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Renato Polimanti, PhD, MSc

Assistant Professor of Psychiatry

Research Summary

My primary research focus is to investigate the predisposition to psychiatric disorders, behavioral traits, and other complex traits using genomic data. The ongoing studies are funded by the National Institute on Drug Abuse, the National Institute on Deafness and Other Communication Disorder, the Department of Veterans Affairs, and the Amyloidosis Foundation.

Extensive Research Description

My research group is developing analytic approaches to investigate the polygenicity and pleiotropy of human traits and diseases using large-scale genome-wide datasets and multi-omics information. We apply a range of methods, such as polygenic risk scoring, causal inference analyses, structural equation modeling, to dissect the molecular basis of complex traits and to understand how genetic information can be used to improve the healthcare of diverse populations.

Investigating the systems genetics of the patterns of polysubstance abuse and addiction. The aim of this project is to conduct a genome-wide analysis of polysubstance use patterns and investigate the results with respect to longitudinal data and epigenetic information.

Genome-wide Investigation of the Interplay Between Age-Related Hearing Loss and Smoking Behaviors. The aim of this project is to conduct a genome-wide analysis to understand the mechanisms by which smoking is associated with hearing loss.

Genomics of Gulf War illness (GWI) in veterans. The primary objective is to identify genetic variants associated with GWI, also understanding their interplay with Gulf War environmental exposures associated with the risk of developing GWI.

Dissecting the Role of the Genetically-Determined TTR Transcriptomic Profile across Human Tissues on Physical and Mental Outcomes Related to Systemic Senile Amyloidosis. The aim of this project is investigate how genetic non-coding variants regulates the expression of TTR gene, affecting susceptibility to systemic senile amyloidosis.


Research Interests

Biological Psychiatry; Genetics; Genetics, Behavioral; Genetics, Medical; Genetics, Population; Genetic Predisposition to Disease; Genetic Research; Genome-Wide Association Study; Mendelian Randomization Analysis; Gene-Environment Interaction

Public Health Interests

Genetics, Genomics, Epigenetics

Research Images

Selected Publications