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Robert Homer, MD, PhD

Professor of Pathology; Director, Thoracic Pathology; Director of Medical Studies; Director, Medical Student Course Module

Contact Information

Robert Homer, MD, PhD

Office Location

Mailing Address

  • Pathology

    310 Cedar Street, PO Box 208023

    New Haven, CT 06520-8023

    United States

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Yale Medicine

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Research Summary

(1). Models of inflammatory lung disease especially fibrosis.

(2) Miscellaneous interests include autopsy pathology, case reports, and quality assurance issues in pathology.

Specialized Terms: Lung pathology; Interstitial lung disease; immunopathology; Pathology of animal models of asthma; Pulmonary fibrosis; Acute lung injury; Emphysema

Extensive Research Description

(1) Pathology of asthma and other inflammatory lung diseases. I am the pathology co-principle investigator on several NIH grants relating to inflammatory lung disease including fibrosis, sepsis and infection. As such I select, perform, and analyze appropriate morphologic assays, primarily for light microscopy.

2) Miscellaneous interests include autopsy pathology, case reports, and quality assurance issues in pathology.

Coauthors

Research Interests

Asthma; Education, Medical; Emphysema; Lung; Pathology; Pulmonary Fibrosis; Lung Diseases, Interstitial; Acute Lung Injury

Research Image

Eosinophilic lung disease

Eosinophilic response in fibrotic lung disease.

Selected Publications

  • A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma.Baine MK, Sinard JH, Cai G, Homer RJ. A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma. American Journal Of Clinical Pathology 2020, 153: 165-174. PMID: 31593583, PMCID: PMC7571487, DOI: 10.1093/ajcp/aqz149.
  • Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations.Starrett JH, Guernet AA, Cuomo ME, Poels KE, van Alderwerelt van Rosenburgh IK, Nagelberg A, Farnsworth D, Price KS, Khan H, Ashtekar KD, Gaefele M, Ayeni D, Stewart TF, Kuhlmann A, Kaech S, Unni AM, Homer R, Lockwood WW, Michor F, Goldberg SB, Lemmon MA, Smith PD, Cross DA, Politi K. Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations. Cancer Research 2020, 80: 2017-2030. PMID: 32193290, PMCID: PMC7392201, DOI: 10.1158/0008-5472.CAN-19-3819.
  • Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling.Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. BioRxiv : The Preprint Server For Biology 2020 PMID: 32577647, PMCID: PMC7302201, DOI: 10.1101/2020.05.27.118893.
  • Mouse Model of SARS-CoV-2 Reveals Inflammatory Role of Type I Interferon Signaling.Goldman-Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer R, Ring A, Wilen C, Iwasaki A. Mouse Model of SARS-CoV-2 Reveals Inflammatory Role of Type I Interferon Signaling. SSRN 2020, 3628297. PMID: 32714125, PMCID: PMC7366812, DOI: 10.2139/ssrn.3628297.
  • Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling.Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. The Journal Of Experimental Medicine 2020, 217 PMID: 32750141, PMCID: PMC7401025, DOI: 10.1084/jem.20201241.
  • Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis.Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Science Advances 2020, 6: eaba1983. PMID: 32832599, PMCID: PMC7439502, DOI: 10.1126/sciadv.aba1983.
  • Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis.Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Science Advances 2020, 6 PMID: 32937511, DOI: 10.1126/sciadv.aba1983.
  • Initial Evaluation of Rapid, Direct-to-Digital Prostate Biopsy Pathology.Torres R, Olson E, Homer R, Martin DT, Levene MJ, Perincheri S, Sprenkle PC, Humphrey PA. Initial Evaluation of Rapid, Direct-to-Digital Prostate Biopsy Pathology. Archives Of Pathology & Laboratory Medicine 2021, 145: 583-591. PMID: 32991670, DOI: 10.5858/arpa.2020-0037-OA.
  • False-positive pathology: improving reproducibility with the next generation of pathologists.Mazer BL, Homer RJ, Rimm DL. False-positive pathology: improving reproducibility with the next generation of pathologists. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2019, 99: 1260-1265. PMID: 31019290, DOI: 10.1038/s41374-019-0257-2.
  • Low ambient humidity impairs barrier function and innate resistance against influenza infection.Kudo E, Song E, Yockey LJ, Rakib T, Wong PW, Homer RJ, Iwasaki A. Low ambient humidity impairs barrier function and innate resistance against influenza infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 10905-10910. PMID: 31085641, PMCID: PMC6561219, DOI: 10.1073/pnas.1902840116.
  • Reanalysis of the NCCN PD-L1 companion diagnostic assay study for lung cancer in the context of PD-L1 expression findings in triple-negative breast cancer.Rimm DL, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, Roden AC, Hirsch FR, Wistuba II, Pusztai L. Reanalysis of the NCCN PD-L1 companion diagnostic assay study for lung cancer in the context of PD-L1 expression findings in triple-negative breast cancer. Breast Cancer Research : BCR 2019, 21: 72. PMID: 31196152, PMCID: PMC6567382, DOI: 10.1186/s13058-019-1156-6.
  • Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors.Ayeni D, Miller B, Kuhlmann A, Ho PC, Robles-Oteiza C, Gaefele M, Levy S, de Miguel FJ, Perry C, Guan T, Krystal G, Lockwood W, Zelterman D, Homer R, Liu Z, Kaech S, Politi K. Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors. Journal For Immunotherapy Of Cancer 2019, 7: 172. PMID: 31291990, PMCID: PMC6617639, DOI: 10.1186/s40425-019-0643-8.
  • Transcriptional regulatory model of fibrosis progression in the human lung.McDonough JE, Ahangari F, Li Q, Jain S, Verleden SE, Herazo-Maya J, Vukmirovic M, DeIuliis G, Tzouvelekis A, Tanabe N, Chu F, Yan X, Verschakelen J, Homer RJ, Manatakis DV, Zhang J, Ding J, Maes K, De Sadeleer L, Vos R, Neyrinck A, Benos PV, Bar-Joseph Z, Tantin D, Hogg JC, Vanaudenaerde BM, Wuyts WA, Kaminski N. Transcriptional regulatory model of fibrosis progression in the human lung. JCI Insight 2019, 4 PMID: 31600171, PMCID: PMC6948862, DOI: 10.1172/jci.insight.131597.
  • Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.Yu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A, de Castro JPW, DeIuliis G, Ahangari F, Woolard T, Aurelien N, Arrojo E Drigo R, Gan Y, Graham M, Liu X, Homer RJ, Scanlan TS, Mannam P, Lee PJ, Herzog EL, Bianco AC, Kaminski N. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nature Medicine 2018, 24: 39-49. PMID: 29200204, PMCID: PMC5760280, DOI: 10.1038/nm.4447.
  • A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report.Kelleher DW, Yaggi M, Homer R, Herzog EL, Ryu C. A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report. Journal Of Medical Case Reports 2018, 12: 94. PMID: 29650028, PMCID: PMC5897926, DOI: 10.1186/s13256-018-1632-0.
  • SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis.Tzouvelekis A, Yu G, Lino Cardenas CL, Herazo-Maya JD, Wang R, Woolard T, Zhang Y, Sakamoto K, Lee H, Yi JS, DeIuliis G, Xylourgidis N, Ahangari F, Lee PJ, Aidinis V, Herzog EL, Homer R, Bennett AM, Kaminski N. SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2017, 195: 500-514. PMID: 27736153, PMCID: PMC5378419, DOI: 10.1164/rccm.201602-0329OC.
  • Zika virus causes testicular atrophy.Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E. Zika virus causes testicular atrophy. Science Advances 2017, 3: e1602899. PMID: 28261663, PMCID: PMC5321463, DOI: 10.1126/sciadv.1602899.
  • Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling.Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM. Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58: 138-143. PMID: 27469361, PMCID: PMC5209638, DOI: 10.2967/jnumed.116.176198.
  • Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis.Vukmirovic M, Herazo-Maya JD, Blackmon J, Skodric-Trifunovic V, Jovanovic D, Pavlovic S, Stojsic J, Zeljkovic V, Yan X, Homer R, Stefanovic B, Kaminski N. Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis. BMC Pulmonary Medicine 2017, 17: 15. PMID: 28081703, PMCID: PMC5228096, DOI: 10.1186/s12890-016-0356-4.
  • Diagnosing idiopathic pulmonary fibrosis without a lung biopsy: honeycombing not required.Homer R, Lederer DJ. Diagnosing idiopathic pulmonary fibrosis without a lung biopsy: honeycombing not required. Thorax 2017, 72: 391-392. PMID: 28280234, DOI: 10.1136/thoraxjnl-2016-209831.
  • A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung Cancer.Rimm DL, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, West WW, Wu H, Roden AC, Fujimoto J, Yu H, Anders R, Kowalewski A, Rivard C, Rehman J, Batenchuk C, Burns V, Hirsch FR, Wistuba II. A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung Cancer. JAMA Oncology 2017, 3: 1051-1058. PMID: 28278348, PMCID: PMC5650234, DOI: 10.1001/jamaoncol.2017.0013.
  • Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report.Ryu C, Herzog EL, Pan H, Homer R, Gulati M. Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report. The American Journal Of Case Reports 2017, 18: 157-159. PMID: 28190872, PMCID: PMC5319306, DOI: 10.12659/ajcr.902231.
  • Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis.Peng X, Moore M, Mathur A, Zhou Y, Sun H, Gan Y, Herazo-Maya JD, Kaminski N, Hu X, Pan H, Ryu C, Osafo-Addo A, Homer RJ, Feghali-Bostwick C, Fares W, Gulati M, Hu B, Lee CG, Elias JA, Herzog EL. Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2016, 30: 4056-4070. PMID: 27609773, PMCID: PMC5102121, DOI: 10.1096/fj.201600373R.
  • Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice.Sureshbabu A, Syed M, Das P, Janér C, Pryhuber G, Rahman A, Andersson S, Homer RJ, Bhandari V. Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice. American Journal Of Respiratory Cell And Molecular Biology 2016, 55: 722-735. PMID: 27374190, PMCID: PMC5105179, DOI: 10.1165/rcmb.2015-0349OC.
  • The Airway in Idiopathic Pulmonary Fibrosis: Protecting the Lung or Promoting Disease?Ryu C, Homer RJ, Herzog EL. The Airway in Idiopathic Pulmonary Fibrosis: Protecting the Lung or Promoting Disease? American Journal Of Respiratory And Critical Care Medicine 2016, 193: 1081-2. PMID: 27174477, PMCID: PMC4872674, DOI: 10.1164/rccm.201601-0055ED.
  • Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells.Forloni M, Gupta R, Nagarajan A, Sun LS, Dong Y, Pirazzoli V, Toki M, Wurtz A, Melnick MA, Kobayashi S, Homer RJ, Rimm DL, Gettinger SJ, Politi K, Dogra SK, Wajapeyee N. Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells. Cell Reports 2016, 16: 457-471. PMID: 27346347, PMCID: PMC4945411, DOI: 10.1016/j.celrep.2016.05.087.
  • Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration.Bramley K, Pisani MA, Murphy TE, Araujo KL, Homer RJ, Puchalski JT. Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration. The Annals Of Thoracic Surgery 2016, 101: 1870-6. PMID: 26912301, PMCID: PMC4861078, DOI: 10.1016/j.athoracsur.2015.11.051.
  • Role of Nitric Oxide Isoforms in Vascular and Alveolar Development and Lung Injury in Vascular Endothelial Growth Factor Overexpressing Neonatal Mice Lungs.Syed MA, Choo-Wing R, Homer RJ, Bhandari V. Role of Nitric Oxide Isoforms in Vascular and Alveolar Development and Lung Injury in Vascular Endothelial Growth Factor Overexpressing Neonatal Mice Lungs. PloS One 2016, 11: e0147588. PMID: 26799210, PMCID: PMC4723240, DOI: 10.1371/journal.pone.0147588.
  • Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science (New York, N.Y.) 2016, 352: 463-6. PMID: 27102485, PMCID: PMC5465864, DOI: 10.1126/science.aaf3926.
  • Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling.Bruscia E, Zhang PX, Barone C, Scholte B, Homer RJ, Krause D, Egan ME. Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2016, 310: L711-9. PMID: 26851259, PMCID: PMC4836110, DOI: 10.1152/ajplung.00284.2015.
  • ORAL01.01: A Prospective, Multi-Institutional Assessment of Four Assays for PD-L1 Expression in NSCLC by Immunohistochemistry: Topic: Pathology.Rimm D, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, West WW, Wu H, Roden AC, Fujimoto J, Yu H, Anders R, Kowalewski A, Rivard C, Rehman J, Hirsch F, Wistuba II. ORAL01.01: A Prospective, Multi-Institutional Assessment of Four Assays for PD-L1 Expression in NSCLC by Immunohistochemistry: Topic: Pathology. Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer 2016, 11: S249. PMID: 27969440, DOI: 10.1016/j.jtho.2016.09.006.
  • Comparison of Transbronchial and Cryobiopsies in Evaluation of Diffuse Parenchymal Lung Disease.Ramaswamy A, Homer R, Killam J, Pisani MA, Murphy TE, Araujo K, Puchalski J. Comparison of Transbronchial and Cryobiopsies in Evaluation of Diffuse Parenchymal Lung Disease. Journal Of Bronchology & Interventional Pulmonology 2016, 23: 14-21. PMID: 26705007, PMCID: PMC4864578, DOI: 10.1097/LBR.0000000000000246.
  • Suppression of NLRX1 in chronic obstructive pulmonary disease.Kang MJ, Yoon CM, Kim BH, Lee CM, Zhou Y, Sauler M, Homer R, Dhamija A, Boffa D, West AP, Shadel GS, Ting JP, Tedrow JR, Kaminski N, Kim WJ, Lee CG, Oh YM, Elias JA. Suppression of NLRX1 in chronic obstructive pulmonary disease. The Journal Of Clinical Investigation 2015, 125: 2458-62. PMID: 25938787, PMCID: PMC4497738, DOI: 10.1172/JCI71747.
  • Pathologists' staging of multiple foci of lung cancer: poor concordance in absence of dramatic histologic or molecular differences.Homer RJ. Pathologists' staging of multiple foci of lung cancer: poor concordance in absence of dramatic histologic or molecular differences. American Journal Of Clinical Pathology 2015, 143: 701-6. PMID: 25873504, DOI: 10.1309/AJCPNBWF55VGKOIW.
  • Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung.Sureshbabu A, Syed MA, Boddupalli CS, Dhodapkar MV, Homer RJ, Minoo P, Bhandari V. Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung. Respiratory Research 2015, 16: 4. PMID: 25591994, PMCID: PMC4307226, DOI: 10.1186/s12931-014-0162-6.
  • CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung.Peng X, Moore MW, Peng H, Sun H, Gan Y, Homer RJ, Herzog EL. CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung. Frontiers In Pharmacology 2014, 5: 80. PMID: 24904415, PMCID: PMC4032896, DOI: 10.3389/fphar.2014.00080.
  • IL-6 receptor α defines effector memory CD8+ T cells producing Th2 cytokines and expanding in asthma.Lee N, You S, Shin MS, Lee WW, Kang KS, Kim SH, Kim WU, Homer RJ, Kang MJ, Montgomery RR, Dela Cruz CS, Shaw AC, Lee PJ, Chupp GL, Hwang D, Kang I. IL-6 receptor α defines effector memory CD8+ T cells producing Th2 cytokines and expanding in asthma. American Journal Of Respiratory And Critical Care Medicine 2014, 190: 1383-94. PMID: 25390970, PMCID: PMC4299645, DOI: 10.1164/rccm.201403-0601OC.
  • Cathepsin E promotes pulmonary emphysema via mitochondrial fission.Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ. Cathepsin E promotes pulmonary emphysema via mitochondrial fission. The American Journal Of Pathology 2014, 184: 2730-41. PMID: 25239563, PMCID: PMC4188869, DOI: 10.1016/j.ajpath.2014.06.017.
  • Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis.Zhou Y, Peng H, Sun H, Peng X, Tang C, Gan Y, Chen X, Mathur A, Hu B, Slade MD, Montgomery RR, Shaw AC, Homer RJ, White ES, Lee CM, Moore MW, Gulati M, Lee CG, Elias JA, Herzog EL. Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis. Science Translational Medicine 2014, 6: 240ra76. PMID: 24920662, PMCID: PMC4340473, DOI: 10.1126/scitranslmed.3007096.
  • An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection.Lafferty EI, Flaczyk A, Angers I, Homer R, d'Hennezel E, Malo D, Piccirillo CA, Vidal SM, Qureshi ST. An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection. Genes And Immunity 2014, 15: 320-32. PMID: 24848930, PMCID: PMC4978536, DOI: 10.1038/gene.2014.22.
  • A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung.Sun H, Choo-Wing R, Sureshbabu A, Fan J, Leng L, Yu S, Jiang D, Noble P, Homer RJ, Bucala R, Bhandari V. A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. PloS One 2013, 8: e60560. PMID: 23637753, PMCID: PMC3639272, DOI: 10.1371/journal.pone.0060560.
  • Semaphorin 7a+ regulatory T cells are associated with progressive idiopathic pulmonary fibrosis and are implicated in transforming growth factor-β1-induced pulmonary fibrosis.Reilkoff RA, Peng H, Murray LA, Peng X, Russell T, Montgomery R, Feghali-Bostwick C, Shaw A, Homer RJ, Gulati M, Mathur A, Elias JA, Herzog EL. Semaphorin 7a+ regulatory T cells are associated with progressive idiopathic pulmonary fibrosis and are implicated in transforming growth factor-β1-induced pulmonary fibrosis. American Journal Of Respiratory And Critical Care Medicine 2013, 187: 180-8. PMID: 23220917, PMCID: PMC3570653, DOI: 10.1164/rccm.201206-1109OC.
  • IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG. IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2013, 304: L112-24. PMID: 23125252, PMCID: PMC3543640, DOI: 10.1152/ajplung.00101.2012.
  • Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway.Choo-Wing R, Syed MA, Harijith A, Bowen B, Pryhuber G, Janér C, Andersson S, Homer RJ, Bhandari V. Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway. American Journal Of Respiratory Cell And Molecular Biology 2013, 48: 749-57. PMID: 23470621, PMCID: PMC3727872, DOI: 10.1165/rcmb.2012-0381OC.
  • Role of tissue protection in lethal respiratory viral-bacterial coinfection.Jamieson AM, Pasman L, Yu S, Gamradt P, Homer RJ, Decker T, Medzhitov R. Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (New York, N.Y.) 2013, 340: 1230-4. PMID: 23618765, PMCID: PMC3933032, DOI: 10.1126/science.1233632.
  • Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma.Cai G, Wong R, Chhieng D, Levy GH, Gettinger SN, Herbst RS, Puchalski JT, Homer RJ, Hui P. Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma. Cancer Cytopathology 2013, 121: 500-7. PMID: 23495083, DOI: 10.1002/cncy.21288.
  • Interstitial lung disease in the connective tissue diseases.Antin-Ozerkis D, Rubinowitz A, Evans J, Homer RJ, Matthay RA. Interstitial lung disease in the connective tissue diseases. Clinics In Chest Medicine 2012, 33: 123-49. PMID: 22365251, DOI: 10.1016/j.ccm.2012.01.004.
  • Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2.Bhandari V, Choo-Wing R, Harijith A, Sun H, Syed MA, Homer RJ, Elias JA. Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2. American Journal Of Respiratory Cell And Molecular Biology 2012, 46: 668-76. PMID: 22227562, PMCID: PMC3359903, DOI: 10.1165/rcmb.2011-0074OC.
  • Susceptibility to progressive Cryptococcus neoformans pulmonary infection is regulated by loci on mouse chromosomes 1 and 9.Carroll SF, Lafferty EI, Flaczyk A, Fujiwara TM, Homer R, Morgan K, Loredo-Osti JC, Qureshi ST. Susceptibility to progressive Cryptococcus neoformans pulmonary infection is regulated by loci on mouse chromosomes 1 and 9. Infection And Immunity 2012, 80: 4167-76. PMID: 22988020, PMCID: PMC3497416, DOI: 10.1128/IAI.00417-12.
  • Molecular classification of nonsmall cell lung cancer using a 4-protein quantitative assay.Anagnostou VK, Dimou AT, Botsis T, Killiam EJ, Gustavson MD, Homer RJ, Boffa D, Zolota V, Dougenis D, Tanoue L, Gettinger SN, Detterbeck FC, Syrigos KN, Bepler G, Rimm DL. Molecular classification of nonsmall cell lung cancer using a 4-protein quantitative assay. Cancer 2012, 118: 1607-18. PMID: 22009766, DOI: 10.1002/cncr.26450.
  • Chronic inflammation and lung fibrosis: pleotropic syndromes but limited distinct phenotypes.Gifford AH, Matsuoka M, Ghoda LY, Homer RJ, Enelow RI. Chronic inflammation and lung fibrosis: pleotropic syndromes but limited distinct phenotypes. Mucosal Immunology 2012, 5: 480-4. PMID: 22806097, DOI: 10.1038/mi.2012.68.
  • RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism.Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA. RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. American Journal Of Respiratory And Critical Care Medicine 2011, 183: 1322-35. PMID: 21278304, PMCID: PMC3114061, DOI: 10.1164/rccm.201008-1276OC.
  • Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease.Gan Y, Reilkoff R, Peng X, Russell T, Chen Q, Mathai SK, Homer R, Gulati M, Siner J, Elias J, Bucala R, Herzog E. Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease. Arthritis And Rheumatism 2011, 63: 2484-94. PMID: 21484765, PMCID: PMC3651701, DOI: 10.1002/art.30386.
  • Modern concepts on the role of inflammation in pulmonary fibrosis.Homer RJ, Elias JA, Lee CG, Herzog E. Modern concepts on the role of inflammation in pulmonary fibrosis. Archives Of Pathology & Laboratory Medicine 2011, 135: 780-8. PMID: 21631273, DOI: 10.5858/2010-0296-RA.1.
  • A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia.Harijith A, Choo-Wing R, Cataltepe S, Yasumatsu R, Aghai ZH, Janér J, Andersson S, Homer RJ, Bhandari V. A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. American Journal Of Respiratory Cell And Molecular Biology 2011, 44: 621-30. PMID: 21216975, PMCID: PMC3095982, DOI: 10.1165/rcmb.2010-0058OC.
  • Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway.Mijares LA, Wangdi T, Sokol C, Homer R, Medzhitov R, Kazmierczak BI. Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 186: 7080-8. PMID: 21572023, PMCID: PMC3110630, DOI: 10.4049/jimmunol.1003687.
  • Approach to the ground-glass nodule.Detterbeck FC, Homer RJ. Approach to the ground-glass nodule. Clinics In Chest Medicine 2011, 32: 799-810. PMID: 22054887, DOI: 10.1016/j.ccm.2011.08.002.
  • Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema.Matsuura H, Hartl D, Kang MJ, Dela Cruz CS, Koller B, Chupp GL, Homer RJ, Zhou Y, Cho WK, Elias JA, Lee CG. Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema. American Journal Of Respiratory Cell And Molecular Biology 2011, 44: 777-86. PMID: 20656949, PMCID: PMC3135840, DOI: 10.1165/rcmb.2010-0081OC.
  • IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease.Mitchell C, Provost K, Niu N, Homer R, Cohn L. IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 187: 3815-20. PMID: 21873527, PMCID: PMC3178669, DOI: 10.4049/jimmunol.1100436.
  • TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P.Murray LA, Chen Q, Kramer MS, Hesson DP, Argentieri RL, Peng X, Gulati M, Homer RJ, Russell T, van Rooijen N, Elias JA, Hogaboam CM, Herzog EL. TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P. The International Journal Of Biochemistry & Cell Biology 2011, 43: 154-62. PMID: 21044893, DOI: 10.1016/j.biocel.2010.10.013.
  • Pulmonary manifestations of rheumatoid arthritis.Antin-Ozerkis D, Evans J, Rubinowitz A, Homer RJ, Matthay RA. Pulmonary manifestations of rheumatoid arthritis. Clinics In Chest Medicine 2010, 31: 451-78. PMID: 20692539, DOI: 10.1016/j.ccm.2010.04.003.
  • Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4.Jiang D, Liang J, Campanella GS, Guo R, Yu S, Xie T, Liu N, Jung Y, Homer R, Meltzer EB, Li Y, Tager AM, Goetinck PF, Luster AD, Noble PW. Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4. The Journal Of Clinical Investigation 2010, 120: 2049-57. PMID: 20484822, PMCID: PMC2877927, DOI: 10.1172/JCI38644.
  • High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology.Anagnostou VK, Lowery FJ, Zolota V, Tzelepi V, Gopinath A, Liceaga C, Panagopoulos N, Frangia K, Tanoue L, Boffa D, Gettinger S, Detterbeck F, Homer RJ, Dougenis D, Rimm DL, Syrigos KN. High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology. BMC Cancer 2010, 10: 186. PMID: 20459695, PMCID: PMC2875218, DOI: 10.1186/1471-2407-10-186.
  • Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. The Journal Of Experimental Medicine 2010, 207: 2595-607. PMID: 20975041, PMCID: PMC2989775, DOI: 10.1084/jem.20100786.
  • Recent advances in pulmonary fibrosis: implications for scleroderma.Homer RJ, Herzog EL. Recent advances in pulmonary fibrosis: implications for scleroderma. Current Opinion In Rheumatology 2010, 22: 683-9. PMID: 20693906, DOI: 10.1097/BOR.0b013e32833ddcc9.
  • Regression of murine lung tumors by the let-7 microRNA.Trang P, Medina PP, Wiggins JF, Ruffino L, Kelnar K, Omotola M, Homer R, Brown D, Bader AG, Weidhaas JB, Slack FJ. Regression of murine lung tumors by the let-7 microRNA. Oncogene 2010, 29: 1580-7. PMID: 19966857, PMCID: PMC2841713, DOI: 10.1038/onc.2009.445.
  • Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation.Niu N, Laufer T, Homer RJ, Cohn L. Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 183: 1523-7. PMID: 19596982, DOI: 10.4049/jimmunol.0901349.
  • Of lungs, lipids, and lollipops.Mathai SK, Rubinowitz AN, Homer RJ, Detterbeck F, Herzog EL. Of lungs, lipids, and lollipops. Chest 2009, 136: 1420-1423. PMID: 19892683, DOI: 10.1378/chest.08-2133.
  • Thyroid transcription factor 1 is an independent prognostic factor for patients with stage I lung adenocarcinoma.Anagnostou VK, Syrigos KN, Bepler G, Homer RJ, Rimm DL. Thyroid transcription factor 1 is an independent prognostic factor for patients with stage I lung adenocarcinoma. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2009, 27: 271-8. PMID: 19064983, DOI: 10.1200/JCO.2008.17.0043.
  • High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma.Anagnostou VK, Bepler G, Syrigos KN, Tanoue L, Gettinger S, Homer RJ, Boffa D, Detterbeck F, Rimm DL. High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2009, 15: 4157-64. PMID: 19509151, DOI: 10.1158/1078-0432.CCR-09-0099.
  • Granulomatous bronchiolitis of Crohn's disease successfully treated with inhaled budesonide.Trow TK, Morris DG, Miller CR, Homer RJ. Granulomatous bronchiolitis of Crohn's disease successfully treated with inhaled budesonide. Thorax 2009, 64: 546-7. PMID: 19478123, DOI: 10.1136/thx.2008.107185.
  • Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA. Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. The Journal Of Experimental Medicine 2009, 206: 1149-66. PMID: 19414556, PMCID: PMC2715037, DOI: 10.1084/jem.20081271.
  • A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma.Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.
  • A critical role of SHP-1 in regulation of type 2 inflammation in the lung.Oh SY, Zheng T, Kim YK, Cohn L, Homer RJ, McKenzie AN, Zhu Z. A critical role of SHP-1 in regulation of type 2 inflammation in the lung. American Journal Of Respiratory Cell And Molecular Biology 2009, 40: 568-74. PMID: 18952567, PMCID: PMC2677436, DOI: 10.1165/rcmb.2008-0225OC.
  • P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway.Yamasaki M, Kang HR, Homer RJ, Chapoval SP, Cho SJ, Lee BJ, Elias JA, Lee CG. P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway. American Journal Of Respiratory Cell And Molecular Biology 2008, 38: 346-53. PMID: 17932374, PMCID: PMC2258454, DOI: 10.1165/rcmb.2007-0276OC.
  • Enhanced innate immune responsiveness to pulmonary Cryptococcus neoformans infection is associated with resistance to progressive infection.Guillot L, Carroll SF, Homer R, Qureshi ST. Enhanced innate immune responsiveness to pulmonary Cryptococcus neoformans infection is associated with resistance to progressive infection. Infection And Immunity 2008, 76: 4745-56. PMID: 18678664, PMCID: PMC2546841, DOI: 10.1128/IAI.00341-08.
  • IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA. IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 180: 522-9. PMID: 18097054, DOI: 10.4049/jimmunol.180.1.522.
  • A 34-year-old man presenting with gradual onset of shortness of breath and interstitial lung disease.Rubinowitz AN, Moon M, Homer R. A 34-year-old man presenting with gradual onset of shortness of breath and interstitial lung disease. Chest 2008, 133: 1041-7. PMID: 18398129, DOI: 10.1378/chest.07-2235.
  • Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.Lee CG, Hartl D, Matsuura H, Dunlop FM, Scotney PD, Fabri LJ, Nash AD, Chen NY, Tang CY, Chen Q, Homer RJ, Baca M, Elias JA. Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production. American Journal Of Respiratory Cell And Molecular Biology 2008, 39: 739-46. PMID: 18617680, PMCID: PMC2586049, DOI: 10.1165/rcmb.2008-0053OC.
  • Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia.Zhou J, Matsuoka M, Cantor H, Homer R, Enelow RI. Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 180: 25-9. PMID: 18096998, DOI: 10.4049/jimmunol.180.1.25.
  • Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells.Hartl D, He CH, Koller B, Da Silva CA, Homer R, Lee CG, Elias JA. Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells. The Journal Of Biological Chemistry 2008, 283: 33472-82. PMID: 18824549, PMCID: PMC2586247, DOI: 10.1074/jbc.M805574200.
  • Developmental regulation of NO-mediated VEGF-induced effects in the lung.Bhandari V, Choo-Wing R, Lee CG, Yusuf K, Nedrelow JH, Ambalavanan N, Malkus H, Homer RJ, Elias JA. Developmental regulation of NO-mediated VEGF-induced effects in the lung. American Journal Of Respiratory Cell And Molecular Biology 2008, 39: 420-30. PMID: 18441284, PMCID: PMC2551703, DOI: 10.1165/rcmb.2007-0024OC.
  • A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk.Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, Kidd KK, Zhu Y, Christiani DC, Belinsky SA, Slack FJ, Weidhaas JB. A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Research 2008, 68: 8535-40. PMID: 18922928, PMCID: PMC2672193, DOI: 10.1158/0008-5472.CAN-08-2129.
  • Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice.Bhandari V, Choo-Wing R, Homer RJ, Elias JA. Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 4993-5000. PMID: 17404281, DOI: 10.4049/jimmunol.178.8.4993.
  • Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12.Kang HR, Cho SJ, Lee CG, Homer RJ, Elias JA. Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. The Journal Of Biological Chemistry 2007, 282: 7723-32. PMID: 17209037, DOI: 10.1074/jbc.M610764200.
  • Airway remodeling and RELM-beta.Homer RJ. Airway remodeling and RELM-beta. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2007, 293: L303-4. PMID: 17586697, DOI: 10.1152/ajplung.00226.2007.
  • Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma.Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR. Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 6191-9. PMID: 17475846, DOI: 10.4049/jimmunol.178.10.6191.
  • Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.Chapoval SP, Al-Garawi A, Lora JM, Strickland I, Ma B, Lee PJ, Homer RJ, Ghosh S, Coyle AJ, Elias JA. Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 179: 7030-41. PMID: 17982094, DOI: 10.4049/jimmunol.179.10.7030.
  • Benign pulmonary epithelial inclusions within the pleura: a case report.Kenney B, Pinto M, Homer R. Benign pulmonary epithelial inclusions within the pleura: a case report. Diagnostic Pathology 2007, 2: 21. PMID: 17603877, PMCID: PMC1914110, DOI: 10.1186/1746-1596-2-21.
  • Diffuse alveolar damage and hemorrhage in acute myelogenous leukemia treated with corticosteroids.Grigoriyan A, Rishi A, Molina J, Homer R, Manthous CA. Diffuse alveolar damage and hemorrhage in acute myelogenous leukemia treated with corticosteroids. Connecticut Medicine 2007, 71: 201-4. PMID: 17487004.
  • Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia.Choo-Wing R, Nedrelow JH, Homer RJ, Elias JA, Bhandari V. Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2007, 293: L142-50. PMID: 17400600, DOI: 10.1152/ajplung.00434.2006.
  • Primary malignant melanoma of the transverse colon: report of a case and review of the literature.Kenney B, Dotto J, Homer R, Shafi N, Davydova L. Primary malignant melanoma of the transverse colon: report of a case and review of the literature. International Journal Of Surgical Pathology 2007, 15: 401-7. PMID: 17913951, DOI: 10.1177/1066896907302370.
  • IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 1948-59. PMID: 17237446, DOI: 10.4049/jimmunol.178.3.1948.
  • IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells.Temann UA, Laouar Y, Eynon EE, Homer R, Flavell RA. IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. International Immunology 2007, 19: 1-10. PMID: 17101709, DOI: 10.1093/intimm/dxl117.
  • A novel pathway that regulates inflammatory disease in the respiratory tract.Niu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. A novel pathway that regulates inflammatory disease in the respiratory tract. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 3846-55. PMID: 17339484, DOI: 10.4049/jimmunol.178.6.3846.
  • Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis.Kang HR, Lee CG, Homer RJ, Elias JA. Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis. The Journal Of Experimental Medicine 2007, 204: 1083-93. PMID: 17485510, PMCID: PMC2118575, DOI: 10.1084/jem.20061273.
  • Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung.Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA. Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 11021-6. PMID: 16832062, PMCID: PMC1544167, DOI: 10.1073/pnas.0601057103.
  • ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo.Lee PJ, Zhang X, Shan P, Ma B, Lee CG, Homer RJ, Zhu Z, Rincon M, Mossman BT, Elias JA. ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. The Journal Of Clinical Investigation 2006, 116: 163-73. PMID: 16374521, PMCID: PMC1319220, DOI: 10.1172/JCI25711.
  • Genetic control of transforming growth factor-beta1-induced emphysema and fibrosis in the murine lung.Lee CG, Cho S, Homer RJ, Elias JA. Genetic control of transforming growth factor-beta1-induced emphysema and fibrosis in the murine lung. Proceedings Of The American Thoracic Society 2006, 3: 476-477. PMID: 16921114, DOI: 10.1513/pats.200603-040MS.
  • Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling.Ma B, Liu W, Homer RJ, Lee PJ, Coyle AJ, Lora JM, Lee CG, Elias JA. Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 176: 4968-78. PMID: 16585593, DOI: 10.4049/jimmunol.176.8.4968.
  • State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice.Elias JA, Kang MJ, Crothers K, Homer R, Lee CG. State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice. Proceedings Of The American Thoracic Society 2006, 3: 494-8. PMID: 16921126, DOI: 10.1513/pats.200603-068MS.
  • Role of 5-lipoxygenase in IL-13-induced pulmonary inflammation and remodeling.Shim YM, Zhu Z, Zheng T, Lee CG, Homer RJ, Ma B, Elias JA. Role of 5-lipoxygenase in IL-13-induced pulmonary inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177: 1918-24. PMID: 16849505, DOI: 10.4049/jimmunol.177.3.1918.
  • Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis.Ma B, Blackburn MR, Lee CG, Homer RJ, Liu W, Flavell RA, Boyden L, Lifton RP, Sun CX, Young HW, Elias JA. Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. The Journal Of Clinical Investigation 2006, 116: 1274-83. PMID: 16670768, PMCID: PMC1451205, DOI: 10.1172/JCI26372.
  • IFN-gamma-dependent DNA injury and/or apoptosis are critical in cigarette smoke-induced murine emphysema.Kang MJ, Lee CG, Cho SJ, Homer RJ, Elias JA. IFN-gamma-dependent DNA injury and/or apoptosis are critical in cigarette smoke-induced murine emphysema. Proceedings Of The American Thoracic Society 2006, 3: 517-8. PMID: 16921135, DOI: 10.1513/pats.200603-075MS.
  • Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nature Medicine 2006, 12: 1286-93. PMID: 17086189, PMCID: PMC2768268, DOI: 10.1038/nm1494.
  • Massive cavitary pulmonary rheumatoid nodules in a patient with HIV.Khazeni N, Homer RJ, Rubinowitz AN, Chupp GL. Massive cavitary pulmonary rheumatoid nodules in a patient with HIV. The European Respiratory Journal 2006, 28: 872-4. PMID: 17012633, DOI: 10.1183/09031936.06.00144105.
  • Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling.Lee CG, Kang HR, Homer RJ, Chupp G, Elias JA. Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling. Proceedings Of The American Thoracic Society 2006, 3: 418-23. PMID: 16799085, PMCID: PMC2658706, DOI: 10.1513/pats.200602-017AW.
  • Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling.Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA, Lee CG. Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. The Journal Of Biological Chemistry 2006, 281: 8161-8. PMID: 16439363, DOI: 10.1074/jbc.M506770200.
  • Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation.Homer RJ, Zhu Z, Cohn L, Lee CG, White WI, Chen S, Elias JA. Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2006, 291: L502-11. PMID: 16556727, DOI: 10.1152/ajplung.00364.2005.
  • Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury.Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW, Lee PJ. Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 175: 4834-8. PMID: 16210584, DOI: 10.4049/jimmunol.175.8.4834.
  • Case study review.Noble PW, Tanoue L, Homer R. Case study review. Chest 2005, 128: 540S-546S. PMID: 16304245, DOI: 10.1378/chest.128.5_suppl_1.540S.
  • Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema.Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 174: 8106-15. PMID: 15944319, DOI: 10.4049/jimmunol.174.12.8106.
  • Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury.He CH, Waxman AB, Lee CG, Link H, Rabach ME, Ma B, Chen Q, Zhu Z, Zhong M, Nakayama K, Nakayama KI, Homer R, Elias JA. Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. The Journal Of Clinical Investigation 2005, 115: 1039-48. PMID: 15841185, PMCID: PMC1070412, DOI: 10.1172/JCI23004.
  • Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma.Elias JA, Homer RJ, Hamid Q, Lee CG. Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma. The Journal Of Allergy And Clinical Immunology 2005, 116: 497-500. PMID: 16159614, DOI: 10.1016/j.jaci.2005.06.028.
  • Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema.Ma B, Kang MJ, Lee CG, Chapoval S, Liu W, Chen Q, Coyle AJ, Lora JM, Picarella D, Homer RJ, Elias JA. Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema. The Journal Of Clinical Investigation 2005, 115: 3460-72. PMID: 16284650, PMCID: PMC1280966, DOI: 10.1172/JCI24858.
  • IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling.Chen Q, Rabach L, Noble P, Zheng T, Lee CG, Homer RJ, Elias JA. IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 174: 2305-13. PMID: 15699166, DOI: 10.4049/jimmunol.174.4.2305.
  • Airway remodeling in asthma: therapeutic implications of mechanisms.Homer RJ, Elias JA. Airway remodeling in asthma: therapeutic implications of mechanisms. Physiology (Bethesda, Md.) 2005, 20: 28-35. PMID: 15653837, DOI: 10.1152/physiol.00035.2004.
  • Regulation of lung injury and repair by Toll-like receptors and hyaluronan.Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nature Medicine 2005, 11: 1173-9. PMID: 16244651, DOI: 10.1038/nm1315.
  • Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury.Severgnini M, Takahashi S, Tu P, Perides G, Homer RJ, Jhung JW, Bhavsar D, Cochran BH, Simon AR. Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury. American Journal Of Respiratory And Critical Care Medicine 2005, 171: 858-67. PMID: 15665321, DOI: 10.1164/rccm.200407-981OC.
  • Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis.Noble PW, Homer RJ. Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2005, 33: 113-20. PMID: 16024580, DOI: 10.1165/rcmb.F301.
  • Idiopathic pulmonary fibrosis: new insights into pathogenesis.Noble PW, Homer RJ. Idiopathic pulmonary fibrosis: new insights into pathogenesis. Clinics In Chest Medicine 2004, 25: 749-58, vii. PMID: 15564020, DOI: 10.1016/j.ccm.2004.04.003.
  • Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q, Elias JA. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science (New York, N.Y.) 2004, 304: 1678-82. PMID: 15192232, DOI: 10.1126/science.1095336.
  • Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma.Kawikova I, Paliwal V, Szczepanik M, Itakura A, Fukui M, Campos RA, Geba GP, Homer RJ, Iliopoulou BP, Pober JS, Tsuji RF, Askenase PW. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology 2004, 113: 234-45. PMID: 15379984, PMCID: PMC1782564, DOI: 10.1111/j.1365-2567.2004.01936.x.
  • Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis.Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. The Journal Of Experimental Medicine 2004, 200: 377-89. PMID: 15289506, PMCID: PMC2211975, DOI: 10.1084/jem.20040104.
  • Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nature Medicine 2004, 10: 1095-103. PMID: 15378055, PMCID: PMC3434232, DOI: 10.1038/nm1105.
  • The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling.Ma B, Zhu Z, Homer RJ, Gerard C, Strieter R, Elias JA. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2004, 172: 1872-81. PMID: 14734772, DOI: 10.4049/jimmunol.172.3.1872.
  • Regulation of pulmonary fibrosis by chemokine receptor CXCR3.Jiang D, Liang J, Hodge J, Lu B, Zhu Z, Yu S, Fan J, Gao Y, Yin Z, Homer R, Gerard C, Noble PW. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. The Journal Of Clinical Investigation 2004, 114: 291-9. PMID: 15254596, PMCID: PMC449741, DOI: 10.1172/JCI16861.
  • Activation of the STAT pathway in acute lung injury.Severgnini M, Takahashi S, Rozo LM, Homer RJ, Kuhn C, Jhung JW, Perides G, Steer M, Hassoun PM, Fanburg BL, Cochran BH, Simon AR. Activation of the STAT pathway in acute lung injury. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2004, 286: L1282-92. PMID: 14729509, DOI: 10.1152/ajplung.00349.2003.
  • Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro.Zheng T, Zhu Z, Liu W, Lee CG, Chen Q, Homer RJ, Elias JA. Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro. The Journal Of Allergy And Clinical Immunology 2003, 111: 720-8. PMID: 12704349, DOI: 10.1067/mai.2003.1383.
  • Interleukin-13 induces surfactant function abnormality in the murine lung.Zhu Z, Enhorning G, Zheng T, Chen Q, Chen NY, Homer R, Elias JA. Interleukin-13 induces surfactant function abnormality in the murine lung. Chest 2003, 123: 375S-6S. PMID: 12628990.
  • New insights into the pathogenesis of asthma.Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z. New insights into the pathogenesis of asthma. The Journal Of Clinical Investigation 2003, 111: 291-7. PMID: 12569150, PMCID: PMC151878, DOI: 10.1172/JCI17748.
  • Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia.Wang J, Chen Q, Corne J, Zhu Z, Lee CG, Bhandari V, Homer RJ, Elias JA. Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia. The Journal Of Biological Chemistry 2003, 278: 31226-32. PMID: 12782633, DOI: 10.1074/jbc.M301820200.
  • Transgenic modeling of interleukin-13 in the lung.Elias JA, Zheng T, Lee CG, Homer RJ, Chen Q, Ma B, Blackburn M, Zhu Z. Transgenic modeling of interleukin-13 in the lung. Chest 2003, 123: 339S-45S. PMID: 12628967.
  • Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways.Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR, Elias JA. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. The Journal Of Biological Chemistry 2002, 277: 35466-74. PMID: 12107190, DOI: 10.1074/jbc.M206395200.
  • Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure.Homer RJ, Zheng T, Chupp G, He S, Zhu Z, Chen Q, Ma B, Hite RD, Gobran LI, Rooney SA, Elias JA. Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2002, 283: L52-9. PMID: 12060560, DOI: 10.1152/ajplung.00438.2001.
  • IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling.Zhu Z, Ma B, Zheng T, Homer RJ, Lee CG, Charo IF, Noble P, Elias JA. IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 168: 2953-62. PMID: 11884467, DOI: 10.4049/jimmunol.168.6.2953.
  • Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9.Whittaker L, Niu N, Temann UA, Stoddard A, Flavell RA, Ray A, Homer RJ, Cohn L. Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. American Journal Of Respiratory Cell And Molecular Biology 2002, 27: 593-602. PMID: 12397019, DOI: 10.1165/rcmb.4838.
  • Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling.Zhu Z, Zheng T, Lee CG, Homer RJ, Elias JA. Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Seminars In Cell & Developmental Biology 2002, 13: 121-8. PMID: 12127145, DOI: 10.1016/s1084-9521(02)00018-6.
  • Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling.Lanone S, Zheng T, Zhu Z, Liu W, Lee CG, Ma B, Chen Q, Homer RJ, Wang J, Rabach LA, Rabach ME, Shipley JM, Shapiro SD, Senior RM, Elias JA. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. The Journal Of Clinical Investigation 2002, 110: 463-74. PMID: 12189240, PMCID: PMC150413, DOI: 10.1172/JCI14136.
  • Cytokine regulation of mucus production in a model of allergic asthma.Cohn L, Whittaker L, Niu N, Homer RJ. Cytokine regulation of mucus production in a model of allergic asthma. Novartis Foundation Symposium 2002, 248: 201-13; discussion 213-20, 277-82. PMID: 12568496.
  • IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation.Cohn L, Herrick C, Niu N, Homer R, Bottomly K. IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 166: 2760-7. PMID: 11160342, DOI: 10.4049/jimmunol.166.4.2760.
  • Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice.Zhu Z, Ma B, Homer RJ, Zheng T, Elias JA. Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. The Journal Of Biological Chemistry 2001, 276: 25222-9. PMID: 11331286, DOI: 10.1074/jbc.M101512200.
  • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, Senior RM, Elias JA. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). The Journal Of Experimental Medicine 2001, 194: 809-21. PMID: 11560996, PMCID: PMC2195954, DOI: 10.1084/jem.194.6.809.
  • IL-11: insights in asthma from overexpression transgenic modeling.Zheng T, Zhu Z, Wang J, Homer RJ, Elias JA. IL-11: insights in asthma from overexpression transgenic modeling. The Journal Of Allergy And Clinical Immunology 2001, 108: 489-96. PMID: 11590369, DOI: 10.1067/mai.2001.118510.
  • Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice.Zhu Z, Lee CG, Zheng T, Chupp G, Wang J, Homer RJ, Noble PW, Hamid Q, Elias JA. Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice. American Journal Of Respiratory And Critical Care Medicine 2001, 164: S67-70. PMID: 11734470, DOI: 10.1164/ajrccm.164.supplement_2.2106070.
  • IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury.Corne J, Chupp G, Lee CG, Homer RJ, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman AB, Elias JA. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. The Journal Of Clinical Investigation 2000, 106: 783-91. PMID: 10995789, PMCID: PMC381393, DOI: 10.1172/JCI9674.
  • IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production.Wang J, Homer RJ, Hong L, Cohn L, Lee CG, Jung S, Elias JA. IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 165: 2222-31. PMID: 10925310, DOI: 10.4049/jimmunol.165.4.2222.
  • Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung.Kuhn C, Homer RJ, Zhu Z, Ward N, Flavell RA, Geba GP, Elias JA. Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung. American Journal Of Respiratory Cell And Molecular Biology 2000, 22: 289-95. PMID: 10696065, DOI: 10.1165/ajrcmb.22.3.3690.
  • Interleukin-6-induced protection in hyperoxic acute lung injury.Ward NS, Waxman AB, Homer RJ, Mantell LL, Einarsson O, Du Y, Elias JA. Interleukin-6-induced protection in hyperoxic acute lung injury. American Journal Of Respiratory Cell And Molecular Biology 2000, 22: 535-42. PMID: 10783124, DOI: 10.1165/ajrcmb.22.5.3808.
  • Morphometry explains variation in airway responsiveness in transgenic mice overexpressing interleukin-6 and interleukin-11 in the lung.Kuhn C, Homer RJ, Zhu Z, Ward N, Elias JA. Morphometry explains variation in airway responsiveness in transgenic mice overexpressing interleukin-6 and interleukin-11 in the lung. Chest 2000, 117: 260S-2S. PMID: 10843940.
  • Clinicians are from Mars and pathologists are from Venus.Powsner SM, Costa J, Homer RJ. Clinicians are from Mars and pathologists are from Venus. Archives Of Pathology & Laboratory Medicine 2000, 124: 1040-6. PMID: 10888781, DOI: 10.1043/0003-9985(2000)124<1040:CAFMAP>2.0.CO;2.
  • Consequences of long-term inflammation. Airway remodeling.Homer RJ, Elias JA. Consequences of long-term inflammation. Airway remodeling. Clinics In Chest Medicine 2000, 21: 331-43, ix. PMID: 10907592, DOI: 10.1016/s0272-5231(05)70270-7.
  • Evidence for the neoplastic transformation of Von-Meyenburg complexes.Jain D, Sarode VR, Abdul-Karim FW, Homer R, Robert ME. Evidence for the neoplastic transformation of Von-Meyenburg complexes. The American Journal Of Surgical Pathology 2000, 24: 1131-9. PMID: 10935654, DOI: 10.1097/00000478-200008000-00011.
  • Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation.Wang J, Homer RJ, Chen Q, Elias JA. Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 165: 4051-61. PMID: 11034416, DOI: 10.4049/jimmunol.165.7.4051.
  • Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema.Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, Riese RJ, Chapman HA, Shapiro SD, Elias JA. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. The Journal Of Clinical Investigation 2000, 106: 1081-93. PMID: 11067861, PMCID: PMC301418, DOI: 10.1172/JCI10458.
  • Interferon gamma induction of pulmonary emphysema in the adult murine lung.Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA, Shapiro SD, Elias JA. Interferon gamma induction of pulmonary emphysema in the adult murine lung. The Journal Of Experimental Medicine 2000, 192: 1587-600. PMID: 11104801, PMCID: PMC2193095, DOI: 10.1084/jem.192.11.1587.
  • Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F, Bottomly K. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. Journal Of Immunology (Baltimore, Md. : 1950) 1999, 162: 6178-83. PMID: 10229862.
  • Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.Zhang DH, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity 1999, 11: 473-82. PMID: 10549629.
  • T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production.Cohn L, Homer RJ, Niu N, Bottomly K. T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. The Journal Of Experimental Medicine 1999, 190: 1309-18. PMID: 10544202, PMCID: PMC2195688, DOI: 10.1084/jem.190.9.1309.
  • Airway remodeling in asthma.Elias JA, Zhu Z, Chupp G, Homer RJ. Airway remodeling in asthma. The Journal Of Clinical Investigation 1999, 104: 1001-6. PMID: 10525034, PMCID: PMC408860, DOI: 10.1172/JCI8124.
  • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. The Journal Of Clinical Investigation 1999, 103: 779-88. PMID: 10079098, PMCID: PMC408149, DOI: 10.1172/JCI5909.
  • Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.Waxman AB, Einarsson O, Seres T, Knickelbein RG, Homer R, Warshaw JB, Johnston R, Elias JA. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. Chest 1999, 116: 8S-9S. PMID: 10424559, DOI: 10.1378/chest.116.suppl_1.8s.
  • Role of tissue factor in metastasis: functions of the cytoplasmic and extracellular domains of the molecule.Bromberg ME, Sundaram R, Homer RJ, Garen A, Konigsberg WH. Role of tissue factor in metastasis: functions of the cytoplasmic and extracellular domains of the molecule. Thrombosis And Haemostasis 1999, 82: 88-92. PMID: 10456459.
  • Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation.Yang L, Cohn L, Zhang DH, Homer R, Ray A, Ray P. Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation. The Journal Of Experimental Medicine 1998, 188: 1739-50. PMID: 9802985, PMCID: PMC2212522, DOI: 10.1084/jem.188.9.1739.
  • Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.Waxman AB, Einarsson O, Seres T, Knickelbein RG, Warshaw JB, Johnston R, Homer RJ, Elias JA. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. The Journal Of Clinical Investigation 1998, 101: 1970-82. PMID: 9576762, PMCID: PMC508784, DOI: 10.1172/JCI1337.
  • Duodenal hemangioendothelioma: a case report.Panzini L, Homer RJ. Duodenal hemangioendothelioma: a case report. The American Journal Of Gastroenterology 1998, 93: 832-3. PMID: 9625139, DOI: 10.1111/j.1572-0241.1998.236_a.x.
  • Antineutrophil cytoplasmic antibodies as markers for systemic autoimmune disease.Homer RJ. Antineutrophil cytoplasmic antibodies as markers for systemic autoimmune disease. Clinics In Chest Medicine 1998, 19: 627-39, viii. PMID: 9917957, DOI: 10.1016/s0272-5231(05)70107-6.
  • Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production.Cohn L, Homer RJ, Marinov A, Rankin J, Bottomly K. Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. The Journal Of Experimental Medicine 1997, 186: 1737-47. PMID: 9362533, PMCID: PMC2199146, DOI: 10.1084/jem.186.10.1737.
  • Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.Ray P, Tang W, Wang P, Homer R, Kuhn C, Flavell RA, Elias JA. Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. The Journal Of Clinical Investigation 1997, 100: 2501-11. PMID: 9366564, PMCID: PMC508450, DOI: 10.1172/JCI119792.
  • Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate.Redlich CA, Karol MH, Graham C, Homer RJ, Holm CT, Wirth JA, Cullen MR. Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate. Scandinavian Journal Of Work, Environment & Health 1997, 23: 227-31. PMID: 9243734, DOI: 10.5271/sjweh.203.
  • Eosinophilic pneumonia as a presentation of occult chronic granulomatous disease.Trawick D, Kotch A, Matthay R, Homer RJ. Eosinophilic pneumonia as a presentation of occult chronic granulomatous disease. The European Respiratory Journal 1997, 10: 2166-70. PMID: 9311521, DOI: 10.1183/09031936.97.10092166.
  • Immunologic responses to isocyanates in sensitized asthmatic subjects.Redlich CA, Homer RJ, Smith BR, Wirth JA, Cullen MR. Immunologic responses to isocyanates in sensitized asthmatic subjects. Chest 1996, 109: 6S-8S. PMID: 8598159.
  • Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.Tang W, Geba GP, Zheng T, Ray P, Homer RJ, Kuhn C, Flavell RA, Elias JA. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. The Journal Of Clinical Investigation 1996, 98: 2845-53. PMID: 8981933, PMCID: PMC507752, DOI: 10.1172/JCI119113.
  • Diffuse panbronchiolitis in a Hispanic man with travel history to Japan.Homer RJ, Khoo L, Smith GJ. Diffuse panbronchiolitis in a Hispanic man with travel history to Japan. Chest 1995, 107: 1176-8. PMID: 7705137, DOI: 10.1378/chest.107.4.1176.
  • Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model.Azrin MA, Ling FS, Chen Q, Pawashe A, Migliaccio F, Homer R, Todd M, Ezekowitz MD. Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model. Circulation Research 1994, 75: 268-77. PMID: 8033340.
  • Hubert Humphrey's bladder cancer.Homer RJ. Hubert Humphrey's bladder cancer. The New England Journal Of Medicine 1994, 331: 880; author reply 880-1. PMID: 8078544.
  • T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model.Homer RJ, Mamalaki C, Kioussis D, Flavell RA. T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model. International Immunology 1993, 5: 1495-500. PMID: 7906139, DOI: 10.1093/intimm/5.12.1495.
  • The role of lymphotoxin in inflammation.Ruddle NH, Homer R. The role of lymphotoxin in inflammation. Progress In Allergy 1988, 40: 162-82. PMID: 3281169.
  • Qc-1, a novel Q-region-controlled CTL determinant expressed on B lymphocytes.Homer RJ, Murphy DB. Qc-1, a novel Q-region-controlled CTL determinant expressed on B lymphocytes. Journal Of Immunology (Baltimore, Md. : 1950) 1987, 138: 4322-8. PMID: 2438340.
  • Genetic, serological and functional analysis of I-J molecules.Murphy DB, Horowitz MC, Homer RJ, Flood PM. Genetic, serological and functional analysis of I-J molecules. Immunological Reviews 1985, 83: 79-103. PMID: 3160653, DOI: 10.1111/j.1600-065x.1985.tb00471.x.
  • Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis.Jiang R, Hoehn KB, Lee CS, Pham MC, Homer RJ, Detterbeck FC, Aban I, Jacobson L, Vincent A, Nowak RJ, Kaminski HJ, Kleinstein SH, O'Connor KC. Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 30649-30660. PMID: 33199596, PMCID: PMC7720237, DOI: 10.1073/pnas.2007206117.
  • Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis.Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis. The Journal Of Clinical Investigation 2021, 131 PMID: 33393489, PMCID: PMC7773383, DOI: 10.1172/JCI136542.
  • Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo.Foggetti G, Li C, Cai H, Hellyer JA, Lin WY, Ayeni D, Hastings K, Choi J, Wurtz A, Andrejka L, Maghini DG, Rashleigh N, Levy S, Homer R, Gettinger SN, Diehn M, Wakelee HA, Petrov DA, Winslow MM, Politi K. Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo. Cancer Discovery 2021, 11: 1736-1753. PMID: 33707235, PMCID: PMC8530463, DOI: 10.1158/2159-8290.CD-20-1385.
  • Effectiveness of Thermal Ablation and Stereotactic Radiotherapy Based on Stage I Lung Cancer Histology.Uhlig J, Mehta S, Case MD, Dhanasopon A, Blasberg J, Homer RJ, Solomon SB, Kim HS. Effectiveness of Thermal Ablation and Stereotactic Radiotherapy Based on Stage I Lung Cancer Histology. Journal Of Vascular And Interventional Radiology : JVIR 2021, 32: 1022-1028.e4. PMID: 33811997, DOI: 10.1016/j.jvir.2021.02.025.
  • Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung.Schupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation 2021, 144: 286-302. PMID: 34030460, PMCID: PMC8300155, DOI: 10.1161/CIRCULATIONAHA.120.052318.
  • Reliability of histopathologic diagnosis of fibrotic interstitial lung disease: an international collaborative standardization project.Camp R, Smith ML, Larsen BT, Roden AC, Farver C, Moreira AL, Attanoos R, Pillappa R, Sansano I, Fabro AT, Homer RJ. Reliability of histopathologic diagnosis of fibrotic interstitial lung disease: an international collaborative standardization project. BMC Pulmonary Medicine 2021, 21: 184. PMID: 34074264, PMCID: PMC8170950, DOI: 10.1186/s12890-021-01522-6.
  • Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma.Robles-Oteiza C, Ayeni D, Levy S, Homer RJ, Kaech SM, Politi K. Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma. Disease Models & Mechanisms 2021, 14 PMID: 34494649, PMCID: PMC8617309, DOI: 10.1242/dmm.049072.
  • Case Report: Bullous Lung Disease Following COVID-19.Pednekar P, Amoah K, Homer R, Ryu C, Lutchmansingh DD. Case Report: Bullous Lung Disease Following COVID-19. Frontiers In Medicine 2021, 8: 770778. PMID: 34869488, PMCID: PMC8635639, DOI: 10.3389/fmed.2021.770778.
  • Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses.Mao T, Israelow B, Suberi A, Zhou L, Reschke M, Peña-Hernández MA, Dong H, Homer RJ, Saltzman WM, Iwasaki A. Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses. BioRxiv : The Preprint Server For Biology 2022 PMID: 35118464, PMCID: PMC8811895, DOI: 10.1101/2022.01.24.477597.
  • Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. American Journal Of Respiratory Cell And Molecular Biology 2022, 66: e1-e14. PMID: 35103557, PMCID: PMC8845128, DOI: 10.1165/rcmb.2021-0531ST.
  • Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination.Suberi A, Grun MK, Mao T, Israelow B, Reschke M, Grundler J, Akhtar L, Lee T, Shin K, Piotrowski-Daspit AS, Homer RJ, Iwasaki A, Suh HW, Saltzman WM. Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination. BioRxiv : The Preprint Server For Biology 2022 PMID: 35350207, PMCID: PMC8963702, DOI: 10.1101/2022.03.22.485401.
  • Development of an immunohistochemical assay for Siglec-15.Shafi S, Aung TN, Robbins C, Zugazagoitia J, Vathiotis I, Gavrielatou N, Yaghoobi V, Fernandez A, Niu S, Liu LN, Cusumano ZT, Leelatian N, Cole K, Wang H, Homer R, Herbst RS, Langermann S, Rimm DL. Development of an immunohistochemical assay for Siglec-15. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2022 PMID: 35459795, DOI: 10.1038/s41374-022-00785-9.

Clinical Trials

ConditionsStudy Title
LungDetermining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer
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