Sameet Mehta, PhD
Associate Research Scientist in Genetics
Research & Publications
Biography
Locations
Coauthors
Selected Publications
- Repeat tick exposure elicits distinct immune responses in guinea pigs and miceKurokawa C, Narasimhan S, Vidyarthi A, Booth CJ, Mehta S, Meister L, Diktas H, Strank N, Lynn GE, DePonte K, Craft J, Fikrig E. Repeat tick exposure elicits distinct immune responses in guinea pigs and mice. Ticks And Tick-borne Diseases 2020, 11: 101529. PMID: 32993942, PMCID: PMC7530331, DOI: 10.1016/j.ttbdis.2020.101529.
- Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic targetLiu R, Yeh YJ, Varabyou A, Collora JA, Sherrill-Mix S, Talbot CC, Mehta S, Albrecht K, Hao H, Zhang H, Pollack RA, Beg SA, Calvi RM, Hu J, Durand CM, Ambinder RF, Hoh R, Deeks SG, Chiarella J, Spudich S, Douek DC, Bushman FD, Pertea M, Ho YC. Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target. Science Translational Medicine 2020, 12 PMID: 32404504, PMCID: PMC7453882, DOI: 10.1126/scitranslmed.aaz0802.
- Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signalingZhou H, Mehta S, Srivastava SP, Grabinska K, Zhang X, Wong C, Hedayat A, Perrotta P, Fernández-Hernando C, Sessa WC, Goodwin JE. Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling. JCI Insight 2020, 5: e131384. PMID: 32051336, PMCID: PMC7098785, DOI: 10.1172/jci.insight.131384.
- Chronic mTOR activation induces a degradative smooth muscle cell phenotypeLi G, Wang M, Caulk AW, Cilfone NA, Gujja S, Qin L, Chen PY, Chen Z, Yousef S, Jiao Y, He C, Jiang B, Korneva A, Bersi MR, Wang G, Liu X, Mehta S, Geirsson A, Gulcher JR, Chittenden TW, Simons M, Humphrey JD, Tellides G. Chronic mTOR activation induces a degradative smooth muscle cell phenotype. Journal Of Clinical Investigation 2020, 130: 1233-1251. PMID: 32039915, PMCID: PMC7269581, DOI: 10.1172/jci131048.
- Genomic sites hypersensitive to ultraviolet radiationPremi S, Han L, Mehta S, Knight J, Zhao D, Palmatier MA, Kornacker K, Brash DE. Genomic sites hypersensitive to ultraviolet radiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 24196-24205. PMID: 31723047, PMCID: PMC6883822, DOI: 10.1073/pnas.1907860116.
- Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune responseSahraei M, Chaube B, Liu Y, Sun J, Kaplan A, Price NL, Ding W, Oyaghire S, García-Milian R, Mehta S, Reshetnyak YK, Bahal R, Fiorina P, Glazer PM, Rimm DL, Fernández-Hernando C, Suárez Y. Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response. Journal Of Clinical Investigation 2019, 129: 5518-5536. PMID: 31710308, PMCID: PMC6877327, DOI: 10.1172/jci127125.
- Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomesGirgenti MJ, Wohleb ES, Mehta S, Ghosal S, Fogaca MV, Duman RS. Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes. Translational Psychiatry 2019, 9: 292. PMID: 31712551, PMCID: PMC6848179, DOI: 10.1038/s41398-019-0642-z.
- The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitorsChiu JE, Thekkiniath J, Mehta S, Müller C, Bracher F, Ben Mamoun C. The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors. Journal Of Biological Chemistry 2019, 294: 14757-14767. PMID: 31409644, PMCID: PMC6779428, DOI: 10.1074/jbc.ra119.009791.
- Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motilityRobson A, Makova SZ, Barish S, Zaidi S, Mehta S, Drozd J, Jin SC, Gelb BD, Seidman CE, Chung WK, Lifton RP, Khokha MK, Brueckner M. Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 14049-14054. PMID: 31235600, PMCID: PMC6628794, DOI: 10.1073/pnas.1808341116.
- Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family membersGonzalo-Gil E, Rapuano PB, Ikediobi U, Leibowitz R, Mehta S, Coskun AK, Porterfield JZ, Lampkin TD, Marconi VC, Rimland D, Walker BD, Deeks S, Sutton RE. Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members. ELife 2019, 8: e44360. PMID: 30964004, PMCID: PMC6456299, DOI: 10.7554/elife.44360.
- Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIVFarhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS. Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV. JCI Insight 2018, 3: e121718. PMID: 30232286, PMCID: PMC6237230, DOI: 10.1172/jci.insight.121718.
- Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to PluripotencyHernandez C, Wang Z, Ramazanov B, Tang Y, Mehta S, Dambrot C, Lee YW, Tessema K, Kumar I, Astudillo M, Neubert TA, Guo S, Ivanova NB. Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency. Cell Stem Cell 2018, 23: 396-411.e8. PMID: 30146411, PMCID: PMC6128737, DOI: 10.1016/j.stem.2018.08.001.
- Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune HepatitisArterbery AS, Yao J, Ling A, Avitzur Y, Martinez M, Lobritto S, Deng Y, Geliang G, Mehta S, Wang G, Knight J, Ekong UD. Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis. Frontiers In Immunology 2018, 9: 1612. PMID: 30072988, PMCID: PMC6060440, DOI: 10.3389/fimmu.2018.01612.
- Translocation of a gut pathobiont drives autoimmunity in mice and humansVieira S, Hiltensperger M, Kumar V, Zegarra-Ruiz D, Dehner C, Khan N, Costa FRC, Tiniakou E, Greiling T, Ruff W, Barbieri A, Kriegel C, Mehta SS, Knight JR, Jain D, Goodman AL, Kriegel MA. Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 2018, 359: 1156-1161. PMID: 29590047, PMCID: PMC5959731, DOI: 10.1126/science.aar7201.
- Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic LeptospiraAdhikarla H, Wunder EA, Mechaly AE, Mehta S, Wang Z, Santos L, Bisht V, Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M, Buschiazzo A, Ko AI. Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira. Frontiers In Cellular And Infection Microbiology 2018, 8: 45. PMID: 29600195, PMCID: PMC5863495, DOI: 10.3389/fcimb.2018.00045.
- Changes in bone marrow innate lymphoid cell subsets in monoclonal gammopathy: target for IMiD therapyKini Bailur J, Mehta S, Zhang L, Neparidze N, Parker T, Bar N, Anderson T, Xu ML, Dhodapkar KM, Dhodapkar MV. Changes in bone marrow innate lymphoid cell subsets in monoclonal gammopathy: target for IMiD therapy. Blood Advances 2017, 1: 2343-2347. PMID: 29296884, PMCID: PMC5729633, DOI: 10.1182/bloodadvances.2017012732.
- Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidyRyu HY, Wilson NR, Mehta S, Hwang SS, Hochstrasser M. Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Genes & Development 2016, 30: 1881-1894. PMID: 27585592, PMCID: PMC5024685, DOI: 10.1101/gad.282194.116.
- Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe.Mizuguchi T, Fudenberg G, Mehta S, Belton JM, Taneja N, Folco HD, FitzGerald P, Dekker J, Mirny L, Barrowman J, Grewal SIS. Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe. Nature 2014, 516: 432-435. PMID: 25307058, PMCID: PMC4465753, DOI: 10.1038/nature13833.
- Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.Lee NN, Chalamcharla VR, Reyes-Turcu F, Mehta S, Zofall M, Balachandran V, Dhakshnamoorthy J, Taneja N, Yamanaka S, Zhou M, Grewal SI. Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. Cell 2013, 155: 1061-74. PMID: 24210919, PMCID: PMC3974623, DOI: 10.1016/j.cell.2013.10.027.
- HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin.Aygün O, Mehta S, Grewal SI. HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin. Nature Structural & Molecular Biology 2013, 20: 547-54. PMID: 23604080, PMCID: PMC3661211, DOI: 10.1038/nsmb.2565.
- RNAi triggered by specialized machinery silences developmental genes and retrotransposons.Yamanaka S, Mehta S, Reyes-Turcu FE, Zhuang F, Fuchs RT, Rong Y, Robb GB, Grewal SI. RNAi triggered by specialized machinery silences developmental genes and retrotransposons. Nature 2013, 493: 557-60. PMID: 23151475, PMCID: PMC3554839, DOI: 10.1038/nature11716.
- A homolog of male sex-determining factor SRY cooperates with a transposon-derived CENP-B protein to control sex-specific directed recombination.Matsuda E, Sugioka-Sugiyama R, Mizuguchi T, Mehta S, Cui B, Grewal SI. A homolog of male sex-determining factor SRY cooperates with a transposon-derived CENP-B protein to control sex-specific directed recombination. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 18754-9. PMID: 22042869, PMCID: PMC3219157, DOI: 10.1073/pnas.1109988108.
- Over-represented promoter motifs in abiotic stress-induced DREB genes of rice and sorghum and their probable role in regulation of gene expression.Srivasta A, Mehta S, Lindlof A, Bhargava S. Over-represented promoter motifs in abiotic stress-induced DREB genes of rice and sorghum and their probable role in regulation of gene expression. Plant Signaling & Behavior 2010, 5: 775-84. PMID: 20495351, PMCID: PMC3115025, DOI: 10.4161/psb.5.7.11769.
- Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner.Notani D, Gottimukkala KP, Jayani RS, Limaye AS, Damle MV, Mehta S, Purbey PK, Joseph J, Galande S. Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner. PLoS Biology 2010, 8: e1000296. PMID: 20126258, PMCID: PMC2811152, DOI: 10.1371/journal.pbio.1000296.
- PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1.Purbey PK, Singh S, Kumar PP, Mehta S, Ganesh KN, Mitra D, Galande S. PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1. Nucleic Acids Research 2008, 36: 2107-22. PMID: 18187506, PMCID: PMC2367706, DOI: 10.1093/nar/gkm1151.
- MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3.Joglekar MV, Parekh VS, Mehta S, Bhonde RR, Hardikar AA. MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3. Developmental Biology 2007, 311: 603-12. PMID: 17936263, DOI: 10.1016/j.ydbio.2007.09.008.
- SATB1-binding sequences and Alu-like motifs define a unique chromatin context in the vicinity of human immunodeficiency virus type 1 integration sites.Kumar PP, Mehta S, Purbey PK, Notani D, Jayani RS, Purohit HJ, Raje DV, Ravi DS, Bhonde RR, Mitra D, Galande S. SATB1-binding sequences and Alu-like motifs define a unique chromatin context in the vicinity of human immunodeficiency virus type 1 integration sites. Journal Of Virology 2007, 81: 5617-27. PMID: 17376900, PMCID: PMC1900249, DOI: 10.1128/JVI.01405-06.