Praveen Suthaharan
Research Assistant 1 HSSAbout
Research
Publications
2024
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerception
2023
Relationships between cognitive biases, decision-making, and delusions
Sheffield J, Smith R, Suthaharan P, Leptourgos P, Corlett P. Relationships between cognitive biases, decision-making, and delusions. Scientific Reports 2023, 13: 9485. PMID: 37301915, PMCID: PMC10257713, DOI: 10.1038/s41598-023-36526-1.Peer-Reviewed Original ResearchConceptsDelusional ideationDelusional thinkingCognitive biasesDistinct cognitive processesSelf-reported dataCognitive processesProbabilistic reversalUnique varianceComputational mechanismsEvidence integrationPsychosis spectrumMultiple measuresProportion of varianceParanoiaRandom explorationIdeationThinkingTaskBiasesMeasuresVarianceDelusionsJTCIndependent studiesRelationshipAssumed shared belief about conspiracy theories in social networks protects paranoid individuals against distress
Suthaharan P, Corlett P. Assumed shared belief about conspiracy theories in social networks protects paranoid individuals against distress. Scientific Reports 2023, 13: 6084. PMID: 37055504, PMCID: PMC10100615, DOI: 10.1038/s41598-023-33305-w.Peer-Reviewed Original ResearchConceptsConspiratorial beliefsConspiracy theoriesLess emotional distressIndividual-level processesParanoid individualsClinical paranoiaParanoid beliefsPsychological studiesConspiracy beliefsEmotional distressPersecutory delusionsBehavioral predictorsSocial supportBelief formationSocial accountsSocial networksOrganizational factorsParanoiaBroader social networksBeliefsLarge social networksSocietal normsDistressTaskLevel processes
2022
Belief Updating and Paranoia in Individuals With Schizophrenia
Sheffield JM, Suthaharan P, Leptourgos P, Corlett PR. Belief Updating and Paranoia in Individuals With Schizophrenia. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 1149-1157. PMID: 35430406, PMCID: PMC9827723, DOI: 10.1016/j.bpsc.2022.03.013.Peer-Reviewed Original ResearchConceptsBelief updatingThought contentPersecutory delusionsUnusual thought contentHierarchical Gaussian FilterMeasures of anxietyPrior beliefsSignificant indirect effectHealthy control participantsCognitive mechanismsProbabilistic reversalPersecutory beliefsParanoia continuumWorry QuestionnaireNegative Syndrome ScaleControl participantsParanoiaModel implicatingIndirect effectsSymptom Rating ScaleSyndrome ScaleWorryBeliefsSchizophreniaSignificant worryRelating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy
Leptourgos P, Bansal S, Dutterer J, Culbreth A, Powers A, Suthaharan P, Kenney J, Erickson M, Waltz J, Wijtenburg SA, Gaston F, Rowland LM, Gold J, Corlett P. Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy. Schizophrenia Bulletin 2022, 48: 912-920. PMID: 35199836, PMCID: PMC9212089, DOI: 10.1093/schbul/sbac006.Peer-Reviewed Original ResearchConceptsGlutamate levelsAnterior insulaPrior beliefsCognitive modelPathophysiological theoriesAuditory cortexClinical hallucinationsAnterior cingulateComputational psychiatryNew treatmentsDorsolateral prefrontalVisual cuesPrior expectationsSame participantsHallucinationsInsulaNegative relationshipCurrent experienceMagnetic resonance spectroscopyBeliefsComputational modelingTone
2021
Paranoia and belief updating during the COVID-19 crisis
Suthaharan P, Reed EJ, Leptourgos P, Kenney JG, Uddenberg S, Mathys CD, Litman L, Robinson J, Moss AJ, Taylor JR, Groman SM, Corlett PR. Paranoia and belief updating during the COVID-19 crisis. Nature Human Behaviour 2021, 5: 1190-1202. PMID: 34316049, PMCID: PMC8458246, DOI: 10.1038/s41562-021-01176-8.Peer-Reviewed Original ResearchComputational modeling of behavioral tasks: An illustration on a classic reinforcement learning paradigm
Suthaharan P, Corlett P, Ang Y. Computational modeling of behavioral tasks: An illustration on a classic reinforcement learning paradigm. The Quantitative Methods For Psychology 2021, 17: 105-140. DOI: 10.20982/tqmp.17.2.p105.Peer-Reviewed Original Research
2020
Paranoia as a deficit in non-social belief updating
Reed EJ, Uddenberg S, Suthaharan P, Mathys C, Taylor JR, Groman SM, Corlett PR. Paranoia as a deficit in non-social belief updating. ELife 2020, 9: e56345. PMID: 32452769, PMCID: PMC7326495, DOI: 10.7554/elife.56345.Peer-Reviewed Original ResearchConceptsParanoid individualsSocial threatLearning differencesTask environmentLearning behaviorOnline participantsMethamphetamine exposureParanoiaBeliefsVolatile environmentMental illnessComputational modelingIndividualsElevated sensitivityDeficitsAnticipationParticipantsParadigmThreatMethamphetamineDifferencesFurther assessmentBehaviorHarm
2015
Evolution of Cooperation in Mobile Populations
Suarez D, Suthaharan P, Rowell J, Rychtar J. Evolution of Cooperation in Mobile Populations. Spora A Journal Of Biomathematics 2015, 1 DOI: 10.30707/spora1.1suarez.Peer-Reviewed Original Research