Robert Shulman, PhD
Professor Emeritus of Molecular Biophysics and Biochemistry
Research & Publications
Biography
News
Research Summary
In vivo NMR spectroscopy of metabolism and brain function
Nuclear magnetic resonance (NMR) is an important approach to study metabolic pathways in vivo. We have been actively extending NMR techniques and developing new applications in order to understand the basic biochemistry of metabolism in vivo. Equipment at the Magnetic Resonance Research Center (MRRC) includes a 4.0 Tesla spectrometer capable of imaging humans for localized spectroscopic studies, similar spectrometers for animal studies at fields of 7T, 9.4T and 11.74T for studying rats and mice. High resolution NMR spectroscopy is used to follow chemical reactions and brain activity in vivo and NMR imaging methods enable functional areas of brain activity to be resolved. Our goals are to understand quantitatively the regulation and control of metabolic fluxes in humans by in vivo NMR measurements of brain and muscle and to relate such metabolic understanding to normal and pathological functions.
Nuclear magnetic resonance (NMR) is an important approach to study metabolic pathways in vivo. We have been actively extending NMR techniques and developing new applications in order to understand the basic biochemistry of metabolism in vivo. Equipment at the Magnetic Resonance Research Center (MRRC) includes a 4.0 Tesla spectrometer capable of imaging humans for localized spectroscopic studies, similar spectrometers for animal studies at fields of 7T, 9.4T and 11.74T for studying rats and mice. High resolution NMR spectroscopy is used to follow chemical reactions and brain activity in vivo and NMR imaging methods enable functional areas of brain activity to be resolved. Our goals are to understand quantitatively the regulation and control of metabolic fluxes in humans by in vivo NMR measurements of brain and muscle and to relate such metabolic understanding to normal and pathological functions.
Coauthors
Selected Publications
- Baseline brain energy supports the state of consciousnessShulman RG, Hyder F, Rothman DL. Baseline brain energy supports the state of consciousness. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 11096-11101. PMID: 19549837, PMCID: PMC2708743, DOI: 10.1073/pnas.0903941106.
- Neurophysiology of functional imagingvan Eijsden P, Hyder F, Rothman DL, Shulman RG. Neurophysiology of functional imaging. NeuroImage 2008, 45: 1047-1054. PMID: 18801442, PMCID: PMC2677905, DOI: 10.1016/j.neuroimage.2008.08.026.
- Energetics of neuronal signaling and fMRI activityMaandag NJ, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG, Hyder F. Energetics of neuronal signaling and fMRI activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20546-20551. PMID: 18079290, PMCID: PMC2154468, DOI: 10.1073/pnas.0709515104.
- A BOLD search for baselineShulman RG, Rothman DL, Hyder F. A BOLD search for baseline. NeuroImage 2007, 36: 277-281. PMID: 17223362, PMCID: PMC2684871, DOI: 10.1016/j.neuroimage.2006.11.035.
- Neuronal–Glial Glucose Oxidation and Glutamatergic–GABAergic FunctionHyder F, Patel AB, Gjedde A, Rothman DL, Behar KL, Shulman RG. Neuronal–Glial Glucose Oxidation and Glutamatergic–GABAergic Function. Cerebrovascular And Brain Metabolism Reviews 2006, 26: 865-877. PMID: 16407855, DOI: 10.1038/sj.jcbfm.9600263.