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Ruth R Montgomery, PhD

Professor of Medicine and Professor of Epidemiology (Microbial Diseases); Director, Yale CyTOF Facility; Associate Dean for Scientific Affairs

Contact Information

Ruth R Montgomery, PhD

Mailing Address

  • Rheumatology

    PO Box 208056, 333 Cedar Street

    New Haven, CT 06520-8056

    United States

Research Summary

My research focuses on translational studies of primary human cells in disease susceptibility and divergent clinical outcomes. The focus of our lab’s research is on innate immunity, specifically the interaction of macrophages, neutrophils, and dendritic cells with pathogens. We study the effect of aging on immune responses in large cohort study of human subjects, and show dysregulation of antiviral immunity in aging. We have published several methods using novel emerging technology to advance translational studies. In collaborative studies, we evaluate immune responses broadly in asthma, dengue virus, hepatitis C virus, humanized mice, leptospirosis, and Zika virus infections.

Our recent work employs CyTOF, a mass-spec based cell analyzer which provides multi-dimensional single cell data in suspension or in tissue sections. CyTOF improves on fluorescent flow cytometry by allowing detection of a greater number of markers per sample (~50) essentially without background signals or overlap between signals. I direct Yale's CyTOF Facility which houses two Helios instruments, one for cells in suspension and one dedicated to the Imaging Mass Cytometer (IMC) and I work with investigators to facilitate use of this novel platform.

Specialized Terms: Innate Immunity; Macrophage; Neutrophil; Aging; West Nile Virus

Extensive Research Description

Immune profiling; Single cell mass cytometry


Research Interests

Aging; Immune System; Immunity, Innate; Immune System Diseases; Macrophages; Neutrophils; Pathology; Public Health; Rheumatology; Virus Diseases; West Nile virus

Public Health Interests


Research Images

Selected Publications

Clinical Trials

ConditionsStudy Title
Immune System; Men's Health; Women's HealthEffects of circadian regulation and sleep on immune responses
Diseases of the Respiratory Systems; COVID-19 Inpatient; COVID-19 OutpatientA Study Tracking Health Care Workers Exposed to COVID-19
Addictive Behaviors; HIV/AIDS; Infectious DiseasesImpact of HIV Infection on Immunologic, Transcriptomic, and Metabolomic Signatures