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Sacit Bulent Omay, MD, FAANS

Assistant Professor of Neurosurgery; Surgical Director of Yale Pituitary Program, Neurosurgery; Section Chief, NeuroTrauma, Neurosurgery

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Sacit Bulent Omay, MD, FAANS

Mailing Address

  • 15 York Street

    New Haven, CT 06510

    United States

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Research Summary

I have a background in translational neurooncology research. I am particularly interested in developing personalized therapies based on genomic and molecular profiles of individual tumors especially skull base tumors like pituitary adenomas. Additionally, I perform clinical research especially in the field of endoscopic skull base surgery in an effort to answer challenging questions that come across as the field progresses.

I am also conducting clinical and translational TBI research focusing on prognostication and outcomes as well colloborations for therapeutic opportunities.

Coauthors

Research Interests

Brain Neoplasms; Cerebrospinal Fluid Rhinorrhea; Craniocerebral Trauma; Hypothalamo-Hypophyseal System; Pituitary Apoplexy; Pituitary Diseases; Pituitary Gland; Cerebrospinal Fluid Pressure; Receptors, Oxytocin; Skull Base; Skull Base Neoplasms; Cerebrospinal Fluid Leak

Selected Publications

  • Primary central nervous system vasculitis presenting as spinal subdural hematoma.Fu M, Omay SB, Morgan J, Kelley B, Abbed K, Bulsara KR. Primary central nervous system vasculitis presenting as spinal subdural hematoma. World Neurosurgery 2012, 78: 192.E5-8. PMID: 22120304, DOI: 10.1016/j.wneu.2011.07.043.
  • Low-grade gliomas: when and how to treat.Omay SB, Piepmeier JM, Knisely JP. Low-grade gliomas: when and how to treat. Hematology/oncology Clinics Of North America 2012, 26: 797-809. PMID: 22794284, DOI: 10.1016/j.hoc.2012.05.001.
  • Maxillary swing approach for extended infratemporal fossa tumors.Otremba M, Adam S, Omay SB, Lowlicht R, Bulsara KR, Judson B. Maxillary swing approach for extended infratemporal fossa tumors. The Laryngoscope 2013, 123: 1607-11. PMID: 23536535, DOI: 10.1002/lary.23947.
  • A step toward customizing radiosurgical care for arteriovenous malformations.Omay SB, Matouk CC, Günel M, Bulsara KR. A step toward customizing radiosurgical care for arteriovenous malformations. World Neurosurgery 2013, 79: 210. PMID: 23266455, DOI: 10.1016/j.wneu.2012.12.031.
  • Decompressive hemicraniectomy for ischemic stroke in the pediatric population.Omay SB, Carrión-Grant GM, Kuzmik GA, Fu M, Grant R, Schindler JL, Diluna ML, Duncan CC, Bulsara KR. Decompressive hemicraniectomy for ischemic stroke in the pediatric population. Neurosurgical Review 2013, 36: 21-4; discussion 24-5. PMID: 22886322, DOI: 10.1007/s10143-012-0411-4.
  • Gamma knife radiosurgery for cerebellopontine angle meningiomas: a multicenter study.Ding D, Starke RM, Kano H, Nakaji P, Barnett GH, Mathieu D, Chiang V, Omay SB, Hess J, McBride HL, Honea N, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD, Sheehan JP. Gamma knife radiosurgery for cerebellopontine angle meningiomas: a multicenter study. Neurosurgery 2014, 75: 398-408; quiz 408. PMID: 24991710, DOI: 10.1227/NEU.0000000000000480.
  • Lung Cancer Brain Metastases.Goldberg SB, Contessa JN, Omay SB, Chiang V. Lung Cancer Brain Metastases. Cancer Journal (Sudbury, Mass.) 2015, 21: 398-403. PMID: 26389765, DOI: 10.1097/PPO.0000000000000146.
  • Visual outcome after pituitary adenoma surgery.Omay SB, Schwartz TH. Visual outcome after pituitary adenoma surgery. Neurology India 2016, 64: 1254-1255. PMID: 27841195, DOI: 10.4103/0028-3886.193770.
  • Limitations of the endonasal endoscopic approach in treating olfactory groove meningiomas. A systematic review.Shetty SR, Ruiz-Treviño AS, Omay SB, Almeida JP, Liang B, Chen YN, Singh H, Schwartz TH. Limitations of the endonasal endoscopic approach in treating olfactory groove meningiomas. A systematic review. Acta Neurochirurgica 2017, 159: 1875-1885. PMID: 28831590, DOI: 10.1007/s00701-017-3303-0.
  • Transtubular excisional biopsy as a rescue for a non-diagnostic stereotactic needle biopsy-case report and literature review.Chen YN, Omay SB, Shetty SR, Liang B, Almeida JP, Ruiz-Treviño AS, Lavi E, Schwartz TH. Transtubular excisional biopsy as a rescue for a non-diagnostic stereotactic needle biopsy-case report and literature review. Acta Neurochirurgica 2017, 159: 1589-1595. PMID: 28688051, DOI: 10.1007/s00701-017-3260-7.
  • Transorbital endoscopic approach for exposure of the sylvian fissure, middle cerebral artery and crural cistern: an anatomical study.Almeida JP, Ruiz-Treviño AS, Shetty SR, Omay SB, Anand VK, Schwartz TH. Transorbital endoscopic approach for exposure of the sylvian fissure, middle cerebral artery and crural cistern: an anatomical study. Acta Neurochirurgica 2017, 159: 1893-1907. PMID: 28808799, DOI: 10.1007/s00701-017-3296-8.
  • Predictors and incidence of orthostatic headache associated with lumbar drain placement following endoscopic endonasal skull base surgery.Liang B, Shetty SR, Omay SB, Almeida JP, Ni S, Chen YN, Ruiz-Treviño AS, Anand VK, Schwartz TH. Predictors and incidence of orthostatic headache associated with lumbar drain placement following endoscopic endonasal skull base surgery. Acta Neurochirurgica 2017, 159: 1379-1385. PMID: 28643170, DOI: 10.1007/s00701-017-3247-4.
  • Transorbital endoscopic eyelid approach for resection of sphenoorbital meningiomas with predominant hyperostosis: report of 2 cases.Almeida JP, Omay SB, Shetty SR, Chen YN, Ruiz-Treviño AS, Liang B, Anand VK, Levine B, Schwartz TH. Transorbital endoscopic eyelid approach for resection of sphenoorbital meningiomas with predominant hyperostosis: report of 2 cases. Journal Of Neurosurgery 2018, 128: 1885-1895. PMID: 28862553, DOI: 10.3171/2017.3.JNS163110.
  • Is the chiasm-pituitary corridor size important for achieving gross-total resection during endonasal endoscopic resection of craniopharyngiomas?Omay SB, Almeida JP, Chen YN, Shetty SR, Liang B, Ni S, Anand VK, Schwartz TH. Is the chiasm-pituitary corridor size important for achieving gross-total resection during endonasal endoscopic resection of craniopharyngiomas? Journal Of Neurosurgery 2018, 129: 642-647. PMID: 29171802, DOI: 10.3171/2017.6.JNS163188.
  • Reoperation for growth hormone-secreting pituitary adenomas: report on an endonasal endoscopic series with a systematic review and meta-analysis of the literature.Almeida JP, Ruiz-Treviño AS, Liang B, Omay SB, Shetty SR, Chen YN, Anand VK, Grover K, Christos P, Schwartz TH. Reoperation for growth hormone-secreting pituitary adenomas: report on an endonasal endoscopic series with a systematic review and meta-analysis of the literature. Journal Of Neurosurgery 2018, 129: 404-416. PMID: 28862548, DOI: 10.3171/2017.2.JNS162673.
  • Do craniopharyngioma molecular signatures correlate with clinical characteristics?Omay SB, Chen YN, Almeida JP, Ruiz-Treviño AS, Boockvar JA, Stieg PE, Greenfield JP, Souweidane MM, Kacker A, Pisapia DJ, Anand VK, Schwartz TH. Do craniopharyngioma molecular signatures correlate with clinical characteristics? Journal Of Neurosurgery 2018, 128: 1473-1478. PMID: 28707994, DOI: 10.3171/2017.1.JNS162232.
  • Endonasal endoscopic pituitary surgery in the elderly.Wilson PJ, Omay SB, Kacker A, Anand VK, Schwartz TH. Endonasal endoscopic pituitary surgery in the elderly. Journal Of Neurosurgery 2018, 128: 429-436. PMID: 28387628, DOI: 10.3171/2016.11.JNS162286.
  • Correlations between genomic subgroup and clinical features in a cohort of more than 3000 meningiomas.Youngblood MW, Duran D, Montejo JD, Li C, Omay SB, Özduman K, Sheth AH, Zhao AY, Tyrtova E, Miyagishima DF, Fomchenko EI, Hong CS, Clark VE, Riche M, Peyre M, Boetto J, Sohrabi S, Koljaka S, Baranoski JF, Knight J, Zhu H, Pamir MN, Avşar T, Kilic T, Schramm J, Timmer M, Goldbrunner R, Gong Y, Bayri Y, Amankulor N, Hamilton RL, Bilguvar K, Tikhonova I, Tomak PR, Huttner A, Simon M, Krischek B, Kalamarides M, Erson-Omay EZ, Moliterno J, Günel M. Correlations between genomic subgroup and clinical features in a cohort of more than 3000 meningiomas. Journal Of Neurosurgery 2019, 1-10. PMID: 31653806, DOI: 10.3171/2019.8.JNS191266.
  • Diagnosis and Management of pituitary disease with focus on the role of Magnetic Resonance Imaging.Mahajan A, Bronen RA, Mian AY, Omay SB, Spencer DD, Inzucchi SE. Diagnosis and Management of pituitary disease with focus on the role of Magnetic Resonance Imaging. Endocrine 2020, 68: 489-501. PMID: 32162185, DOI: 10.1007/s12020-020-02242-3.
  • Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial.Goldberg SB, Schalper KA, Gettinger SN, Mahajan A, Herbst RS, Chiang AC, Lilenbaum R, Wilson FH, Omay SB, Yu JB, Jilaveanu L, Tran T, Pavlik K, Rowen E, Gerrish H, Komlo A, Gupta R, Wyatt H, Ribeiro M, Kluger Y, Zhou G, Wei W, Chiang VL, Kluger HM. Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial. The Lancet. Oncology 2020, 21: 655-663. PMID: 32251621, PMCID: PMC7380514, DOI: 10.1016/S1470-2045(20)30111-X.
  • Large-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature.Gummadavelli A, Dinauer C, McGuone D, Vining EM, Erson-Omay EZ, Omay SB. Large-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature. Journal Of Clinical Neuroscience : Official Journal Of The Neurosurgical Society Of Australasia 2020, 78: 420-422. PMID: 32336638, DOI: 10.1016/j.jocn.2020.04.103.
  • Molecular Diagnosis and Extracranial Extension in Cushing Disease.Hong CS, Murari K, Gossmann M, Mahajan A, Erson-Omay Z, Manes RP, Omay SB. Molecular Diagnosis and Extracranial Extension in Cushing Disease. JAMA Otolaryngology-- Head & Neck Surgery 2020, 146: 865-867. PMID: 32644156, DOI: 10.1001/jamaoto.2020.1471.
  • Association of race and ethnicity to incident epilepsy, or epileptogenesis, after subdural hematoma.Brown SC, King ZA, Kuohn L, Kamel H, Gilmore EJ, Frontera JA, Murthy S, Kim JA, Omay SB, Falcone GJ, Sheth KN. Association of race and ethnicity to incident epilepsy, or epileptogenesis, after subdural hematoma. Neurology 2020, 95: e2890-e2899. PMID: 32907969, PMCID: PMC7734738, DOI: 10.1212/WNL.0000000000010742.
  • Genetic characterization of a case of sellar metastasis from bronchial carcinoid neuroendocrine tumor.Christopher S H, Kundishora AJ, Elsamadicy AA, Koo AB, Beckta JM, McGuone D, Erson-Omay EZ, Omay SB. Genetic characterization of a case of sellar metastasis from bronchial carcinoid neuroendocrine tumor. Surgical Neurology International 2020, 11: 303. PMID: 33093980, PMCID: PMC7568119, DOI: 10.25259/SNI_265_2020.
  • Case Report: Suprasellar Pituitary Adenoma Presenting With Temporal Lobe Seizures.Hong CS, Gorrepati R, Kundishora AJ, Elsamadicy AA, Peter PR, Damisah EC, Manes RP, Omay SB. Case Report: Suprasellar Pituitary Adenoma Presenting With Temporal Lobe Seizures. Frontiers In Surgery 2020, 7: 598138. PMID: 33335912, PMCID: PMC7736041, DOI: 10.3389/fsurg.2020.598138.
  • Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma.Hong CS, Partovi E, Clune J, Huttner A, Park HS, Omay SB. Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma. Case Reports In Genetics 2021, 2021: 5586072. PMID: 33747576, PMCID: PMC7960067, DOI: 10.1155/2021/5586072.
  • Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells.Tran TT, Rane CK, Zito CR, Weiss SA, Jessel S, Lucca L, Lu BY, Oria VO, Adeniran A, Chiang VL, Omay SB, Hafler DA, Kluger HM, Jilaveanu LB. Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells. Cancers 2021, 13 PMID: 33801444, PMCID: PMC7958624, DOI: 10.3390/cancers13051049.
  • Somatic NF1 mutations in pituitary adenomas: Report of two cases.Hong CS, Kundishora AJ, Elsamadicy AA, Koo AB, McGuone D, Inzucchi SE, Omay SB, Erson-Omay EZ. Somatic NF1 mutations in pituitary adenomas: Report of two cases. Cancer Genetics 2021, 256-257: 26-30. PMID: 33862521, DOI: 10.1016/j.cancergen.2021.03.004.
  • Sporadic adamantinomatous craniopharyngioma with double-hit somatic APC mutations.Hong CS, Omuro A, An Y, Inzucchi SE, Kohli AA, McGuone D, Vining EM, Omay SB, Erson-Omay EZ. Sporadic adamantinomatous craniopharyngioma with double-hit somatic APC mutations. Neuro-oncology Advances 2021, 3: vdab124. PMID: 34549183, PMCID: PMC8446933, DOI: 10.1093/noajnl/vdab124.
  • PIK3CA mutation in a case of CTNNB1-mutant sinonasal glomangiopericytoma.Hong C, Khan M, Sukys JM, Prasad M, Erson-Omay EZ, Vining EM, Omay SB. PIK3CA mutation in a case of CTNNB1-mutant sinonasal glomangiopericytoma. Cold Spring Harbor Molecular Case Studies 2022, 8 PMID: 34667073, DOI: 10.1101/mcs.a006120.
  • Sinonasal Glomangiopericytoma: Review of Imaging Appearance and Clinical Management Update for a Rare Sinonasal Neoplasm.Al-Jobory YM, Pan Z, Manes RP, Omay SB, Ikuta I. Sinonasal Glomangiopericytoma: Review of Imaging Appearance and Clinical Management Update for a Rare Sinonasal Neoplasm. The Yale Journal Of Biology And Medicine 2021, 94: 593-597. PMID: 34970096, PMCID: PMC8686777.
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