneumonia: update on publicly reported outcomes measures based on the 2013 release. Journal Of General Internal Medicine 2014, 29: 1333-40. PMID: 24825244, PMCID: PMC4175654, DOI: 10.1007/s11606-014-2862-5.
• Hospital variation in the use of noninvasive cardiac imaging and its association with downstream testing, interventions, and outcomes.Safavi KC, Li SX, Dharmarajan K, Venkatesh AK, Strait KM, Lin H, Lowe TJ, Fazel R, Nallamothu BK, Krumholz HM. Hospital variation in the use of noninvasive cardiac imaging and its association with downstream testing, interventions, and outcomes. JAMA Internal Medicine 2014, 174: 546-53. PMID: 24515551, PMCID: PMC5459406, DOI: 10.1001/jamainternmed.2013.14407.
• Hospital variation in admission to intensive care units for patients with acute myocardial infarction.Chen R, Strait KM, Dharmarajan K, Li SX, Ranasinghe I, Martin J, Fazel R, Masoudi FA, Cooke CR, Nallamothu BK, Krumholz HM. Hospital variation in admission to intensive care units for patients with acute myocardial infarction. American Heart Journal 2015, 170: 1161-9. PMID: 26678638, PMCID: PMC5459386, DOI: 10.1016/j.ahj.2015.09.003.
• Hospital variability in use of anticoagulant strategies during acute myocardial infarction treated with an early invasive strategy.Arnold SV, Li SX, Alexander KP, Spertus JA, Nallamothu BK, Curtis JP, Kosiborod M, Gupta A, Wang TY, Lin H, Dharmarajan K, Strait KM, Lowe TJ, Krumholz HM. Hospital variability in use of anticoagulant strategies during acute myocardial infarction treated with an early invasive strategy. Journal Of The American Heart Association 2015, 4: e002009. PMID: 26077589, PMCID: PMC4599539, DOI: 10.1161/JAHA.115.002009.
• Intravenous fluids in acute decompensated heart failure.Bikdeli B, Strait KM, Dharmarajan K, Li SX, Mody P, Partovian C, Coca SG, Kim N, Horwitz LI, Testani JM, Krumholz HM. Intravenous fluids in acute decompensated heart failure. JACC. Heart Failure 2015, 3: 127-33. PMID: 25660836, PMCID: PMC4438991, DOI: 10.1016/j.jchf.2014.09.007.
• Hospital Phenotypes in the Management of Patients Admitted for Acute Myocardial Infarction.Xu X, Li SX, Lin H, Normand SL, Lagu T, Desai N, Duan M, Kroch EA, Krumholz HM. Hospital Phenotypes in the Management of Patients Admitted for Acute Myocardial Infarction. Medical Care 2016, 54: 929-36. PMID: 27261637, PMCID: PMC5305177, DOI: 10.1097/MLR.0000000000000571.
• Treatment for Multiple Acute Cardiopulmonary Conditions in Older Adults Hospitalized with Pneumonia, Chronic Obstructive Pulmonary Disease, or Heart Failure.Dharmarajan K, Strait KM, Tinetti ME, Lagu T, Lindenauer PK, Lynn J, Krukas MR, Ernst FR, Li SX, Krumholz HM. Treatment for Multiple Acute Cardiopulmonary Conditions in Older Adults Hospitalized with Pneumonia, Chronic Obstructive Pulmonary Disease, or Heart Failure. Journal Of The American Geriatrics Society 2016, 64: 1574-82. PMID: 27448329, PMCID: PMC4988873, DOI: 10.1111/jgs.14303.
• Analysis of Machine Learning Techniques for Heart Failure Readmissions.Mortazavi BJ, Downing NS, Bucholz EM, Dharmarajan K, Manhapra A, Li SX, Negahban SN, Krumholz HM. Analysis of Machine Learning Techniques for Heart Failure Readmissions. Circulation. Cardiovascular Quality And Outcomes 2016, 9: 629-640. PMID: 28263938, PMCID: PMC5459389, DOI: 10.1161/CIRCOUTCOMES.116.003039.
• The china patient-centered evaluative assessment of cardiac events (PEACE) prospective study of percutaneous coronary intervention: Study design.Du X, Pi Y, Dreyer RP, Li J, Li X, Downing NS, Li L, Feng F, Zhan L, Zhang H, Guan W, Xu X, Li SX, Lin Z, Masoudi FA, Spertus JA, Krumholz HM, Jiang L. The china patient-centered evaluative assessment of cardiac events (PEACE) prospective study of percutaneous coronary intervention: Study design. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2016, 88: E212-E221. PMID: 26945565, PMCID: PMC5215582, DOI: 10.1002/ccd.26461.
• Identification of Hospital Cardiac Services for Acute Myocardial Infarction Using Individual Patient Discharge Data.Chang TE, Krumholz HM, Li SX, Martin J, Ranasinghe I. Identification of Hospital Cardiac Services for Acute Myocardial Infarction Using Individual Patient Discharge Data. Journal Of The American Heart Association 2016, 5 PMID: 27628573, PMCID: PMC5079029, DOI: 10.1161/JAHA.116.003680.
• Can machine learning complement traditional medical device surveillance? A case study of dual-chamber implantable cardioverter-defibrillators.Ross JS, Bates J, Parzynski CS, Akar JG, Curtis JP, Desai NR, Freeman JV, Gamble GM, Kuntz R, Li SX, Marinac-Dabic D, Masoudi FA, Normand ST, Ranasinghe I, Shaw RE, Krumholz HM. Can machine learning complement traditional medical device surveillance? A case study of dual-chamber implantable cardioverter-defibrillators. Medical Devices (Auckland, N.Z.) 2017, 10: 165-188. PMID: 28860874, PMCID: PMC5566316, DOI: 10.2147/MDER.S138158.
• The Relationship Between Nutritional Risks and Cancer-Related Fatigue in Patients With Colorectal Cancer Fast-Track Surgery.Wei JN, Li SX. The Relationship Between Nutritional Risks and Cancer-Related Fatigue in Patients With Colorectal Cancer Fast-Track Surgery. Cancer Nursing 2018, 41: E41-E47. PMID: 29049040, DOI: 10.1097/NCC.0000000000000541.
• Discovery of temporal and disease association patterns in condition-specific hospital utilization rates.Haimovich JS, Venkatesh AK, Shojaee A, Coppi A, Warner F, Li SX, Krumholz HM. Discovery of temporal and disease association patterns in condition-specific hospital utilization rates. PloS One 2017, 12: e0172049. PMID: 28355219, PMCID: PMC5371293, DOI: 10.1371/journal.pone.0172049.
• Systolic Blood Pressure Response in SPRINT (Systolic Blood Pressure Intervention Trial) and ACCORD (Action to Control Cardiovascular Risk in Diabetes): A Possible Explanation for Discordant Trial Results.Huang C, Dhruva SS, Coppi AC, Warner F, Li SX, Lin H, Nasir K, Krumholz HM. Systolic Blood Pressure Response in SPRINT (Systolic Blood Pressure Intervention Trial) and ACCORD (Action to Control Cardiovascular Risk in Diabetes): A Possible Explanation for Discordant Trial Results. Journal Of The American Heart Association 2017, 6 PMID: 29133522, PMCID: PMC5721802, DOI: 10.1161/JAHA.117.007509.
• Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).Dhruva SS, Huang C, Spatz ES, Coppi AC, Warner F, Li SX, Lin H, Xu X, Furberg CD, Davis BR, Pressel SL, Coifman RR, Krumholz HM. Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). Hypertension 2017, 70: 94-102. PMID: 28559399, DOI: 10.1161/HYPERTENSIONAHA.117.09221.
• Association between journal citation distribution and impact factor: a novel application of the Gini coefficient.Nuti SV, Ranasinghe I, Murugiah K, Shojaee A, Li SX, Krumholz HM. Association between journal citation distribution and impact factor: a novel application of the Gini coefficient. Journal Of The American College Of Cardiology 2015, 65: 1711-1712. PMID: 25908079, PMCID: PMC5459371, DOI: 10.1016/j.jacc.2014.12.071.