Mohammad-Reza Ghovanloo, PhD

• Stephen Waxman
• Sulayman Dib-Hajj

Biophysics; Electrophysiology; Ion Channels; Neurosciences; Pharmacology

• Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes.Fouda MA, Ghovanloo MR, Ruben PC. Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes. The Journal Of Physiology 2022 PMID: 35436004, DOI: 10.1113/JP282768.
• Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability.Ghovanloo MR, Estacion M, Higerd-Rusli GP, Zhao P, Dib-Hajj S, Waxman SG. Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability. British Journal Of Pharmacology 2022 PMID: 35297036, DOI: 10.1111/bph.15833.
• Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications.Ghovanloo MR, Ruben PC. Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications. The Neuroscientist : A Review Journal Bringing Neurobiology, Neurology And Psychiatry 2021, 10738584211017009. PMID: 34027742, DOI: 10.1177/10738584211017009.
• Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.Ghovanloo MR, Choudhury K, Bandaru TS, Fouda MA, Rayani K, Rusinova R, Phaterpekar T, Nelkenbrecher K, Watkins AR, Poburko D, Thewalt J, Andersen OS, Delemotte L, Goodchild SJ, Ruben PC. Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity. The Journal Of General Physiology 2021, 153 PMID: 33836525, DOI: 10.1085/jgp.202012701.
• Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death.Ghovanloo MR, Atallah J, Escudero CA, Ruben PC. Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death. Frontiers In Physiology 2020, 11: 610436. PMID: 33414724, PMCID: PMC7783455, DOI: 10.3389/fphys.2020.610436.
• Cannabidiol interactions with voltage-gated sodium channels.Sait LG, Sula A, Ghovanloo MR, Hollingworth D, Ruben PC, Wallace BA. Cannabidiol interactions with voltage-gated sodium channels. ELife 2020, 9 PMID: 33089780, PMCID: PMC7641581, DOI: 10.7554/eLife.58593.
• Say Cheese: Structure of the Cardiac Electrical Engine Is Captured.Ghovanloo MR, Ruben PC. Say Cheese: Structure of the Cardiac Electrical Engine Is Captured. Trends In Biochemical Sciences 2020, 45: 369-371. PMID: 32311330, DOI: 10.1016/j.tibs.2020.02.003.
• Cannabidiol protects against high glucose-induced oxidative stress and cytotoxicity in cardiac voltage-gated sodium channels.Fouda MA, Ghovanloo MR, Ruben PC. Cannabidiol protects against high glucose-induced oxidative stress and cytotoxicity in cardiac voltage-gated sodium channels. British Journal Of Pharmacology 2020, 177: 2932-2946. PMID: 32077098, PMCID: PMC7279989, DOI: 10.1111/bph.15020.
• Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3.Ghovanloo MR, Peters CH, Ruben PC. Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3. Channels (Austin, Tex.) 2018, 12: 367-377. PMID: 30362397, PMCID: PMC6284583, DOI: 10.1080/19336950.2018.1539611.
• Inhibitory effects of cannabidiol on voltage-dependent sodium currents.Ghovanloo MR, Shuart NG, Mezeyova J, Dean RA, Ruben PC, Goodchild SJ. Inhibitory effects of cannabidiol on voltage-dependent sodium currents. The Journal Of Biological Chemistry 2018, 293: 16546-16558. PMID: 30219789, PMCID: PMC6204917, DOI: 10.1074/jbc.RA118.004929.
• A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels.Ghovanloo MR, Abdelsayed M, Peters CH, Ruben PC. A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels. Scientific Reports 2018, 8: 6304. PMID: 29674667, PMCID: PMC5908869, DOI: 10.1038/s41598-018-24719-y.
• pH Modulation of Voltage-Gated Sodium Channels.Peters CH, Ghovanloo MR, Gershome C, Ruben PC. pH Modulation of Voltage-Gated Sodium Channels. Handbook Of Experimental Pharmacology 2018, 246: 147-160. PMID: 29460150, DOI: 10.1007/164_2018_99.
• Physiology and Pathophysiology of Sodium Channel Inactivation.Ghovanloo MR, Aimar K, Ghadiry-Tavi R, Yu A, Ruben PC. Physiology and Pathophysiology of Sodium Channel Inactivation. Current Topics In Membranes 2016, 78: 479-509. PMID: 27586293, DOI: 10.1016/bs.ctm.2016.04.001.
• Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels.Ghovanloo MR, Abdelsayed M, Ruben PC. Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels. Frontiers In Pharmacology 2016, 7: 39. PMID: 26973526, PMCID: PMC4771766, DOI: 10.3389/fphar.2016.00039.