Sarah Slavoff
Associate Professor of Chemistry and of Molecular Biophysics and Biochemistry
Research & Publications
Biography
News
Coauthors
Selected Publications
- Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroIDNa Z, Dai X, Zheng SJ, Bryant CJ, Loh KH, Su H, Luo Y, Buhagiar AF, Cao X, Baserga SJ, Chen S, Slavoff SA. Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID. Molecular Cell 2022, 82: 2900-2911.e7. PMID: 35905735, PMCID: PMC9662605, DOI: 10.1016/j.molcel.2022.06.035.
- Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitorCao X, Khitun A, Harold CM, Bryant CJ, Zheng SJ, Baserga SJ, Slavoff SA. Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor. Nature Chemical Biology 2022, 18: 643-651. PMID: 35393574, PMCID: PMC9423127, DOI: 10.1038/s41589-022-01003-9.
- Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24Cao X, Khitun A, Luo Y, Na Z, Phoodokmai T, Sappakhaw K, Olatunji E, Uttamapinant C, Slavoff SA. Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24. Nature Communications 2021, 12: 508. PMID: 33479206, PMCID: PMC7820019, DOI: 10.1038/s41467-020-20841-6.
- Phosphorylation of a Human Microprotein Promotes Dissociation of Biomolecular CondensatesNa Z, Luo Y, Cui DS, Khitun A, Smelyansky S, Loria JP, Slavoff SA. Phosphorylation of a Human Microprotein Promotes Dissociation of Biomolecular Condensates. Journal Of The American Chemical Society 2021, 143: 12675-12687. PMID: 34346674, PMCID: PMC8564862, DOI: 10.1021/jacs.1c05386.
- Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitorLuo Y, Schofield JA, Na Z, Hann T, Simon MD, Slavoff SA. Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor. Cell Chemical Biology 2020, 28: 463-474.e7. PMID: 33357462, PMCID: PMC8052284, DOI: 10.1016/j.chembiol.2020.12.003.
- A Genetic Code Expansion‐Derived Molecular Beacon for the Detection of Intracellular Amyloid‐β Peptide GenerationSappakhaw K, Jantarug K, Slavoff S, Israsena N, Uttamapinant C. A Genetic Code Expansion‐Derived Molecular Beacon for the Detection of Intracellular Amyloid‐β Peptide Generation. Angewandte Chemie 2020, 133: 3980-3985. PMID: 38504667, PMCID: PMC10946459, DOI: 10.1002/ange.202010703.
- The NBDY Microprotein Regulates Cellular RNA DecappingNa Z, Luo Y, Schofield JA, Smelyansky S, Khitun A, Muthukumar S, Valkov E, Simon MD, Slavoff SA. The NBDY Microprotein Regulates Cellular RNA Decapping. Biochemistry 2020, 59: 4131-4142. PMID: 33059440, PMCID: PMC7682656, DOI: 10.1021/acs.biochem.0c00672.
- Comparative Proteomic Profiling of Unannotated Microproteins and Alternative Proteins in Human Cell LinesCao X, Khitun A, Na Z, Dumitrescu DG, Kubica M, Olatunji E, Slavoff SA. Comparative Proteomic Profiling of Unannotated Microproteins and Alternative Proteins in Human Cell Lines. Journal Of Proteome Research 2020, 19: 3418-3426. PMID: 32449352, PMCID: PMC7429271, DOI: 10.1021/acs.jproteome.0c00254.
- Global Profiling of Cellular Substrates of Human Dcp2Luo Y, Schofield J, Simon MD, Slavoff SA. Global Profiling of Cellular Substrates of Human Dcp2. Biochemistry 2020, 59: 4176-4188. PMID: 32365300, PMCID: PMC7641959, DOI: 10.1021/acs.biochem.0c00069.
- Non-AUG start codons: Expanding and regulating the small and alternative ORFeomeCao X, Slavoff SA. Non-AUG start codons: Expanding and regulating the small and alternative ORFeome. Experimental Cell Research 2020, 391: 111973. PMID: 32209305, PMCID: PMC7256928, DOI: 10.1016/j.yexcr.2020.111973.
- Nucleolar localization of RAG1 modulates V(D)J recombination activityBrecht RM, Liu CC, Beilinson HA, Khitun A, Slavoff SA, Schatz DG. Nucleolar localization of RAG1 modulates V(D)J recombination activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 4300-4309. PMID: 32047031, PMCID: PMC7049140, DOI: 10.1073/pnas.1920021117.
- Proteomic Detection and Validation of Translated Small Open Reading FramesKhitun A, Slavoff SA. Proteomic Detection and Validation of Translated Small Open Reading Frames. Current Protocols In Chemical Biology 2019, 11: e77. PMID: 31750990, PMCID: PMC6878975, DOI: 10.1002/cpch.77.
- Small open reading frames and cellular stress responsesKhitun A, Ness TJ, Slavoff SA. Small open reading frames and cellular stress responses. Molecular Omics 2019, 15: 108-116. PMID: 30810554, PMCID: PMC6662920, DOI: 10.1039/c8mo00283e.
- The translation of non-canonical open reading frames controls mucosal immunityJackson R, Kroehling L, Khitun A, Bailis W, Jarret A, York AG, Khan OM, Brewer JR, Skadow MH, Duizer C, Harman CCD, Chang L, Bielecki P, Solis AG, Steach HR, Slavoff S, Flavell RA. The translation of non-canonical open reading frames controls mucosal immunity. Nature 2018, 564: 434-438. PMID: 30542152, PMCID: PMC6939389, DOI: 10.1038/s41586-018-0794-7.
- P‑Bodies: Composition, Properties, and FunctionsLuo Y, Na Z, Slavoff SA. P‑Bodies: Composition, Properties, and Functions. Biochemistry 2018, 57: 2424-2431. PMID: 29381060, PMCID: PMC6296482, DOI: 10.1021/acs.biochem.7b01162.
- Comparative Membrane Proteomics Reveals a Nonannotated E. coli Heat Shock ProteinYuan P, D’Lima N, Slavoff SA. Comparative Membrane Proteomics Reveals a Nonannotated E. coli Heat Shock Protein. Biochemistry 2017, 57: 56-60. PMID: 29039649, PMCID: PMC5761644, DOI: 10.1021/acs.biochem.7b00864.
- Comparative Proteomics Enables Identification of Nonannotated Cold Shock Proteins in E. coliD’Lima N, Khitun A, Rosenbloom AD, Yuan P, Gassaway BM, Barber KW, Rinehart J, Slavoff SA. Comparative Proteomics Enables Identification of Nonannotated Cold Shock Proteins in E. coli. Journal Of Proteome Research 2017, 16: 3722-3731. PMID: 28861998, PMCID: PMC5647875, DOI: 10.1021/acs.jproteome.7b00419.
- A human microprotein that interacts with the mRNA decapping complexD'Lima NG, Ma J, Winkler L, Chu Q, Loh KH, Corpuz EO, Budnik BA, Lykke-Andersen J, Saghatelian A, Slavoff SA. A human microprotein that interacts with the mRNA decapping complex. Nature Chemical Biology 2016, 13: 174-180. PMID: 27918561, PMCID: PMC5247292, DOI: 10.1038/nchembio.2249.
- The Discovery of Human sORF‐Encoded Polypeptides (SEPs) in Cell Lines and TissueMa J, Ward C, Jungreis I, Slavoff S, Schwaid A, Neveu J, Budnik B, Kellis M, Saghatelian A. The Discovery of Human sORF‐Encoded Polypeptides (SEPs) in Cell Lines and Tissue. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.567.21.
- A Human Short Open Reading Frame (sORF)-encoded Polypeptide That Stimulates DNA End Joining*Slavoff SA, Heo J, Budnik BA, Hanakahi LA, Saghatelian A. A Human Short Open Reading Frame (sORF)-encoded Polypeptide That Stimulates DNA End Joining*. Journal Of Biological Chemistry 2014, 289: 10950-10957. PMID: 24610814, PMCID: PMC4036235, DOI: 10.1074/jbc.c113.533968.
- Discovery of Human sORF-Encoded Polypeptides (SEPs) in Cell Lines and TissueMa J, Ward CC, Jungreis I, Slavoff SA, Schwaid AG, Neveu J, Budnik BA, Kellis M, Saghatelian A. Discovery of Human sORF-Encoded Polypeptides (SEPs) in Cell Lines and Tissue. Journal Of Proteome Research 2014, 13: 1757-1765. PMID: 24490786, PMCID: PMC3993966, DOI: 10.1021/pr401280w.
- Chemoproteomic Discovery of Cysteine-Containing Human Short Open Reading FramesSchwaid AG, Shannon DA, Ma J, Slavoff SA, Levin JZ, Weerapana E, Saghatelian A. Chemoproteomic Discovery of Cysteine-Containing Human Short Open Reading Frames. Journal Of The American Chemical Society 2013, 135: 16750-16753. PMID: 24152191, PMCID: PMC3868496, DOI: 10.1021/ja406606j.
- Peptidomic discovery of short open reading frame–encoded peptides in human cellsSlavoff SA, Mitchell AJ, Schwaid AG, Cabili MN, Ma J, Levin JZ, Karger AD, Budnik BA, Rinn JL, Saghatelian A. Peptidomic discovery of short open reading frame–encoded peptides in human cells. Nature Chemical Biology 2012, 9: 59-64. PMID: 23160002, PMCID: PMC3625679, DOI: 10.1038/nchembio.1120.
- Discovering ligand-receptor interactionsSlavoff SA, Saghatelian A. Discovering ligand-receptor interactions. Nature Biotechnology 2012, 30: 959-961. PMID: 23051814, DOI: 10.1038/nbt.2373.
- Imaging Protein–Protein Interactions inside Living Cells via Interaction-Dependent Fluorophore LigationSlavoff SA, Liu DS, Cohen JD, Ting AY. Imaging Protein–Protein Interactions inside Living Cells via Interaction-Dependent Fluorophore Ligation. Journal Of The American Chemical Society 2011, 133: 19769-19776. PMID: 22098454, PMCID: PMC3547671, DOI: 10.1021/ja206435e.
- Expanding the Substrate Tolerance of Biotin Ligase through Exploration of Enzymes from Diverse SpeciesSlavoff SA, Chen I, Choi YA, Ting AY. Expanding the Substrate Tolerance of Biotin Ligase through Exploration of Enzymes from Diverse Species. Journal Of The American Chemical Society 2008, 130: 1160-1162. PMID: 18171066, PMCID: PMC3501195, DOI: 10.1021/ja076655i.
- Isolation and characterisation of selected germander diterpenoids from authenticated Teucrium chamaedrys and T. canadense by HPLC, HPLC‐MS and NMRSundaresan PR, Slavoff SA, Grundel E, White KD, Mazzola E, Koblenz D, Rader JI. Isolation and characterisation of selected germander diterpenoids from authenticated Teucrium chamaedrys and T. canadense by HPLC, HPLC‐MS and NMR. Phytochemical Analysis 2006, 17: 243-250. PMID: 16910040, DOI: 10.1002/pca.912.