Sajid A Khan
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Research Summary
Dr. Khan is an NIH-funded, well published, surgeon-scientist who seeks to use modern molecular biology to improve our understanding and treatment of patients with gastrointestinal cancers. The Khan lab performs basic scientific investigation and translational research in close collaboration with other experts at the Yale Cancer Center in order to advance the field of oncology. Our lab is currently studying the genetic basis underlying the mechanism of metastasis, in addition to the relationship between sex hormones, metabolite and protein expression on colon cancer patient outcomes. Furthermore, we perform clinical outcomes research in surgery for cancers which arise from the stomach, liver, pancreas, bile duct, small intestine, colon, appendix, and skin. Dr. Khan is also the Principal Investigator at Yale for a national clinical trial sponsored by the Southwest Oncology Group (SWOG) studying colorectal cancer chemoprevention.
Extensive Research Description
Dr. Khan is an NIH-funded, well published, surgeon-scientist who seeks to use modern molecular biology to improve our understanding and treatment of patients with gastrointestinal cancers. The Khan lab performs basic scientific investigation and translational research in close collaboration with other experts at the Yale Cancer Center in order to advance the field of oncology. Our lab is currently studying the genetic basis underlying the mechanism of metastasis, in addition to the relationship between sex hormones, metabolite and protein expression on colon cancer patient outcomes. Furthermore, we perform clinical outcomes research in surgery for cancers which arise from the stomach, liver, pancreas, bile duct, small intestine, colon, appendix, and skin. Dr. Khan is also the Principal Investigator at Yale for a national clinical trial sponsored by the Southwest Oncology Group (SWOG) studying colorectal cancer chemoprevention.
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Research Interests
Liver; Molecular Biology; Neoplasm Metastasis; Stomach Neoplasms; Colorectal Neoplasms; Cholangiocarcinoma; Carcinoma, Pancreatic Ductal; Gastrointestinal Stromal Tumors; Translational Medical Research; Metastasectomy
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Selected Publications
- c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases.Zeng ZS, Weiser MR, Kuntz E, Chen CT, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT, D'Alessio M, Barany F, Paty PB. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Letters 2008, 265:258-69.
- Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer.Khan SA, Idrees K, Forslund A, Zeng Z, Rosenberg S, Pincas H, Barany F, Offit K, Laquaglia MP, Paty PB. Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer. Journal Of Surgical Oncology 2008, 97:621-5.
- CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer.Cheng YW, Pincas H, Bacolod MD, Schemmann G, Giardina SF, Huang J, Barral S, Idrees K, Khan SA, Zeng Z, Rosenberg S, Notterman DA, Ott J, Paty P, Barany F. CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2008, 14:6005-13.
- Improved testing for microsatellite instability in colorectal cancer using a simplified 3-marker assay.Esemuede I, Forslund A, Khan SA, Qin LX, Gimbel MI, Nash GM, Zeng Z, Rosenberg S, Shia J, Barany F, Paty PB. Improved testing for microsatellite instability in colorectal cancer using a simplified 3-marker assay. Annals Of Surgical Oncology 2010, 17:3370-8.
- Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer.Cheng YW, Idrees K, Shattock R, Khan SA, Zeng Z, Brennan CW, Paty P, Barany F. Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. International Journal Of Cancer. Journal International Du Cancer 2010, 127:568-77.
- Radiofrequency ablation of advanced head and neck cancer.Owen RP, Khan SA, Negassa A, Beitler JJ, Bello JA, Brook A, Farinhas J, Garg MK, Haigentz M, Miller TS, Hsu MS, Ravikumar TS, Shifteh K, Smith RV, Silver CE. Radiofrequency ablation of advanced head and neck cancer. Archives Of Otolaryngology--head & Neck Surgery 2011, 137:493-8.
- MicroRNA expression characterizes oligometastasis(es).Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. MicroRNA expression characterizes oligometastasis(es). PloS One 2011, 6:e28650.
- Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs.Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich JL, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR. Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs. PloS One 2012, 7:e50141.
- Tumor endothelial inflammation predicts clinical outcome in diverse human cancers.Pitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR. Tumor endothelial inflammation predicts clinical outcome in diverse human cancers. PloS One 2012, 7:e46104.
- Intraoperative margin re-resection for colorectal cancer liver metastases.Khan SA, Matthews JB. Intraoperative margin re-resection for colorectal cancer liver metastases. Hepatobiliary Surgery And Nutrition 2013, 2:108-12.
- Skin and Subcutaneous TissueKhan SA, Bank J, Choi E, Song D. Skin and Subcutaneous Tissue. Schwartz's Principles of Surgery, Tenth Edition, 2014.
- Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer TherapeuticsGrisotti G, Khan SA. Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer Therapeutics. Difficult Decisions in Hepatobiliary and Pancreatic Surgery – An Evidence Based Approach 2015
- Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome.Wightman SC, Uppal A, Pitroda SP, Ganai S, Burnette B, Stack M, Oshima G, Khan S, Huang X, Posner MC, Weichselbaum RR, Khodarev NN. Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome. British Journal Of Cancer 2015, 113:327-35.
- Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer.Zhu R, Grisotti G, Salem RR, Khan SA. Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer. World Journal Of Surgical Oncology 2016, 14:12.
- Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients.Khan SA, Morris M, Idrees K, Gimbel MI, Rosenberg S, Zeng Z, Li F, Gan G, Shia J, LaQuaglia MP, Paty PB. Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients. Journal Of Pediatric Surgery 2016, 51:1812-1817.
- Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancerKole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancer. Journal of National Comprehensive Cancer Network 2017.
- Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complicationAlkukhun A, Grisotti G, Salem RR, Cha C, Khan SA. Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complication. In press at American College of Surgeons Case Reviews in Surgery 2017.
- Predictors of Nonadherence to NCCN Guideline Recommendations for the Management of Stage I Anal Canal Cancer.Kole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of Nonadherence to NCCN Guideline Recommendations for the Management of Stage I Anal Canal Cancer. Journal Of The National Comprehensive Cancer Network : JNCCN 2017, 15:355-362.
- EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer.Khan SA, Zeng Z, Shia J, Paty PB. EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer. Pathology Oncology Research : POR 2017, 23:673-677.
- miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism.Liu J, Guo B, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pan W, Khan S, Chen S, Kyba M, Fan R, Guo S, Lu J. miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Blood 2017, 129:1491-1502.
- The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression.Pan W, Zhu S, Qu K, Meeth K, Cheng J, He K, Ma H, Liao Y, Wen X, Roden C, Tobiasova Z, Wei Z, Zhao J, Liu J, Zheng J, Guo B, Khan SA, Bosenberg M, Flavell RA, Lu J. The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression. Immunity 2017, 47:284-297.e5.
- Hyperparathyroidism-Jaw Tumor Syndrome Associated With Large-Scale 1q31 Deletion.Rubinstein JC, Majumdar SK, Laskin W, Lazaga F, Prasad ML, Carling T, Khan SA. Hyperparathyroidism-Jaw Tumor Syndrome Associated With Large-Scale 1q31 Deletion. Journal Of The Endocrine Society 2017, 1:926-930.
- Post-operative radiotherapy is associated with improved survival in esophageal cancer with positive surgical margins.Gao SJ, Park HS, Corso CD, Rutter CE, Khan SA, Johung KL. Post-operative radiotherapy is associated with improved survival in esophageal cancer with positive surgical margins. Journal Of Gastrointestinal Oncology 2017, 8:953-961.
- Beyond genomics: understanding exposotypes through metabolomics.Rattray NJW, Deziel NC, Wallach JD, Khan SA, Vasiliou V, Ioannidis JPA, Johnson CH. Beyond genomics: understanding exposotypes through metabolomics. Human Genomics 2018, 12:4.
- Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis.Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nature Communications 2018, 9:1793.
- Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum.Zhu R, Liu F, Grisotti G, Pérez-Irizarry J, Cha CH, Johnson CH, Boffa DJ, Han D, Johung KL, Zhang Y, Khan SA. Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum. Journal Of Gastrointestinal Oncology 2018, 9:231-240.
- Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinoma.Zhu R, Liu F, Grisotti G, Perez-Irizarry J, Salem RR, Cha CH, Johung KL, Boffa DJ, Zhang Y, Khan SA. Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinoma. Journal Of Gastrointestinal Oncology 2018, 9:517-526.
- NCCN Guidelines Insights: Neuroendocrine and Adrenal Tumors, Version 2.2018.Shah MH, Goldner WS, Halfdanarson TR, Bergsland E, Berlin JD, Halperin D, Chan J, Kulke MH, Benson AB, Blaszkowsky LS, Eads J, Engstrom PF, Fanta P, Giordano T, He J, Heslin MJ, Kalemkerian GP, Kandeel F, Khan SA, Kidwai WZ, Kunz PL, Kuvshinoff BW, Lieu C, Pillarisetty VG, Saltz L, Sosa JA, Strosberg JR, Sussman CA, Trikalinos NA, Uboha NA, Whisenant J, Wong T, Yao JC, Burns JL, Ogba N, Zuccarino-Catania G. NCCN Guidelines Insights: Neuroendocrine and Adrenal Tumors, Version 2.2018. Journal Of The National Comprehensive Cancer Network : JNCCN 2018, 16:693-702.
- Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis.Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nature Communications 2018, 9:4827.
- Defining Early-Onset Colon and Rectal Cancers.Jacobs D, Zhu R, Luo J, Grisotti G, Heller DR, Kurbatov V, Johnson CH, Zhang Y, Khan SA. Defining Early-Onset Colon and Rectal Cancers. Frontiers In Oncology 2018, 8:504.
- Review and current state of radiation therapy for locally advanced pancreatic adenocarcinoma.Blakaj A, Stein SM, Khan SA, Johung KL. Review and current state of radiation therapy for locally advanced pancreatic adenocarcinoma. Journal Of Gastrointestinal Oncology 2018, 9:1027-1036.
- Regional Differences in Palliative Care Utilization Among Geriatric Colorectal Cancer Patients Needing Emergent Surgery.Heller DR, Jean RA, Chiu AS, Feder SI, Kurbatov V, Cha C, Khan SA. Regional Differences in Palliative Care Utilization Among Geriatric Colorectal Cancer Patients Needing Emergent Surgery. Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract 2019, 23:153-162.
- Intrahepatic Cholangiocarcinoma: Socioeconomic Discrepancies, Contemporary Treatment Approaches and Survival Trends from the National Cancer Database.Uhlig J, Sellers CM, Cha C, Khan SA, Lacy J, Stein SM, Kim HS. Intrahepatic Cholangiocarcinoma: Socioeconomic Discrepancies, Contemporary Treatment Approaches and Survival Trends from the National Cancer Database. Annals Of Surgical Oncology 2019, 26:1993-2000.
- Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma?Pavri SN, Han G, Khan S, Han D. Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma? Journal Of Surgical Oncology 2019, 119:1060-1069.
- Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors.Heller DR, Jean RA, Luo J, Kurbatov V, Grisotti G, Jacobs D, Chiu AS, Zhang Y, Khan SA. Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors. Journal Of The American College Of Surgeons 2019, 228:839-851.
- The Role of Bowel Preparation in Open, Minimally Invasive, and Converted-to-Open Colectomy.Luo J, Liu Z, Pei KY, Khan SA, Wang X, Yang M, Wang X, Zhang Y. The Role of Bowel Preparation in Open, Minimally Invasive, and Converted-to-Open Colectomy. The Journal Of Surgical Research 2019, 242:183-192.
- Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanoma.Klemen ND, Wang M, Feingold PL, Cooper K, Pavri SN, Han D, Detterbeck FC, Boffa DJ, Khan SA, Olino K, Clune J, Ariyan S, Salem RR, Weiss SA, Kluger HM, Sznol M, Cha C. Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanoma. Journal For Immunotherapy Of Cancer 2019, 7:196.
- Comparison on Clinicopathological Features, Treatments and Prognosis between Proximal Gastric Cancer and Distal Gastric Cancer: A National Cancer Data Base Analysis.Wang X, Liu F, Li Y, Tang S, Zhang Y, Chen Y, Khan SA. Comparison on Clinicopathological Features, Treatments and Prognosis between Proximal Gastric Cancer and Distal Gastric Cancer: A National Cancer Data Base Analysis. Journal Of Cancer 2019, 10:3145-3153.
- APC Mutational Patterns in Gastric Adenocarcinoma are Enriched for Missense Variants with Associated Decreased Survival.Rubinstein JC, Khan SA, Christison-Lagay ER, Cha C. APC Mutational Patterns in Gastric Adenocarcinoma are Enriched for Missense Variants with Associated Decreased Survival. Genes, Chromosomes & Cancer 2019.
- How I Treat Gastric and Esophageal Cancer, Surgery.Khan SA, Kurbatov V, Posner MC. Handbook of Gastrointestinal Cancers: Evidence-Based Treatment and Multidisciplinary Patient Care 2019.
- Hepatocellular carcinoma: Impact of academic setting and hospital volume on patient survival.Uhlig J, Sellers CM, Khan SA, Cha C, Kim HS. Hepatocellular carcinoma: Impact of academic setting and hospital volume on patient survival. Surgical Oncology 2019, 31:111-118.
- Lymph Node Status: In Reply to Carr.Heller DR, Jean RA, Khan SA. Lymph Node Status: In Reply to Carr. Journal Of The American College Of Surgeons 2019, 229:516-517.
- Appendiceal Carcinoid Tumors: In Reply to Sugarbaker.Heller DR, Jean RA, Khan SA. Appendiceal Carcinoid Tumors: In Reply to Sugarbaker. Journal Of The American College Of Surgeons 2019, 229:519.
- Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma Survival.Heller DR, Nicolson NG, Ahuja N, Khan S, Kunstman JW. Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma Survival. JAMA Surgery 2020, 155:e195047.
- Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer Database.Miccio JA, Jairam V, Gao S, Augustyn A, Oladeru OT, Onderdonk BE, Chowdhary M, Han D, Khan S, Friedlaender G, Lindskog DM, Desphande HA, Osborn H, Roberts KB, Patel KR. Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer Database. Cure¯us 2019, 11:e6038.
- Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma.Kurbatov V, Balayev A, Saffarzadeh A, Heller DR, Boffa DJ, Blasberg JD, Lu J, Khan SA. Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma. The Annals Of Thoracic Surgery 2020, 109:343-349.
- Exploring Microsatellite Instability (MSI) in Colorectal Cancer at Elevated Microsatellite Alterations at Selected Tetranucleotides (EMAST).Kurbatov V, Khan SA. Exploring Microsatellite Instability (MSI) in Colorectal Cancer at Elevated Microsatellite Alterations at Selected Tetranucleotides (EMAST). Annals Of Surgical Oncology 2020, 27:973-974.
- Molecular Pathway Analysis Indicates a Distinct Metabolic Phenotype in Women With Right-Sided Colon Cancer.Sun Y, Mironova V, Chen Y, Lundh EPF, Zhang Q, Cai Y, Vasiliou V, Zhang Y, Garcia-Milian R, Khan SA, Johnson CH. Molecular Pathway Analysis Indicates a Distinct Metabolic Phenotype in Women With Right-Sided Colon Cancer. Translational Oncology 2020, 13:42-56.
- Palliative care is underutilized and affects healthcare costs in ruptured abdominal aortic aneurysms.Liu S, Heller DR, Jean RA, Chiu AS, Khan SA, Dardik A. Palliative care is underutilized and affects healthcare costs in ruptured abdominal aortic aneurysms. Surgery 2020, 168:234-236.
- Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype.Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. Scientific Reports 2020, 10:4905.
- Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy.Liu Z, Luo JJ, Pei KY, Khan SA, Wang XX, Zhao ZX, Yang M, Johnson CH, Wang XS, Zhang Y. Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy. Gastroenterology Report 2020, 8:151-157.
- Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases.Kurbatov V, Resio BJ, Cama CA, Heller DR, Cha C, Zhang Y, Lu J, Khan SA. Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases. Journal Of Gastrointestinal Oncology 2020, 11:76-83.
- Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage.Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Muca E, Vollmar AKR, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage. Metabolites 2020, 10.
- Kynurenic acid underlies sex-specific immune responses to COVID-19.Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker CM, Silva J, Wong P, Ko AJ, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid underlies sex-specific immune responses to COVID-19. MedRxiv : The Preprint Server For Health Sciences 2020.
- Treatment Selection and Survival Outcomes in Locally Advanced Proximal Gastric Cancer: A National Cancer Data Base Analysis.Tang S, Liu F, Li Y, Zhao L, Wang X, Khan SA, Chen Y, Zhang Y. Treatment Selection and Survival Outcomes in Locally Advanced Proximal Gastric Cancer: A National Cancer Data Base Analysis. Frontiers In Oncology 2020, 10:537051.
- Gene Alterations of N6-Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study.Zhang Q, Cai Y, Kurbatov V, Khan SA, Lu L, Zhang Y, Johnson CH. Gene Alterations of N6-Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study. BioMed Research International 2020, 2020:8826456.
- Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis.Miccio JA, Talcott WJ, Patel T, Park HS, Cecchini M, Salem RR, Khan SA, Stein S, Kortmansky JS, Lacy J, Narang A, Herman J, Jabbour SK, Hallemeier CL, Johung K, Jethwa KR. Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis. Clinical And Translational Radiation Oncology 2021, 27:15-23.
- 5-Fluorouracil efficacy requires anti-tumor immunity triggered by cancer-cell-intrinsic STING.Tian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, Lu Q, Yan Q, Lu J. 5-Fluorouracil efficacy requires anti-tumor immunity triggered by cancer-cell-intrinsic STING. The EMBO Journal 2021, e106065.
Clinical Trials
Conditions | Study Title |
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Diseases of the Digestive System - Pancreas; Prevention | A prospective, multi-center investigational study of IMMray PanCan-d diagnostic platform for early detection of pancreatic ductal adenocarcinoma in high-risk populations (PANFAM-1) |
Colon | S0820, Adenoma and Second Primary Prevention Trial (PACES) |