Petr Protiva, MD, MPH
Research & Publications
Biography
Research Summary
Major goal of our research is to identify molecular pathways that modulate the risk of colon cancer.
Extensive Research Description
Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM)
This is a VA Multisite Study. The purpose of this study is to compare two types of colon cancer screening tests and determine which is more effective in preventing death from colon and rectal cancer. These tests have not been compared in a large study and it is not clear which test is more effective Role: Site Principal Investigator/Local Site Investigator
Effect of Dietary Folate Supplementation and Depletion on Human Colonic Mucosa
Adequate folate status is important for optimal one carbon metabolic processes including the synthesis and methylation of DNA and genomic stability. This may impact the risk of cancer. The purpose of this study was to examine the effect of folate depletion-repletion and supplementation on gene expression and genomic stability in human colorectal mucosa. Multiple additional biomarkers were measured.
Inadequate calcium and vitamin D levels/intake are implicated in colorectal carcinogenesis. The purpose of this study was to examine the effect of Western style diet +/- calcium and/or vitamin D on gene expression in human colorectal mucosa.
Coauthors
Research Interests
Colorectal Neoplasms; Molecular Epidemiology; Endpoint Determination; Nontherapeutic Human Experimentation; Therapeutic Human Experimentation
Public Health Interests
Biomarkers; Cancer; Clinical Trials; Genetics, Genomics, Epigenetics; Nutrition
Selected Publications
- Dietary methyl donor depletion protects against intestinal tumorigenesis in Apc(Min/+) mice.Kadaveru K, Protiva P, Greenspan EJ, Kim YI, Rosenberg DW. Dietary methyl donor depletion protects against intestinal tumorigenesis in Apc(Min/+) mice. Cancer Prevention Research (Philadelphia, Pa.) 2012, 5:911-20.
- Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy.Anderson JC, Swede H, Rustagi T, Protiva P, Pleau D, Brenner BM, Rajan TV, Heinen CD, Levine JB, Rosenberg DW. Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes & Control : CCC 2012, 23:355-61.
- Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury.Davern TJ, Chalasani N, Fontana RJ, Hayashi PH, Protiva P, Kleiner DE, Engle RE, Nguyen H, Emerson SU, Purcell RH, Tillmann HL, Gu J, Serrano J, Hoofnagle JH. Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury. Gastroenterology 2011, 141:1665-72.e1-9.
- Risk factors for sessile serrated adenomas.Anderson JC, Rangasamy P, Rustagi T, Myers M, Sanders M, Vaziri H, Wu G, Birk JW, Protiva P. Risk factors for sessile serrated adenomas. Journal Of Clinical Gastroenterology 2011, 45:694-9.
- Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis.Protiva P, Mason JB, Liu Z, Hopkins ME, Nelson C, Marshall JR, Lambrecht RW, Pendyala S, Kopelovich L, Kim M, Kleinstein SH, Laird PW, Lipkin M, Holt PR. Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis. Cancer Prevention Research (Philadelphia, Pa.) 2011, 4:530-43.
- Chemoprevention of colorectal neoplasia by estrogen: potential role of vitamin D activity.Protiva P, Cross HS, Hopkins ME, Kállay E, Bises G, Dreyhaupt E, Augenlicht L, Lipkin M, Lesser M, Livote E, Holt PR. Chemoprevention of colorectal neoplasia by estrogen: potential role of vitamin D activity. Cancer Prevention Research (Philadelphia, Pa.) 2009, 2:43-51.
- Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug-induced liver injury.Rochon J, Protiva P, Seeff LB, Fontana RJ, Liangpunsakul S, Watkins PB, Davern T, McHutchison JG. Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug-induced liver injury. Hepatology (Baltimore, Md.) 2008, 48:1175-83.
- Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response.Protiva P, Hopkins ME, Baggett S, Yang H, Lipkin M, Holt PR, Kennelly EJ, Bernard WI. Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response. International Journal Of Cancer. Journal International Du Cancer 2008, 123:687-94.
- Alcohol regulates gene expression in neurons via activation of heat shock factor 1.Pignataro L, Miller AN, Ma L, Midha S, Protiva P, Herrera DG, Harrison NL. Alcohol regulates gene expression in neurons via activation of heat shock factor 1. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2007, 27:12957-66.
- Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men.Clark BT, Protiva P, Nagar A, Imaeda A, Ciarleglio MM, Deng Y, Laine L. Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men. Gastroenterology 2016, 150:396-405; quiz e14-5.
- Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver.Protiva P, Gong J, Sreekumar B, Torres R, Zhang X, Belinsky GS, Cornwell M, Crawford SE, Iwakiri Y, Chung C. Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver. Cellular And Molecular Gastroenterology And Hepatology 2015, 1:535-549.e14.
- Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial.Protiva P, Pendyala S, Nelson C, Augenlicht LH, Lipkin M, Holt PR. Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial. The American Journal Of Clinical Nutrition 2016, 103:1224-31.