Seth Guller, PhD

• Aaron Ring
• Aileen Gariepy
• Akiko Iwasaki
• Albert Ko
• Brett Lindenbach
• Carla Rothlin
• Chantal Vogels
• Charles Lockwood
• Erol Fikrig
• Gang Peng
• Graciela Krikun
• Harvey Kliman
• John Fournier
• Joshua Copel
• Karla M Neugebauer
• Katherine Harper Campbell
• Lingeng Lu
• Liza Konnikova
• Lubna Pal
• Mancy Tong
• Mert Ozan Bahtiyar
• Nancy Stanwood
• Nathan Grubaugh
• Raffaella Morotti
• Robert Means
• Rolando Garcia Milian
• Shannon Whirledge
• Shelli Farhadian
• Vasilis Vasiliou
• Vikki M Abrahams
• Wade Schulz
• Yingqun Huang

Gynecology; Obstetrics; Placenta Diseases; Pre-Eclampsia; Pregnancy Outcome

• Effect of culture conditions on the phenotype of THP-1 monocyte cell line.Aldo PB, Craveiro V, Guller S, Mor G. Effect of culture conditions on the phenotype of THP-1 monocyte cell line. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2013, 70: 80-6. PMID: 23621670, PMCID: PMC3703650, DOI: 10.1111/aji.12129.
• Decreased levels of folate receptor-β and reduced numbers of fetal macrophages (Hofbauer cells) in placentas from pregnancies with severe pre-eclampsia.Tang Z, Buhimschi IA, Buhimschi CS, Tadesse S, Norwitz E, Niven-Fairchild T, Huang ST, Guller S. Decreased levels of folate receptor-β and reduced numbers of fetal macrophages (Hofbauer cells) in placentas from pregnancies with severe pre-eclampsia. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2013, 70: 104-15. PMID: 23480364, PMCID: PMC3686834, DOI: 10.1111/aji.12112.
• Glucocorticoids enhance CD163 expression in placental Hofbauer cells.Tang Z, Niven-Fairchild T, Tadesse S, Norwitz ER, Buhimschi CS, Buhimschi IA, Guller S. Glucocorticoids enhance CD163 expression in placental Hofbauer cells. Endocrinology 2013, 154: 471-82. PMID: 23142809, PMCID: PMC3529384, DOI: 10.1210/en.2012-1575.
• Isolation of hofbauer cells from human term placentas with high yield and purity.Tang Z, Tadesse S, Norwitz E, Mor G, Abrahams VM, Guller S. Isolation of hofbauer cells from human term placentas with high yield and purity. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2011, 66: 336-48. PMID: 21545365, PMCID: PMC3154981, DOI: 10.1111/j.1600-0897.2011.01006.x.
• Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: potential role of fibroblast monocyte chemotactic protein-1.Toti P, Arcuri F, Tang Z, Schatz F, Zambrano E, Mor G, Niven-Fairchild T, Abrahams VM, Krikun G, Lockwood CJ, Guller S. Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: potential role of fibroblast monocyte chemotactic protein-1. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2011, 65: 470-9. PMID: 21087336, PMCID: PMC3071455, DOI: 10.1111/j.1600-0897.2010.00927.x.
• Protein composition of microparticles shed from human placenta during placental perfusion: Potential role in angiogenesis and fibrinolysis in preeclampsia.Guller S, Tang Z, Ma YY, Di Santo S, Sager R, Schneider H. Protein composition of microparticles shed from human placenta during placental perfusion: Potential role in angiogenesis and fibrinolysis in preeclampsia. Placenta 2011, 32: 63-9. PMID: 21074265, PMCID: PMC3762591, DOI: 10.1016/j.placenta.2010.10.011.
• Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia.Guller S, Buhimschi CS, Ma YY, Huang ST, Yang L, Kuczynski E, Zambrano E, Lockwood CJ, Buhimschi IA. Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2008, 88: 1057-67. PMID: 18679377, PMCID: PMC2682720, DOI: 10.1038/labinvest.2008.74.
• Method to enhance transfection efficiency of cell lines and placental fibroblasts.Zhang M, Guller S, Huang Y. Method to enhance transfection efficiency of cell lines and placental fibroblasts. Placenta 2007, 28: 779-82. PMID: 17355893, DOI: 10.1016/j.placenta.2007.01.012.
• Role of hypoxia-inducible transcription factors 1alpha and 2alpha in the regulation of plasminogen activator inhibitor-1 expression in a human trophoblast cell line.Meade ES, Ma YY, Guller S. Role of hypoxia-inducible transcription factors 1alpha and 2alpha in the regulation of plasminogen activator inhibitor-1 expression in a human trophoblast cell line. Placenta 2007, 28: 1012-9. PMID: 17570486, PMCID: PMC2001228, DOI: 10.1016/j.placenta.2007.04.005.
• Differential release of plasminogen activator inhibitors (PAIs) during dual perfusion of human placenta: implications in preeclampsia.Guller S, Ma Y, Malek A, Di Santo S, Schneider H. Differential release of plasminogen activator inhibitors (PAIs) during dual perfusion of human placenta: implications in preeclampsia. Placenta 2007, 28: 278-85. PMID: 16820203, DOI: 10.1016/j.placenta.2006.05.005.
• Expression and regulation of glucocorticoid receptor in human placental villous fibroblasts.Lee MJ, Wang Z, Yee H, Ma Y, Swenson N, Yang L, Kadner SS, Baergen RN, Logan SK, Garabedian MJ, Guller S. Expression and regulation of glucocorticoid receptor in human placental villous fibroblasts. Endocrinology 2005, 146: 4619-26. PMID: 16055431, DOI: 10.1210/en.2005-0235.
• Role of the syncytium in placenta-mediated complications of preeclampsia.Guller S. Role of the syncytium in placenta-mediated complications of preeclampsia. Thrombosis Research 2009, 124: 389-92. PMID: 19535132, PMCID: PMC2764997, DOI: 10.1016/j.thromres.2009.05.016.
• Regulation of plasminogen activator inhibitor (PAI)-1 expression in a human trophoblast cell line by glucocorticoid (GC) and transforming growth factor (TGF)-beta.Ma Y, Ryu JS, Dulay A, Segal M, Guller S. Regulation of plasminogen activator inhibitor (PAI)-1 expression in a human trophoblast cell line by glucocorticoid (GC) and transforming growth factor (TGF)-beta. Placenta 2002, 23: 727-34. PMID: 12398812.
• Circulating soluble Fas levels and risk of ovarian cancer.Akhmedkhanov A, Lundin E, Guller S, Lukanova A, Micheli A, Ma Y, Afanasyeva Y, Zeleniuch-Jacquotte A, Krogh V, Lenner P, Muti P, Rinaldi S, Kaaks R, Berrino F, Hallmans G, Toniolo P. Circulating soluble Fas levels and risk of ovarian cancer. BMC Cancer 2003, 3: 33. PMID: 14690548, PMCID: PMC317312, DOI: 10.1186/1471-2407-3-33.
• First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis.Abrahams VM, Straszewski-Chavez SL, Guller S, Mor G. First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. Molecular Human Reproduction 2004, 10: 55-63. PMID: 14665707, DOI: 10.1093/molehr/gah006.
• A novel immortalized human endometrial stromal cell line with normal progestational response.Krikun G, Mor G, Alvero A, Guller S, Schatz F, Sapi E, Rahman M, Caze R, Qumsiyeh M, Lockwood CJ. A novel immortalized human endometrial stromal cell line with normal progestational response. Endocrinology 2004, 145: 2291-6. PMID: 14726435, DOI: 10.1210/en.2003-1606.
• Glucocorticoid enhances transforming growth factor-beta effects on extracellular matrix protein expression in human placental mesenchymal cells.Lee MJ, Ma Y, LaChapelle L, Kadner SS, Guller S. Glucocorticoid enhances transforming growth factor-beta effects on extracellular matrix protein expression in human placental mesenchymal cells. Biology Of Reproduction 2004, 70: 1246-52. PMID: 14681196, DOI: 10.1095/biolreprod.103.021956.
• Differential effects of lipopolysaccharide and thrombin on interleukin-8 expression in syncytiotrophoblasts and endothelial cells: implications for fetal survival.Ma Y, Kadner SS, Guller S. Differential effects of lipopolysaccharide and thrombin on interleukin-8 expression in syncytiotrophoblasts and endothelial cells: implications for fetal survival. Annals Of The New York Academy Of Sciences 2004, 1034: 236-44. PMID: 15731315, DOI: 10.1196/annals.1335.025.
• Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia.Buhimschi CS, Norwitz ER, Funai E, Richman S, Guller S, Lockwood CJ, Buhimschi IA. Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia. American Journal Of Obstetrics And Gynecology 2005, 192: 734-41. PMID: 15746665, DOI: 10.1016/j.ajog.2004.12.052.
• A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells.Abrahams VM, Visintin I, Aldo PB, Guller S, Romero R, Mor G. A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 175: 8096-104. PMID: 16339547, DOI: 10.4049/jimmunol.175.12.8096.
• Thrombin-dependent regulation of matrix metalloproteinase (MMP)-9 levels in human fetal membranes.Stephenson CD, Lockwood CJ, Ma Y, Guller S. Thrombin-dependent regulation of matrix metalloproteinase (MMP)-9 levels in human fetal membranes. The Journal Of Maternal-fetal & Neonatal Medicine : The Official Journal Of The European Association Of Perinatal Medicine, The Federation Of Asia And Oceania Perinatal Societies, The International Society Of Perinatal Obstetricians 2005, 18: 17-22. PMID: 16105787, DOI: 10.1080/14767050500123632.
• Alterations in syncytiotrophoblast cytokine expression following treatment with lipopolysaccharide.Ma Y, Mor G, Abrahams VM, Buhimschi IA, Buhimschi CS, Guller S. Alterations in syncytiotrophoblast cytokine expression following treatment with lipopolysaccharide. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2006, 55: 12-8. PMID: 16364007, DOI: 10.1111/j.1600-0897.2005.00347.x.
• Fractional excretion of angiogenic factors in women with severe preeclampsia.Buhimschi CS, Magloire L, Funai E, Norwitz ER, Kuczynski E, Martin R, Richman S, Guller S, Lockwood CJ, Buhimschi IA. Fractional excretion of angiogenic factors in women with severe preeclampsia. Obstetrics And Gynecology 2006, 107: 1103-13. PMID: 16648417, DOI: 10.1097/01.AOG.0000207698.74104.4f.
• Tumor necrosis factor-alpha and interleukin-1beta regulate interleukin-8 expression in third trimester decidual cells: implications for the genesis of chorioamnionitis.Lockwood CJ, Arcuri F, Toti P, Felice CD, Krikun G, Guller S, Buchwalder LF, Schatz F. Tumor necrosis factor-alpha and interleukin-1beta regulate interleukin-8 expression in third trimester decidual cells: implications for the genesis of chorioamnionitis. The American Journal Of Pathology 2006, 169: 1294-302. PMID: 17003486, PMCID: PMC1698845, DOI: 10.2353/ajpath.2006.060185.
• First-trimester trophoblast cell model gene response to hypoxia.Koklanaris N, Nwachukwu JC, Huang SJ, Guller S, Karpisheva K, Garabedian M, Lee MJ. First-trimester trophoblast cell model gene response to hypoxia. American Journal Of Obstetrics And Gynecology 2006, 194: 687-93. PMID: 16522398, DOI: 10.1016/j.ajog.2006.01.067.
• Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction.Bahtiyar MO, Buhimschi C, Ravishankar V, Copel J, Norwitz E, Julien S, Guller S, Buhimschi IA. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. American Journal Of Obstetrics And Gynecology 2007, 196: 72.e1-6. PMID: 17240241, DOI: 10.1016/j.ajog.2006.07.048.
• Expression of Toll-like receptors in the human decidua.Krikun G, Lockwood CJ, Abrahams VM, Mor G, Paidas M, Guller S. Expression of Toll-like receptors in the human decidua. Histology And Histopathology 2007, 22: 847-54. PMID: 17503341, DOI: 10.14670/HH-22.847.
• The placental syncytium and the pathophysiology of preeclampsia and intrauterine growth restriction: a novel assay to assess syncytial protein expression.Guller S, Ma YY, Fu HH, Krikun G, Abrahams VM, Mor G. The placental syncytium and the pathophysiology of preeclampsia and intrauterine growth restriction: a novel assay to assess syncytial protein expression. Annals Of The New York Academy Of Sciences 2008, 1127: 129-33. PMID: 18443340, PMCID: PMC3671376, DOI: 10.1196/annals.1434.015.
• Preface: novel features of the physiology and pathology of human reproduction.Bulletti C, Guller S, DE Ziegler D, Lockwood CJ. Preface: novel features of the physiology and pathology of human reproduction. Annals Of The New York Academy Of Sciences 2008, 1127: xi. PMID: 18443322, DOI: 10.1196/annals.1434.022.
• Regulation of Nod1 and Nod2 in first trimester trophoblast cells.Mulla MJ, Yu AG, Cardenas I, Guller S, Panda B, Abrahams VM. Regulation of Nod1 and Nod2 in first trimester trophoblast cells. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2009, 61: 294-302. PMID: 19260860, DOI: 10.1111/j.1600-0897.2009.00694.x.
• Role of GnRH-GnRH receptor signaling at the maternal-fetal interface.Lee HJ, Snegovskikh VV, Park JS, Foyouzi N, Han KT, Hodgson EJ, Guller S, Norwitz ER. Role of GnRH-GnRH receptor signaling at the maternal-fetal interface. Fertility And Sterility 2010, 94: 2680-7. PMID: 20400076, DOI: 10.1016/j.fertnstert.2010.03.016.
• Placental Hofbauer cells and complications of pregnancy.Tang Z, Abrahams VM, Mor G, Guller S. Placental Hofbauer cells and complications of pregnancy. Annals Of The New York Academy Of Sciences 2011, 1221: 103-8. PMID: 21401637, PMCID: PMC3707113, DOI: 10.1111/j.1749-6632.2010.05932.x.
• Inflammation and pregnancy: the role of the immune system at the implantation site.Mor G, Cardenas I, Abrahams V, Guller S. Inflammation and pregnancy: the role of the immune system at the implantation site. Annals Of The New York Academy Of Sciences 2011, 1221: 80-7. PMID: 21401634, PMCID: PMC3078586, DOI: 10.1111/j.1749-6632.2010.05938.x.
• Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression.Wu XX, Guller S, Rand JH. Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression. American Journal Of Obstetrics And Gynecology 2011, 205: 576.e7-14. PMID: 21871597, PMCID: PMC3224185, DOI: 10.1016/j.ajog.2011.06.064.
• Toll-like receptor 4 expression in decidual cells and interstitial trophoblasts across human pregnancy.Schatz F, Kayisli UA, Vatandaslar E, Ocak N, Guller S, Abrahams VM, Krikun G, Lockwood CJ. Toll-like receptor 4 expression in decidual cells and interstitial trophoblasts across human pregnancy. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2012, 68: 146-53. PMID: 22564191, PMCID: PMC3395732, DOI: 10.1111/j.1600-0897.2012.01148.x.
• Lipopolysaccharide appears to activate human endometrial endothelial cells through TLR-4-dependent and TLR-4-independent mechanisms.Krikun G, Trezza J, Shaw J, Rahman M, Guller S, Abrahams VM, Lockwood CJ. Lipopolysaccharide appears to activate human endometrial endothelial cells through TLR-4-dependent and TLR-4-independent mechanisms. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2012, 68: 233-7. PMID: 22672000, PMCID: PMC3418410, DOI: 10.1111/j.1600-0897.2012.01164.x.
• Viral infection of the pregnant cervix predisposes to ascending bacterial infection.Racicot K, Cardenas I, Wünsche V, Aldo P, Guller S, Means RE, Romero R, Mor G. Viral infection of the pregnant cervix predisposes to ascending bacterial infection. Journal Of Immunology (Baltimore, Md. : 1950) 2013, 191: 934-41. PMID: 23752614, PMCID: PMC4153356, DOI: 10.4049/jimmunol.1300661.
• Cutting-edge report: TLR10 plays a role in mediating bacterial peptidoglycan-induced trophoblast apoptosis.Mulla MJ, Myrtolli K, Tadesse S, Stanwood NL, Gariepy A, Guller S, Norwitz ER, Abrahams VM. Cutting-edge report: TLR10 plays a role in mediating bacterial peptidoglycan-induced trophoblast apoptosis. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2013, 69: 449-53. PMID: 23279063, PMCID: PMC3620725, DOI: 10.1111/aji.12065.
• Human fetal membranes generate distinct cytokine profiles in response to bacterial Toll-like receptor and nod-like receptor agonists.Hoang M, Potter JA, Gysler SM, Han CS, Guller S, Norwitz ER, Abrahams VM. Human fetal membranes generate distinct cytokine profiles in response to bacterial Toll-like receptor and nod-like receptor agonists. Biology Of Reproduction 2014, 90: 39. PMID: 24429216, PMCID: PMC4076407, DOI: 10.1095/biolreprod.113.115428.
• Trophoblast induces monocyte differentiation into CD14+/CD16+ macrophages.Aldo PB, Racicot K, Craviero V, Guller S, Romero R, Mor G. Trophoblast induces monocyte differentiation into CD14+/CD16+ macrophages. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2014, 72: 270-84. PMID: 24995492, PMCID: PMC4230492, DOI: 10.1111/aji.12288.
• In vivo and in vitro evidence for placental DNA damage in preeclampsia.Tadesse S, Kidane D, Guller S, Luo T, Norwitz NG, Arcuri F, Toti P, Norwitz ER. In vivo and in vitro evidence for placental DNA damage in preeclampsia. PloS One 2014, 9: e86791. PMID: 24466242, PMCID: PMC3899334, DOI: 10.1371/journal.pone.0086791.
• Syncytiotrophoblast vesicles show altered micro-RNA and haemoglobin content after ex-vivo perfusion of placentas with haemoglobin to mimic preeclampsia.Cronqvist T, Saljé K, Familari M, Guller S, Schneider H, Gardiner C, Sargent IL, Redman CW, Mörgelin M, Åkerström B, Gram M, Hansson SR. Syncytiotrophoblast vesicles show altered micro-RNA and haemoglobin content after ex-vivo perfusion of placentas with haemoglobin to mimic preeclampsia. PloS One 2014, 9: e90020. PMID: 24587192, PMCID: PMC3937405, DOI: 10.1371/journal.pone.0090020.
• Single- and double-stranded viral RNA generate distinct cytokine and antiviral responses in human fetal membranes.Bakaysa SL, Potter JA, Hoang M, Han CS, Guller S, Norwitz ER, Abrahams VM. Single- and double-stranded viral RNA generate distinct cytokine and antiviral responses in human fetal membranes. Molecular Human Reproduction 2014, 20: 701-8. PMID: 24723465, PMCID: PMC4072183, DOI: 10.1093/molehr/gau028.
• Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages.Young OM, Tang Z, Niven-Fairchild T, Tadesse S, Krikun G, Norwitz ER, Mor G, Abrahams VM, Guller S. Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2015, 73: 22-35. PMID: 25345551, PMCID: PMC4268350, DOI: 10.1111/aji.12336.
• Enhanced Human Decidual Cell-Expressed FKBP51 May Promote Labor-Related Functional Progesterone Withdrawal.Schatz F, Guzeloglu-Kayisli O, Basar M, Buchwalder LF, Ocak N, Guzel E, Guller S, Semerci N, Kayisli UA, Lockwood CJ. Enhanced Human Decidual Cell-Expressed FKBP51 May Promote Labor-Related Functional Progesterone Withdrawal. The American Journal Of Pathology 2015, 185: 2402-11. PMID: 26207680, DOI: 10.1016/j.ajpath.2015.05.014.
• Inflammatory processes are specifically enhanced in endothelial cells by placental-derived TNF-α: Implications in preeclampsia (PE).Shaw J, Tang Z, Schneider H, Saljé K, Hansson SR, Guller S. Inflammatory processes are specifically enhanced in endothelial cells by placental-derived TNF-α: Implications in preeclampsia (PE). Placenta 2016, 43: 1-8. PMID: 27324092, DOI: 10.1016/j.placenta.2016.04.015.
• Optimization of techniques for multiple platform testing in small, precious samples such as human chorionic villus sampling.Pisarska MD, Akhlaghpour M, Lee B, Barlow GM, Xu N, Wang ET, Mackey AJ, Farber CR, Rich SS, Rotter JI, Chen YI, Goodarzi MO, Guller S, Williams J. Optimization of techniques for multiple platform testing in small, precious samples such as human chorionic villus sampling. Prenatal Diagnosis 2016, 36: 1061-1070. PMID: 27718505, PMCID: PMC5142835, DOI: 10.1002/pd.4936.
• H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction.Zuckerwise L, Li J, Lu L, Men Y, Geng T, Buhimschi CS, Buhimschi IA, Bukowski R, Guller S, Paidas M, Huang Y. H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction. Oncotarget 2016, 7: 38398-38407. PMID: 27223264, PMCID: PMC5122399, DOI: 10.18632/oncotarget.9534.
• Zika virus productively infects primary human placenta-specific macrophages.Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S, Fikrig E. Zika virus productively infects primary human placenta-specific macrophages. JCI Insight 2016, 1 PMID: 27595140, PMCID: PMC5007065, DOI: 10.1172/jci.insight.88461.
• Dynamics of Base Excision Repair at the Maternal-Fetal Interface in Pregnancies Complicated by Preeclampsia.Tadesse S, Norwitz NG, Guller S, Arcuri F, Toti P, Norwitz ER, Kidane D. Dynamics of Base Excision Repair at the Maternal-Fetal Interface in Pregnancies Complicated by Preeclampsia. Reproductive Sciences (Thousand Oaks, Calif.) 2017, 24: 856-864. PMID: 27707956, DOI: 10.1177/1933719116670519.
• Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation.Cross SN, Potter JA, Aldo P, Kwon JY, Pitruzzello M, Tong M, Guller S, Rothlin CV, Mor G, Abrahams VM. Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation. Journal Of Immunology (Baltimore, Md. : 1950) 2017, 199: 2885-2895. PMID: 28916522, PMCID: PMC5659726, DOI: 10.4049/jimmunol.1700870.
• Nucleated Red Blood Cells as a Marker of Acute and Chronic Fetal Hypoxia in a Rat Model.Minior VK, Levine B, Ferber A, Guller S, Divon MY. Nucleated Red Blood Cells as a Marker of Acute and Chronic Fetal Hypoxia in a Rat Model. Rambam Maimonides Medical Journal 2017, 8 PMID: 28467759, PMCID: PMC5415371, DOI: 10.5041/RMMJ.10302.
• Zika virus infection of Hofbauer cells.Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S. Zika virus infection of Hofbauer cells. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2017, 77 PMID: 27966815, PMCID: PMC5299062, DOI: 10.1111/aji.12613.
• Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies.Quao ZC, Tong M, Bryce E, Guller S, Chamley LW, Abrahams VM. Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2018, 79 PMID: 29135051, PMCID: PMC5728699, DOI: 10.1111/aji.12785.
• Glucocorticoid signaling regulates cell invasion and migration in the human first-trimester trophoblast cell line Sw.71.Kisanga EP, Tang Z, Guller S, Whirledge S. Glucocorticoid signaling regulates cell invasion and migration in the human first-trimester trophoblast cell line Sw.71. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2018, 80: e12974. PMID: 29774963, DOI: 10.1111/aji.12974.
• In memoriam: mortimer levitz.Guller S. In memoriam: mortimer levitz. Steroids 2018 PMID: 29750995, DOI: 10.1016/j.steroids.2018.05.004.
• Excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of Toll-Like receptor 4.Heim KR, Mulla MJ, Potter JA, Han CS, Guller S, Abrahams VM. Excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of Toll-Like receptor 4. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2018, 80: e13044. PMID: 30175447, DOI: 10.1111/aji.13044.
• Differential gene expression during placentation in pregnancies conceived with different fertility treatments compared with spontaneous pregnancies.Lee B, Koeppel AF, Wang ET, Gonzalez TL, Sun T, Kroener L, Lin Y, Joshi NV, Ghadiali T, Turner SD, Rich SS, Farber CR, Rotter JI, Ida Chen YD, Goodarzi MO, Guller S, Harwood B, Serna TB, Williams J, Pisarska MD. Differential gene expression during placentation in pregnancies conceived with different fertility treatments compared with spontaneous pregnancies. Fertility And Sterility 2019, 111: 535-546. PMID: 30611556, PMCID: PMC7156023, DOI: 10.1016/j.fertnstert.2018.11.005.
• In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines.Kisanga EP, Tang Z, Guller S, Whirledge S. In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines. Journal Of Visualized Experiments : JoVE 2019 PMID: 30907868, DOI: 10.3791/58942.
• IL-10 to TNFα ratios throughout early first trimester can discriminate healthy pregnancies from pregnancy losses.Kaislasuo J, Simpson S, Petersen JF, Peng G, Aldo P, Lokkegaard E, Paidas M, Pal L, Guller S, Mor G. IL-10 to TNFα ratios throughout early first trimester can discriminate healthy pregnancies from pregnancy losses. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2020, 83: e13195. PMID: 31585488, DOI: 10.1111/aji.13195.
• Thermal stability of cytokines: A review.Simpson S, Kaislasuo J, Guller S, Pal L. Thermal stability of cytokines: A review. Cytokine 2020, 125: 154829. PMID: 31472404, DOI: 10.1016/j.cyto.2019.154829.
• Dynamics of Base Excision Repair at the Maternal-Fetal Interface in Pregnancies Complicated by Preeclampsia.Tadesse S, Norwitz NG, Guller S, Arcuri F, Toti P, Norwitz ER, Kidane D. Dynamics of Base Excision Repair at the Maternal-Fetal Interface in Pregnancies Complicated by Preeclampsia. Reproductive Sciences (Thousand Oaks, Calif.) 2017, 24: 856-864. PMID: 31975341, DOI: 10.1177/1933719116670519.
• Herpesvirus-infected Hofbauer cells activate endothelial cells through an IL-1β-dependent mechanism.Hendrix P, Tang Z, Silasi M, Racicot KE, Mor G, Abrahams VM, Guller S. Herpesvirus-infected Hofbauer cells activate endothelial cells through an IL-1β-dependent mechanism. Placenta 2020, 91: 59-65. PMID: 32174308, PMCID: PMC7078070, DOI: 10.1016/j.placenta.2020.01.010.
• Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua.Silasi M, You Y, Simpson S, Kaislasuo J, Pal L, Guller S, Peng G, Ramhorst R, Grasso E, Etemad S, Durosier S, Aldo P, Mor G. Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua. Scientific Reports 2020, 10: 5785. PMID: 32238853, PMCID: PMC7113245, DOI: 10.1038/s41598-020-62593-9.
• Trophoblast-secreted soluble-PD-L1 modulates macrophage polarization and function.Zhang YH, Aldo P, You Y, Ding J, Kaislasuo J, Petersen JF, Lokkegaard E, Peng G, Paidas MJ, Simpson S, Pal L, Guller S, Liu H, Liao AH, Mor G. Trophoblast-secreted soluble-PD-L1 modulates macrophage polarization and function. Journal Of Leukocyte Biology 2020, 108: 983-998. PMID: 32386458, PMCID: PMC8190653, DOI: 10.1002/JLB.1A0420-012RR.
• Cell type-specific expression and function of toll-like receptors 2 and 4 in human placenta: implications in fetal infection.Ma Y, Krikun G, Abrahams VM, Mor G, Guller S. Cell type-specific expression and function of toll-like receptors 2 and 4 in human placenta: implications in fetal infection. Placenta 2007, 28: 1024-31. PMID: 17588655, PMCID: PMC2064901, DOI: 10.1016/j.placenta.2007.05.003.
• The isolation and characterization of a novel telomerase immortalized first trimester trophoblast cell line, Swan 71.Straszewski-Chavez SL, Abrahams VM, Alvero AB, Aldo PB, Ma Y, Guller S, Romero R, Mor G. The isolation and characterization of a novel telomerase immortalized first trimester trophoblast cell line, Swan 71. Placenta 2009, 30: 939-48. PMID: 19766308, PMCID: PMC2784169, DOI: 10.1016/j.placenta.2009.08.007.
• Peri-implantation cytokine profile differs between singleton and twin IVF pregnancies.Simpson S, Kaislasuo J, Peng G, Aldo P, Paidas M, Guller S, Mor G, Pal L. Peri-implantation cytokine profile differs between singleton and twin IVF pregnancies. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2021, 85: e13348. PMID: 32946159, PMCID: PMC8221280, DOI: 10.1111/aji.13348.
• NLRP3 inflammasome function and pyroptotic cell death in human placental Hofbauer cells.Abrahams VM, Tang Z, Mor G, Guller S. NLRP3 inflammasome function and pyroptotic cell death in human placental Hofbauer cells. Journal Of Reproductive Immunology 2020, 142: 103214. PMID: 33152658, PMCID: PMC7770077, DOI: 10.1016/j.jri.2020.103214.
• Zika Virus-Infected Decidual Cells Elicit a Gestational Age-Dependent Innate Immune Response and Exaggerate Trophoblast Zika Permissiveness: Implication for Vertical Transmission.Guzeloglu-Kayisli O, Guo X, Tang Z, Semerci N, Ozmen A, Larsen K, Mutluay D, Guller S, Schatz F, Kayisli UA, Lockwood CJ. Zika Virus-Infected Decidual Cells Elicit a Gestational Age-Dependent Innate Immune Response and Exaggerate Trophoblast Zika Permissiveness: Implication for Vertical Transmission. Journal Of Immunology (Baltimore, Md. : 1950) 2020, 205: 3083-3094. PMID: 33139490, DOI: 10.4049/jimmunol.2000713.
• Acetaminophen Attenuates invasion and alters the expression of extracellular matrix enzymes and vascular factors in human first trimester trophoblast cells.Burman A, Garcia-Milian R, Wood M, DeWitt NA, Vasiliou V, Guller S, Abrahams VM, Whirledge S. Acetaminophen Attenuates invasion and alters the expression of extracellular matrix enzymes and vascular factors in human first trimester trophoblast cells. Placenta 2021, 104: 146-160. PMID: 33348283, DOI: 10.1016/j.placenta.2020.12.002.
• SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface.Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface. MedRxiv : The Preprint Server For Health Sciences 2021 PMID: 33532791, PMCID: PMC7852242, DOI: 10.1101/2021.01.25.21250452.
• Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface.Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med (New York, N.Y.) 2021, 2: 591-610.e10. PMID: 33969332, PMCID: PMC8084634, DOI: 10.1016/j.medj.2021.04.016.
• YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion.Feliciano D, Ott CM, Espinosa-Medina I, Weigel AV, Benedetti L, Milano KM, Tang Z, Lee T, Kliman HJ, Guller SM, Lippincott-Schwartz J. YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. Nature Communications 2021, 12: 4502. PMID: 34301937, PMCID: PMC8302681, DOI: 10.1038/s41467-021-24708-2.